| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrey B Petrenko, Maya Yamazaki, Kenji Sakimura, Masanobu Kano, Hiroshi Bab. Genetic inactivation and prolonged pharmacologic inhibition of monoacylglycerol lipase have opposite effects on anesthetic sensitivity to propofol. European journal of pharmacology. vol 765. 2016-08-12. PMID:26318148. |
monoacylglycerol lipase (mgl) is a major enzyme involved in degradation of the endocannabinoid 2-arachidonoylglycerol (2-ag). |
2016-08-12 |
2023-08-13 |
mouse |
| Rea Pihlaja, Jatta Takkinen, Olli Eskola, Jenni Vasara, Francisco R López-Picón, Merja Haaparanta-Solin, Juha O Rinn. Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells. Journal of neuroinflammation. vol 12. 2016-08-08. PMID:25927213. |
recently, the role of monoacylglycerol lipase (magl) as the principal regulator of simultaneous prostaglandin synthesis and endocannabinoid receptor activation in the cns was demonstrated. |
2016-08-08 |
2023-08-13 |
mouse |
| Jenny L Wilkerson, Micah J Niphakis, Travis W Grim, Mohammed A Mustafa, Rehab A Abdullah, Justin L Poklis, William L Dewey, Hamid Akbarali, Matthew L Banks, Laura E Wise, Benjamin F Cravatt, Aron H Lichtma. The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model. The Journal of pharmacology and experimental therapeutics. vol 357. issue 1. 2016-07-19. PMID:26791602. |
here, we tested whether elevating the endogenous cannabinoid 2-arachidonoylglycerol through the inhibition of its primary hydrolytic enzyme monoacylglycerol lipase (magl), will produce opioid-sparing effects in the mouse chronic constriction injury (cci) of the sciatic nerve model of neuropathic pain. |
2016-07-19 |
2023-08-13 |
mouse |
| Sergiy Tyukhtenko, Ioannis Karageorgos, Girija Rajarshi, Nikolai Zvonok, Spiro Pavlopoulos, David R Janero, Alexandros Makriyanni. Specific Inter-residue Interactions as Determinants of Human Monoacylglycerol Lipase Catalytic Competency: A ROLE FOR GLOBAL CONFORMATIONAL CHANGES. The Journal of biological chemistry. vol 291. issue 6. 2016-06-27. PMID:26555264. |
the serine hydrolase monoacylglycerol lipase (mgl) functions as the main metabolizing enzyme of 2-arachidonoyl glycerol, an endocannabinoid signaling lipid whose elevation through genetic or pharmacological mgl ablation exerts therapeutic effects in various preclinical disease models. |
2016-06-27 |
2023-08-13 |
human |
| K R Patil, S N Goyal, C Sharma, C R Patil, S Ojh. Phytocannabinoids for Cancer Therapeutics: Recent Updates and Future Prospects. Current medicinal chemistry. vol 22. issue 30. 2016-06-07. PMID:26179998. |
the ecs includes two g-protein-coupled receptors; the cannabinoid receptors-1 and -2 (cb1 and cb2) for marijuana's psychoactive principle Δ(9)-tetrahydrocannabinol (Δ(9)-thc), their endogenous small lipid ligands; namely anandamide (aea) and 2-arachidonoylglycerol (2-ag), also known as endocannabinoids and the enzymes for endocannabinoid biosynthesis and degradation such as fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl). |
2016-06-07 |
2023-08-13 |
Not clear |
| Marc P Baggelaar, Pascal J P Chameau, Vasudev Kantae, Jessica Hummel, Ku-Lung Hsu, Freek Janssen, Tom van der Wel, Marjolein Soethoudt, Hui Deng, Hans den Dulk, Marco Allarà, Bogdan I Florea, Vincenzo Di Marzo, Wytse J Wadman, Chris G Kruse, Herman S Overkleeft, Thomas Hankemeier, Taco R Werkman, Benjamin F Cravatt, Mario van der Stel. Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons. Journal of the American Chemical Society. vol 137. issue 27. 2016-05-23. PMID:26083464. |
lei105 did not affect other enzymes involved in endocannabinoid metabolism including abhydrolase domain-containing protein 6, abhydrolase domain-containing protein 12, monoacylglycerol lipase, and fatty acid amide hydrolase and did not display affinity for the cannabinoid cb1 receptor. |
2016-05-23 |
2023-08-13 |
mouse |
| Dina Navia-Paldanius, Niina Aaltonen, Marko Lehtonen, Juha R Savinainen, Ulrike Taschler, Franz P W Radner, Robert Zimmermann, Jarmo T Laitine. Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 77. 2016-05-13. PMID:26070239. |
increased tonic cannabinoid cb1r activity and brain region-specific desensitization of cb1r gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase. |
2016-05-13 |
2023-08-13 |
mouse |
| Dina Navia-Paldanius, Niina Aaltonen, Marko Lehtonen, Juha R Savinainen, Ulrike Taschler, Franz P W Radner, Robert Zimmermann, Jarmo T Laitine. Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 77. 2016-05-13. PMID:26070239. |
in mammalian brain, monoacylglycerol lipase (magl) is the primary enzyme responsible for terminating signaling function of the endocannabinoid 2-arachidonoylglycerol (2-ag). |
2016-05-13 |
2023-08-13 |
mouse |
| Chihiro Nozaki, Astrid Markert, Andreas Zimme. Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 8. 2016-05-06. PMID:25910421. |
we have therefore investigated mice with a genetic deletion of the two main cannabinoid receptors cb1 and cb2, or the main endocannabinoid degrading enzymes, faah and monoacylglycerol lipase (magl), which degrades 2-arachidonoylglycerol (2-ag), in a nitroglycerine-induced animal model of migraine. |
2016-05-06 |
2023-08-13 |
mouse |
| Sara R Nass, Jonathan Z Long, Joel E Schlosburg, Benjamin F Cravatt, Aron H Lichtman, Steven G Kinse. Endocannabinoid Catabolic Enzymes Play Differential Roles in Thermal Homeostasis in Response to Environmental or Immune Challenge. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 10. issue 2. 2016-04-01. PMID:25715681. |
inhibiting endocannabinoid catabolic enzymes, monoacylglycerol lipase (magl) or fatty acid amide hydrolase (faah), elevates levels of 2-ag or anandamide in vivo, respectively. |
2016-04-01 |
2023-08-13 |
mouse |
| Emmanuel Y Dotsey, Kwang-Mook Jung, Abdul Basit, Don Wei, Jennifer Daglian, Federica Vacondio, Andrea Armirotti, Marco Mor, Daniele Piomell. Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons. Chemistry & biology. vol 22. issue 5. 2016-02-18. PMID:26000748. |
here, we report that hydrogen peroxide heightens endocannabinoid signaling in brain neurons through sulfenylation of cysteines c201 and c208 in monoacylglycerol lipase (mgl), a serine hydrolase that deactivates the endocannabinoid 2-arachidonoyl-sn-glycerol (2-ag) in nerve terminals. |
2016-02-18 |
2023-08-13 |
Not clear |
| E L von Rüden, R M Bogdanovic, C T Wotjak, H Potschk. Inhibition of monoacylglycerol lipase mediates a cannabinoid 1-receptor dependent delay of kindling progression in mice. Neurobiology of disease. vol 77. 2016-01-06. PMID:25796567. |
inhibition of monoacylglycerol lipase mediates a cannabinoid 1-receptor dependent delay of kindling progression in mice. |
2016-01-06 |
2023-08-13 |
mouse |
| D Matthew Walentiny, Robert E Vann, Jenny L Wile. Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice. Neuropharmacology. vol 93. 2016-01-01. PMID:25698527. |
pharmacological inhibition of monoacylglycerol lipase (magl), the primary catabolic enzyme for the endocannabinoid 2-arachidonoylglycerol (2-ag), with jzl184 resulted in full substitution for thc in faah knockout mice and nearly full substitution in wildtypes. |
2016-01-01 |
2023-08-13 |
mouse |
| Thomas F Gamage, Bogna M Ignatowska-Jankowska, Pretal P Muldoon, Benjamin F Cravatt, M Imad Damaj, Aron H Lichtma. Differential effects of endocannabinoid catabolic inhibitors on morphine withdrawal in mice. Drug and alcohol dependence. vol 146. 2015-12-18. PMID:25479915. |
inhibition of endocannabinoid catabolic enzymes fatty acid amide hydrolase (faah) and/or monoacylglycerol lipase (magl) reduces somatic morphine withdrawal signs, but its effects on aversive aspects of withdrawal are unknown. |
2015-12-18 |
2023-08-13 |
mouse |
| S Del Carlo, C Manera, A Chicca, C Arena, S Bertini, S Burgalassi, S Tampucci, J Gertsch, M Macchia, G Saccomann. Development of an HPLC/UV assay for the evaluation of inhibitors of human recombinant monoacylglycerol lipase. Journal of pharmaceutical and biomedical analysis. vol 108. 2015-12-01. PMID:25743577. |
monoacylglycerol lipase (magl) is a membrane-associated cytosolic serine hydrolase which catalyses the hydrolysis of the endocannabinoid 2-arachidonoylglycerol into arachidonic acid and glycerol. |
2015-12-01 |
2023-08-13 |
human |
| Nurcan Calimli Tosun, Ozgur Gunduz, Ahmet Ulugo. Attenuation of serotonin-induced itch responses by inhibition of endocannabinoid degradative enzymes, fatty acid amide hydrolase and monoacylglycerol lipase. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 3. 2015-11-10. PMID:24915981. |
attenuation of serotonin-induced itch responses by inhibition of endocannabinoid degradative enzymes, fatty acid amide hydrolase and monoacylglycerol lipase. |
2015-11-10 |
2023-08-13 |
mouse |
| Manman Dong, Yongli Lu, Ziliang Zou, Hongwei Yan. Monoacylglycerol lipase inhibitor protects primary cultured neurons against homocysteine-induced impairments in rat caudate nucleus through COX-2 signaling. Life sciences. vol 138. 2015-11-09. PMID:25818189. |
urb602 is a selective inhibitor of monoacylglycerol lipase (magl), a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl glycerol (2-ag). |
2015-11-09 |
2023-08-13 |
rat |
| Guy Griebel, Philippe Pichat, Sandra Beeské, Thibaud Leroy, Nicolas Redon, Agnès Jacquet, Dominique Françon, Lionel Bert, Luc Even, Mati Lopez-Grancha, Tatiana Tolstykh, Fangxian Sun, Qunyan Yu, Scott Brittain, Heike Arlt, Timothy He, Bailin Zhang, Dmitri Wiederschain, Thomas Bertrand, Jacques Houtmann, Alexey Rak, François Vallée, Nadine Michot, Franck Augé, Véronique Menet, Olivier E Bergis, Pascal George, Patrick Avenet, Vincent Mikol, Michel Didier, Johanna Escoube. Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents. Scientific reports. vol 5. 2015-11-03. PMID:25560837. |
monoacylglycerol lipase (magl) represents a primary degradation enzyme of the endogenous cannabinoid (ecb), 2-arachidonoyglycerol (2-ag). |
2015-11-03 |
2023-08-13 |
mouse |
| P P Muldoon, J Chen, J L Harenza, R A Abdullah, L J Sim-Selley, B F Cravatt, M F Miles, X Chen, A H Lichtman, M I Dama. Inhibition of monoacylglycerol lipase reduces nicotine withdrawal. British journal of pharmacology. vol 172. issue 3. 2015-11-02. PMID:25258021. |
while blockade of fatty acid amide hydrolase, the primary catabolic enzyme of the endocannabinoid arachidonoylethanolamine (anandamide), exacerbates withdrawal responses in nicotine-dependent mice, the role of monoacylglycerol lipase (magl), the main hydrolytic enzyme of a second endocannabinoid 2-arachidonylglycerol (2-ag), in nicotine withdrawal remains unexplored. |
2015-11-02 |
2023-08-13 |
mouse |
| Diana Fernández-Suárez, Marta Celorrio, José Ignacio Riezu-Boj, Ana Ugarte, Rodrigo Pacheco, Hugo González, Julen Oyarzabal, Cecilia J Hillard, Rafael Franco, María S Aymeric. Monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model. Neurobiology of aging. vol 35. issue 11. 2015-10-19. PMID:24973119. |
to evaluate whether targeting the endocannabinoid system could provide potential benefits in the treatment of the disease, the effect of a monoacylglycerol lipase inhibitor that prevents degradation of 2-arachidonyl-glycerol was tested in mice treated chronically with probenecid and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptpp). |
2015-10-19 |
2023-08-13 |
mouse |