| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexius Lampkin, Vaishali Baksh. Effects of Increasing Endocannabinoid 2-AG Tone on Sensorimotor Gating and Anxiety-like behavior. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556730. |
we were particularly interested in pursuing an understudied approach, augmentation of endogenous endocannabinoid 'tone' via inhibition of monoacylglycerol lipase (magl), the breakdown enzyme for the endocannabinoid 2-ag. |
2022-05-13 |
2023-08-13 |
rat |
| Ran Cheng, Masayuki Fujinaga, Jing Yang, Jian Rong, Ahmed Haider, Daisuke Ogasawara, Richard S Van, Tuo Shao, Zhen Chen, Xiaofei Zhang, Erick R Calderon Leon, Yiding Zhang, Wakana Mori, Katsushi Kumata, Tomoteru Yamasaki, Lin Xie, Shaofa Sun, Lu Wang, Chongzhao Ran, Yihan Shao, Benjamin Cravatt, Lee Josephson, Ming-Rong Zhang, Steven H Lian. A novel monoacylglycerol lipase-targeted Acta pharmacologica Sinica. 2022-05-05. PMID:35513432. |
a novel monoacylglycerol lipase-targeted monoacylglycerol lipase (magl) constitutes a serine hydrolase that orchestrates endocannabinoid homeostasis and exerts its function by catalyzing the degradation of 2-arachidonoylglycerol (2-ag) to arachidonic acid (aa). |
2022-05-05 |
2023-08-13 |
Not clear |
| Min-Che Tung, Kit-Man Fung, Hsin-Mie Hsu, Tien-Sheng Tsen. Discovery of 8-prenylnaringenin from hop ( RSC advances. vol 11. issue 49. 2022-05-02. PMID:35498911. |
discovery of 8-prenylnaringenin from hop ( monoacylglycerol lipase (magl), a serine hydrolase, converts endocannabinoid 2-arachidonoylglycerol (2-ag) to arachidonic acid (aa) and glycerol in the brain and plays a bidirectional role in controlling nueroinflammation. |
2022-05-02 |
2023-08-13 |
human |
| Shivanshu Bajaj, Saima Zameer, Shreshta Jain, Vaishali Yadav, Divya Vohor. Effect of the MAGL/FAAH Dual Inhibitor JZL-195 on Streptozotocin-Induced Alzheimer's Disease-like Sporadic Dementia in Mice with an Emphasis on Aβ, HSP-70, Neuroinflammation, and Oxidative Stress. ACS chemical neuroscience. 2022-03-22. PMID:35316021. |
recently, pharmacological inhibition of endocannabinoid (ecb)-degrading enzymes, fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), is being investigated to modulate the pathology of alzheimer's disease. |
2022-03-22 |
2023-08-13 |
mouse |
| Erin Jordan, Gia-Nam Nguyen, Alexander Piechot, Oliver Kayse. Cannabinoids as New Drug Candidates for the Treatment of Glaucoma. Planta medica. 2022-03-17. PMID:35299275. |
especially the role of the endocannabinoid system (fatty acid amide hydrolase, monoacylglycerol lipase) impacting the prostaglandin network (cyclooxygenase, pge, pgf) and neuroprotection by inhibition of nitric oxide radical formation is in the focus of this review. |
2022-03-17 |
2023-08-13 |
Not clear |
| Yingfang He, Luca C Gobbi, Adrienne Müller Herde, Didier Rombach, Martin Ritter, Bernd Kuhn, Matthias B Wittwer, Dominik Heer, Benoit Hornsperger, Charles Bell, Fionn O'Hara, Jörg Benz, Michael Honer, Claudia Keller, Ludovic Collin, Hans Richter, Roger Schibli, Uwe Grether, Linjing M. Discovery, synthesis and evaluation of novel reversible monoacylglycerol lipase radioligands bearing a morpholine-3-one scaffold. Nuclear medicine and biology. vol 108-109. 2022-03-06. PMID:35248850. |
monoacylglycerol lipase (magl) is a serine hydrolase that plays an important role in the endocannabinoid degradation in the brain. |
2022-03-06 |
2023-08-13 |
Not clear |
| Ryosuke Arakawa, Akihiro Takano, Sangram Nag, Zhisheng Jia, Nahid Amini, Kevin P Maresca, Lei Zhang, Edmund J Keliher, Christopher R Butler, Justin R Piro, Tarek A Samad, Deborah Smith, Deane Nason, Steve O'Neil, Patrick Trapa, Kari R Fonseca, John Litchfield, Timothy McCarthy, Richard E Carson, Christer Halldi. Target occupancy study and whole-body dosimetry with a MAGL PET ligand [ EJNMMI research. vol 12. issue 1. 2022-03-04. PMID:35244788. |
target occupancy study and whole-body dosimetry with a magl pet ligand [ monoacylglycerol lipase (magl) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. |
2022-03-04 |
2023-08-13 |
Not clear |
| Mei Hu, Dexiao Zhu, Jian Zhang, Fei Gao, Jack Hashem, Philip Kingsley, Lawrence J Marnett, Ken Mackie, Chu Che. Enhancing endocannabinoid signalling in astrocytes promotes recovery from traumatic brain injury. Brain : a journal of neurology. 2022-02-09. PMID:35136958. |
previous studies showed that pharmacological inhibition of monoacylglycerol lipase, a key enzyme degrading the endocannabinoid 2-arachidonoylglycerol, attenuates traumatic brain injury-induced neuropathology. |
2022-02-09 |
2023-08-13 |
mouse |
| Mei Hu, Dexiao Zhu, Jian Zhang, Fei Gao, Jack Hashem, Philip Kingsley, Lawrence J Marnett, Ken Mackie, Chu Che. Enhancing endocannabinoid signalling in astrocytes promotes recovery from traumatic brain injury. Brain : a journal of neurology. 2022-02-09. PMID:35136958. |
the monoacylglycerol lipase inactivation-produced neuroprotection is abrogated by deletion of the cannabinoid receptor-1 or by adeno-associated virus vector-mediated silencing of astrocytic peroxisome proliferator-activated receptor-γ. |
2022-02-09 |
2023-08-13 |
mouse |
| Tuo Shao, Zhen Chen, Jian Rong, Vasily Belov, Jiahui Chen, Andre Jeyarajan, Xiaoyun Deng, Hualong Fu, Qingzhen Yu, Steve H Rwema, Wenyu Lin, Mikhail Papisov, Lee Josephson, Raymond T Chung, Steven H Lian. [ Acta pharmaceutica Sinica. B. vol 12. issue 1. 2022-02-07. PMID:35127387. |
[ monoacylglycerol lipase (magl) is a pivotal enzyme in the endocannabinoid system, which metabolizes 2-arachidonoylglycerol (2-ag) into the proinflammatory eicosanoid precursor arachidonic acid (aa). |
2022-02-07 |
2023-08-13 |
Not clear |
| Yingfang He, Matthias Schild, Uwe Grether, Jörg Benz, Lea Leibrock, Dominik Heer, Andreas Topp, Ludovic Collin, Bernd Kuhn, Matthias Wittwer, Claudia Keller, Luca C Gobbi, Roger Schibli, Linjing M. Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging. Journal of medicinal chemistry. 2022-01-28. PMID:35089028. |
monoacylglycerol lipase (magl) is one of the key enzymes in the endocannabinoid system. |
2022-01-28 |
2023-08-13 |
Not clear |
| Maximilian Barth, Stefan Rudolph, Jan Kampschulze, Imke Meyer Zu Vilsendorf, Walburga Hanekamp, Dennis Mulac, Klaus Langer, Matthias Leh. Hexafluoroisopropyl carbamates as selective MAGL and dual MAGL/FAAH inhibitors: biochemical and physicochemical properties. ChemMedChem. 2022-01-24. PMID:35072346. |
a series of hexafluoroisopropyl carbamates with indolyl-alkyl- and azaindolylalkyl-substituents at the carbamate nitrogen was synthesized and evaluated for inhibition of the endocannabinoid degrading enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl). |
2022-01-24 |
2023-08-13 |
Not clear |
| Keisuke Takahata, Chie Seki, Yasuyuki Kimura, Manabu Kubota, Masanori Ichise, Yasunori Sano, Yasuharu Yamamoto, Kenji Tagai, Hitoshi Shimada, Soichiro Kitamura, Kiwamu Matsuoka, Hironobu Endo, Hitoshi Shinotoh, Kazunori Kawamura, Ming-Rong Zhang, Yuhei Takado, Makoto Higuch. First-in-human in vivo undefined imaging and quantification of monoacylglycerol lipase in the brain: a PET study with European journal of nuclear medicine and molecular imaging. 2022-01-13. PMID:35022846. |
first-in-human in vivo undefined imaging and quantification of monoacylglycerol lipase in the brain: a pet study with monoacylglycerol lipase (magl) regulates cannabinoid neurotransmission and the pro-inflammatory arachidonic acid pathway by degrading endocannabinoids. |
2022-01-13 |
2023-08-13 |
human |
| Szymon Hryhorowicz, Marta Kaczmarek-Ryś, Aleksandra Zielińska, Rodney J Scott, Ryszard Słomski, Andrzej Pławsk. Endocannabinoid System as a Promising Therapeutic Target in Inflammatory Bowel Disease - A Systematic Review. Frontiers in immunology. vol 12. 2022-01-10. PMID:35003109. |
it consists of cannabinoid receptors (cb1 and cb2), transporters for cellular uptake of endocannabinoid ligands, endogenous bioactive lipids (anandamide and 2-arachidonoylglycerol), and the enzymes responsible for their synthesis and degradation (fatty acid amide hydrolase and monoacylglycerol lipase), the manipulation of which through agonists and antagonists of the system, shows a potential therapeutic role for ecs in inflammatory bowel disease. |
2022-01-10 |
2023-08-13 |
Not clear |
| Hui Jing, Alex Reed, Olesya A Ulanovskaya, Jan-Sebastian Grigoleit, Dylan M Herbst, Cassandra L Henry, Haoxin Li, Sabrina Barbas, Jason Germain, Kim Masuda, Benjamin F Cravat. Phospholipase Cγ2 regulates endocannabinoid and eicosanoid networks in innate immune cells. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 41. 2021-12-06. PMID:34607960. |
here, we show that phospholipase cγ2 (plcγ2 or plcg2)-mutations in which are associated with autoinflammatory disorders and alzheimer's disease-serves as a principal source of diacylglycerol (dag) pools that are converted into a cascade of bioactive endocannabinoid and eicosanoid lipids by dag lipase (dagl) and monoacylglycerol lipase (mgll) enzymes in innate immune cells. |
2021-12-06 |
2023-08-13 |
mouse |
| Kirsten R Müller-Vahl, Carolin Fremer, Chan Beals, Jelena Ivkovic, Henrik Loft, Christoph Schindle. Endocannabinoid Modulation Using Monoacylglycerol Lipase Inhibition in Tourette Syndrome: A Phase 1 Randomized, Placebo-Controlled Study. Pharmacopsychiatry. 2021-11-30. PMID:34847610. |
endocannabinoid modulation using monoacylglycerol lipase inhibition in tourette syndrome: a phase 1 randomized, placebo-controlled study. |
2021-11-30 |
2023-08-13 |
Not clear |
| Kirsten R Müller-Vahl, Carolin Fremer, Chan Beals, Jelena Ivkovic, Henrik Loft, Christoph Schindle. Endocannabinoid Modulation Using Monoacylglycerol Lipase Inhibition in Tourette Syndrome: A Phase 1 Randomized, Placebo-Controlled Study. Pharmacopsychiatry. 2021-11-30. PMID:34847610. |
lu ag06466 (previously abx-1431) is a highly selective inhibitor of monoacylglycerol lipase, the primary enzyme responsible for the degradation of the endocannabinoid ligand 2-arachidonoylglycerol. |
2021-11-30 |
2023-08-13 |
Not clear |
| Shuwen Cao, Phei Er Saw, Qian Shen, Rong Li, Yun Liu, Xiaoding X. Reduction-responsive RNAi nanoplatform to reprogram tumor lipid metabolism and repolarize macrophage for combination pancreatic cancer therapy. Biomaterials. 2021-11-26. PMID:34823884. |
herein, we identified an important enzyme catabolizing lipids (monoacylglycerol lipase, mgll) and a key receptor regulating macrophage phenotype (endocannabinoid receptor-2, cb-2) that are over-expressed in pac cells and on tams, respectively. |
2021-11-26 |
2023-08-13 |
Not clear |
| Jenny L Wilkerson, Joshua A Bilbrey, Jasmine S Felix, Alexandros Makriyannis, Lance R McMaho. Untapped endocannabinoid pharmacological targets: Pipe dream or pipeline? Pharmacology, biochemistry, and behavior. vol 206. 2021-11-24. PMID:33932409. |
the endocannabinoid system comprises both cannabinoid receptors, their endogenous ligands including 2-arachidonoylglycerol (2-ag), n-arachidonylethanolamine (anandamide, aea), and enzymes that regulate the synthesis and degradation of endogenous ligands which include diacylglycerol lipase alpha (dagl-α), diacylglycerol lipase beta (dagl-β), fatty acid amide hydrolase (faah), monoacylglycerol lipase (magl), α/β hydrolase domain 6 (abhd6). |
2021-11-24 |
2023-08-13 |
Not clear |
| Dan P Covey, Edith Hernandez, Miguel Á Luján, Joseph F Chee. Chronic Augmentation of Endocannabinoid Levels Persistently Increases Dopaminergic Encoding of Reward Cost and Motivation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 32. 2021-11-22. PMID:34230105. |
because endocannabinoid (ecb) signaling facilitates goal seeking and nac da release, we further investigated whether repeated augmentation of the ecb 2-arachidonoylglycerol with a low dose of a monoacylglycerol lipase (magl) inhibitor facilitates motivation and da signaling without the development of tolerance. |
2021-11-22 |
2023-08-13 |
mouse |