| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Duyckaerts, M A Colle, F Dessi, Y Grignon, F Piette, J J Hau. The progression of the lesions in Alzheimer disease: insights from a prospective clinicopathological study. Journal of neural transmission. Supplementum. vol 53. 1998-11-12. PMID:9700650. |
in the isocortex, the progression of the tau positive alterations is, on the contrary, stepwise--in a "all or none" fashion--from the hippocampus to the primary cortices, through the associative multimodal areas. |
1998-11-12 |
2023-08-12 |
Not clear |
| B A Bahr, J S Vicent. Age-related phosphorylation and fragmentation events influence the distribution profiles of distinct tau isoforms in mouse brain. Journal of neuropathology and experimental neurology. vol 57. issue 2. 1998-06-08. PMID:9600203. |
the hippocampus and neocortex had concentrated levels of 55 kda tau, and moderate amounts of 62-69 kda isoforms. |
1998-06-08 |
2023-08-12 |
mouse |
| P Giannakopoulos, S Silhol, V Jallageas, J Mallet, N Bons, C Bouras, P Delaèr. Quantitative analysis of tau protein-immunoreactive accumulations and beta amyloid protein deposits in the cerebral cortex of the mouse lemur, Microcebus murinus. Acta neuropathologica. vol 94. issue 2. 1997-09-17. PMID:9255387. |
the prevalence and density of tau protein-immunoreactive accumulations in the neocortex of this prosimian increased steadily with age. |
1997-09-17 |
2023-08-12 |
mouse |
| P Giannakopoulos, S Silhol, V Jallageas, J Mallet, N Bons, C Bouras, P Delaèr. Quantitative analysis of tau protein-immunoreactive accumulations and beta amyloid protein deposits in the cerebral cortex of the mouse lemur, Microcebus murinus. Acta neuropathologica. vol 94. issue 2. 1997-09-17. PMID:9255387. |
although all animals with diffuse a beta deposits had tau protein-immunoreactive accumulations in the neocortex, no correlation was found between the densities of these lesions in each area and among the areas studied. |
1997-09-17 |
2023-08-12 |
mouse |
| L Buée, J Pérez-Tur, B Leveugle, V Buée-Scherrer, E J Mufson, A J Loerzel, M C Chartier-Harlin, D P Perl, A Delacourte, P R Ho. Apolipoprotein E in Guamanian amyotrophic lateral sclerosis/parkinsonism-dementia complex: genotype analysis and relationships to neuropathological changes. Acta neuropathologica. vol 91. issue 3. 1996-12-10. PMID:8834536. |
compared to tau protein immunoreactivity, there were generally fewer apo e-immunoreactive neurofibrillary tangles, particularly in the deep layers of the neocortex and in the hippocampus. |
1996-12-10 |
2023-08-12 |
Not clear |
| E B Mukaetova-Ladinska, C R Harrington, M Roth, C M Wischi. Alterations in tau protein metabolism during normal aging. Dementia (Basel, Switzerland). vol 7. issue 2. 1996-12-03. PMID:8866683. |
we have examined phf-bound and normal tau fractions in frontal, temporal, parietal and occipital neocortex, cerebellum, hippocampus and entorhinal cortex in 15 cognitively unimpaired individuals aged 19-88 years at death. |
1996-12-03 |
2023-08-12 |
Not clear |
| P T Nelson, K Stefansson, J Gulcher, C B Sape. Molecular evolution of tau protein: implications for Alzheimer's disease. Journal of neurochemistry. vol 67. issue 4. 1996-12-02. PMID:8858947. |
the major difference we observed was that some tau mrnas from rhesus monkey neocortex contain exon 8, whereas this exon has not been found in cortical tau from human or goat. |
1996-12-02 |
2023-08-12 |
human |
| P Vermersch, J P David, B Frigard, C Fallet-Bianco, A Wattez, H Petit, A Delacourt. Cortical mapping of Alzheimer pathology in brains of aged non-demented subjects. Progress in neuro-psychopharmacology & biological psychiatry. vol 19. issue 6. 1996-03-19. PMID:8584681. |
in few control cases abnormal tau proteins were also detected in the isocortex, in ba38 alone or also in ba20. |
1996-03-19 |
2023-08-12 |
human |
| P Vermersch, J P David, B Frigard, C Fallet-Bianco, A Wattez, H Petit, A Delacourt. Cortical mapping of Alzheimer pathology in brains of aged non-demented subjects. Progress in neuro-psychopharmacology & biological psychiatry. vol 19. issue 6. 1996-03-19. PMID:8584681. |
some cases and especially those with tau pathology in the temporal lobe contained numerous senile plaques (sp) in the neocortex. |
1996-03-19 |
2023-08-12 |
human |
| P Vermersch, J P David, B Frigard, C Fallet-Bianco, A Wattez, H Petit, A Delacourt. Cortical mapping of Alzheimer pathology in brains of aged non-demented subjects. Progress in neuro-psychopharmacology & biological psychiatry. vol 19. issue 6. 1996-03-19. PMID:8584681. |
the authors conclude that control cases with tau pathology in the temporal lobe and numerous sp in the neocortex were likely to be subclinical stages of ad whereas others with tau pathology exclusively detected in the ec and hippocampus and without or few sp in the neocortex were related to normal aging. |
1996-03-19 |
2023-08-12 |
human |
| D Dewar, D Dawso. Tau protein is altered by focal cerebral ischaemia in the rat: an immunohistochemical and immunoblotting study. Brain research. vol 684. issue 1. 1995-12-12. PMID:7583206. |
immunoblotting revealed the presence of additional tau bands in tissue extracts of the caudate nucleus and ventrolateral neocortex ipsilateral to the occluded middle cerebral artery as detected by both tau antibodies after either 2 or 6 h. the results suggest that tau is dephosphorylated and/or degraded in axons and some neuronal perikarya in response to focal cerebral ischaemia. |
1995-12-12 |
2023-08-12 |
rat |
| S S Zhan, W Kamphorst, W E Van Nostrand, P Eikelenboo. Distribution of neuronal growth-promoting factors and cytoskeletal proteins in altered neurites in Alzheimer's disease and non-demented elderly. Acta neuropathologica. vol 89. issue 4. 1995-08-17. PMID:7610767. |
extensive neuropil threads (nt) and many neurofibrillary tangles (nft), immunostained with tau and alz50 antibodies, were present in ad neocortex but not seen in control cases. |
1995-08-17 |
2023-08-12 |
Not clear |
| T D Garver, G A Oyler, K A Harris, R Polavarapu, Z Damuni, R A Lehman, M L Billingsle. Tau phosphorylation in brain slices: pharmacological evidence for convergent effects of protein phosphatases on tau and mitogen-activated protein kinase. Molecular pharmacology. vol 47. issue 4. 1995-05-19. PMID:7723735. |
incubation of rat, human, and rhesus monkey temporal neocortex slices with the phosphatase inhibitor okadaic acid induced epitopes of tau similar to those found in phfs. |
1995-05-19 |
2023-08-12 |
human |
| K Iqbal, A C Alonso, C X Gong, S Khatoon, T J Singh, I Grundke-Iqba. Mechanism of neurofibrillary degeneration in Alzheimer's disease. Molecular neurobiology. vol 9. issue 1-3. 1995-04-18. PMID:7888088. |
the level of tau in alzheimer's disease neocortex is severalfold higher than in aged control brain, and this increase is in the form of the abnormally phosphorylated protein. |
1995-04-18 |
2023-08-12 |
Not clear |
| T D Garver, K A Harris, R A Lehman, V M Lee, J Q Trojanowski, M L Billingsle. Tau phosphorylation in human, primate, and rat brain: evidence that a pool of tau is highly phosphorylated in vivo and is rapidly dephosphorylated in vitro. Journal of neurochemistry. vol 63. issue 6. 1994-12-23. PMID:7964748. |
tau was rapidly isolated from human temporal neocortex and hippocampus, rhesus monkey temporal neocortex, and rat temporal neocortex and hippocampus under conditions that minimized dephosphorylation. |
1994-12-23 |
2023-08-12 |
human |
| H Braak, E Braak, M Strothjohan. Abnormally phosphorylated tau protein related to the formation of neurofibrillary tangles and neuropil threads in the cerebral cortex of sheep and goat. Neuroscience letters. vol 171. issue 1-2. 1994-10-10. PMID:7521944. |
frontal sections including temporal isocortex, entorhinal region and hippocampus from aged domestic animals (dog, cat, horse, sheep and goat) were studied for alzheimer-related changes using immunostaining with the at8 antibody for abnormally phosphorylated tau protein and selective silver techniques for a4 amyloid and neurofibrillary changes of the alzheimer type. |
1994-10-10 |
2023-08-12 |
human |
| M L Schmidt, A G DiDario, V M Lee, J Q Trojanowsk. An extensive network of PHF tau-rich dystrophic neurites permeates neocortex and nearly all neuritic and diffuse amyloid plaques in Alzheimer disease. FEBS letters. vol 344. issue 1. 1994-06-14. PMID:8181568. |
unlike controls, a dense network of phf tau positive dystrophic neurites extended throughout the ad neocortex permeating nearly all neuritic and diffuse plaques. |
1994-06-14 |
2023-08-12 |
Not clear |
| R W Shin, G T Bramblett, V M Lee, J Q Trojanowsk. Alzheimer disease A68 proteins injected into rat brain induce codeposits of beta-amyloid, ubiquitin, and alpha 1-antichymotrypsin. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 14. 1993-08-30. PMID:8393578. |
to probe the biological properties of a68 in vivo, and to assess interactions of a68 with endogenous proteins in the rodent brain, we injected a68, dephosphorylated a68 (dep-a68), and normal adult human tau protein into the hippocampus and neocortex of rats. |
1993-08-30 |
2023-08-12 |
human |
| K Iqbal, A Alonso, C Gong, S Khatoon, T Kudo, T Singh, I Grundke-Iqba. Molecular pathology of Alzheimer neurofibrillary degeneration. Acta neurobiologiae experimentalis. vol 53. issue 1. 1993-07-29. PMID:8317268. |
the level of tau in neocortex is several-fold higher than in ad aged control cases, but this increase is in the form of the abnormally phosphorylated protein. |
1993-07-29 |
2023-08-12 |
Not clear |
| E Masliah, M Ellisman, B Carragher, M Mallory, S Young, L Hansen, R DeTeresa, R D Terr. Three-dimensional analysis of the relationship between synaptic pathology and neuropil threads in Alzheimer disease. Journal of neuropathology and experimental neurology. vol 51. issue 4. 1992-08-06. PMID:1619440. |
recent studies have shown that the alzheimer disease (ad) neocortex is characterized by a loss of large neurons, the presence of dilated terminal axons, widespread loss of synapses, and a disruption of the dendritic cytoskeleton which is manifested as tau immunoreactive threads. |
1992-08-06 |
2023-08-11 |
Not clear |