| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jani Korhonen, Anne Kuusisto, John van Bruchem, Jayendra Z Patel, Tuomo Laitinen, Dina Navia-Paldanius, Jarmo T Laitinen, Juha R Savinainen, Teija Parkkari, Tapio J Nevalaine. Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). Bioorganic & medicinal chemistry. vol 22. issue 23. 2015-10-05. PMID:25282655. |
the key hydrolytic enzymes of the endocannabinoid system, fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), are potential targets for various therapeutic applications. |
2015-10-05 |
2023-08-13 |
Not clear |
| Noemi Pasquarelli, Christoph Porazik, Johannes Hanselmann, Patrick Weydt, Boris Ferger, Anke Wittin. Comparative biochemical characterization of the monoacylglycerol lipase inhibitor KML29 in brain, spinal cord, liver, spleen, fat and muscle tissue. Neuropharmacology. vol 91. 2015-09-28. PMID:25497453. |
monoacylglycerol lipase (magl) is part of the endocannabinoid and the prostaglandin signaling system. |
2015-09-28 |
2023-08-13 |
mouse |
| Sang-Hun Lee, Marco Ledri, Blanka Tóth, Ivan Marchionni, Christopher M Henstridge, Barna Dudok, Kata Kenesei, László Barna, Szilárd I Szabó, Tibor Renkecz, Michelle Oberoi, Masahiko Watanabe, Charles L Limoli, George Horvai, Ivan Soltesz, István Katon. Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 27. 2015-09-22. PMID:26157003. |
jzl184 (4-nitrophenyl 4-[bis(1,3-benzodioxol-5-yl)(hydroxy)methyl]piperidine-1-carboxylate), a selective inhibitor of monoacylglycerol lipase (mgl), the presynaptic degrading enzyme of the endocannabinoid 2-arachidonoylglycerol (2-ag), elicited a robust increase in 2-ag levels and concomitantly decreased gabaergic transmission. |
2015-09-22 |
2023-08-13 |
mouse |
| Ana Bernal-Chico, Manuel Canedo, Andrea Manterola, María Victoria Sánchez-Gómez, Alberto Pérez-Samartín, Rafael Rodríguez-Puertas, Carlos Matute, Susana Mat. Blockade of monoacylglycerol lipase inhibits oligodendrocyte excitotoxicity and prevents demyelination in vivo. Glia. vol 63. issue 1. 2015-09-14. PMID:25130621. |
here we show that the selective monoacylglycerol lipase (magl) inhibitor jzl184 suppressed cell death by mild activation of ampa receptors in oligodendrocytes in vitro, an effect that was mimicked by magl substrate 2-ag and by the second major endocannabinoid aea, in a concentration-dependent manner, whereas inhibition of the aea metabolizing enzyme fatty acid amide hydrolase with urb597 was devoid of effect. |
2015-09-14 |
2023-08-13 |
Not clear |
| Fabricio A Moreira, Bianca Jupp, David Belin, Jeffrey W Dalle. Endocannabinoids and striatal function: implications for addiction-related behaviours. Behavioural pharmacology. vol 26. issue 1-2. 2015-09-03. PMID:25369747. |
we highlight the potential of selective inhibitors of endocannabinoid metabolism, directed at fatty acid amide hydrolase and monoacylglycerol lipase, to reduce anxiety and stress responses, and discuss novel mechanisms underlying the modulation of the endocannabinoid system, including the attenuation of impulsivity, anxiety, and drug reward by selective cb2 receptor agonists. |
2015-09-03 |
2023-08-13 |
Not clear |
| Benjamin K Lau, Geoffrey M Drew, Vanessa A Mitchell, Christopher W Vaugha. Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey. British journal of pharmacology. vol 171. issue 23. 2015-08-14. PMID:25041240. |
endocannabinoid modulation by faah and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey. |
2015-08-14 |
2023-08-13 |
Not clear |
| V Kiran Vemuri, A Makriyanni. Medicinal chemistry of cannabinoids. Clinical pharmacology and therapeutics. vol 97. issue 6. 2015-08-12. PMID:25801236. |
drug discovery efforts relating to the endocannabinoid system have been focused mainly on the two cannabinoid receptors and the two endocannabinoid deactivating enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (mgl). |
2015-08-12 |
2023-08-13 |
Not clear |
| Zhen Zhang, Wei Wang, Peng Zhong, Sarah J Liu, Jonathan Z Long, Li Zhao, Hai-Qing Gao, Benjamin F Cravatt, Qing-Song Li. Blockade of 2-arachidonoylglycerol hydrolysis produces antidepressant-like effects and enhances adult hippocampal neurogenesis and synaptic plasticity. Hippocampus. vol 25. issue 1. 2015-08-11. PMID:25131612. |
the endocannabinoid ligand 2-arachidonoylglycerol (2-ag) is inactivated primarily by monoacylglycerol lipase (magl). |
2015-08-11 |
2023-08-13 |
mouse |
| Andrey B Petrenko, Maya Yamazaki, Kenji Sakimura, Masanobu Kano, Hiroshi Bab. Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol. Behavioural brain research. vol 271. 2015-08-06. PMID:24906199. |
augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol. |
2015-08-06 |
2023-08-13 |
mouse |
| Andrey B Petrenko, Maya Yamazaki, Kenji Sakimura, Masanobu Kano, Hiroshi Bab. Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol. Behavioural brain research. vol 271. 2015-08-06. PMID:24906199. |
monoacylglycerol lipase (mgl) is the main enzyme responsible for degradation of the endocannabinoid 2-arachidonoylglycerol (2-ag). |
2015-08-06 |
2023-08-13 |
mouse |
| Gloria Hernández-Torres, Mariateresa Cipriano, Erika Hedén, Emmelie Björklund, Ángeles Canales, Debora Zian, Ana Feliú, Miriam Mecha, Carmen Guaza, Christopher J Fowler, Silvia Ortega-Gutiérrez, María L López-Rodrígue. A reversible and selective inhibitor of monoacylglycerol lipase ameliorates multiple sclerosis. Angewandte Chemie (International ed. in English). vol 53. issue 50. 2015-07-20. PMID:25298214. |
monoacylglycerol lipase (magl) is the enzyme responsible for the inactivation of the endocannabinoid 2-arachidonoylglycerol (2-ag). |
2015-07-20 |
2023-08-13 |
mouse |
| Jason M Wiebelhaus, Travis W Grim, Robert A Owens, Matthew F Lazenka, Laura J Sim-Selley, Rehab A Abdullah, Micah J Niphakis, Robert E Vann, Benjamin F Cravatt, Jenny L Wiley, S Stevens Negus, Aron H Lichtma. Δ9-tetrahydrocannabinol and endocannabinoid degradative enzyme inhibitors attenuate intracranial self-stimulation in mice. The Journal of pharmacology and experimental therapeutics. vol 352. issue 2. 2015-07-08. PMID:25398241. |
in this study, we investigated the impact of thc and inhibitors of the endocannabinoid hydrolytic enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) on operant responding for electrical stimulation of the medial forebrain bundle [intracranial self-stimulation (icss)], which is known to activate the mesolimbic dopamine system. |
2015-07-08 |
2023-08-13 |
mouse |
| Yasushi Kishimoto, Barbara Cagniard, Maya Yamazaki, Junko Nakayama, Kenji Sakimura, Yutaka Kirino, Masanobu Kan. Task-specific enhancement of hippocampus-dependent learning in mice deficient in monoacylglycerol lipase, the major hydrolyzing enzyme of the endocannabinoid 2-arachidonoylglycerol. Frontiers in behavioral neuroscience. vol 9. 2015-06-17. PMID:26082696. |
task-specific enhancement of hippocampus-dependent learning in mice deficient in monoacylglycerol lipase, the major hydrolyzing enzyme of the endocannabinoid 2-arachidonoylglycerol. |
2015-06-17 |
2023-08-13 |
mouse |
| Yasushi Kishimoto, Barbara Cagniard, Maya Yamazaki, Junko Nakayama, Kenji Sakimura, Yutaka Kirino, Masanobu Kan. Task-specific enhancement of hippocampus-dependent learning in mice deficient in monoacylglycerol lipase, the major hydrolyzing enzyme of the endocannabinoid 2-arachidonoylglycerol. Frontiers in behavioral neuroscience. vol 9. 2015-06-17. PMID:26082696. |
to elucidate the physiological role of 2-arachidonoylglycerol (2-ag), a major endocannabinoid, in behavioral and cognitive functions, we conducted a comprehensive behavioral test battery in knockout (ko) mice deficient in monoacylglycerol lipase (mgl), the major hydrolyzing enzyme of 2-ag. |
2015-06-17 |
2023-08-13 |
mouse |
| Bogna Ignatowska-Jankowska, Jenny L Wilkerson, Mohammed Mustafa, Rehab Abdullah, Micah Niphakis, Jenny L Wiley, Benjamin F Cravatt, Aron H Lichtma. Selective monoacylglycerol lipase inhibitors: antinociceptive versus cannabimimetic effects in mice. The Journal of pharmacology and experimental therapeutics. vol 353. issue 2. 2015-05-26. PMID:25762694. |
the endogenous cannabinoid 2-arachidonoylglycerol (2-ag) plays an important role in a variety of physiologic processes, but its rapid breakdown by monoacylglycerol lipase (magl) results in short-lived actions. |
2015-05-26 |
2023-08-13 |
mouse |
| Jian Zhang, Zhaoqian Teng, Yunping Song, Mei Hu, Chu Che. Inhibition of monoacylglycerol lipase prevents chronic traumatic encephalopathy-like neuropathology in a mouse model of repetitive mild closed head injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 3. 2015-04-20. PMID:25492114. |
here we demonstrate that inhibition of monoacylglycerol lipase (magl), the key enzyme that metabolizes the endocannabinoid 2-arachidonoylglycerol (2-ag) in the brain, significantly reduced cte-like neuropathologic changes in a mouse model of repetitive mild closed head injury (rmchi). |
2015-04-20 |
2023-08-13 |
mouse |
| Russell L Carr, Casey A Graves, Lee C Mangum, Carole A Nail, Matthew K Ros. Low level chlorpyrifos exposure increases anandamide accumulation in juvenile rat brain in the absence of brain cholinesterase inhibition. Neurotoxicology. vol 43. 2015-04-17. PMID:24373905. |
we have previously reported that repeated exposure to cpf results in greater inhibition of fatty acid amide hydrolase (faah), the enzyme that metabolizes the endocannabinoid anandamide (aea), than inhibition of either forebrain che or monoacylglycerol lipase (magl), the enzyme that metabolizes the endocannabinoid 2-arachidonylglycerol (2-ag). |
2015-04-17 |
2023-08-12 |
rat |
| Luara A Batista, Pedro H Gobira, Thercia G Viana, Daniele C Aguiar, Fabricio A Moreir. Inhibition of endocannabinoid neuronal uptake and hydrolysis as strategies for developing anxiolytic drugs. Behavioural pharmacology. vol 25. issue 5-6. 2015-03-31. PMID:25083569. |
the endocannabinoid system comprises the cb1 and cb2 receptors (the targets of the cannabis sativa compound delta-9-tetrahydrocannabinol), the endogenous ligands (endocannabinoids) arachidonoyl ethanolamide (anandamide) and 2-arachidonoyl glycerol, their synthesizing machinery and membrane transport system, and the hydrolyzing enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), respectively. |
2015-03-31 |
2023-08-13 |
Not clear |
| Justin W Hicks, Jun Parkes, Junchao Tong, Sylvain Houle, Neil Vasdev, Alan A Wilso. Radiosynthesis and ex vivo evaluation of [(11)C-carbonyl]carbamate- and urea-based monoacylglycerol lipase inhibitors. Nuclear medicine and biology. vol 41. issue 8. 2015-03-12. PMID:24969632. |
monoacylglycerol lipase (magl) and fatty acid amide hydrolase (faah) are the two primary enzymes that regulate the tone of endocannabinoid signaling. |
2015-03-12 |
2023-08-13 |
mouse |
| Simon Nicolussi, Andrea Chicca, Mark Rau, Sabine Rihs, Michael Soeberdt, Christoph Abels, Jürg Gertsc. Correlating FAAH and anandamide cellular uptake inhibition using N-alkylcarbamate inhibitors: from ultrapotent to hyperpotent. Biochemical pharmacology. vol 92. issue 4. 2015-03-09. PMID:25283614. |
while being inactive at cannabinoid receptors and monoacylglycerol lipase, these n-alkylcarbamates showed potent to ultrapotent picomolar faah inhibition in u937 cells. |
2015-03-09 |
2023-08-13 |
Not clear |