| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lauren D Stutzbach, Sharon X Xie, Adam C Naj, Roger Albin, Sid Gilman, Virginia M Y Lee, John Q Trojanowski, Bernie Devlin, Gerard D Schellenber. The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer's disease. Acta neuropathologica communications. vol 1. 2015-03-31. PMID:24252572. |
progressive supranuclear palsy (psp) is a neurodegenerative disorder pathologically characterized by intracellular tangles of hyperphosphorylated tau protein distributed throughout the neocortex, basal ganglia, and brainstem. |
2015-03-31 |
2023-08-12 |
human |
| E Orta-Salazar, A Aguilar-Vázquez, H Martínez-Coria, S Luquín-De Anda, M Rivera-Cervantes, C Beas-Zarate, A Feria-Velasco, S Díaz-Cintr. REST/NRSF-induced changes of ChAT protein expression in the neocortex and hippocampus of the 3xTg-AD mouse model for Alzheimer's disease. Life sciences. vol 116. issue 2. 2015-01-28. PMID:25261598. |
the objective of this work was to determine the rest/nrsf involvement in altered chat expression in the neocortex and hippocampus of an ad transgenic mouse (homozygous 3xtg-ad) that over-expresses 3 proteins, amyloid-β precursor protein, presenilin-1, and tau, all of which are associated with ad and cause cellular degeneration. |
2015-01-28 |
2023-08-13 |
mouse |
| Sylvia E Perez, Mary Ann Raghanti, Patrick R Hof, Lynn Kramer, Milos D Ikonomovic, Pascale N Lacor, Joseph M Erwin, Chet C Sherwood, Elliott J Mufso. Alzheimer's disease pathology in the neocortex and hippocampus of the western lowland gorilla (Gorilla gorilla gorilla). The Journal of comparative neurology. vol 521. issue 18. 2014-06-11. PMID:23881733. |
neurons stained for the tau marker alz50 were found in the neocortex and hippocampus of gorillas at all ages. |
2014-06-11 |
2023-08-12 |
Not clear |
| Johannes Wolf, Carsten Jäger, Ingolf Lachmann, Peter Schönknecht, Markus Morawski, Thomas Arendt, Thomas Mothe. Tissue transglutaminase is not a biochemical marker for Alzheimer's disease. Neurobiology of aging. vol 34. issue 11. 2014-03-05. PMID:23747046. |
immunohistologically, we found no colocalization of ttg in neocortex sections with tau or aβ deposits but with blood vessels. |
2014-03-05 |
2023-08-12 |
human |
| Jessica M Posimo, Amanda M Titler, Hailey J H Choi, Ajay S Unnithan, Rehana K Lea. Neocortex and allocortex respond differentially to cellular stress in vitro and aging in vivo. PloS one. vol 8. issue 3. 2013-12-27. PMID:23536801. |
in parkinson's and alzheimer's diseases, the allocortex accumulates aggregated proteins such as synuclein and tau well before neocortex. |
2013-12-27 |
2023-08-12 |
rat |
| Florence Clavaguera, Isabelle Lavenir, Ben Falcon, Stephan Frank, Michel Goedert, Markus Tolna. "Prion-like" templated misfolding in tauopathies. Brain pathology (Zurich, Switzerland). vol 23. issue 3. 2013-10-28. PMID:23587140. |
in alzheimer's disease, tau pathology develops in a stereotypical manner, with the first lesions appearing in the locus coeruleus and entorhinal cortex, from where they appear to spread to the hippocampus and neocortex. |
2013-10-28 |
2023-08-12 |
Not clear |
| Ann C McKee, Robert A Stern, Christopher J Nowinski, Thor D Stein, Victor E Alvarez, Daniel H Daneshvar, Hyo-Soon Lee, Sydney M Wojtowicz, Garth Hall, Christine M Baugh, David O Riley, Caroline A Kubilus, Kerry A Cormier, Matthew A Jacobs, Brett R Martin, Carmela R Abraham, Tsuneya Ikezu, Robert Ross Reichard, Benjamin L Wolozin, Andrew E Budson, Lee E Goldstein, Neil W Kowall, Robert C Cant. The spectrum of disease in chronic traumatic encephalopathy. Brain : a journal of neurology. vol 136. issue Pt 1. 2013-04-23. PMID:23208308. |
in chronic traumatic encephalopathy, the spectrum of hyperphosphorylated tau pathology ranged in severity from focal perivascular epicentres of neurofibrillary tangles in the frontal neocortex to severe tauopathy affecting widespread brain regions, including the medial temporal lobe, thereby allowing a progressive staging of pathology from stages i-iv. |
2013-04-23 |
2023-08-12 |
human |
| Elizabeta B Mukaetova-Ladinska, Alina Andras, Joan Milne, Zeinab Abdel-All, Iwo Borr, Evelyn Jaros, Robert H Perry, William G Honer, Andrea Cleghorn, Jeanette Doherty, Gary McIntosh, Elaine K Perry, Raj N Kalaria, Ian G McKeit. Synaptic proteins and choline acetyltransferase loss in visual cortex in dementia with Lewy bodies. Journal of neuropathology and experimental neurology. vol 72. issue 1. 2013-02-18. PMID:23242284. |
the observed synaptic and chat changes in the visual cortices were not associated with tau or β-amyloid pathology in the occipital or the frontal, temporal, and parietal neocortex. |
2013-02-18 |
2023-08-12 |
human |
| Janna Hackett Neltner, Erin Lynn Abner, Frederick A Schmitt, Stephanie Kay Denison, Sonya Anderson, Ela Patel, Peter T Nelso. Digital pathology and image analysis for robust high-throughput quantitative assessment of Alzheimer disease neuropathologic changes. Journal of neuropathology and experimental neurology. vol 71. issue 12. 2013-02-04. PMID:23147505. |
using an aperio scanscope xt and its accompanying image analysis software, we designed algorithms for quantitation of amyloid and tau pathologies on 65 β-amyloid (6f/3d antibody) and 48 phospho-tau (phf-1)-immunostained sections of human temporal neocortex. |
2013-02-04 |
2023-08-12 |
human |
| Nadia Postupna, Shannon E Rose, Thomas D Bird, Luis F Gonzalez-Cuyar, Joshua A Sonnen, Eric B Larson, C Dirk Keene, Thomas J Montin. Novel antibody capture assay for paraffin-embedded tissue detects wide-ranging amyloid beta and paired helical filament-tau accumulation in cognitively normal older adults. Brain pathology (Zurich, Switzerland). vol 22. issue 4. 2012-10-12. PMID:21999410. |
ad cases had significantly increased amyloid beta (aβ) peptide and paired helical filament- (phf-) tau per area of neocortex that was proteinase k-sensitive, and significantly decreased amount of synaptophysin. |
2012-10-12 |
2023-08-12 |
human |
| Stanley I Rapoport, Peter T Nelso. Biomarkers and evolution in Alzheimer disease. Progress in neurobiology. vol 95. issue 4. 2012-04-09. PMID:21801803. |
biomarkers such as reduced glucose metabolism in association neocortex, defects in long white matter tracts, rna neurochemical changes, and high csf levels of total and phosphorylated tau protein, which are helpful to identify mci and preclinical alzheimer disease patients, may also provide insights into what brain changes led to this disease being introduced during hominid evolution. |
2012-04-09 |
2023-08-12 |
Not clear |
| Jose L Cantero, Bernardo Moreno-Lopez, Federico Portillo, Alicia Rubio, Eva Hita-Yañez, Jesus Avil. Role of tau protein on neocortical and hippocampal oscillatory patterns. Hippocampus. vol 21. issue 8. 2012-03-16. PMID:20607795. |
because of its elevated expression in neocortical regions and hippocampus, tau might play a role in sculpting collective neural responses underlying slow and fast brain oscillations and/or long-range synchronization patterns between hippocampus and neocortex. |
2012-03-16 |
2023-08-12 |
mouse |
| Odete A B da Cruz e Silva, Ana Gabriela Henriques, Sara Catarina Timóteo Santos Domingues, Edgar F da Cruz e Silv. Wnt signalling is a relevant pathway contributing to amyloid beta- peptide-mediated neuropathology in Alzheimer's disease. CNS & neurological disorders drug targets. vol 9. issue 6. 2011-02-28. PMID:20942790. |
individuals with alzheimer's disease (ad) exhibit extracellular senile plaques (sps) of aggregated a beta and intracellular neurofibrillary tangles that contain hyperphosphorylated tau protein (nfts), and also an extensive loss in basal forebrain cholinergic neurons that innervate the hippocampus and neocortex. |
2011-02-28 |
2023-08-12 |
mouse |
| Rahul S Desikan, Mert R Sabuncu, Nicholas J Schmansky, Martin Reuter, Howard J Cabral, Christopher P Hess, Michael W Weiner, Alessandro Biffi, Christopher D Anderson, Jonathan Rosand, David H Salat, Thomas L Kemper, Anders M Dale, Reisa A Sperling, Bruce Fisch. Selective disruption of the cerebral neocortex in Alzheimer's disease. PloS one. vol 5. issue 9. 2011-02-18. PMID:20886094. |
alzheimer's disease (ad) and its transitional state mild cognitive impairment (mci) are characterized by amyloid plaque and tau neurofibrillary tangle (nft) deposition within the cerebral neocortex and neuronal loss within the hippocampal formation. |
2011-02-18 |
2023-08-12 |
Not clear |
| Akihiko Takashim. [Significance of tau in the development of Alzheimer's disease]. Brain and nerve = Shinkei kenkyu no shinpo. vol 62. issue 7. 2010-10-07. PMID:20675874. |
neurofibrillary tangles (nfts), which contain hyperphosphorylated tau are the other pathological hallmark of ad; clinical progression of nfts is from the entorhinal cortex to the limbic cortex, and neocortex. |
2010-10-07 |
2023-08-12 |
mouse |
| Cheng-Xin Gong, Inge Grundke-Iqbal, Khalid Iqba. Targeting tau protein in Alzheimer's disease. Drugs & aging. vol 27. issue 5. 2010-09-17. PMID:20450234. |
furthermore, while approximately 30% of normal aged individuals have as much compact plaque burden in the neocortex as is seen in typical cases of ad, in several tauopathies, such as cortical basal degeneration and pick's disease, neurofibrillary degeneration of abnormally hyperphosphorylated tau in the absence of abeta plaques is associated with dementia. |
2010-09-17 |
2023-08-12 |
Not clear |
| Anhar Hassan, Jennifer L Whitwell, Bradley F Boeve, Clifford R Jack, Joseph E Parisi, Dennis W Dickson, Keith A Joseph. Symmetric corticobasal degeneration (S-CBD). Parkinsonism & related disorders. vol 16. issue 3. 2010-05-24. PMID:20018548. |
corticobasal degeneration (cbd) is a neurodegenerative disease characterized pathologically by neuronal loss, gliosis and tau deposition in neocortex, basal ganglia and brainstem. |
2010-05-24 |
2023-08-12 |
Not clear |
| Charles Duyckaerts, Benoît Delatour, Marie-Claude Potie. Classification and basic pathology of Alzheimer disease. Acta neuropathologica. vol 118. issue 1. 2009-07-29. PMID:19381658. |
the progression of tau pathology is stepwise and stereotyped from the entorhinal cortex, through the hippocampus, to the isocortex. |
2009-07-29 |
2023-08-12 |
Not clear |
| Florence Clavaguera, Tristan Bolmont, R Anthony Crowther, Dorothee Abramowski, Stephan Frank, Alphonse Probst, Graham Fraser, Anna K Stalder, Martin Beibel, Matthias Staufenbiel, Mathias Jucker, Michel Goedert, Markus Tolna. Transmission and spreading of tauopathy in transgenic mouse brain. Nature cell biology. vol 11. issue 7. 2009-07-20. PMID:19503072. |
in the disease process, neuronal tau inclusions first appear in the transentorhinal cortex from where they seem to spread to the hippocampal formation and neocortex. |
2009-07-20 |
2023-08-12 |
mouse |
| Rawan Tarawneh, David M Holtzma. Critical issues for successful immunotherapy in Alzheimer's disease: development of biomarkers and methods for early detection and intervention. CNS & neurological disorders drug targets. vol 8. issue 2. 2009-07-06. PMID:19355934. |
clinico-pathological and biomarker studies have shown that in terms of the time course of ad, abeta deposition probably begins about 10-15 years prior to symptom onset (preclinical ad) and that tau aggregation in tangles and in neurites does not begin to accelerate and build up in larger amounts in the neocortex until just prior to symptom onset. |
2009-07-06 |
2023-08-12 |
human |