| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laia Bosch de Basea, Marina Boguñà, Alicia Sánchez, Montserrat Esteve, Mar Grasa, Maria Del Mar Romer. Sex-Dependent Metabolic Effects in Diet-Induced Obese Rats following Intermittent Fasting Compared with Continuous Food Restriction. Nutrients. vol 16. issue 7. 2024-04-13. PMID:38613042. |
both caloric restrictions improved insulin sensitivity, but more markedly in females, which showed a more pronounced decrease in homa-ir score and an upregulation of hepatic irs2 and sirt1 gene expression that was not observed in males. |
2024-04-13 |
2024-04-15 |
rat |
| Troy C Krzysiak, You-Jin Choi, Yong Joon Kim, Yunhan Yang, Christopher DeHaven, Lariah Thompson, Ryan Ponticelli, Mara M Mermigos, Laurel Thomas, Andrea Marquez, Ian Sipula, Jongsook Kim Kemper, Michael Jurczak, Gary Thomas, Angela M Gronenbor. Inhibitory protein-protein interactions of the SIRT1 deacetylase are choreographed by post-translational modification. Protein science : a publication of the Protein Society. vol 33. issue 4. 2024-03-27. PMID:38533551. |
we previously showed that insulin triggers the epigenetic regulator dbc1 to prime sirt1 for repression by the multifunctional trafficking protein pacs-2. |
2024-03-27 |
2024-03-29 |
human |
| Sanghee Park, Filip Jevtovic, Polina M Krassovskaia, Alec B Chaves, Donghai Zheng, Jonas T Treebak, Joseph A Houmar. Effect of resveratrol on insulin action in primary myotubes from lean individuals and individuals with severe obesity. American journal of physiology. Endocrinology and metabolism. vol 326. issue 3. 2024-03-05. PMID:38324260. |
primary skeletal muscle cells were derived from biopsies obtained from age-matched lean and insulin-resistant women with severe obesity and incubated with resveratrol (1 µm) for 24 h. insulin-stimulated glucose oxidation and incorporation into glycogen, insulin signal transduction, and energy-sensitive protein targets [amp-activated protein kinase (ampk), sirt1, and pgc1α] were analyzed. |
2024-03-05 |
2024-03-07 |
human |
| Gholamreza Taheripak, Niusha Sabeti, Naba Najar, Zahrasadat Razavi, Saber Saharkhiz, Iraj Alipourfar. SIRT1 activation attenuates palmitate induced apoptosis in C Molecular biology reports. vol 51. issue 1. 2024-02-24. PMID:38400872. |
sirt1 activation attenuates palmitate induced apoptosis in c type 2 diabetes is characterized by insulin resistance, which manifests mainly in skeletal muscles. |
2024-02-24 |
2024-02-27 |
Not clear |
| Gholamreza Taheripak, Niusha Sabeti, Naba Najar, Zahrasadat Razavi, Saber Saharkhiz, Iraj Alipourfar. SIRT1 activation attenuates palmitate induced apoptosis in C Molecular biology reports. vol 51. issue 1. 2024-02-24. PMID:38400872. |
sirt1 has been found to play a role in the insulin signaling pathway. |
2024-02-24 |
2024-02-27 |
Not clear |
| Rashmi Patil, Urmila Aswar, Nishant Vya. Pterostilbene alleviates cafeteria diet-induced obesity and underlying depression in adolescent male Swiss albino mice and affects insulin resistance, inflammation, HPA axis dysfunction and SIRT1 mediated leptin-ghrelin signaling. Hormones and behavior. vol 161. 2024-02-14. PMID:38354494. |
pterostilbene alleviates cafeteria diet-induced obesity and underlying depression in adolescent male swiss albino mice and affects insulin resistance, inflammation, hpa axis dysfunction and sirt1 mediated leptin-ghrelin signaling. |
2024-02-14 |
2024-02-17 |
mouse |
| Yahia A Kaabi, Ammar A Abdelmola, Siddig I Abdelwahab, Nahla A Alshaikh, Mustafa A Halawi, Hadi M Kurir. Common Genetic Variants in SIRT1 Gene Promoter and Type 2 Diabetes Mellitus in Saudi Arabia. Clinical laboratory. vol 70. issue 2. 2024-02-13. PMID:38345973. |
silent information regulator of transcription-1 (sirt1) positively influences insulin sensitivity and might contribute to the pathogenesis of t2dm. |
2024-02-13 |
2024-02-15 |
Not clear |
| Badr Qasem, Agnieszka Dąbrowska, Jarosław Króliczewski, Jacek Łyczko, Krzysztof Maryc. Trodusquemine (MSI-1436) Restores Metabolic Flexibility and Mitochondrial Dynamics in Insulin-Resistant Equine Hepatic Progenitor Cells (HPCs). Cells. vol 13. issue 2. 2024-01-22. PMID:38247843. |
furthermore, our findings suggest that msi-1436 enhances 2-nbdg uptake by increasing the expression of sirt1, which is associated with liver insulin sensitivity. |
2024-01-22 |
2024-01-24 |
Not clear |
| Valeria Melissa García-Cruz, Clorinda Aria. Palmitic Acid Induces Posttranslational Modifications of Tau Protein in Alzheimer's Disease-Related Epitopes and Increases Intraneuronal Tau Levels. Molecular neurobiology. 2024-01-03. PMID:38167971. |
among other effects, pa induces insulin resistance, increases intracellular calcium and reactive oxygen species (ros) production, and reduces the nad+/nadh ratio, resulting in decreased activity of the deacetylase sirtuin1 (sirt1) in neurons. |
2024-01-03 |
2024-01-06 |
human |
| Deepsikha Swargiary, Bhaswati Kashyap, Pranamika Sarma, Semim Akhtar Ahmed, Shalini Gurumayum, Sagar Ramrao Barge, Devi Basumatary, Jagat C Bora. Free radical scavenging polyphenols isolated from Phyllanthus niruri L. ameliorates hyperglycemia via SIRT1 induction and GLUT4 translocation in in vitro and in vivo models. Fitoterapia. 2024-01-03. PMID:38171388. |
pneaf treated ir c2c12 myotubes and stz induced wistar rats elevated sirt1, pgc1-α signaling cascade through phosphorylation of ampk and glut4 translocation resulting in insulin sensitization. |
2024-01-03 |
2024-01-06 |
rat |
| Jinxiao He, Fang Fan, Jingxian Li, Yi Han, Ye Song, Rong Zhang, Yang Xu, Huajie Wu, Rui Fa. SIRT1 alleviates insulin resistance and respiratory distress in late preterm rats by activating QKI5-mediated PPARγ/PI3K/AKT pathway. Cell cycle (Georgetown, Tex.). 2023-12-26. PMID:38146686. |
sirt1 alleviates insulin resistance and respiratory distress in late preterm rats by activating qki5-mediated pparγ/pi3k/akt pathway. |
2023-12-26 |
2023-12-28 |
rat |
| Decheng Meng, Fengxia Zhang, Wenfei Yu, Xin Zhang, Guoliang Yin, Pengpeng Liang, Yanan Feng, Suwen Chen, Hongshuai Li. Biological Role and Related Natural Products of SIRT1 in Nonalcoholic Fatty Liver. Diabetes, metabolic syndrome and obesity : targets and therapy. vol 16. 2023-12-13. PMID:38089432. |
sirt1 is a member of sirtuins, a group of highly conserved histone deacetylases regulated by nad+, and plays a vital role in regulating cholesterol and lipid metabolism, improving oxidative stress, inflammation, and insulin resistance through deacetylating some downstream transcription factors and thus improving nafld. |
2023-12-13 |
2023-12-17 |
Not clear |
| Yan-Juan Song, Qi Huang, Li Chen, Ya-Yuan Wang, Yu-Dian Zhou, Feng-Xia Lian. Electroacupuncture improving obesity-induced insulin resistance via regulating intestinal SIRT1/TLR4 signaling pathway. Zhen ci yan jiu = Acupuncture research. vol 48. issue 11. 2023-11-24. PMID:37984910. |
to observe the effect of electroacupuncture (ea) in obese rats with insulin resistance (ir) through regulating intestinal silent information regulator 1 (sirt1)/toll-like receptor 4 (tlr4) signaling pathway, so as to explore the underlying mechanism of ea in improving obesity-induced ir. |
2023-11-24 |
2023-11-28 |
rat |
| Qiuxia Li, Quanjiang Zhang, Young-Rae Kim, Ravinder Reddy Gaddam, Julia S Jacobs, Markus M Bachschmid, Tsneem Younis, Zhiyong Zhu, Leonid Zingman, Barry London, Adam J Rauckhorst, Eric B Taylor, Andrew W Norris, Ajit Vikram, Kaikobad Iran. Deficiency of endothelial sirtuin1 in mice stimulates skeletal muscle insulin sensitivity by modifying the secretome. Nature communications. vol 14. issue 1. 2023-09-11. PMID:37696839. |
downregulation of endothelial sirtuin1 (sirt1) in insulin resistant states contributes to vascular dysfunction. |
2023-09-11 |
2023-10-07 |
mouse |
| Qiuxia Li, Quanjiang Zhang, Young-Rae Kim, Ravinder Reddy Gaddam, Julia S Jacobs, Markus M Bachschmid, Tsneem Younis, Zhiyong Zhu, Leonid Zingman, Barry London, Adam J Rauckhorst, Eric B Taylor, Andrew W Norris, Ajit Vikram, Kaikobad Iran. Deficiency of endothelial sirtuin1 in mice stimulates skeletal muscle insulin sensitivity by modifying the secretome. Nature communications. vol 14. issue 1. 2023-09-11. PMID:37696839. |
furthermore, sirt1 deficiency in skeletal myocytes promotes insulin resistance. |
2023-09-11 |
2023-10-07 |
mouse |
| Qiuxia Li, Quanjiang Zhang, Young-Rae Kim, Ravinder Reddy Gaddam, Julia S Jacobs, Markus M Bachschmid, Tsneem Younis, Zhiyong Zhu, Leonid Zingman, Barry London, Adam J Rauckhorst, Eric B Taylor, Andrew W Norris, Ajit Vikram, Kaikobad Iran. Deficiency of endothelial sirtuin1 in mice stimulates skeletal muscle insulin sensitivity by modifying the secretome. Nature communications. vol 14. issue 1. 2023-09-11. PMID:37696839. |
here, we show that deletion of endothelial sirt1, while impairing endothelial function, paradoxically improves skeletal muscle insulin sensitivity. |
2023-09-11 |
2023-10-07 |
mouse |
| Qiuxia Li, Quanjiang Zhang, Young-Rae Kim, Ravinder Reddy Gaddam, Julia S Jacobs, Markus M Bachschmid, Tsneem Younis, Zhiyong Zhu, Leonid Zingman, Barry London, Adam J Rauckhorst, Eric B Taylor, Andrew W Norris, Ajit Vikram, Kaikobad Iran. Deficiency of endothelial sirtuin1 in mice stimulates skeletal muscle insulin sensitivity by modifying the secretome. Nature communications. vol 14. issue 1. 2023-09-11. PMID:37696839. |
compared to wild-type mice, male mice lacking endothelial sirt1 (e-sirt1-ko) preferentially utilize glucose over fat, and have higher insulin sensitivity, glucose uptake, and akt signaling in fast-twitch skeletal muscle. |
2023-09-11 |
2023-10-07 |
mouse |
| Qiuxia Li, Quanjiang Zhang, Young-Rae Kim, Ravinder Reddy Gaddam, Julia S Jacobs, Markus M Bachschmid, Tsneem Younis, Zhiyong Zhu, Leonid Zingman, Barry London, Adam J Rauckhorst, Eric B Taylor, Andrew W Norris, Ajit Vikram, Kaikobad Iran. Deficiency of endothelial sirtuin1 in mice stimulates skeletal muscle insulin sensitivity by modifying the secretome. Nature communications. vol 14. issue 1. 2023-09-11. PMID:37696839. |
endothelial sirt1 deficiency, by inhibiting autophagy and activating nuclear factor-kappa b signaling, augments expression and secretion of thymosin beta-4 (tβ4) that promotes insulin signaling in skeletal myotubes. |
2023-09-11 |
2023-10-07 |
mouse |
| Qiuxia Li, Quanjiang Zhang, Young-Rae Kim, Ravinder Reddy Gaddam, Julia S Jacobs, Markus M Bachschmid, Tsneem Younis, Zhiyong Zhu, Leonid Zingman, Barry London, Adam J Rauckhorst, Eric B Taylor, Andrew W Norris, Ajit Vikram, Kaikobad Iran. Deficiency of endothelial sirtuin1 in mice stimulates skeletal muscle insulin sensitivity by modifying the secretome. Nature communications. vol 14. issue 1. 2023-09-11. PMID:37696839. |
thus, unlike in skeletal myocytes, sirt1 deficiency in the endothelium promotes glucose homeostasis by stimulating skeletal muscle insulin sensitivity through a blood-borne mechanism, and augmented secretion of tβ4 by sirt1-deficient endothelial cells boosts insulin signaling in skeletal muscle cells. |
2023-09-11 |
2023-10-07 |
mouse |
| Julia Matuszewska, Joanna Nowacka-Woszuk, Anna Radziejewska, Emilia Grzęda, Ewa Pruszynska-Oszmałek, Łukasz Dylewski, Agata Chmurzynska, Joanna H Sliwowsk. Maternal cafeteria diet and reproductive functions in offspring. Biology of reproduction. 2023-09-04. PMID:37665248. |
we found that caf offspring had: lower weight and altered body composition; increased cholesterol and triglycerides levels, sex-specific changes in glucose and insulin levels; sex-dependent changes in sirt1/kiss1 mrna ratio in the hypothalamus, sex-specific alterations in kiss1 and sirt1 mrna in the liver with more diversity in males; a delayed puberty onset in females. |
2023-09-04 |
2023-09-07 |
rat |