| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Charles Duyckaerts, Claire Perruchini, Thibaud Lebouvier, Marie-Claude Potie. [The lesions of Alzheimer's disease: which therapeutic perspectives?]. Bulletin de l'Academie nationale de medecine. vol 192. issue 2. 2008-11-14. PMID:18819685. |
the abeta deposits first involve the neocortex, while the tau pathology is initially found in the hippocampal region. |
2008-11-14 |
2023-08-12 |
mouse |
| Charles Duyckaerts, Claire Perruchini, Thibaud Lebouvier, Marie-Claude Potie. [The lesions of Alzheimer's disease: which therapeutic perspectives?]. Bulletin de l'Academie nationale de medecine. vol 192. issue 2. 2008-11-14. PMID:18819685. |
abeta deposits first occur in the neocortex, while intracellular tau accumulation mainly affect the hippocampal region. |
2008-11-14 |
2023-08-12 |
mouse |
| Rebecca F Rosen, Aaron S Farberg, Marla Gearing, Jeromy Dooyema, Patrick M Long, Daniel C Anderson, Jeremy Davis-Turak, Giovanni Coppola, Daniel H Geschwind, Jean-Francois Paré, Timothy Q Duong, William D Hopkins, Todd M Preuss, Lary C Walke. Tauopathy with paired helical filaments in an aged chimpanzee. The Journal of comparative neurology. vol 509. issue 3. 2008-07-15. PMID:18481275. |
pathologic forms of tau in neuronal somata, neuropil threads, and plaque-like clusters of neurites were histologically identified throughout the neocortex and, to a lesser degree, in allocortical and subcortical structures. |
2008-07-15 |
2023-08-12 |
human |
| Cyntia Tremblay, Mireille Pilote, Alix Phivilay, Vincent Emond, David A Bennett, Frédéric Calo. Biochemical characterization of Abeta and tau pathologies in mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 12. issue 4. 2008-03-25. PMID:18198424. |
we report a post mortem biochemical analysis of amyloid-beta (abeta) (elisa) and tau (western immunoblots) in the temporo-parietal neocortex of subjects with a clinical diagnosis of mild cognitive impairment (mci, n=12), alzheimer's disease (ad, n=12) or no cognitive impairment (nci, n=12). |
2008-03-25 |
2023-08-12 |
human |
| Alphonse Probst, Kirsten I Taylor, Markus Tolna. Hippocampal sclerosis dementia: a reappraisal. Acta neuropathologica. vol 114. issue 4. 2007-12-26. PMID:17639426. |
the most striking finding besides the tau pathology was the presence of concomitant neuronal cytoplasmic inclusions and neurites immunoreactive for the transactive response dna-binding protein-43 (tdp-43) in the dentate gyrus and temporal neocortex, similar to those found in ftld-u. |
2007-12-26 |
2023-08-12 |
Not clear |
| Arianna Bellucci, Maria Cristina Rosi, Cristina Grossi, Anna Fiorentini, Ilaria Luccarini, Fiorella Casament. Abnormal processing of tau in the brain of aged TgCRND8 mice. Neurobiology of disease. vol 27. issue 3. 2007-10-31. PMID:17656099. |
in the neocortex and hippocampus of aged tgcrnd8 mice, tau is hyperphosphorylated at different sites recognized by phf-1, at100, at8 and cp13 antibodies. |
2007-10-31 |
2023-08-12 |
mouse |
| Matthew J Winton, Sonali Joyce, Victoria Zhukareva, Domenico Practico, Daniel P Perl, Douglas Galasko, Ula Craig, John Q Trojanowski, Virginia M-Y Le. Characterization of tau pathologies in gray and white matter of Guam parkinsonism-dementia complex. Acta neuropathologica. vol 111. issue 5. 2007-01-09. PMID:16609851. |
using phosphorylation dependent anti-tau antibodies, abundant tau inclusions were detected by immunohistochemistry in both neuronal and glial cells of the neocortex, while less alpha-synuclein pathology was observed in more limited brain regions. |
2007-01-09 |
2023-08-12 |
human |
| Ian R Mackenzie, Stefanie L Butland, Rebecca S Devon, Emily Dwosh, Howard Feldman, Caroline Lindholm, Scott J Neal, B F Francis Ouellette, Blair R Leavit. Familial frontotemporal dementia with neuronal intranuclear inclusions is not a polyglutamine expansion disease. BMC neurology. vol 6. 2006-11-20. PMID:16945149. |
most of the remaining familial cases do not exhibit tau pathology, but display neuropathology similar to patients with dementia and motor neuron disease, characterized by the presence of ubiquitin-immunoreactive (ub-ir), dystrophic neurites and neuronal cytoplasmic inclusions in the neocortex and hippocampus (ftld-u). |
2006-11-20 |
2023-08-12 |
Not clear |
| Wolfgang Härtig, Jörg Lehmann, Jens Stieler, David Singer, Jens Grosche, Thomas Arendt, Ralf Hoffman. Simultaneous detection of tau phospho-epitopes with haptenylated antibodies. Neuroreport. vol 17. issue 9. 2006-09-05. PMID:16738478. |
at8-immunolabelling of phospho-serine 202 and phospho-threonine 205 combined with hpt-1 and hpt-101-staining revealed similar distribution patterns of the three double-phosphorylated tau epitopes in the neocortex of patients with alzheimer's disease. |
2006-09-05 |
2023-08-12 |
Not clear |
| Klaus Heese, Hiroyasu Akats. Alzheimer's disease--an interactive perspective. Current Alzheimer research. vol 3. issue 2. 2006-07-28. PMID:16611011. |
the brain of an individual with ad exhibits extracellular senile plaques of aggregated amyloid-beta-peptide (abeta), intracellular neurofibrillary tangles (nfts) that consist of hyperphosphorylated tau protein (p-tau) and a profound loss of basal forebrain cholinergic neurons that innervate the hippocampus and the neocortex. |
2006-07-28 |
2023-08-12 |
Not clear |
| Isidro Ferrer, Marta Barrachina, Berta Puig, M Martínez de Lagrán, Eulalia Martí, Jesús Avila, Mara Diersse. Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models. Neurobiology of disease. vol 20. issue 2. 2006-01-23. PMID:16242644. |
transgenic mice bearing a triple tau mutation (g272v, p301l, and r406w) and expressing hyper-phosphoyrylated tau in neurons of the entorhinal cortex, hippocampus, and cerebral neocortex show increased expression of dyrk1a in individual neurons in the same regions. |
2006-01-23 |
2023-08-12 |
mouse |
| Satyabrata Kar, Stephen P M Slowikowski, David Westaway, Howard T J Moun. Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease. Journal of psychiatry & neuroscience : JPN. vol 29. issue 6. 2005-02-23. PMID:15644984. |
the brain of an individual with alzheimer's disease exhibits extracellular plaques of aggregated beta-amyloid protein (abeta), intracellular neurofibrillary tangles that contain hyperphosphorylated tau protein and a profound loss of basal forebrain cholinergic neurons that innervate the hippocampus and the neocortex. |
2005-02-23 |
2023-08-12 |
Not clear |
| Gary W Arendash, Jada Lewis, Ralph E Leighty, Eileen McGowan, Jennifer R Cracchiolo, Mike Hutton, Marcos F Garci. Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain. Brain research. vol 1012. issue 1-2. 2004-08-17. PMID:15158158. |
moreover, correlation analyses involving tau mice alone revealed linkage between poorer cognitive performance in all three water maze tasks and the number of neurofibrillary tangle (nft)-containing neurons in neocortex and hippocampus. |
2004-08-17 |
2023-08-12 |
mouse |
| I Ferre. Differential expression of phosphorylated translation initiation factor 2 alpha in Alzheimer's disease and Creutzfeldt-Jakob's disease. Neuropathology and applied neurobiology. vol 28. issue 6. 2003-01-23. PMID:12445160. |
phosphorylated tif 2 alpha is restricted to neurones with abnormal tau deposition, but only approximately 80% of neurones with nfts in the hippocampus and 60% in the isocortex colocalize phosphorylated tif 2 alpha, thus indicating that not all neurones with nfts over-express phosphorylated tif 2 alpha. |
2003-01-23 |
2023-08-12 |
human |
| Béatrice Desgranges, Jean-Claude Baron, Catherine Lalevée, Bénédicte Giffard, Fausto Viader, Vincent de La Sayette, Francis Eustach. The neural substrates of episodic memory impairment in Alzheimer's disease as revealed by FDG-PET: relationship to degree of deterioration. Brain : a journal of neurology. vol 125. issue Pt 5. 2002-06-17. PMID:11960900. |
however, the subgroup analysis disclosed that, in the less severe subgroup, all significant correlations (p < 0.005, uncorrected) were restricted to the parahippocampal gyrus and retrosplenial cortex, in accordance with both the distribution of changes in tau in early alzheimer's disease and the known involvement of this network in normal and impaired memory function, while in the more severe subgroup they mainly involved the left temporal neocortex, which is known to be implicated in semantic memory. |
2002-06-17 |
2023-08-12 |
Not clear |
| B Ghetti, J R Murrell, P Zolo, M G Spillantini, M Goeder. Progress in hereditary tauopathies: a mutation in the Tau gene (G389R) causes a Pick disease-like syndrome. Annals of the New York Academy of Sciences. vol 920. 2001-02-08. PMID:11193177. |
pick body-like and axonal filamentous inclusions found in the neocortex and subcortical white matter, respectively, are tau immunoreactive. |
2001-02-08 |
2023-08-12 |
Not clear |
| F García-Sierra, J J Hauw, C Duyckaerts, C M Wischik, J Luna-Muñoz, R Men. The extent of neurofibrillary pathology in perforant pathway neurons is the key determinant of dementia in the very old. Acta neuropathologica. vol 100. issue 1. 2000-12-07. PMID:10912917. |
in this study, we assessed the densities and distribution of structures recognized by the monoclonal antibody (mab) to phosphorylated tau (at8) in the hippocampal formation and medial temporal isocortex of 19 centenarians. |
2000-12-07 |
2023-08-12 |
Not clear |
| E B Mukaetova-Ladinska, F Garcia-Siera, J Hurt, H J Gertz, J H Xuereb, R Hills, C Brayne, F A Huppert, E S Paykel, M McGee, R Jakes, W G Honer, C R Harrington, C M Wischi. Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease. The American journal of pathology. vol 157. issue 2. 2000-08-23. PMID:10934165. |
loss of synaptic proteins was seen only after the emergence of the full spectrum of tau and beta-amyloid pathology in the neocortex at stage 4, but not in the presence of beta-amyloid plaques alone. |
2000-08-23 |
2023-08-12 |
human |
| D A Shackelford, R Y Ye. Dephosphorylation of tau during transient forebrain ischemia in the rat. Molecular and chemical neuropathology. vol 34. issue 2-3. 1999-06-21. PMID:10327411. |
in this study, tau was rapidly dephosphorylated during ischemia in the hippocampus, neocortex, and striatum. |
1999-06-21 |
2023-08-12 |
rat |
| M G Spillantini, R A Crowther, W Kamphorst, P Heutink, J C van Swiete. Tau pathology in two Dutch families with mutations in the microtubule-binding region of tau. The American journal of pathology. vol 153. issue 5. 1998-11-25. PMID:9811325. |
numerous intracytoplasmic tau deposits in neurons, glial cells, and neurites were found in hippocampal formation, neocortex, and substantia nigra. |
1998-11-25 |
2023-08-12 |
Not clear |