| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mehdi Mahmudpour, Katayoun Vahdat, Mohsen Keshavarz, Iraj Nabipou. The COVID-19-diabetes mellitus molecular tetrahedron. Molecular biology reports. 2022-01-24. PMID:35067816. |
in another arm of the molecular cascade, the sars-cov-2 hijacking and replication induces a series of molecular events in the host cell metabolic machinery, including upregulation of srebp-2, decrement in sirt1 expression, dysregulation in ppar-ɣ, and lpi resulting in insulin resistance. |
2022-01-24 |
2023-08-13 |
Not clear |
| Jing Li, Yingjiang Zhang, Xin Zeng, Yahong Cheng, Liu Tang, Ding Hong, Xiaolong Yan. Lycopene ameliorates insulin resistance and increases muscle capillary density in aging via activation of SIRT1. The Journal of nutritional biochemistry. vol 99. 2021-11-26. PMID:34530111. |
lycopene ameliorates insulin resistance and increases muscle capillary density in aging via activation of sirt1. |
2021-11-26 |
2023-08-13 |
human |
| Jing Li, Yingjiang Zhang, Xin Zeng, Yahong Cheng, Liu Tang, Ding Hong, Xiaolong Yan. Lycopene ameliorates insulin resistance and increases muscle capillary density in aging via activation of SIRT1. The Journal of nutritional biochemistry. vol 99. 2021-11-26. PMID:34530111. |
finally, in the insulin resistance cell model, we knocked down the sirt1 and administrated with ly, and found that it couldn't restore insulin transdution. |
2021-11-26 |
2023-08-13 |
human |
| Jing Li, Yingjiang Zhang, Xin Zeng, Yahong Cheng, Liu Tang, Ding Hong, Xiaolong Yan. Lycopene ameliorates insulin resistance and increases muscle capillary density in aging via activation of SIRT1. The Journal of nutritional biochemistry. vol 99. 2021-11-26. PMID:34530111. |
in conclusion, all the data in this study demonstrate that ly could reactivate sirt1 and improve insulin resistance, which was a reversible cause of vascular aging. |
2021-11-26 |
2023-08-13 |
human |
| Faiza Alam, Hareem Syed, Sofia Amjad, Mukhtiar Baig, Taseer Ahmed Khan, Rehana Rehma. Interplay between oxidative stress, SIRT1, reproductive and metabolic functions. Current research in physiology. vol 4. 2021-11-10. PMID:34746831. |
sirt1 improves insulin resistance by reducing os and regulating mitochondrial biogenesis and function. |
2021-11-10 |
2023-08-13 |
Not clear |
| Do Hyeon Pyun, Tae Jin Kim, Seung Yeon Park, Hyun Jung Lee, A M Abd El-Aty, Ji Hoon Jeong, Tae Woo Jun. Patchouli alcohol ameliorates skeletal muscle insulin resistance and NAFLD via AMPK/SIRT1-mediated suppression of inflammation. Molecular and cellular endocrinology. vol 538. 2021-10-27. PMID:34601002. |
sirna-mediated suppression of ampk or sirt1 mitigated the effects of pa on palmitate-induced inflammation and insulin resistance in c2c12 myocytes and lipid accumulation in hepg2 cells. |
2021-10-27 |
2023-08-13 |
mouse |
| Do Hyeon Pyun, Tae Jin Kim, Seung Yeon Park, Hyun Jung Lee, A M Abd El-Aty, Ji Hoon Jeong, Tae Woo Jun. Patchouli alcohol ameliorates skeletal muscle insulin resistance and NAFLD via AMPK/SIRT1-mediated suppression of inflammation. Molecular and cellular endocrinology. vol 538. 2021-10-27. PMID:34601002. |
animal experiments demonstrated that pa administration increased ampk phosphorylation and sirt1 expression, and ameliorated inflammation, thereby attenuating skeletal muscle insulin resistance and hepatic steatosis in high-fat diet-fed mice. |
2021-10-27 |
2023-08-13 |
mouse |
| X Charlie Don. Sirtuin biology and relevance to diabetes treatment. Diabetes management (London, England). vol 2. issue 3. 2021-10-21. PMID:23024708. |
sirt1 regulates glucose and lipid homeostasis in the liver, modulates insulin secretion in pancreatic islets, controls insulin sensitivity and glucose uptake in skeletal muscle, increases adiponectin expression in white adipose tissue and controls food intake and energy expenditure in the brain. |
2021-10-21 |
2023-08-12 |
mouse |
| X Charlie Don. Sirtuin biology and relevance to diabetes treatment. Diabetes management (London, England). vol 2. issue 3. 2021-10-21. PMID:23024708. |
although it is controversial, the sirt1 activator srt1720 has been reported to be effective in improving glucose metabolism and insulin sensitivity in animal models. |
2021-10-21 |
2023-08-12 |
mouse |
| Dorota Rogacka, Irena Audzeyenka, Patrycja Rachubik, Maria Szrejder, Marlena Typiak, Stefan Angielski, Agnieszka Piwkowsk. Involvement of nitric oxide synthase/nitric oxide pathway in the regulation of SIRT1-AMPK crosstalk in podocytes: Impact on glucose uptake. Archives of biochemistry and biophysics. vol 709. 2021-09-30. PMID:34252390. |
the protein deacetylase sirtuin 1 (sirt1) and adenosine monophosphate-dependent protein kinase (ampk) play important roles in the development of insulin resistance. |
2021-09-30 |
2023-08-13 |
Not clear |
| Dorota Rogacka, Irena Audzeyenka, Patrycja Rachubik, Maria Szrejder, Marlena Typiak, Stefan Angielski, Agnieszka Piwkowsk. Involvement of nitric oxide synthase/nitric oxide pathway in the regulation of SIRT1-AMPK crosstalk in podocytes: Impact on glucose uptake. Archives of biochemistry and biophysics. vol 709. 2021-09-30. PMID:34252390. |
sirt1 protein levels and activity and ampk phosphorylation decrease under hyperglycemic conditions, with concomitant inhibition of the effect of insulin on glucose uptake into these cells. |
2021-09-30 |
2023-08-13 |
Not clear |
| Dorota Rogacka, Irena Audzeyenka, Patrycja Rachubik, Maria Szrejder, Marlena Typiak, Stefan Angielski, Agnieszka Piwkowsk. Involvement of nitric oxide synthase/nitric oxide pathway in the regulation of SIRT1-AMPK crosstalk in podocytes: Impact on glucose uptake. Archives of biochemistry and biophysics. vol 709. 2021-09-30. PMID:34252390. |
inhibition of the nos/no pathway reduced sirt1 protein levels and activity, leading to a decrease in ampk phosphorylation and blockade of the effect of insulin on glucose uptake. |
2021-09-30 |
2023-08-13 |
Not clear |
| Patricia S Pardo, Aladin M Borie. SIRT1 Regulation in Ageing and Obesity. Mechanisms of ageing and development. vol 188. 2021-09-27. PMID:32320732. |
sirt1 activation has been shown to regulate pathways with beneficiary effects on 1) ageing and obesity-associated metabolic disorders such as metabolic syndrome, insulin resistance and type-ii diabetes with, 2) chronic inflammatory processes such as arthritis, atherosclerosis and emphysema, 3) dna damage and oxidative stress with impact on neurodegenerative diseases, cardiovascular health and some cancers. |
2021-09-27 |
2023-08-13 |
Not clear |
| Carmen Escalona-Garrido, Patricia Vázquez, Paula Mera, Sebastián Zagmutt, Ester García-Casarrubios, Ana Montero-Pedrazuela, Fernanda Rey-Stolle, Ana Guadaño-Ferraz, Francisco J Rupérez, Dolors Serra, Laura Herrero, Maria Jesus Obregon, Ángela M Valverd. Moderate SIRT1 overexpression protects against brown adipose tissue inflammation. Molecular metabolism. vol 42. 2021-09-07. PMID:33049408. |
in this study, we explored the impact of moderate sirtuin 1 (sirt1) overexpression on insulin sensitivity and β-adrenergic responses in bat and brown adipocytes (ba) under pro-inflammatory conditions. |
2021-09-07 |
2023-08-13 |
Not clear |
| Matthew J Myers, Fathima Shaik, Fahema Shaik, Stephen E Alway, Junaith S Mohame. Skeletal Muscle Gene Expression Profile in Response to Caloric Restriction and Aging: A Role for SirT1. Genes. vol 12. issue 5. 2021-08-30. PMID:34063079. |
sirt1 oe did not affect whole-body energy expenditure or augment skeletal muscle insulin sensitivity associated pathways, regardless of aging or diet. |
2021-08-30 |
2023-08-13 |
mouse |
| Anna Bizoń, Anna Słowiak, Grzegorz Franik, Aleksandra Biernacka-Bartnik, Paweł Made. Zinc, copper, sirtuin 1 concentration, and glucose metabolism parameters in the blood of women with polycystic ovary syndrome. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 36. issue 11. 2021-08-27. PMID:32281435. |
however, increased value of body mass index, waist-hip ratio and homeostatic model assessment of insulin resistance (homa-ir) was not associated with changes in zn and sirt1 concentration. |
2021-08-27 |
2023-08-13 |
Not clear |
| Ainaz Mihanfar, Maryam Akbarzadeh, Saber Ghazizadeh Darband, Shirin Sadighparvar, Maryam Majidini. SIRT1: a promising therapeutic target in type 2 diabetes mellitus. Archives of physiology and biochemistry. 2021-08-11. PMID:34379994. |
sirtuin 1 (sirt1) is an nad + dependent protein deacetylase with a critical function in the regulation of glucose/lipid metabolism, insulin resistance, inflammation, oxidative stress, and mitochondrial function. |
2021-08-11 |
2023-08-13 |
Not clear |
| Ainaz Mihanfar, Maryam Akbarzadeh, Saber Ghazizadeh Darband, Shirin Sadighparvar, Maryam Majidini. SIRT1: a promising therapeutic target in type 2 diabetes mellitus. Archives of physiology and biochemistry. 2021-08-11. PMID:34379994. |
sirt1 is also involved in the regulation of insulin secretion from pancreatic β-cells and protecting these cells from inflammation and oxidative stress-mediated tissue damages. |
2021-08-11 |
2023-08-13 |
Not clear |
| Ivana Sirangelo, Margherita Borriello, Maria Liccardo, Marika Scafuro, Paola Russo, Clara Iannuzz. Hydroxytyrosol Selectively Affects Non-Enzymatic Glycation in Human Insulin and Protects by AGEs Cytotoxicity. Antioxidants (Basel, Switzerland). vol 10. issue 7. 2021-08-09. PMID:34356360. |
our data show that ht selectively inhibits protein glycation reaction in human insulin, and it is able to counteract the age-induced cytotoxicity in human neurotypical cells by acting on sirt1 level and oxidative stress, as well as on inflammatory response. |
2021-08-09 |
2023-08-13 |
human |
| Yanyan Zhu, Haixia Yang, Jianjun Deng, Daidi Fa. Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice. Journal of agricultural and food chemistry. vol 69. issue 30. 2021-08-05. PMID:34309383. |
rg5 treatment also increased the level of glycogen synthesis and activated sirtuin1 (sirt1) to increase glucose uptake and insulin sensitivity in insulin-resistant hepg2 (ir-hepg2) cells. |
2021-08-05 |
2023-08-13 |
mouse |