| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samuel S Aguiar, Thiago S Rosa, Rodrigo V P Neves, Patrício L A Leite, Larissa A Maciel, Sara D Gutierrez, Erica C Rosa, Rosângela V Andrade, Hans Degens, Marko T Korhonen, John E Lewis, Herbert G Simõe. Telomere Length, SIRT1, and Insulin in Male Master Athletes: The Path to Healthy Longevity? International journal of sports medicine. 2021-07-15. PMID:34256387. |
telomere length, sirt1, and insulin in male master athletes: the path to healthy longevity? |
2021-07-15 |
2023-08-13 |
Not clear |
| Samuel S Aguiar, Thiago S Rosa, Rodrigo V P Neves, Patrício L A Leite, Larissa A Maciel, Sara D Gutierrez, Erica C Rosa, Rosângela V Andrade, Hans Degens, Marko T Korhonen, John E Lewis, Herbert G Simõe. Telomere Length, SIRT1, and Insulin in Male Master Athletes: The Path to Healthy Longevity? International journal of sports medicine. 2021-07-15. PMID:34256387. |
lower sirt1 and insulin resistance are associated with accelerated telomere shortening. |
2021-07-15 |
2023-08-13 |
Not clear |
| Samuel S Aguiar, Thiago S Rosa, Rodrigo V P Neves, Patrício L A Leite, Larissa A Maciel, Sara D Gutierrez, Erica C Rosa, Rosângela V Andrade, Hans Degens, Marko T Korhonen, John E Lewis, Herbert G Simõe. Telomere Length, SIRT1, and Insulin in Male Master Athletes: The Path to Healthy Longevity? International journal of sports medicine. 2021-07-15. PMID:34256387. |
we compared insulin, sirt1, and telomere length in highly trained male master athletes (n=52; aged 49.9±7.2 yrs) and age-matched non-athletes (n=19; aged 47.3±8.9 yrs). |
2021-07-15 |
2023-08-13 |
Not clear |
| Samuel S Aguiar, Thiago S Rosa, Rodrigo V P Neves, Patrício L A Leite, Larissa A Maciel, Sara D Gutierrez, Erica C Rosa, Rosângela V Andrade, Hans Degens, Marko T Korhonen, John E Lewis, Herbert G Simõe. Telomere Length, SIRT1, and Insulin in Male Master Athletes: The Path to Healthy Longevity? International journal of sports medicine. 2021-07-15. PMID:34256387. |
overnight fasted sirt1 and insulin levels in whole blood were assessed using commercial kits. |
2021-07-15 |
2023-08-13 |
Not clear |
| Samuel S Aguiar, Thiago S Rosa, Rodrigo V P Neves, Patrício L A Leite, Larissa A Maciel, Sara D Gutierrez, Erica C Rosa, Rosângela V Andrade, Hans Degens, Marko T Korhonen, John E Lewis, Herbert G Simõe. Telomere Length, SIRT1, and Insulin in Male Master Athletes: The Path to Healthy Longevity? International journal of sports medicine. 2021-07-15. PMID:34256387. |
master athletes had higher sirt1, lower insulin, and longer telomere length than age-matched non-athletes ( |
2021-07-15 |
2023-08-13 |
Not clear |
| Ying Zhang, Yuhang Ma, Mingyu Gu, Yongde Pen. lncRNA TUG1 promotes the brown remodeling of white adipose tissue by regulating miR‑204‑targeted SIRT1 in diabetic mice. International journal of molecular medicine. vol 46. issue 6. 2021-07-08. PMID:33125086. |
body weight, serum glucose levels, insulin levels and testicular fat, as well as the expression levels of tug1, mir‑204, sirtuin 1 (sirt1) and the amp‑activated protein kinase (ampk)/acetyl‑coa carboxylase (acc) signaling pathway were detected. |
2021-07-08 |
2023-08-13 |
mouse |
| Chiara Lanzillotta, Antonella Tramutola, Graziella Di Giacomo, Federico Marini, D Allan Butterfield, Fabio Di Domenico, Marzia Perluigi, Eugenio Baron. Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: A harmful synergistic path in down syndrome. Free radical biology & medicine. vol 165. 2021-06-28. PMID:33516914. |
furthermore, we analyzed whether changes of brain insulin signaling were associated with alterations of: (i) proteins regulating brain energy metabolism (mitochondrial complexes, hexokinase-ii, sirt1); (ii) oxidative stress (os) markers (iii) app cleavage; and (iv) proteins mediating synaptic plasticity mechanisms (psd95, syntaxin-1 and bdnf). |
2021-06-28 |
2023-08-13 |
mouse |
| Ying Zhang, Mingyu Gu, Yuhang Ma, Yongde Pen. LncRNA TUG1 reduces inflammation and enhances insulin sensitivity in white adipose tissue by regulating miR-204/SIRT1 axis in obesity mice. Molecular and cellular biochemistry. vol 475. issue 1-2. 2021-06-23. PMID:32888158. |
then, body weight, serum glucose, insulin tolerance, testicular fat weight were detected, as well as the expression of tug1, microrna-204 (mir-204), sirtuin1 (sirt1), and inflammation and fatty accumulation associated proteins and cytokines. |
2021-06-23 |
2023-08-13 |
mouse |
| Ying Zhang, Mingyu Gu, Yuhang Ma, Yongde Pen. LncRNA TUG1 reduces inflammation and enhances insulin sensitivity in white adipose tissue by regulating miR-204/SIRT1 axis in obesity mice. Molecular and cellular biochemistry. vol 475. issue 1-2. 2021-06-23. PMID:32888158. |
overexpression of tug1 could significantly attenuate the weight, serum glucose, glucose, insulin tolerance, fatty accumulation, and inflammation in obesity mice, as well as the elevation of mir-204, but increase the expression of sirt1, phosphorylated akt (p-akt), glucose transporter4 (glut4), and peroxisome proliferator activated receptorγ (pparγ). |
2021-06-23 |
2023-08-13 |
mouse |
| Hossein Nikroo, Seyyed Reza Attarzadeh Hosseini, Mehrdad Fathi, Mohammad Ali Sardar, Majid Khazae. The effect of aerobic, resistance, and combined training on PPAR-α, SIRT1 gene expression, and insulin resistance in high-fat diet-induced NAFLD male rats. Physiology & behavior. vol 227. 2021-06-21. PMID:32888948. |
the effect of aerobic, resistance, and combined training on ppar-α, sirt1 gene expression, and insulin resistance in high-fat diet-induced nafld male rats. |
2021-06-21 |
2023-08-13 |
rat |
| Hossein Nikroo, Seyyed Reza Attarzadeh Hosseini, Mehrdad Fathi, Mohammad Ali Sardar, Majid Khazae. The effect of aerobic, resistance, and combined training on PPAR-α, SIRT1 gene expression, and insulin resistance in high-fat diet-induced NAFLD male rats. Physiology & behavior. vol 227. 2021-06-21. PMID:32888948. |
insulin resistance (ir) is known as the most important cause of non-alcoholic fatty liver disease (nafld), which is accompanied by a decline in gene expression of hepatic's peroxisomes proliferator-activated receptors-alpha (ppar-α) and sirtuin-1 (sirt1). |
2021-06-21 |
2023-08-13 |
rat |
| Bin Feng, Bin Huang, Yali Jing, Shanmei Shen, Wenhuan Feng, Weimin Wang, Ran Meng, Dalong Zh. Silymarin ameliorates the disordered glucose metabolism of mice with diet-induced obesity by activating the hepatic SIRT1 pathway. Cellular signalling. vol 84. 2021-05-31. PMID:33901577. |
these findings suggest that hepatic sirt1 may be an important pharmacological target of slm and mediate effects on insulin resistance and gluconeogenesis, which may underlie its anti-diabetic activity. |
2021-05-31 |
2023-08-13 |
mouse |
| Chunjie Su, Qian Cheng, Liyun Wan. Roux-en-Y Gastric Bypass Improves Hepatic Glucose Metabolism Involving Upregulation of Sirt1 in Type 2 Diabetes Mellitus. Diabetes, metabolic syndrome and obesity : targets and therapy. vol 14. 2021-05-30. PMID:34045876. |
previous studies have reported that silent information regulator 1 (sirt1) closely relates to many pathological processes of glucose metabolism and insulin resistance (ir). |
2021-05-30 |
2023-08-13 |
Not clear |
| Yan-Mei Wang, Ting-Lei Huang, Chao Meng, Jia Zhang, Ning-Yuan Fan. SIRT1 deacetylates mitochondrial trifunctional enzyme α subunit to inhibit ubiquitylation and decrease insulin resistance. Cell death & disease. vol 11. issue 10. 2021-05-13. PMID:33009367. |
sirt1 deacetylates mitochondrial trifunctional enzyme α subunit to inhibit ubiquitylation and decrease insulin resistance. |
2021-05-13 |
2023-08-13 |
mouse |
| Yu Chen, Jingfan Zhang, Ping Li, Cong Liu, Ling L. N1‑methylnicotinamide ameliorates insulin resistance in skeletal muscle of type 2 diabetic mice by activating the SIRT1/PGC‑1α signaling pathway. Molecular medicine reports. vol 23. issue 4. 2021-05-10. PMID:33576435. |
the present study aimed to determine the effects of n1‑methylnicotinamide (mnam) on insulin resistance (ir) in skeletal muscle from a mouse model of type 2 diabetes mellitus (t2dm), and to investigate the regulatory mechanisms of the sirtuin 1 (sirt1)/peroxisome proliferator‑activated receptor γ coactivator‑1α (pgc‑1α) signaling pathway. |
2021-05-10 |
2023-08-13 |
mouse |
| Hasan Gencogl. Maca modulates fat and liver energy metabolism markers insulin, IRS1, leptin, and SIRT1 in rats fed normal and high-fat diets. Archives of physiology and biochemistry. 2021-05-06. PMID:32951476. |
maca modulates fat and liver energy metabolism markers insulin, irs1, leptin, and sirt1 in rats fed normal and high-fat diets. |
2021-05-06 |
2023-08-13 |
rat |
| Hasan Gencogl. Maca modulates fat and liver energy metabolism markers insulin, IRS1, leptin, and SIRT1 in rats fed normal and high-fat diets. Archives of physiology and biochemistry. 2021-05-06. PMID:32951476. |
maca root extract on insulin, insulin receptor substrate-1 (irs1), leptin, and nad-dependent deacetylase sirtuin-1 (sirt1), as well as body weight changes evaluated in this study for a 60 days model of normal and high-fat diet (hfd) fed rats. |
2021-05-06 |
2023-08-13 |
rat |
| Viola J Kosgei, David Coelho, Rosa-Maria Guéant-Rodriguez, Jean-Louis Guéan. Sirt1-PPARS Cross-Talk in Complex Metabolic Diseases and Inherited Disorders of the One Carbon Metabolism. Cells. vol 9. issue 8. 2021-04-12. PMID:32796716. |
sirt1 plays an important role in the differentiation of adipocytes and in insulin signaling regulated by foxo1 and phosphatidylinositol 3'-kinase (pi3k) signaling. |
2021-04-12 |
2023-08-13 |
rat |
| Munehiro Kitada, Yoshio Ogura, Itaru Monno, Daisuke Koy. Supplementation with Red Wine Extract Increases Insulin Sensitivity and Peripheral Blood Mononuclear Sirt1 Expression in Nondiabetic Humans. Nutrients. vol 12. issue 10. 2021-04-12. PMID:33053742. |
supplementation with red wine extract increases insulin sensitivity and peripheral blood mononuclear sirt1 expression in nondiabetic humans. |
2021-04-12 |
2023-08-13 |
human |
| Munehiro Kitada, Yoshio Ogura, Itaru Monno, Daisuke Koy. Supplementation with Red Wine Extract Increases Insulin Sensitivity and Peripheral Blood Mononuclear Sirt1 Expression in Nondiabetic Humans. Nutrients. vol 12. issue 10. 2021-04-12. PMID:33053742. |
the aim of this study was to investigate the effects of dietary supplementation with a nonalcoholic red wine extract (rwe), including resveratrol and polyphenols, on insulin sensitivity and sirt1 expression in nondiabetic humans. |
2021-04-12 |
2023-08-13 |
human |