| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiang Li, Shaofeng Xu, Ling Wang, Xiaoliang Wan. PHPB Attenuated Cognitive Impairment in Type 2 Diabetic KK-Ay Mice by Modulating SIRT1/Insulin Signaling Pathway and Inhibiting Generation of AGEs. Pharmaceuticals (Basel, Switzerland). vol 16. issue 2. 2023-06-01. PMID:37259448. |
also, phpb treatment improved the insulin signaling pathway by increasing sirtuin1 (sirt1) deacetylase activity and attenuated oxidative stress evidenced by elevating glucose-6-phosphate dehydrogenase (g-6-pd) protein expression, promoting the production of reduced glutathione (gsh) and reduced nicotinamide adenine dinucleotide phosphate (nadph), restoring mitochondrial membrane potential, increasing adenosine triphosphate (atp) generation, and reducing malondialdehyde (mda) levels in the brain. |
2023-06-01 |
2023-08-14 |
mouse |
| Zhipeng Tao, Zhiyong Chen. Hormonal regulation of metabolism-recent lessons learned from insulin and estrogen. Clinical science (London, England : 1979). vol 137. issue 6. 2023-03-21. PMID:36942499. |
insulin and estrogen signaling converge on sirt1, mtor, and pi3k in the joint regulation of autophagy and mitochondrial metabolism. |
2023-03-21 |
2023-08-14 |
Not clear |
| Zhipeng Tao, Zhiyong Chen. Hormonal regulation of metabolism-recent lessons learned from insulin and estrogen. Clinical science (London, England : 1979). vol 137. issue 6. 2023-03-21. PMID:36942499. |
in addition, we discuss the cross-talk between estrogen signaling and insulin signaling via sirt1, mtor, and pi3k, as well as new therapeutic options such as agonists of glp1 receptor, gip receptor, and β3-ar. |
2023-03-21 |
2023-08-14 |
Not clear |
| Masroor Anwar, Rashmita Pradhan, Sharmistha Dey, Rahul Kuma. The Role of Sirtuins in Sarcopenia and Frailty. Aging and disease. vol 14. issue 1. 2023-02-23. PMID:36818553. |
in addition, sirt1 improves insulin sensitivity and induces autophagy in the aged mice. |
2023-02-23 |
2023-08-14 |
mouse |
| Dorota Rogacka, Patrycja Rachubik, Irena Audzeyenka, Tomasz Kulesza, Maria Szrejder, Dorota Myślińska, Stefan Angielski, Agnieszka Piwkowsk. Inhibition of phosphodiesterase 5A by tadalafil improves SIRT1 expression and activity in insulin-resistant podocytes. Cellular signalling. 2023-02-08. PMID:36754339. |
we found that pde5a protein levels increased in hyperglycemia, and pde5a downregulation improved the insulin responsiveness of podocytes with reestablished sirt1 expression and activity. |
2023-02-08 |
2023-08-14 |
Not clear |
| Dorota Rogacka, Patrycja Rachubik, Irena Audzeyenka, Tomasz Kulesza, Maria Szrejder, Dorota Myślińska, Stefan Angielski, Agnieszka Piwkowsk. Inhibition of phosphodiesterase 5A by tadalafil improves SIRT1 expression and activity in insulin-resistant podocytes. Cellular signalling. 2023-02-08. PMID:36754339. |
therefore, we investigated the effects of tadalafil on sirt1 and ampk in the context of improving the insulin sensitivity in podocytes and podocyte function in hyperglycemia. |
2023-02-08 |
2023-08-14 |
Not clear |
| Shuchao Pang, Zhengjun Zhang, Yu Zhou, Jie Zhang, Bo Ya. Genetic Variants of International journal of endocrinology. vol 2023. 2023-02-07. PMID:36747995. |
accumulating evidence indicates that sirt1 is involved in insulin resistance and impaired pancreatic |
2023-02-07 |
2023-08-14 |
human |
| Jing Li, Xin Zeng, Xiaolong Yang, Hong Din. Lycopene ameliorates skin aging by regulating the insulin resistance pathway and activating SIRT1. Food & function. 2022-10-13. PMID:36226790. |
lycopene ameliorates skin aging by regulating the insulin resistance pathway and activating sirt1. |
2022-10-13 |
2023-08-14 |
Not clear |
| Hai-Feng Han, Shao-Zhuang Liu, Xiang Zhang, Meng Wei, Xin Huang, Wen-Bin Y. Duodenal-jejunal bypass increases intraduodenal bile acids and upregulates duodenal SIRT1 expression in high-fat diet and streptozotocin-induced diabetic rats. World journal of gastroenterology. vol 28. issue 31. 2022-09-26. PMID:36159018. |
however, the duodenum has emerged as an important regulator of glucose homeostasis, and elevated duodenal sirt1 leads to improved hepatic insulin sensitivity. |
2022-09-26 |
2023-08-14 |
rat |
| Dorota Rogacka, Patrycja Rachubik, Irena Audzeyenka, Maria Szrejder, Tomasz Kulesza, Dorota Myślińska, Stefan Angielski, Agnieszka Piwkowsk. Enhancement of cGMP-dependent pathway activity ameliorates hyperglycemia-induced decrease in SIRT1-AMPK activity in podocytes: Impact on glucose uptake and podocyte function. Biochimica et biophysica acta. Molecular cell research. 2022-09-24. PMID:36152759. |
in podocytes that are exposed to high glucose concentrations, crosstalk between the protein deacetylase sirtuin 1 (sirt1) and adenosine monophosphate-dependent protein kinase (ampk) decreased, attenuating insulin responsiveness and impairing podocyte function. |
2022-09-24 |
2023-08-14 |
Not clear |
| Jie Yang, Zi-Xuan Wang, Lei Fang, Tu-Shuai Li, Zhi-Hong Liu, Ying Pan, Ling-Dong Kon. Atractylodes lancea and Magnolia officinalis combination protects against high fructose-impaired insulin signaling in glomerular podocytes through upregulating Sirt1 to inhibit p53-driven miR-221. Journal of ethnopharmacology. 2022-09-06. PMID:36067838. |
atractylodes lancea and magnolia officinalis combination protects against high fructose-impaired insulin signaling in glomerular podocytes through upregulating sirt1 to inhibit p53-driven mir-221. |
2022-09-06 |
2023-08-14 |
Not clear |
| Mali Wu, Jie Zhang, Ran Gu, Fangfang Dai, Dongyong Yang, Yajing Zheng, Wei Tan, Yifan Jia, Bingshu Li, Yanxiang Chen. The role of Sirtuin 1 in the pathophysiology of polycystic ovary syndrome. European journal of medical research. vol 27. issue 1. 2022-08-27. PMID:36030228. |
moreover, sirt1 participates in the pathophysiological processes of oxidative stress, autophagy, ovulation disturbance and insulin resistance, which may be a vital link in the occurrence of pcos. |
2022-08-27 |
2023-08-14 |
human |
| Ishitha Reddy, Yamini Yadav, Chinmoy Sankar De. Cellular and Molecular Regulation of Exercise-A Neuronal Perspective. Cellular and molecular neurobiology. 2022-08-20. PMID:35986789. |
exerkines such as fndc5/irisin, cathepsin b, adiponectin, and il-6 circulate through the bloodstream, cross the blood-brain barrier, and modulate the expression of important signaling molecules such as ampk, sirt1, pgc1α, bdnf, igf-1, and vegf which further contribute to improved energy metabolism, glucose homeostasis, insulin sensitivity, neurogenesis, synaptic plasticity, and overall well-being of the body and brain. |
2022-08-20 |
2023-08-14 |
Not clear |
| Pei-Pei Su, Dong-Wei Liu, Si-Jie Zhou, Hang Chen, Xian-Ming Wu, Zhang-Suo Li. Down-regulation of Risa improves podocyte injury by enhancing autophagy in diabetic nephropathy. Military Medical Research. vol 9. issue 1. 2022-05-25. PMID:35614465. |
lncrna ak044604 (regulator of insulin sensitivity and autophagy, risa) and autophagy-related factors sirt1 and gsk3β play important roles in diabetic nephropathy (dn). |
2022-05-25 |
2023-08-13 |
Not clear |
| Emily Leong, Reena Dosanjh, Johnson Huynh, Yujin Hur, Christiane Cabreros, Yue Tong Lee, Ningkun Wan. Dissecting the Mechanism of Allosteric Regulation of SIRT1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555597. |
the enzyme sirt1 is a lysine deacetylase that plays a part in various pathways in the body, including insulin secretion and neurodegeneration, rendering it as a potential drug target for common diseases such as type ii diabetes and alzheimer's disease. |
2022-05-13 |
2023-08-13 |
Not clear |
| Rebecca A S Palu, Katie G Owings, John G Garces, Audrey Nico. A natural genetic variation screen identifies insulin signaling, neuronal communication, and innate immunity as modifiers of hyperglycemia in the absence of Sirt1. G3 (Bethesda, Md.). 2022-04-18. PMID:35435227. |
a natural genetic variation screen identifies insulin signaling, neuronal communication, and innate immunity as modifiers of hyperglycemia in the absence of sirt1. |
2022-04-18 |
2023-08-13 |
drosophila_melanogaster |
| Samanta Taurone, Chiara De Ponte, Dante Rotili, Elena De Santis, Antonello Mai, Francesco Fiorentino, Susanna Scarpa, Marco Artico, Alessandra Micer. Biochemical Functions and Clinical Characterizations of the Sirtuins in Diabetes-Induced Retinal Pathologies. International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35409409. |
sirt1, 3, 5, and 6 are key enzymes in dr since they modulate glucose metabolism, insulin sensitivity, and inflammation. |
2022-04-12 |
2023-08-13 |
Not clear |
| Kunpeng Liu, Xiaogao Jin, Xiaoying Zhang, Hongkai Lian, Jianping Y. The mechanisms of nucleotide actions in insulin resistance. Journal of genetics and genomics = Yi chuan xue bao. 2022-02-08. PMID:35134563. |
atp and nadh, derivatives of adenosine, inhibit insulin signaling inside cells by downregulation of activities of ampk and sirt1, respectively. |
2022-02-08 |
2023-08-13 |
Not clear |
| Chao Geng, Yuan Xue, Jia Hui Yang, Ming Yue Gao, Wei Zhao, Chun Mei Li, Xiang Hong Xie, Wei Hong Zhang, Hua Bing Zhang, Fu De Fang, Hong Yao, Xiao Jun Li. SIRT1 Mediates Sestrin1-Induced Improvement in Hepatic Insulin Resistance. Biomedical and environmental sciences : BES. vol 35. issue 1. 2022-01-26. PMID:35078566. |
sirt1 mediates sestrin1-induced improvement in hepatic insulin resistance. |
2022-01-26 |
2023-08-13 |
Not clear |
| Mehdi Mahmudpour, Katayoun Vahdat, Mohsen Keshavarz, Iraj Nabipou. The COVID-19-diabetes mellitus molecular tetrahedron. Molecular biology reports. 2022-01-24. PMID:35067816. |
the entrance of sars-cov-2 using ace2 receptor triggers an array of multiple molecular signaling beyond that of the angiotensin ii/ace2-ang-(1-7) axis, such as down-regulation of pgc-1 α/irisin, increased srebp-1c activity, upregulation of cd36 and sirt1 inhibition leading to insulin resistance. |
2022-01-24 |
2023-08-13 |
Not clear |