| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M M Ten Brinke, H J Boele, C I De Zeeu. Conditioned climbing fiber responses in cerebellar cortex and nuclei. Neuroscience letters. vol 688. 2019-02-18. PMID:29689340. |
cerebellar cortical purkinje cell simple spike suppression is widely regarded as the main process underlying conditioned responses (crs), leading to disinhibition of neurons in the cerebellar nuclei that innervate eyelid muscles downstream. |
2019-02-18 |
2023-08-13 |
Not clear |
| N Sumru Bayin, Alexandre Wojcinski, Aurelien Mourton, Hiromitsu Saito, Noboru Suzuki, Alexandra L Joyne. Age-dependent dormant resident progenitors are stimulated by injury to regenerate Purkinje neurons. eLife. vol 7. 2019-02-05. PMID:30091706. |
new pcs are produced from immature foxp2+ purkinje cell precursors (ipcs) that are able to enter the cell cycle and support normal cerebellum development. |
2019-02-05 |
2023-08-13 |
mouse |
| Aaron Sathyanesan, Srikanya Kundu, Joseph Abbah, Vittorio Gall. Neonatal brain injury causes cerebellar learning deficits and Purkinje cell dysfunction. Nature communications. vol 9. issue 1. 2018-12-17. PMID:30104642. |
neonatal brain injury causes cerebellar learning deficits and purkinje cell dysfunction. |
2018-12-17 |
2023-08-13 |
mouse |
| Waqas Tahir, Saima Zafar, Franc Llorens, Amandeep Singh Arora, Katrin Thüne, Matthias Schmitz, Nadine Gotzmann, Niels Kruse, Brit Mollenhauer, Juan Maria Torres, Olivier Andréoletti, Isidre Ferrer, Inga Zer. Molecular Alterations in the Cerebellum of Sporadic Creutzfeldt-Jakob Disease Subtypes with DJ-1 as a Key Regulator of Oxidative Stress. Molecular neurobiology. vol 55. issue 1. 2018-12-11. PMID:27975168. |
cerebellar damage and granular and purkinje cell loss in sporadic creutzfeldt-jakob disease (scjd) highlight a critical involvement of the cerebellum during symptomatic progression of the disease. |
2018-12-11 |
2023-08-13 |
mouse |
| Joshua J White, Roy V Sillito. Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice. Nature communications. vol 8. 2018-12-11. PMID:28374839. |
by blocking olivocerebellar excitatory neurotransmission, we eliminated purkinje cell complex spikes and induced aberrant cerebellar nuclear activity. |
2018-12-11 |
2023-08-13 |
mouse |
| Ruslan L Nuryyev, Toni L Uhlendorf, Wesley Tierney, Suren Zatikyan, Oleg Kopyov, Alex Kopyov, Jessica Ochoa, William Van Trigt, Cindy S Malone, Randy W Cohe. Transplantation of Human Neural Progenitor Cells Reveals Structural and Functional Improvements in the Spastic Han-Wistar Rat Model of Ataxia. Cell transplantation. vol 26. issue 11. 2018-12-11. PMID:29338380. |
in addition, cerebellar histology revealed that the transplanted hnpcs displayed signs of migration and signs of neuronal development in the degenerated purkinje cell layer. |
2018-12-11 |
2023-08-13 |
human |
| Tomoo Hiran. Purkinje Neurons: Development, Morphology, and Function. Cerebellum (London, England). vol 17. issue 6. 2018-12-11. PMID:30284678. |
in other words, all computational results within the cortex are transmitted by purkinje cell axons, which inhibit neurons in the cerebellar or vestibular nucleus. |
2018-12-11 |
2023-08-13 |
Not clear |
| Daniel R Scoles, Stefan M Puls. Oligonucleotide therapeutics in neurodegenerative diseases. RNA biology. vol 15. issue 6. 2018-11-14. PMID:29560813. |
we demonstrated that reduction of atxn2 expression in sca2 mice treated by intracerebroventicular injection (icv) of atxn2 aso delayed motor phenotype onset, improved the expression of several genes demonstrated abnormally reduced by transcriptomic profiling of sca2 mice, and restored abnormal purkinje cell firing frequency in acute cerebellar sections. |
2018-11-14 |
2023-08-13 |
mouse |
| Christina Valkova, Lutz Liebmann, Andreas Krämer, Christian A Hübner, Christoph Kaethe. The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels. Scientific reports. vol 7. 2018-10-29. PMID:28117367. |
mice with a purkinje cell (pc) specific deletion of rer1 showed normal polarization and differentiation of pcs and normal development of the cerebellum. |
2018-10-29 |
2023-08-13 |
mouse |
| Anis Anis, Mohammed AboElkhair, Mahmoud Ibrahi. Characterization of highly pathogenic avian influenza H5N8 virus from Egyptian domestic waterfowl in 2017. Avian pathology : journal of the W.V.P.A. vol 47. issue 4. 2018-10-22. PMID:29701481. |
the granular layer of cerebellum showed multifocal areas of hydropic degeneration and the purkinje cell neurons were necrotized or lost. |
2018-10-22 |
2023-08-13 |
Not clear |
| Koichi Okamoto, Isao Naito, Toshio Fukuda, Keiji Suzuki, Masamitsu Takatam. Adult moyamoya disease associated with abundant phosphorylated tau accumulation in the brainstem: Report of a case with autopsy findings. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 38. issue 3. 2018-10-15. PMID:29282774. |
a few tiny and short at8-immunoreactive processes were observed in the molecular, purkinje cell and granular layers of the cerebellum. |
2018-10-15 |
2023-08-13 |
Not clear |
| Elan D Loui. Essential tremor and the cerebellum. Handbook of clinical neurology. vol 155. 2018-10-01. PMID:29891062. |
in terms of treatment, most of these pharmacotherapeutic agents serve to enhance gabaergic neurotransmission, further bolstering the notion that et may very well be a disorder with a primary purkinje cell dysfunction resulting in reduced cerebellar cortical inhibition. |
2018-10-01 |
2023-08-13 |
Not clear |
| Kristbjörg Sveinsdóttir, John-Kalle Länsberg, Snjólaug Sveinsdóttir, Martin Garwicz, Lennart Ohlsson, Ann Hellström, Lois Smith, Magnus Gram, David Le. Impaired Cerebellar Maturation, Growth Restriction, and Circulating Insulin-Like Growth Factor 1 in Preterm Rabbit Pups. Developmental neuroscience. vol 39. issue 6. 2018-09-28. PMID:28972955. |
preterm birth in rabbit pups is associated with lower circulating levels of igf-1, decreased postnatal growth, and decreased cerebellar egl proliferation and purkinje cell maturation. |
2018-09-28 |
2023-08-13 |
human |
| Emma Lejeune, Ali Javili, Johannes Weickenmeier, Ellen Kuhl, Christian Linde. Tri-layer wrinkling as a mechanism for anchoring center initiation in the developing cerebellum. Soft matter. vol 12. issue 25. 2018-09-17. PMID:27252048. |
motivated by the cerebellar microstructure, we model the developing cerebellum as a tri-layer system with an external molecular layer and an internal granular layer of similar stiffness and a significantly softer intermediate purkinje cell layer. |
2018-09-17 |
2023-08-13 |
Not clear |
| Jean-Marc Good, Michael Mahoney, Taisuke Miyazaki, Kenji F Tanaka, Kenji Sakimura, Masahiko Watanabe, Kazuo Kitamura, Masanobu Kan. Maturation of Cerebellar Purkinje Cell Population Activity during Postnatal Refinement of Climbing Fiber Network. Cell reports. vol 21. issue 8. 2018-08-02. PMID:29166599. |
in the developing cerebellum, the climbing fiber (cf) to purkinje cell (pc) network is drastically reshaped by eliminating early-formed redundant cf to pc synapses. |
2018-08-02 |
2023-08-13 |
mouse |
| Shu Wang, Xiuqiang Chen, Weilin Wu, Zhida Chen, Huiping Du, Xingfu Wang, Yu Vincent Fu, Liwen Hu, Jianxin Che. Rapid, label-free identification of cerebellar structures using multiphoton microscopy. Journal of biophotonics. vol 10. issue 12. 2018-07-23. PMID:28464515. |
together with custom-developed image processing algorithms, mpm could further differentiate between the gray and white matter, as well as evaluate the purkinje cell layer, identify the cerebellar tumor boundary, and distinguish between the tumor core and peritumor regions. |
2018-07-23 |
2023-08-13 |
rat |
| Jui-Yi Hsieh, Diane M Papazia. In Vivo Analysis of Potassium Channelopathies: Loose Patch Recording of Purkinje Cell Firing in Living, Awake Zebrafish. Methods in molecular biology (Clifton, N.J.). vol 1684. 2018-07-23. PMID:29058196. |
purkinje cell excitability and a functional cerebellar circuit develop rapidly in zebrafish and show strong conservation with the mammalian cerebellum. |
2018-07-23 |
2023-08-13 |
zebrafish |
| Adriana Mañas, Aislinn Davis, Sydney Lamerand, Jialing Xian. Detection of pro-apoptotic Bax∆2 proteins in the human cerebellum. Histochemistry and cell biology. vol 150. issue 1. 2018-07-23. PMID:29663074. |
we found bax∆2 positive cells scattered in all areas of the cerebellum, but most strikingly concentrated in purkinje cell bodies and dendrites. |
2018-07-23 |
2023-08-13 |
human |
| Aleksandra Badura, Claudia Clopath, Martijn Schonewille, Chris I De Zeeu. Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments. Scientific reports. vol 6. 2018-05-04. PMID:27805050. |
here, we used our model to predict purkinje cell spiking as well as behavior before and after learning of five different lines of mutant mice with distinct cell-specific alterations of the cerebellar cortical circuitry. |
2018-05-04 |
2023-08-13 |
mouse |
| Jun Ju, Qian Liu, Yang Zhang, Yuanxiu Liu, Mei Jiang, Liguo Zhang, Xuelian He, Chenchen Peng, Tao Zheng, Q Richard Lu, Hedong L. Olig2 regulates Purkinje cell generation in the early developing mouse cerebellum. Scientific reports. vol 6. 2018-04-30. PMID:27469598. |
olig2 regulates purkinje cell generation in the early developing mouse cerebellum. |
2018-04-30 |
2023-08-13 |
mouse |