| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kang Jun Cho, Mamoru Hashimoto, Sergei Karnup, Kanako Matsuoka, Tadanobu Kamijo, Joon Chul Kim, Jun Sung Koh, Naoki Yoshimur. Improvement of lower urinary tract dysfunction by a monoacylglycerol lipase inhibitor in mice with spinal cord injury. Neurourology and urodynamics. 2024-03-27. PMID:38533637. |
activation of the endocannabinoid system by monoacylglycerol lipase (magl) blockade may affect the lower urinary tract function. |
2024-03-27 |
2024-03-29 |
mouse |
| Qingjing Hao, Junwei Shi, Zhilan Zhang, Guoqing Yang, Yunbao Zhi, Ke Wang, Dingchen Ma, Shengnan Fu, Haijuan Dong, Zhuoer Zhi, Wenting Zhang, Tingting Li, Jinxin Wan. Discovery of a novel class of reversible monoacylglycerol lipase inhibitors for potential treatment of depression. European journal of medicinal chemistry. vol 268. 2024-03-01. PMID:38428273. |
biological studies on the endocannabinoid system (ecs) have suggested that monoacylglycerol lipase (magl), an essential enzyme responsible for the hydrolysis of 2-arachidonoylglycerol (2-ag), is a novel target for developing antidepressants. |
2024-03-01 |
2024-03-04 |
Not clear |
| Barkha J Yadav-Samudrala, Havilah P Ravula, Karenna M Barmada, Hailey Dodson, Justin L Poklis, Bogna M Ignatowska-Jankowska, Aron H Lichtman, Kathryn J Reissner, Sylvia Fittin. Acute Effects of Monoacylglycerol Lipase Inhibitor ABX1431 on Neuronal Hyperexcitability, Nociception, Locomotion, and the Endocannabinoid System in HIV-1 Tat Male Mice. Cannabis and cannabinoid research. 2024-02-23. PMID:38394322. |
acute effects of monoacylglycerol lipase inhibitor abx1431 on neuronal hyperexcitability, nociception, locomotion, and the endocannabinoid system in hiv-1 tat male mice. |
2024-02-23 |
2024-02-26 |
mouse |
| Clare M Diester, Hallie Balint, James C Gillespie, Aron H Lichtman, Laura J Sim-Selley, Dana E Selley, S Stevens Negu. The Journal of pharmacology and experimental therapeutics. 2024-01-23. PMID:38262742. |
mjn110 inhibits the enzyme monoacylglycerol lipase (magl) to increase levels of the endocannabinoid (ecb) 2-arachidonoylglycerol (2-ag), an endogenous high-efficacy agonist of cannabinoid 1 and 2 receptors (cb |
2024-01-23 |
2024-01-26 |
Not clear |
| Ming Jiang, Mirjam C W Huizenga, Jonah L Wirt, Janos Paloczi, Avand Amedi, Richard J B H N van den Berg, Joerg Benz, Ludovic Collin, Hui Deng, Xinyu Di, Wouter F Driever, Bogdan I Florea, Uwe Grether, Antonius P A Janssen, Thomas Hankemeier, Laura H Heitman, Tsang-Wai Lam, Florian Mohr, Anto Pavlovic, Iris Ruf, Helma van den Hurk, Anna F Stevens, Daan van der Vliet, Tom van der Wel, Matthias B Wittwer, Constant A A van Boeckel, Pal Pacher, Andrea G Hohmann, Mario van der Stel. A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence. Nature communications. vol 14. issue 1. 2023-12-05. PMID:38052772. |
monoacylglycerol lipase (magl) regulates endocannabinoid 2-arachidonoylglycerol (2-ag) and eicosanoid signalling. |
2023-12-05 |
2023-12-10 |
mouse |
| Junlai Wang, Sen Li. [Advances in the development of covalent small molecule inhibitors of monoacylglycerol lipase]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. vol 39. issue 11. 2023-11-28. PMID:38013174. |
monoacylglycerol lipase (mgl) is a serine hydrolase that plays a major role in the degradation of endogenous cannabinoid 2-arachidonoylglycerol. |
2023-11-28 |
2023-11-29 |
Not clear |
| Corina Andrei, Dragos Paul Mihai, Georgiana Nitulescu, Anca Ungurianu, Denisa Marilena Margina, George Mihai Nitulescu, Octavian Tudorel Olaru, Radu Mihai Busca, Anca Zanfiresc. Cetirizine and Levetiracetam as Inhibitors of Monoacylglycerol Lipase: Investigating Their Repurposing Potential as Novel Osteoarthritic Pain Therapies. Pharmaceuticals (Basel, Switzerland). vol 16. issue 11. 2023-11-25. PMID:38004429. |
considering that the endocannabinoid 2-arachidonoyl glycerol is involved in pain processing, increasing its concentration through monoacylglycerol lipase (magl) inhibition reduces pain in various animal models. |
2023-11-25 |
2023-11-28 |
Not clear |
| Miriana Di Stefano, Samuele Masoni, Giulia Bononi, Giulio Poli, Salvatore Galati, Francesca Gado, Simone Manzi, Chiara Vagaggini, Annalaura Brai, Isabella Caligiuri, Kanwal Asif, Flavio Rizzolio, Marco Macchia, Andrea Chicca, Andrea Sodi, Valeria Di Bussolo, Filippo Minutolo, Philip Meier, Jürg Gertsch, Carlotta Granchi, Elena Dreassi, Tiziano Tuccinard. Design, synthesis, ADME and biological evaluation of benzylpiperidine and benzylpiperazine derivatives as novel reversible monoacylglycerol lipase (MAGL) inhibitors. European journal of medicinal chemistry. vol 263. 2023-11-17. PMID:37976705. |
the degradation of the endocannabinoid 2-arachidonoylglycerol is mediated by the enzyme monoacylglycerol lipase (magl), thus generating arachidonic acid, the precursor of prostaglandins and other pro-inflammatory mediators. |
2023-11-17 |
2023-11-20 |
mouse |
| Felix Wittig, Liza Pannenberg, Rico Schwarz, Sander Bekeschus, Robert Ramer, Burkhard Hin. Antiangiogenic Action of JZL184 on Endothelial Cells via Inhibition of VEGF Expression in Hypoxic Lung Cancer Cells. Cells. vol 12. issue 19. 2023-10-13. PMID:37830546. |
jzl184, an inhibitor of monoacylglycerol lipase (magl) and thus of the degradation of the endocannabinoid 2-arachidonoylglycerol (2-ag), mediates various anticancer effects in preclinical studies. |
2023-10-13 |
2023-10-15 |
human |
| Marta Kruk-Slomka, Bartlomiej Adamski, Tomasz Slomka, Grazyna Bial. Inhibitors of Endocannabinoids' Enzymatic Degradation as a Potential Target of the Memory Disturbances in an Acute N-Methyl-D-Aspartate (NMDA) Receptor Hypofunction Model of Schizophrenia in Mice. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511157. |
the ecs is comprised of cannabinoid (cb) receptors, endocannabinoids and enzymes responsible for the metabolism of endocannabinoids (fatty acid hydrolase (faah) and monoacylglycerol lipase (magl)). |
2023-07-29 |
2023-08-14 |
mouse |
| Karen Jaqueline Paredes-Ruiz, Karla Chavira-Ramos, Sonia Galvan-Arzate, Edgar Rangel-López, Çimen Karasu, Isaac Túnez, Anatoly V Skalny, Tao Ke, Michael Aschner, Mario Orozco-Morales, Ana Laura Colín-González, Abel Santamarí. Monoacylglycerol Lipase Inhibition Prevents Short-Term Mitochondrial Dysfunction and Oxidative Damage in Rat Brain Synaptosomal/Mitochondrial Fractions and Cortical Slices: Role of Cannabinoid Receptors. Neurotoxicity research. 2023-07-17. PMID:37458923. |
monoacylglycerol lipase inhibition prevents short-term mitochondrial dysfunction and oxidative damage in rat brain synaptosomal/mitochondrial fractions and cortical slices: role of cannabinoid receptors. |
2023-07-17 |
2023-08-14 |
rat |
| Karen Jaqueline Paredes-Ruiz, Karla Chavira-Ramos, Sonia Galvan-Arzate, Edgar Rangel-López, Çimen Karasu, Isaac Túnez, Anatoly V Skalny, Tao Ke, Michael Aschner, Mario Orozco-Morales, Ana Laura Colín-González, Abel Santamarí. Monoacylglycerol Lipase Inhibition Prevents Short-Term Mitochondrial Dysfunction and Oxidative Damage in Rat Brain Synaptosomal/Mitochondrial Fractions and Cortical Slices: Role of Cannabinoid Receptors. Neurotoxicity research. 2023-07-17. PMID:37458923. |
monoacylglycerol lipase (magl) is the enzyme responsible for degrading 2-arachydonoylglycerol (2-ag), the most abundant endocannabinoid in the central nervous system (cns). |
2023-07-17 |
2023-08-14 |
rat |
| Courtney A Bouchet, Kylie B McPherson, Basile Coutens, Aaron Janowsky, Susan L Ingra. Monoacylglycerol lipase protects the presynaptic cannabinoid 1 receptor from desensitization by endocannabinoids after persistent inflammation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-07-06. PMID:37414560. |
monoacylglycerol lipase protects the presynaptic cannabinoid 1 receptor from desensitization by endocannabinoids after persistent inflammation. |
2023-07-06 |
2023-08-14 |
rat |
| Takehito Terajima, Hirofumi Inoue, Kenji Shimomura, Fuki Iwasaki, Aya Sasaki, Yuki Ito, Michihiro Kamijima, Motohiro Tomizaw. Organophosphate agent action at the fatty acid amide hydrolase enhancing anandamide-induced apoptosis in NG108-15 cells. The Journal of toxicological sciences. vol 48. issue 7. 2023-07-02. PMID:37394655. |
op agent as an anticholinesterase also acts on the endocannabinoid (ec)-hydrolases, i.e., fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), to reveal unexpected adverse effects including adhd-like behaviors in adolescent male rats. |
2023-07-02 |
2023-08-14 |
human |
| Adriana Della Pietra, Georgii Krivoshein, Konstantin Ivanov, Raisa Giniatullina, Henna-Kaisa Jyrkkänen, Ville Leinonen, Marko Lehtonen, Arn M J M van den Maagdenberg, Juha Savinainen, Rashid Giniatulli. Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain. The journal of headache and pain. vol 24. issue 1. 2023-04-10. PMID:37038131. |
engaging the endocannabinoid system through inhibition of monoacylglycerol lipase (magl) and fatty acid amide hydrolase (faah), degrading endocannabinoids (endocbs) 2-arachidonoylglycerol (2-ag) and anandamide (aea), was proposed as a promising approach to ameliorate migraine pain. |
2023-04-10 |
2023-08-14 |
human |
| Barbara Emons, Larissa Arning, Vera-Estelle Makulla, Maria-Theresia Suchy, Dimitrios Tsikas, Thomas Lücke, Jörg T Epplen, Georg Juckel, Patrik Rose. Endocannabinergic modulation of central serotonergic activity in healthy human volunteers. Annals of general psychiatry. vol 22. issue 1. 2023-03-18. PMID:36932421. |
since the cannabinoid (cb) 1 receptor is activated by endogenous ligands such as aea and 2ag, whose concentration are controlled by the fatty acid amide hydrolase (faah) and monoacylglycerol lipase, respectively, we investigated the effects on serotonergic utilization. |
2023-03-18 |
2023-08-14 |
human |
| Rosiane Aparecida Miranda, Vanessa Silva Tavares Rodrigues, Thamara Cherem Peixoto, Alex C Manhães, Egberto Gaspar de Moura, Patricia Cristina Lisbo. Nicotine exposure during breastfeeding alters the expression of endocannabinoid system biomarkers in female but not in male offspring at adulthood. Journal of developmental origins of health and disease. 2023-02-23. PMID:36815400. |
we evaluated protein expression of n-acylphosphatidylethanolamide-phospholipase d (nape-pld), fatty acid amide hydrolase (faah), diacylglycerol lipase (dagl), monoacylglycerol lipase (magl) and cannabinoid receptors (cb1 and/or cb2) in lateral hypothalamus, paraventricular nucleus of the hypothalamus, liver, visceral adipose tissue (vat), adrenal and thyroid. |
2023-02-23 |
2023-08-14 |
rat |
| Lakhan S Khara, Declan W Al. The endocannabinoid system's involvement in motor development relies on cannabinoid receptors, TRP channels, and Sonic Hedgehog signaling. Physiological reports. vol 11. issue 1. 2023-01-13. PMID:36636759. |
to investigate the involvement of canonical and non-canonical cannabinoid receptors, trp channels, and the shh pathway in the development of sensorimotor function in zebrafish, we treated developing animals with pharmacological inhibitors of the cb1r, cb2r, trpa1/trpv1/trpm8, and a smoothened (smo) agonist, along with inhibitors of the ecs catabolic enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) during the first ~24 h of zebrafish embryogenesis. |
2023-01-13 |
2023-08-14 |
zebrafish |
| Meenakshi Ahluwalia, Hannah Mcmichael, Manish Kumar, Mario P Espinosa, Asamoah Bosomtwi, Yujiao Lu, Hesam Khodadadi, Abbas Jarrahi, Mohammad B Khan, David C Hess, Scott Y Rahimi, John R Vender, Fernando L Vale, Molly Braun, Babak Baban, Krishnan M Dhandapani, Kumar Vaibha. Altered endocannabinoid metabolism compromises the brain-CSF barrier and exacerbates chronic deficits after traumatic brain injury in mice. Experimental neurology. 2023-01-10. PMID:36627040. |
reductions in endocannabinoid (2-ag and aea) levels in plasma were supported by higher expression of their respective metabolizing enzymes, monoacylglycerol lipase (magl), fatty acid amide hydrolase (faah), and cyclooxygenase 2 (cox-2) in the post-tbi mouse brain. |
2023-01-10 |
2023-08-14 |
mouse |
| Alessandro Papa, Silvia Pasquini, Francesca Galvani, Mariarosaria Cammarota, Chiara Contri, Gabriele Carullo, Sandra Gemma, Anna Ramunno, Stefania Lamponi, Beatrice Gorelli, Simona Saponara, Katia Varani, Marco Mor, Giuseppe Campiani, Francesca Boscia, Fabrizio Vincenzi, Alessio Lodola, Stefania Butin. Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions. European journal of medicinal chemistry. vol 246. 2022-12-03. PMID:36462439. |
all the newly developed inhibitors showed an excellent selectivity profile evaluated against monoacylglycerol lipase and cannabinoid receptors. |
2022-12-03 |
2023-08-14 |
mouse |