| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tuo Shao, Zhen Chen, Jian Rong, Vasily Belov, Jiahui Chen, Andre Jeyarajan, Xiaoyun Deng, Hualong Fu, Qingzhen Yu, Steve H Rwema, Wenyu Lin, Mikhail Papisov, Lee Josephson, Raymond T Chung, Steven H Lian. [ Acta pharmaceutica Sinica. B. vol 12. issue 1. 2022-02-07. PMID:35127387. |
[ monoacylglycerol lipase (magl) is a pivotal enzyme in the endocannabinoid system, which metabolizes 2-arachidonoylglycerol (2-ag) into the proinflammatory eicosanoid precursor arachidonic acid (aa). |
2022-02-07 |
2023-08-13 |
Not clear |
| Yingfang He, Matthias Schild, Uwe Grether, Jörg Benz, Lea Leibrock, Dominik Heer, Andreas Topp, Ludovic Collin, Bernd Kuhn, Matthias Wittwer, Claudia Keller, Luca C Gobbi, Roger Schibli, Linjing M. Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging. Journal of medicinal chemistry. 2022-01-28. PMID:35089028. |
monoacylglycerol lipase (magl) is one of the key enzymes in the endocannabinoid system. |
2022-01-28 |
2023-08-13 |
Not clear |
| Maximilian Barth, Stefan Rudolph, Jan Kampschulze, Imke Meyer Zu Vilsendorf, Walburga Hanekamp, Dennis Mulac, Klaus Langer, Matthias Leh. Hexafluoroisopropyl carbamates as selective MAGL and dual MAGL/FAAH inhibitors: biochemical and physicochemical properties. ChemMedChem. 2022-01-24. PMID:35072346. |
a series of hexafluoroisopropyl carbamates with indolyl-alkyl- and azaindolylalkyl-substituents at the carbamate nitrogen was synthesized and evaluated for inhibition of the endocannabinoid degrading enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl). |
2022-01-24 |
2023-08-13 |
Not clear |
| Keisuke Takahata, Chie Seki, Yasuyuki Kimura, Manabu Kubota, Masanori Ichise, Yasunori Sano, Yasuharu Yamamoto, Kenji Tagai, Hitoshi Shimada, Soichiro Kitamura, Kiwamu Matsuoka, Hironobu Endo, Hitoshi Shinotoh, Kazunori Kawamura, Ming-Rong Zhang, Yuhei Takado, Makoto Higuch. First-in-human in vivo undefined imaging and quantification of monoacylglycerol lipase in the brain: a PET study with European journal of nuclear medicine and molecular imaging. 2022-01-13. PMID:35022846. |
first-in-human in vivo undefined imaging and quantification of monoacylglycerol lipase in the brain: a pet study with monoacylglycerol lipase (magl) regulates cannabinoid neurotransmission and the pro-inflammatory arachidonic acid pathway by degrading endocannabinoids. |
2022-01-13 |
2023-08-13 |
human |
| Szymon Hryhorowicz, Marta Kaczmarek-Ryś, Aleksandra Zielińska, Rodney J Scott, Ryszard Słomski, Andrzej Pławsk. Endocannabinoid System as a Promising Therapeutic Target in Inflammatory Bowel Disease - A Systematic Review. Frontiers in immunology. vol 12. 2022-01-10. PMID:35003109. |
it consists of cannabinoid receptors (cb1 and cb2), transporters for cellular uptake of endocannabinoid ligands, endogenous bioactive lipids (anandamide and 2-arachidonoylglycerol), and the enzymes responsible for their synthesis and degradation (fatty acid amide hydrolase and monoacylglycerol lipase), the manipulation of which through agonists and antagonists of the system, shows a potential therapeutic role for ecs in inflammatory bowel disease. |
2022-01-10 |
2023-08-13 |
Not clear |
| Hui Jing, Alex Reed, Olesya A Ulanovskaya, Jan-Sebastian Grigoleit, Dylan M Herbst, Cassandra L Henry, Haoxin Li, Sabrina Barbas, Jason Germain, Kim Masuda, Benjamin F Cravat. Phospholipase Cγ2 regulates endocannabinoid and eicosanoid networks in innate immune cells. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 41. 2021-12-06. PMID:34607960. |
here, we show that phospholipase cγ2 (plcγ2 or plcg2)-mutations in which are associated with autoinflammatory disorders and alzheimer's disease-serves as a principal source of diacylglycerol (dag) pools that are converted into a cascade of bioactive endocannabinoid and eicosanoid lipids by dag lipase (dagl) and monoacylglycerol lipase (mgll) enzymes in innate immune cells. |
2021-12-06 |
2023-08-13 |
mouse |
| Kirsten R Müller-Vahl, Carolin Fremer, Chan Beals, Jelena Ivkovic, Henrik Loft, Christoph Schindle. Endocannabinoid Modulation Using Monoacylglycerol Lipase Inhibition in Tourette Syndrome: A Phase 1 Randomized, Placebo-Controlled Study. Pharmacopsychiatry. 2021-11-30. PMID:34847610. |
endocannabinoid modulation using monoacylglycerol lipase inhibition in tourette syndrome: a phase 1 randomized, placebo-controlled study. |
2021-11-30 |
2023-08-13 |
Not clear |
| Kirsten R Müller-Vahl, Carolin Fremer, Chan Beals, Jelena Ivkovic, Henrik Loft, Christoph Schindle. Endocannabinoid Modulation Using Monoacylglycerol Lipase Inhibition in Tourette Syndrome: A Phase 1 Randomized, Placebo-Controlled Study. Pharmacopsychiatry. 2021-11-30. PMID:34847610. |
lu ag06466 (previously abx-1431) is a highly selective inhibitor of monoacylglycerol lipase, the primary enzyme responsible for the degradation of the endocannabinoid ligand 2-arachidonoylglycerol. |
2021-11-30 |
2023-08-13 |
Not clear |
| Shuwen Cao, Phei Er Saw, Qian Shen, Rong Li, Yun Liu, Xiaoding X. Reduction-responsive RNAi nanoplatform to reprogram tumor lipid metabolism and repolarize macrophage for combination pancreatic cancer therapy. Biomaterials. 2021-11-26. PMID:34823884. |
herein, we identified an important enzyme catabolizing lipids (monoacylglycerol lipase, mgll) and a key receptor regulating macrophage phenotype (endocannabinoid receptor-2, cb-2) that are over-expressed in pac cells and on tams, respectively. |
2021-11-26 |
2023-08-13 |
Not clear |
| Jenny L Wilkerson, Joshua A Bilbrey, Jasmine S Felix, Alexandros Makriyannis, Lance R McMaho. Untapped endocannabinoid pharmacological targets: Pipe dream or pipeline? Pharmacology, biochemistry, and behavior. vol 206. 2021-11-24. PMID:33932409. |
the endocannabinoid system comprises both cannabinoid receptors, their endogenous ligands including 2-arachidonoylglycerol (2-ag), n-arachidonylethanolamine (anandamide, aea), and enzymes that regulate the synthesis and degradation of endogenous ligands which include diacylglycerol lipase alpha (dagl-α), diacylglycerol lipase beta (dagl-β), fatty acid amide hydrolase (faah), monoacylglycerol lipase (magl), α/β hydrolase domain 6 (abhd6). |
2021-11-24 |
2023-08-13 |
Not clear |
| Dan P Covey, Edith Hernandez, Miguel Á Luján, Joseph F Chee. Chronic Augmentation of Endocannabinoid Levels Persistently Increases Dopaminergic Encoding of Reward Cost and Motivation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 32. 2021-11-22. PMID:34230105. |
because endocannabinoid (ecb) signaling facilitates goal seeking and nac da release, we further investigated whether repeated augmentation of the ecb 2-arachidonoylglycerol with a low dose of a monoacylglycerol lipase (magl) inhibitor facilitates motivation and da signaling without the development of tolerance. |
2021-11-22 |
2023-08-13 |
mouse |
| Yasushi Hattori, Chie Seki, Jun Maeda, Yuji Nagai, Kazunobu Aoyama, Ming-Rong Zhang, Takafumi Minamimoto, Tatsuki Koike, Makoto Higuch. Quantification of monoacylglycerol lipase and its occupancy by an exogenous ligand in rhesus monkey brains using [ Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021-11-13. PMID:34727758. |
quantification of monoacylglycerol lipase and its occupancy by an exogenous ligand in rhesus monkey brains using [ monoacylglycerol lipase (magl) is a cytosolic serine hydrolase that cleaves monoacylglycerols into fatty acids and is a potential target for the novel treatment of cns disorders related to the endocannabinoid system and neuroinflammation. |
2021-11-13 |
2023-08-13 |
monkey |
| Anca Zanfirescu, Anca Ungurianu, Dragos Paul Mihai, Denise Radulescu, George Mihai Nitulesc. Targeting Monoacylglycerol Lipase in Pursuit of Therapies for Neurological and Neurodegenerative Diseases. Molecules (Basel, Switzerland). vol 26. issue 18. 2021-11-11. PMID:34577139. |
monoacylglycerol lipase (magl) is a key enzyme involved in the metabolism of 2-ag (2-arachidonoylglycerol), a neuroprotective endocannabinoid intimately linked to the generation of pro- and anti-inflammatory molecules. |
2021-11-11 |
2023-08-13 |
Not clear |
| Sahar Rostami-Mansoor, Narges Kalantari, Tahmineh Gorgani-Firouzjaee, Salman Ghaffari, Maryam Ghasemi-Kasma. Modulation of mRNA Expression of Monoacylglycerol Lipase, Diacylglycerol Lipase and Cannabinoid Receptor-1 in Mice Experimentally Infected with International journal of molecular and cellular medicine. vol 10. issue 2. 2021-10-28. PMID:34703798. |
modulation of mrna expression of monoacylglycerol lipase, diacylglycerol lipase and cannabinoid receptor-1 in mice experimentally infected with |
2021-10-28 |
2023-08-13 |
mouse |
| Alex J Berry, Olga Zubko, Suzanne J Reeves, Robert J Howar. Endocannabinoid system alterations in Alzheimer's disease: A systematic review of human studies. Brain research. vol 1749. 2021-10-27. PMID:32980333. |
we attempted to identify reported changes in the expression and activity of: cannabinoid receptors 1 and 2; anandamide (aea); 2-arachidonoylglycerol (2-ag); monoacylglycerol lipase (magl); fatty acid amide hydrolase (faah); and transient receptor potential cation channel v1 (trpv1). |
2021-10-27 |
2023-08-13 |
human |
| Despina Kokona, Dimitris Spyridakos, Manolis Tzatzarakis, Sofia Papadogkonaki, Eirini Filidou, Konstantinos I Arvanitidis, George Kolios, Manjunath Lamani, Alexandros Makriyannis, Michael S Malamas, Kyriaki Thermo. The endocannabinoid 2-arachidonoylglycerol and dual ABHD6/MAGL enzyme inhibitors display neuroprotective and anti-inflammatory actions in the in vivo retinal model of AMPA excitotoxicity. Neuropharmacology. vol 185. 2021-10-21. PMID:33450278. |
here, we aimed to investigate the ability of the endocannabinoid 2-arachidonoylglycerol (2-ag) and novel inhibitors of its metabolic enzymes, α/β-hydrolase domain-containing 6 (abhd6) and monoacylglycerol lipase (magl), a) to protect the retina against excitotoxicity and b) the mechanisms involved in the neuroprotection. |
2021-10-21 |
2023-08-13 |
rat |
| Kirsten R Müller-Vahl, Carolin Fremer, Chan Beals, Jelena Ivkovic, Henrik Loft, Christoph Schindle. Monoacylglycerol Lipase Inhibition in Tourette Syndrome: A 12-Week, Randomized, Controlled Study. Movement disorders : official journal of the Movement Disorder Society. vol 36. issue 10. 2021-10-21. PMID:34117788. |
modulation of the endocannabinoid system via monoacylglycerol lipase inhibition with lu ag06466 (formerly known as abx-1431) has previously been shown to reduce tics in patients with tourette syndrome. |
2021-10-21 |
2023-08-13 |
Not clear |
| Tomoteru Yamasaki, Akiko Hatori, Yiding Zhang, Wakana Mori, Yusuke Kurihara, Masanao Ogawa, Hidekatsu Wakizaka, Jian Rong, Lu Wang, Steven Liang, Ming-Rong Zhan. Neuroprotective effects of minocycline and KML29, a potent inhibitor of monoacylglycerol lipase, in an experimental stroke model: a small-animal positron emission tomography study. Theranostics. vol 11. issue 19. 2021-10-15. PMID:34646382. |
monoacylglycerol lipase (magl) is a modulator of 2-arachidonoylglycerol (2-ag), which is involved in retrograde inhibition of glutamate release in the endocannabinoid system. |
2021-10-15 |
2023-08-13 |
rat |
| Giulia Bononi, Giacomo Tonarini, Giulio Poli, Ivana Barravecchia, Isabella Caligiuri, Marco Macchia, Flavio Rizzolio, Gian Carlo Demontis, Filippo Minutolo, Carlotta Granchi, Tiziano Tuccinard. Monoacylglycerol lipase (MAGL) inhibitors based on a diphenylsulfide-benzoylpiperidine scaffold. European journal of medicinal chemistry. vol 223. 2021-10-12. PMID:34218085. |
monoacylglycerol lipase (magl) is an enzyme belonging to the endocannabinoid system that mainly metabolizes the endocannabinoid 2-arachidonoylglycerol (2-ag). |
2021-10-12 |
2023-08-13 |
Not clear |
| Swarup Mitra, Pedro H Gobira, Craig T Werner, Jennifer A Martin, Madoka Iida, Shruthi A Thomas, Kyra Erias, Sophia Miracle, Charles Lafargue, Chunna An, David M Diet. A role for the endocannabinoid enzymes monoacylglycerol and diacylglycerol lipases in cue-induced cocaine craving following prolonged abstinence. Addiction biology. vol 26. issue 5. 2021-10-06. PMID:33496035. |
at prolonged abstinence (30 days) from cocaine self-administration, there is an increase in the nac levels of diacylglycerol lipase (dagl), the enzyme responsible for the synthesis of the endocannabinoid 2-ag, along with decreased levels of monoacylglycerol lipase (magl), which hydrolyzes 2-ag. |
2021-10-06 |
2023-08-13 |
Not clear |