| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takahiro Shimizu, Kenjiro Tanaka, Kunihiko Yokotan. Stimulatory and inhibitory roles of brain 2-arachidonoylglycerol in bombesin-induced central activation of adrenomedullary outflow in rats. Journal of pharmacological sciences. vol 121. issue 2. 2014-02-04. PMID:23386378. |
2-arachidonoylglycerol (2-ag) is recognized as a potent endocannabinoid, which reduces synaptic transmission through cannabinoid cb(1) receptors, and is hydrolyzed by monoacylglycerol lipase (mgl) to arachidonic acid (aa), a cyclooxygenase substrate. |
2014-02-04 |
2023-08-12 |
rat |
| Divya Ramesh, Thomas F Gamage, Tim Vanuytsel, Robert A Owens, Rehab A Abdullah, Micah J Niphakis, Terez Shea-Donohue, Benjamin F Cravatt, Aron H Lichtma. Dual inhibition of endocannabinoid catabolic enzymes produces enhanced antiwithdrawal effects in morphine-dependent mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 6. 2014-01-21. PMID:23303065. |
inhibition of the endocannabinoid catabolic enzymes, monoacylglycerol lipase (magl) or fatty acid amide hydrolase (faah) attenuates naloxone-precipitated opioid withdrawal signs in mice via activation of cb1 receptors. |
2014-01-21 |
2023-08-12 |
mouse |
| Heikki Käsnänen, Anna Minkkilä, Susanna Taupila, Jayendra Z Patel, Teija Parkkari, Maija Lahtela-Kakkonen, Susanna M Saario, Tapio Nevalainen, Antti Pos. 1,3,4-Oxadiazol-2-ones as fatty-acid amide hydrolase and monoacylglycerol lipase inhibitors: Synthesis, in vitro evaluation and insight into potency and selectivity determinants by molecular modelling. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 49. issue 3. 2014-01-07. PMID:23557840. |
inhibition of the key hydrolytic enzymes of the endocannabinoid system, fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), has been proposed as potential mode of action for various therapeutic applications. |
2014-01-07 |
2023-08-12 |
Not clear |
| Mahmoud L Nasr, Xiaomeng Shi, Anna L Bowman, Michael Johnson, Nikolai Zvonok, David R Janero, V Kiran Vemuri, Thomas E Wales, John R Engen, Alexandros Makriyanni. Membrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoire. Protein science : a publication of the Protein Society. vol 22. issue 6. 2013-12-09. PMID:23553709. |
the membrane-associated serine hydrolase, monoacylglycerol lipase (mgl), is a well-recognized therapeutic target that regulates endocannabinoid signaling. |
2013-12-09 |
2023-08-12 |
human |
| Angela Holtfrerich, Walburga Hanekamp, Matthias Leh. (4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). European journal of medicinal chemistry. vol 63. 2013-11-27. PMID:23455058. |
inhibitors of the enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), the principle enzymes involved in the degradation of endogenous cannabinoids like anandamide and 2-arachidonoylglycerol, have potential utility in the treatment of several disorders including pain, inflammation and anxiety. |
2013-11-27 |
2023-08-12 |
rat |
| María Jesús Luque-Rojas, Pablo Galeano, Juan Suárez, Pedro Araos, Luis J Santín, Fernando Rodríguez de Fonseca, Eduardo Blanco Calv. Hyperactivity induced by the dopamine D2/D3 receptor agonist quinpirole is attenuated by inhibitors of endocannabinoid degradation in mice. The international journal of neuropsychopharmacology. vol 16. issue 3. 2013-10-31. PMID:22647577. |
we analysed the effects of inhibition of the two main endocannabinoid degradation enzymes: fatty acid amide hydrolase (faah), using inhibitor urb597 (1 mg/kg); monoacylglycerol lipase (magl), using inhibitor urb602 (10 mg/kg). |
2013-10-31 |
2023-08-12 |
mouse |
| Panayiotis Filis, Peter C Kind, Norah Spear. Implantation failure in mice with a disruption in Phospholipase C beta 1 gene: lack of embryonic attachment, aberrant steroid hormone signalling and defective endocannabinoid metabolism. Molecular human reproduction. vol 19. issue 5. 2013-10-30. PMID:23295235. |
ko implantation sites expressed markedly less fatty acid amide hydrolase and monoacylglycerol lipase, indicating that endocannabinoid metabolism was also affected. |
2013-10-30 |
2023-08-12 |
mouse |
| Jason Barricklow, Matthew Blatni. 2-Arachidonoylglycerol is a substrate for butyrylcholinesterase: A potential mechanism for extracellular endocannabinoid regulation. Archives of biochemistry and biophysics. vol 536. issue 1. 2013-09-23. PMID:23689009. |
2-arachidonoylglycerol (2-ag) is a component of the endocannabinoid receptor pathway and is primarily hydrolyzed by monoacylglycerol lipase (magl) in vivo. |
2013-09-23 |
2023-08-12 |
human |
| Niina Aaltonen, Juha R Savinainen, Casandra Riera Ribas, Jani Rönkkö, Anne Kuusisto, Jani Korhonen, Dina Navia-Paldanius, Jukka Häyrinen, Piia Takabe, Heikki Käsnänen, Tatu Pantsar, Tuomo Laitinen, Marko Lehtonen, Sanna Pasonen-Seppänen, Antti Poso, Tapio Nevalainen, Jarmo T Laitine. Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase. Chemistry & biology. vol 20. issue 3. 2013-09-06. PMID:23521796. |
monoacylglycerol lipase (magl) terminates the signaling function of the endocannabinoid, 2-arachidonoylglycerol (2-ag). |
2013-09-06 |
2023-08-12 |
mouse |
| Laura E Wise, Kelly A Long, Rehab A Abdullah, Jonathan Z Long, Benjamin F Cravatt, Aron H Lichtma. Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces THC-like Morris water maze deficits in mice. ACS chemical neuroscience. vol 3. issue 5. 2013-08-20. PMID:22860205. |
n-arachidonoylethanolamine (anandamide; aea) and 2-arachidonoylglycerol (2-ag) are endogenous cannabinoids that are predominantly metabolized by the respective enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl). |
2013-08-20 |
2023-08-12 |
mouse |
| Ioannis Karageorgos, Nikolai Zvonok, David R Janero, V Kiran Vemuri, Vidyanand Shukla, Thomas E Wales, John R Engen, Alexandros Makriyanni. Endocannabinoid enzyme engineering: soluble human thio-monoacylglycerol lipase (sol-S-hMGL). ACS chemical neuroscience. vol 3. issue 5. 2013-08-20. PMID:22860208. |
in the mammalian central nervous system, monoacylglycerol lipase (mgl) is principally responsible for inactivating the endocannabinoid signaling lipid 2-arachidonoylglycerol (2-ag) and modulates cannabinoid-1 receptor (cb1r) desensitization and signal intensity. |
2013-08-20 |
2023-08-12 |
human |
| Micah J Niphakis, Douglas S Johnson, T Eric Ballard, Cory Stiff, Benjamin F Cravat. O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors. ACS chemical neuroscience. vol 3. issue 5. 2013-08-20. PMID:22860211. |
the two major endocannabinoid transmitters, anandamide (aea) and 2-arachidonoylglycerol (2-ag), are degraded by distinct enzymes in the nervous system, fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), respectively. |
2013-08-20 |
2023-08-12 |
Not clear |
| Vinogran Naidoo, David A Karanian, Subramanian K Vadivel, Johnathan R Locklear, JodiAnne T Wood, Mahmoud Nasr, Pamela Marie P Quizon, Emily E Graves, Vidyanand Shukla, Alexandros Makriyannis, Ben A Bah. Equipotent inhibition of fatty acid amide hydrolase and monoacylglycerol lipase - dual targets of the endocannabinoid system to protect against seizure pathology. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 9. issue 4. 2013-06-19. PMID:22270809. |
equipotent inhibition of fatty acid amide hydrolase and monoacylglycerol lipase - dual targets of the endocannabinoid system to protect against seizure pathology. |
2013-06-19 |
2023-08-12 |
Not clear |
| Josée Guindon, Yvonne Lai, Sara M Takacs, Heather B Bradshaw, Andrea G Hohman. Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. Pharmacological research. vol 67. issue 1. 2013-05-23. PMID:23127915. |
alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. |
2013-05-23 |
2023-08-12 |
Not clear |
| Zongxian Cao, Melinda M Mulvihill, Partha Mukhopadhyay, Huan Xu, Katalin Erdélyi, Enkui Hao, Eileen Holovac, György Haskó, Benjamin F Cravatt, Daniel K Nomura, Pál Pache. Monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in mice. Gastroenterology. vol 144. issue 4. 2013-05-20. PMID:23295443. |
monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in mice. |
2013-05-20 |
2023-08-12 |
mouse |
| Zongxian Cao, Melinda M Mulvihill, Partha Mukhopadhyay, Huan Xu, Katalin Erdélyi, Enkui Hao, Eileen Holovac, György Haskó, Benjamin F Cravatt, Daniel K Nomura, Pál Pache. Monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in mice. Gastroenterology. vol 144. issue 4. 2013-05-20. PMID:23295443. |
monoacylglycerol lipase (magl) links these pathways, hydrolyzing the endocannabinoid 2-arachidonoylglycerol to generate the arachidonic acid precursor pool for prostaglandin production. |
2013-05-20 |
2023-08-12 |
mouse |
| Rongqing Chen, Jian Zhang, Yan Wu, Dongqing Wang, Guoping Feng, Ya-Ping Tang, Zhaoqian Teng, Chu Che. Monoacylglycerol lipase is a therapeutic target for Alzheimer's disease. Cell reports. vol 2. issue 5. 2013-05-09. PMID:23122958. |
monoacylglycerol lipase (magl) is the primary enzyme metabolizing the endocannabinoid 2-arachidonoylglycerol in the brain. |
2013-05-09 |
2023-08-12 |
mouse |
| S G Woodhams, A Wong, D A Barrett, A J Bennett, V Chapman, S P H Alexande. Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat. British journal of pharmacology. vol 167. issue 8. 2013-05-06. PMID:22924700. |
the cannabinoid receptor-mediated analgesic effects of 2-arachidonoylglycerol (2-ag) are limited by monoacylglycerol lipase (magl). |
2013-05-06 |
2023-08-12 |
mouse |
| Erik Keimpema, Giuseppe Tortoriello, Alán Alpár, Simona Capsoni, Ivan Arisi, Daniela Calvigioni, Sherry Shu-Jung Hu, Antonino Cattaneo, Patrick Doherty, Kenneth Mackie, Tibor Harkan. Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 5. 2013-05-03. PMID:23319656. |
nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons. |
2013-05-03 |
2023-08-12 |
Not clear |
| Erik Keimpema, Giuseppe Tortoriello, Alán Alpár, Simona Capsoni, Ivan Arisi, Daniela Calvigioni, Sherry Shu-Jung Hu, Antonino Cattaneo, Patrick Doherty, Kenneth Mackie, Tibor Harkan. Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 5. 2013-05-03. PMID:23319656. |
in doing so, ngf limits the sorting of monoacylglycerol lipase (mgl), rate limiting 2-ag bioavailability, to proximal neurites, allowing cell-autonomous 2-ag signaling at cb(1) cannabinoid receptors to persist at atypical locations to induce superfluous neurite extension. |
2013-05-03 |
2023-08-12 |
Not clear |