| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chang Liu, Shanshan Guan, Jingwen E, Zhijie Yang, Xinyue Zhang, Jianan Ju, Song Wang, Hao Zhan. Insight into the Inhibitory Mechanism of Aryl Formyl Piperidine Derivatives on Monoacylglycerol Lipase through Molecular Dynamics Simulations. Molecules (Basel, Switzerland). vol 27. issue 21. 2022-11-11. PMID:36364337. |
monoacylglycerol lipase (magl) can regulate the endocannabinoid system and thus becomes a target of antidepressant drugs. |
2022-11-11 |
2023-08-14 |
Not clear |
| Chu Che. Endocannabinoid control of neuroinflammation in traumatic brain injury by monoacylglycerol lipase in astrocytes. Neural regeneration research. vol 18. issue 5. 2022-10-18. PMID:36254984. |
endocannabinoid control of neuroinflammation in traumatic brain injury by monoacylglycerol lipase in astrocytes. |
2022-10-18 |
2023-08-14 |
Not clear |
| Jing Xu, Guanghui Zheng, Juntao Hu, Weiwei Ge, Jennifer L Bradley, Joseph P Ornato, Wanchun Tan. The monoacylglycerol lipase inhibitor, JZL184, has comparable effects to therapeutic hypothermia, attenuating global cerebral injury in a rat model of cardiac arrest. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 156. 2022-10-17. PMID:36252353. |
monoacylglycerol lipase (magl) is an enzyme that is predominantly responsible for the metabolism of endocannabinoid 2-arachidonoylglycerol (2-ag) to arachidonic acid (aa) metabolites, which are associated with inflammation. |
2022-10-17 |
2023-08-14 |
rat |
| Alba Navarro-Romero, Lorena Galera-López, Paula Ortiz-Romero, Alberto Llorente-Ovejero, Lucía de Los Reyes-Ramírez, Iker Bengoetxea de Tena, Anna Garcia-Elias, Aleksandra Mas-Stachurska, Marina Reixachs-Solé, Antoni Pastor, Rafael de la Torre, Rafael Maldonado, Begoña Benito, Eduardo Eyras, Rafael Rodríguez-Puertas, Victoria Campuzano, Andres Ozait. Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams-Beuren syndrome. eLife. vol 11. 2022-10-11. PMID:36217821. |
endocannabinoid signaling modulation with subchronic (10 days) jzl184, a selective inhibitor of monoacylglycerol lipase, specifically normalized the social and cognitive phenotype of cd mice. |
2022-10-11 |
2023-08-14 |
mouse |
| Kwang-Mook Jung, Daniele Piomell. Assay of Monoacylglycerol Lipase Activity. Methods in molecular biology (Clifton, N.J.). vol 2576. 2022-09-24. PMID:36152196. |
monoacylglycerol lipase (mgl/magl/mgll) is a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-ag). |
2022-09-24 |
2023-08-14 |
Not clear |
| Yingfang He, Uwe Grether, Marco F Taddio, Carla Meier, Claudia Keller, Martin R Edelmann, Michael Honer, Sylwia Huber, Matthias B Wittwer, Dominik Heer, Hans Richter, Ludovic Collin, Melanie N Hug, Manuel Hilbert, Annemarieke G J Postmus, Anna Floor Stevens, Mario van der Stelt, Stefanie D Krämer, Roger Schibli, Linjing Mu, Luca C Gobb. Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain. European journal of medicinal chemistry. vol 243. 2022-09-22. PMID:36137365. |
monoacylglycerol lipase (magl) is a gatekeeper in regulating endocannabinoid signaling and has gained substantial attention as a therapeutic target for neurological disorders. |
2022-09-22 |
2023-08-14 |
Not clear |
| Hui Deng, Qianwen Zhang, Qian Lei, Na Yang, Kai Yang, Jianbing Jiang, Zhiyi Y. Discovering monoacylglycerol lipase inhibitors by a combination of fluorogenic substrate assay and activity-based protein profiling. Frontiers in pharmacology. vol 13. 2022-09-15. PMID:36105202. |
the endocannabinoid 2-arachidonoylglycerol (2-ag) is predominantly metabolized by monoacylglycerol lipase (magl) in the brain. |
2022-09-15 |
2023-08-14 |
Not clear |
| Alicia M Kemble, Benoit Hornsperger, Iris Ruf, Hans Richter, Jörg Benz, Bernd Kuhn, Dominik Heer, Matthias Wittwer, Britta Engelhardt, Uwe Grether, Ludovic Colli. A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature. PloS one. vol 17. issue 9. 2022-09-09. PMID:36084029. |
monoacylglycerol lipase hydrolyzes the endocannabinoid signaling lipid 2-arachidonyl glycerol, enhancing local pools of arachidonic acid in the brain and leading to cyclooxygenase-mediated prostaglandin production and neuroinflammation. |
2022-09-09 |
2023-08-14 |
mouse |
| Rantaro Kamimura, Mohammad Zakir Hossain, Kojiro Takahashi, Isao Saito, Junichi Kitagaw. Attenuation of allodynia and microglial reactivity by inhibiting the degradation of 2-arachidonoylglycerol following injury to the trigeminal nerve in mice. Heliyon. vol 8. issue 8. 2022-08-22. PMID:35991988. |
in our previous study, we observed that preventing the degradation of a endocannabinoid, 2-arachidonoylglycerol (2-ag), using an inhibitor of monoacylglycerol lipase (jzl184), attenuated neuropathic orofacial pain (nop). |
2022-08-22 |
2023-08-14 |
mouse |
| Laura Micheli, Samuele Maramai, Alessandra Toti, Valentina Ferrara, Clara Ciampi, Lorenzo Di Cesare Mannelli, Carla Ghelardin. Inhibition of Monoacylglycerol Lipase by NSD1819 as an Effective Strategy for the Endocannabinoid System Modulation against Neuroinflammation-Related Disorders. International journal of molecular sciences. vol 23. issue 15. 2022-08-12. PMID:35955562. |
inhibition of monoacylglycerol lipase by nsd1819 as an effective strategy for the endocannabinoid system modulation against neuroinflammation-related disorders. |
2022-08-12 |
2023-08-14 |
mouse |
| Yuta Kudo, Keiichi Konoki, Mari Yotsu-Yamashit. Mass spectrometry-guided discovery of new analogues of bicyclic phosphotriester salinipostin and evaluation of their monoacylglycerol lipase inhibitory activity. Bioscience, biotechnology, and biochemistry. 2022-08-02. PMID:35918181. |
previously known and herein-identified spt analogues inhibited the activity of human monoacylglycerol lipase (magl), a key serine hydrolase in the endocannabinoid system, in the nanomolar range. |
2022-08-02 |
2023-08-14 |
human |
| Alexius Lampkin, Vaishali Baksh. Effects of Increasing Endocannabinoid 2-AG Tone on Sensorimotor Gating and Anxiety-like behavior. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556730. |
we were particularly interested in pursuing an understudied approach, augmentation of endogenous endocannabinoid 'tone' via inhibition of monoacylglycerol lipase (magl), the breakdown enzyme for the endocannabinoid 2-ag. |
2022-05-13 |
2023-08-13 |
rat |
| Ran Cheng, Masayuki Fujinaga, Jing Yang, Jian Rong, Ahmed Haider, Daisuke Ogasawara, Richard S Van, Tuo Shao, Zhen Chen, Xiaofei Zhang, Erick R Calderon Leon, Yiding Zhang, Wakana Mori, Katsushi Kumata, Tomoteru Yamasaki, Lin Xie, Shaofa Sun, Lu Wang, Chongzhao Ran, Yihan Shao, Benjamin Cravatt, Lee Josephson, Ming-Rong Zhang, Steven H Lian. A novel monoacylglycerol lipase-targeted Acta pharmacologica Sinica. 2022-05-05. PMID:35513432. |
a novel monoacylglycerol lipase-targeted monoacylglycerol lipase (magl) constitutes a serine hydrolase that orchestrates endocannabinoid homeostasis and exerts its function by catalyzing the degradation of 2-arachidonoylglycerol (2-ag) to arachidonic acid (aa). |
2022-05-05 |
2023-08-13 |
Not clear |
| Min-Che Tung, Kit-Man Fung, Hsin-Mie Hsu, Tien-Sheng Tsen. Discovery of 8-prenylnaringenin from hop ( RSC advances. vol 11. issue 49. 2022-05-02. PMID:35498911. |
discovery of 8-prenylnaringenin from hop ( monoacylglycerol lipase (magl), a serine hydrolase, converts endocannabinoid 2-arachidonoylglycerol (2-ag) to arachidonic acid (aa) and glycerol in the brain and plays a bidirectional role in controlling nueroinflammation. |
2022-05-02 |
2023-08-13 |
human |
| Shivanshu Bajaj, Saima Zameer, Shreshta Jain, Vaishali Yadav, Divya Vohor. Effect of the MAGL/FAAH Dual Inhibitor JZL-195 on Streptozotocin-Induced Alzheimer's Disease-like Sporadic Dementia in Mice with an Emphasis on Aβ, HSP-70, Neuroinflammation, and Oxidative Stress. ACS chemical neuroscience. 2022-03-22. PMID:35316021. |
recently, pharmacological inhibition of endocannabinoid (ecb)-degrading enzymes, fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), is being investigated to modulate the pathology of alzheimer's disease. |
2022-03-22 |
2023-08-13 |
mouse |
| Erin Jordan, Gia-Nam Nguyen, Alexander Piechot, Oliver Kayse. Cannabinoids as New Drug Candidates for the Treatment of Glaucoma. Planta medica. 2022-03-17. PMID:35299275. |
especially the role of the endocannabinoid system (fatty acid amide hydrolase, monoacylglycerol lipase) impacting the prostaglandin network (cyclooxygenase, pge, pgf) and neuroprotection by inhibition of nitric oxide radical formation is in the focus of this review. |
2022-03-17 |
2023-08-13 |
Not clear |
| Yingfang He, Luca C Gobbi, Adrienne Müller Herde, Didier Rombach, Martin Ritter, Bernd Kuhn, Matthias B Wittwer, Dominik Heer, Benoit Hornsperger, Charles Bell, Fionn O'Hara, Jörg Benz, Michael Honer, Claudia Keller, Ludovic Collin, Hans Richter, Roger Schibli, Uwe Grether, Linjing M. Discovery, synthesis and evaluation of novel reversible monoacylglycerol lipase radioligands bearing a morpholine-3-one scaffold. Nuclear medicine and biology. vol 108-109. 2022-03-06. PMID:35248850. |
monoacylglycerol lipase (magl) is a serine hydrolase that plays an important role in the endocannabinoid degradation in the brain. |
2022-03-06 |
2023-08-13 |
Not clear |
| Ryosuke Arakawa, Akihiro Takano, Sangram Nag, Zhisheng Jia, Nahid Amini, Kevin P Maresca, Lei Zhang, Edmund J Keliher, Christopher R Butler, Justin R Piro, Tarek A Samad, Deborah Smith, Deane Nason, Steve O'Neil, Patrick Trapa, Kari R Fonseca, John Litchfield, Timothy McCarthy, Richard E Carson, Christer Halldi. Target occupancy study and whole-body dosimetry with a MAGL PET ligand [ EJNMMI research. vol 12. issue 1. 2022-03-04. PMID:35244788. |
target occupancy study and whole-body dosimetry with a magl pet ligand [ monoacylglycerol lipase (magl) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. |
2022-03-04 |
2023-08-13 |
Not clear |
| Mei Hu, Dexiao Zhu, Jian Zhang, Fei Gao, Jack Hashem, Philip Kingsley, Lawrence J Marnett, Ken Mackie, Chu Che. Enhancing endocannabinoid signalling in astrocytes promotes recovery from traumatic brain injury. Brain : a journal of neurology. 2022-02-09. PMID:35136958. |
previous studies showed that pharmacological inhibition of monoacylglycerol lipase, a key enzyme degrading the endocannabinoid 2-arachidonoylglycerol, attenuates traumatic brain injury-induced neuropathology. |
2022-02-09 |
2023-08-13 |
mouse |
| Mei Hu, Dexiao Zhu, Jian Zhang, Fei Gao, Jack Hashem, Philip Kingsley, Lawrence J Marnett, Ken Mackie, Chu Che. Enhancing endocannabinoid signalling in astrocytes promotes recovery from traumatic brain injury. Brain : a journal of neurology. 2022-02-09. PMID:35136958. |
the monoacylglycerol lipase inactivation-produced neuroprotection is abrogated by deletion of the cannabinoid receptor-1 or by adeno-associated virus vector-mediated silencing of astrocytic peroxisome proliferator-activated receptor-γ. |
2022-02-09 |
2023-08-13 |
mouse |