| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Carlos Ledesma, Marta Rodríguez-Arias, Ana L Gavito, Ana M Sánchez-Pérez, José Viña, Dina Medina Vera, Fernando Rodríguez de Fonseca, José Miñarr. Adolescent binge-ethanol accelerates cognitive impairment and β-amyloid production and dysregulates endocannabinoid signaling in the hippocampus of APP/PSE mice. Addiction biology. vol 26. issue 1. 2021-10-05. PMID:32043730. |
at 6 and 12 months of age, we evaluated hippocampal-dependent learning and memory: β-amyloid concentrations and rna and protein levels of cannabinoid type-2 receptors (cb2), diacylglycerol lipase-α (daglα), and monoacylglycerol lipase (magl) in the hippocampus. |
2021-10-05 |
2023-08-13 |
mouse |
| Reshed Abohalaka, Turgut Emrah Bozkurt, Tuba Reçber, Sevgen Celik Onder, Emirhan Nemutlu, Sedef Kır, Inci Sahin-Erdeml. The effects of systemic and local fatty acid amide hydrolase and monoacylglycerol lipase inhibitor treatments on the metabolomic profile of lungs. Biomedical chromatography : BMC. 2021-09-17. PMID:34449902. |
previously, we have shown that increasing the tissue endocannabinoid levels by fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) inhibitors can prevent airway inflammation and hyperreactivity. |
2021-09-17 |
2023-08-13 |
mouse |
| Xiaoru Dong, Dingang Zhang, Rongzhe Zhu, Xiaochen Liu, Yonghong Ye, Yan Jian. Spatio-temporal effects of acute alcohol intoxication on endocannabinoid system in rat brain and blood. Alcohol (Fayetteville, N.Y.). vol 88. 2021-09-15. PMID:32738384. |
we have closely monitored the critical indicators reflecting changes of the ecs during the entire process from alcohol absorption to its metabolization, after acute alcohol (4.5 g/kg) intake by intragastric administration, including two key endocannabinoids (arachidonoylethanolamide and 2-arachidonoylglycerol) and their hydrolytic enzymes (fatty acid amide hydrolase and monoacylglycerol lipase) in blood and three brain regions, as well as a crucial and abundant receptor (cannabinoid 1 receptor) of the ecs in the three brain regions. |
2021-09-15 |
2023-08-13 |
human |
| Vibhu Jha, Marzia Biagi, Valeria Spinelli, Miriana Di Stefano, Marco Macchia, Filippo Minutolo, Carlotta Granchi, Giulio Poli, Tiziano Tuccinard. Discovery of Monoacylglycerol Lipase (MAGL) Inhibitors Based on a Pharmacophore-Guided Virtual Screening Study. Molecules (Basel, Switzerland). vol 26. issue 1. 2021-09-10. PMID:33375358. |
monoacylglycerol lipase (magl) is an important enzyme of the endocannabinoid system that catalyzes the degradation of the major endocannabinoid 2-arachidonoylglycerol (2-ag). |
2021-09-10 |
2023-08-13 |
Not clear |
| Alexis F League, Benjamin L Gorman, Douglas J Hermes, Clare T Johnson, Ian R Jacobs, Barkha J Yadav-Samudrala, Justin L Poklis, Micah J Niphakis, Benjamin F Cravatt, Aron H Lichtman, Bogna M Ignatowska-Jankowska, Sylvia Fittin. Monoacylglycerol Lipase Inhibitor MJN110 Reduces Neuronal Hyperexcitability, Restores Dendritic Arborization Complexity, and Regulates Reward-Related Behavior in Presence of HIV-1 Tat. Frontiers in neurology. vol 12. 2021-09-07. PMID:34484091. |
as demand grows for supplemental strategies to combat virus-associated pathology presenting frequently as hiv-associated neurocognitive disorders (hand), the present study aimed to characterize the potential utility of inhibiting monoacylglycerol lipase (magl) activity to increase inhibitory activity at cannabinoid receptor-type 1 receptors through upregulation of 2-arachidonoylglycerol (2-ag) and downregulation of its degradation into proinflammatory metabolite arachidonic acid (aa). |
2021-09-07 |
2023-08-13 |
human |
| Ning Yang, Houyi Sun, Yi Xue, Weicheng Zhang, Hongzhi Wang, Huaqiang Tao, Xiaolong Liang, Meng Li, Yaozeng Xu, Liang Chen, Liang Zhang, Lixin Huang, Dechun Gen. Inhibition of MAGL activates the Keap1/Nrf2 pathway to attenuate glucocorticoid-induced osteonecrosis of the femoral head. Clinical and translational medicine. vol 11. issue 6. 2021-09-02. PMID:34185425. |
here, we found that monoacylglycerol lipase (magl), a key molecule in the endocannabinoid system, was significantly upregulated during gc treatment in osteoblasts both in vitro and in vivo. |
2021-09-02 |
2023-08-13 |
Not clear |
| Jack Hashem, Mei Hu, Jian Zhang, Fei Gao, Chu Che. Inhibition of 2-Arachidonoylglycerol Metabolism Alleviates Neuropathology and Improves Cognitive Function in a Tau Mouse Model of Alzheimer's Disease. Molecular neurobiology. vol 58. issue 8. 2021-07-17. PMID:33939165. |
it has been proposed that monoacylglycerol lipase (magl), the key enzyme degrading the endocannabinoid 2-arachidonoylglycerol (2-ag) in the brain, is a therapeutic target for ad based on the studies using the app transgenic models of ad. |
2021-07-17 |
2023-08-13 |
mouse |
| Silvia Marino, Giovana Carrasco, Boya Li, Karan M Shah, Darren L Lath, Antonia Sophocleous, Michelle A Lawson, Aymen I Idri. JZL184, A Monoacylglycerol Lipase Inhibitor, Induces Bone Loss in a Multiple Myeloma Model of Immunocompetent Mice. Calcified tissue international. vol 107. issue 1. 2021-07-14. PMID:32285169. |
pharmacological manipulation of monoacylglycerol lipase (magl), an enzyme responsible for the degradation of the endocannabinoid 2-arachidonoyl glycerol (2-ag), reduced skeletal tumour burden and osteolysis associated with osteosarcoma and advanced breast and prostate cancers. |
2021-07-14 |
2023-08-13 |
mouse |
| Si-Yu Ren, Zhen-Zhen Wang, Yi Zhang, Nai-Hong Che. Potential application of endocannabinoid system agents in neuropsychiatric and neurodegenerative diseases-focusing on FAAH/MAGL inhibitors. Acta pharmacologica Sinica. vol 41. issue 10. 2021-06-28. PMID:32203086. |
the inhibitors of two endocannabinoid hydrolases, i.e., fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), have the capacity to increase the level of endocannabinoids indirectly, causing fewer side effects than those associated with direct supplementation of cannabinoids. |
2021-06-28 |
2023-08-13 |
Not clear |
| Devon Ivy, Francesca Palese, Valentina Vozella, Yannick Fotio, Aylin Yalcin, Gina Ramirez, David Mears, Gary Wynn, Daniele Piomell. Cannabinoid CB Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 8. 2021-06-23. PMID:32375160. |
inhibitors of monoacylglycerol lipase (mgl), the enzyme that deactivates the endocannabinoid 2-arachidonoyl-sn-glycerol (2-ag), exert anxiolytic-like effects in rodent models via 2-ag-dependent activation of cb |
2021-06-23 |
2023-08-13 |
Not clear |
| Ziad Omra. New Disulfiram Derivatives as MAGL-Selective Inhibitors. Molecules (Basel, Switzerland). vol 26. issue 11. 2021-06-22. PMID:34070869. |
monoacylglycerol lipase (magl) is a key enzyme in the human endocannabinoid system. |
2021-06-22 |
2023-08-13 |
human |
| Estefania Rojo-Bustamante, Ignacio Íñigo-Marco, Miguel Angel Abellanas, Rodrigo Vinueza-Gavilanes, Ana Baltanás, Esther Luquin, Montserrat Arrasate, Maria S Aymeric. CB2 Receptors and Neuron-Glia Interactions Modulate Neurotoxicity Generated by MAGL Inhibition. Biomolecules. vol 10. issue 8. 2021-06-14. PMID:32824740. |
monoacylglycerol lipase inhibition (magl) has emerged as an interesting therapeutic target for neurodegenerative disease treatment due to its ability to modulate the endocannabinoid system and to prevent the production of proinflammatory mediators. |
2021-06-14 |
2023-08-13 |
rat |
| Jan Lukas Prüser, Robert Ramer, Felix Wittig, Igor Ivanov, Jutta Merkord, Burkhard Hin. The Monoacylglycerol Lipase Inhibitor JZL184 Inhibits Lung Cancer Cell Invasion and Metastasis via the CB Molecular cancer therapeutics. vol 20. issue 5. 2021-06-11. PMID:33632876. |
the monoacylglycerol lipase inhibitor jzl184 inhibits lung cancer cell invasion and metastasis via the cb a targeted modulation of the endocannabinoid system is currently discussed as a promising strategy for cancer treatment. |
2021-06-11 |
2023-08-13 |
mouse |
| Jan Lukas Prüser, Robert Ramer, Felix Wittig, Igor Ivanov, Jutta Merkord, Burkhard Hin. The Monoacylglycerol Lipase Inhibitor JZL184 Inhibits Lung Cancer Cell Invasion and Metastasis via the CB Molecular cancer therapeutics. vol 20. issue 5. 2021-06-11. PMID:33632876. |
an important enzyme for the endocannabinoid metabolism is the monoacylglycerol lipase (magl), which catalyzes the degradation of 2-arachidonoylglycerol (2-ag) to glycerol and free fatty acids. |
2021-06-11 |
2023-08-13 |
mouse |
| Bin Zhu, Peter J Connolly, Yue-Mei Zhang, Mark E McDonnell, Haiyan Bian, Shu-Chen Lin, Li Liu, Sui-Po Zhang, Kristen M Chevalier, Michael R Brandt, Cynthia M Milligan, Christopher M Flores, Mark J Maciela. The discovery of azetidine-piperazine di-amides as potent, selective and reversible monoacylglycerol lipase (MAGL) inhibitors. Bioorganic & medicinal chemistry letters. vol 30. issue 14. 2021-06-01. PMID:32527545. |
monoacylglycerol lipase (magl) is the enzyme that is primarily responsible for hydrolyzing the endocannabinoid 2-arachidononylglycerol (2-ag) to arachidonic acid (aa). |
2021-06-01 |
2023-08-13 |
rat |
| Cherry P Ho, Abdolsamad Borazjani, Matthew K Ross, Chinling Wan. Effects of the monoacylglycerol lipase inhibitor JZL184 on chickens infected with avian pathogenic Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. vol 84. issue 3. 2021-05-18. PMID:32801453. |
effects of the monoacylglycerol lipase inhibitor jzl184 on chickens infected with avian pathogenic the endocannabinoid (ecb) system modulates the degree of injury caused by inflammation, while enhancing the activity of phagocytes that promote resolution of inflammation and tissue repair. |
2021-05-18 |
2023-08-13 |
Not clear |
| Jinming Zhang, Lizi Zhang, Yuan Chang, Qiaofen Gu, Junmin Zhang, Zhou Zhu, Zhaoqiang Qian, Chunling Wei, Zhiqiang Liu, Wei Ren, Jing Ha. The Endocannabinoid System Contributes to Memory Deficits Induced by Rapid-eye-movement Sleep Deprivation in Adolescent Mice. Neuroscience. vol 433. 2021-05-14. PMID:32198011. |
remsd downregulated monoacylglycerol lipase, a hydrolase for the endocannabinoid 2-arachidonoylglycerol (2-ag), suggesting the involvement of ecb accumulation and the consequent synaptic plasticity in remsd-elicited memory impairment in adolescent mice. |
2021-05-14 |
2023-08-13 |
mouse |
| Matteo Tardell. Monoacylglycerol lipase reprograms lipid precursors signaling in liver disease. World journal of gastroenterology. vol 26. issue 25. 2021-05-14. PMID:32742127. |
notably, monoacylglycerol lipase (mgl) also hydrolyzes 2-arachidonoylglycerol, which is a potent ligand within the endocannabinoid system, into arachidonic acid - a precursor for prostaglandin synthesis; thus representing a pivotal substrates provider in multiple organs for several intersecting biological pathways ranging from fa metabolism to inflammation, pain and appetite. |
2021-05-14 |
2023-08-13 |
Not clear |
| C M Diester, A H Lichtman, S S Negu. Behavioral Battery for Testing Candidate Analgesics in Mice. II. Effects of Endocannabinoid Catabolic Enzyme Inhibitors and ∆9-Tetrahydrocannabinol. The Journal of pharmacology and experimental therapeutics. vol 377. issue 2. 2021-05-13. PMID:33622769. |
enhanced signaling of the endocannabinoid (ecb) system through inhibition of the catabolic enzymes monoacylglycerol lipase (magl) and fatty acid amide hydrolase (faah) has received increasing interest for development of candidate analgesics. |
2021-05-13 |
2023-08-13 |
mouse |
| Bin Zhu, Peter J Connolly, Sui-Po Zhang, Kristen M Chevalier, Cynthia M Milligan, Christopher M Flores, Mark J Maciela. The discovery of diazetidinyl diamides as potent and reversible inhibitors of monoacylglycerol lipase (MAGL). Bioorganic & medicinal chemistry letters. vol 30. issue 12. 2021-05-12. PMID:32334914. |
monoacylglycerol lipase (magl) has emerged as an attractive drug target because of its important role in regulating the endocannabinoid 2-arachidonoylglycerol (2-ag) and its hydrolysis product arachidonic acid (aa) in the brain. |
2021-05-12 |
2023-08-13 |
rat |