| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ludi Zhang, Jing Wang, Chenxu Niu, Yu Zhang, Tiantian Zhu, Dongyang Huang, Jing Ma, Hui Sun, Nikita Gamper, Xiaona Du, Hailin Zhan. Activation of parabrachial nucleus - ventral tegmental area pathway underlies the comorbid depression in chronic neuropathic pain in mice. Cell reports. vol 37. issue 5. 2021-11-17. PMID:34731609. |
in parallel, we observe increased activity of the dopaminergic (da) neuron in the midbrain ventral tegmental area (vta), and inhibition of this elevated vta da neuron activity reverses the behavioral manifestations of depression. |
2021-11-17 |
2023-08-13 |
mouse |
| Gabriela Rodríguez-Manzo, Estefanía González-Morales, René Garduño-Gutiérre. Endocannabinoids Released in the Ventral Tegmental Area During Copulation to Satiety Modulate Changes in Glutamate Receptors Associated With Synaptic Plasticity Processes. Frontiers in synaptic neuroscience. vol 13. 2021-09-07. PMID:34483875. |
enhanced da neuron activity triggers the synthesis and release of endocannabinoids (ecbs) in the vta, which participate in several long-term synaptic plasticity processes. |
2021-09-07 |
2023-08-13 |
rat |
| Gabriela Rodríguez-Manzo, Estefanía González-Morales, René Garduño-Gutiérre. Endocannabinoids Released in the Ventral Tegmental Area During Copulation to Satiety Modulate Changes in Glutamate Receptors Associated With Synaptic Plasticity Processes. Frontiers in synaptic neuroscience. vol 13. 2021-09-07. PMID:34483875. |
glutamatergic inputs to the vta express cb1rs and contribute to da neuron burst firing and synaptic plasticity. |
2021-09-07 |
2023-08-13 |
rat |
| Ekaterina Morozova, Philippe Faure, Boris Gutkin, Christoper Lapish, Alexey Kuznetso. Distinct Temporal Structure of Nicotinic ACh Receptor Activation Determines Responses of VTA Neurons to Endogenous ACh and Nicotine. eNeuro. vol 7. issue 4. 2021-06-18. PMID:32737187. |
altogether, this study highlights how β2-nachrs influence coactivation of the vta da and gaba neurons required for motivation and saliency signals carried by da neuron activity. |
2021-06-18 |
2023-08-13 |
Not clear |
| Gabriela Rodríguez-Manzo, Estefanía González-Morale. Endocannabinoids mediate long-lasting behavioural and physiological changes in male rats induced by the repeated activation of the mesolimbic system by copulation to satiety. Behavioural brain research. vol 383. 2021-05-25. PMID:31987931. |
copulation activates the mesolimbic circuit increasing dopamine (da) release in the nucleus accumbens (nacc) and, enhanced midbrain da neuron activity promotes endocannabinoid (ecb) release in the ventral tegmental area (vta). |
2021-05-25 |
2023-08-13 |
rat |
| Felipe V Gomes, Xiyu Zhu, Anthony A Grac. The pathophysiological impact of stress on the dopamine system is dependent on the state of the critical period of vulnerability. Molecular psychiatry. vol 25. issue 12. 2021-05-14. PMID:31488866. |
ventral tegmental area (vta) da neuron population activity and vhipp activity was increased 1-2 and 5-6 weeks post-adolescent stress, along with a decrease in the number of pv+, pnn+, pv + /pnn + cells in the vhipp, which are consistent with the mam model of schizophrenia. |
2021-05-14 |
2023-08-13 |
Not clear |
| Felipe V Gomes, Xiyu Zhu, Anthony A Grac. The pathophysiological impact of stress on the dopamine system is dependent on the state of the critical period of vulnerability. Molecular psychiatry. vol 25. issue 12. 2021-05-14. PMID:31488866. |
in contrast, adult stress decreased vta da neuron population activity only at 1-2 weeks post stress, which is consistent with what has been observed in animal models of depression, without impacting vhipp activity and pv/pnn expression. |
2021-05-14 |
2023-08-13 |
Not clear |
| Yuhan Wang, Safa Bouabid, Martin Darvas, Fu-Ming Zho. The antiparkinson drug ropinirole inhibits movement in a Parkinson's disease mouse model with residual dopamine neurons. Experimental neurology. vol 333. 2021-03-05. PMID:32735872. |
we found that in pitx3null mice with residual da neurons and normal mice with normal da system, systemically injected ropinirole inhibited locomotion, whereas bilateral dorsal striatal-microinjected ropinirole stimulated movement in pitx3null mice; bilateral microinjection of ropinirole into the ventral tegmental area also inhibited movement in pitx3null mice; we further determined that ropinirole inhibited nigral da neuron spike firing in wt mice. |
2021-03-05 |
2023-08-13 |
mouse |
| Claudia I Aghaie, Kathryn A Hausknecht, Ruixiang Wang, Parisa Halaji Dezfuli, Samir Haj-Dahmane, Cynthia J M Kane, Wade J Sigurdson, Roh-Yu She. Prenatal Ethanol Exposure and Postnatal Environmental Intervention Alter Dopaminergic Neuron and Microglia Morphology in the Ventral Tegmental Area During Adulthood. Alcoholism, clinical and experimental research. vol 44. issue 2. 2021-02-04. PMID:31872887. |
in the present study, we investigated pe effects on microglial activation and da neuron density and morphology in the ventral tegmental area (vta). |
2021-02-04 |
2023-08-13 |
Not clear |
| David M Bortz, Anthony A Grac. Medial septum activation produces opposite effects on dopamine neuron activity in the ventral tegmental area and substantia nigra in MAM vs. normal rats. NPJ schizophrenia. vol 4. issue 1. 2020-09-28. PMID:30177811. |
as adults, nmda (0.75 µg/0.2 µl) was infused into the ms, and either da neuron activity in the vta and snc (7-9 anesthetized rats per group) or amphetamine-induced hyperlocomotion (aih, 11-13 rats per group) was measured. |
2020-09-28 |
2023-08-13 |
rat |
| Katharina Klinger, Felipe V Gomes, Millie Rincón-Cortés, Anthony A Grac. Female rats are resistant to the long-lasting neurobehavioral changes induced by adolescent stress exposure. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 29. issue 10. 2020-07-14. PMID:31371105. |
similar to adolescent stress, adult stress did not induce long-lasting behavioral deficits and changes in vta da system activity, but fs+rs decreased vta da neuron population activity 1-2 weeks post-adult stress. |
2020-07-14 |
2023-08-13 |
rat |
| Ronald Keiflin, Heather J Pribut, Nisha B Shah, Patricia H Jana. Ventral Tegmental Dopamine Neurons Participate in Reward Identity Predictions. Current biology : CB. vol 29. issue 1. 2020-01-23. PMID:30581025. |
here, we show that, although both vta and snc da neuron activation reinforces instrumental responding, only vta da neuron activation during consumption of expected sucrose reward restores error-driven learning and promotes formation of a new cue→sucrose association. |
2020-01-23 |
2023-08-13 |
Not clear |
| Stephen V Mahler, Zachary D Brodnik, Brittney M Cox, William C Buchta, Brandon S Bentzley, Julian Quintanilla, Zackary A Cope, Edwin C Lin, Matthew D Riedy, Michael D Scofield, Justin Messinger, Christina M Ruiz, Arthur C Riegel, Rodrigo A España, Gary Aston-Jone. Chemogenetic Manipulations of Ventral Tegmental Area Dopamine Neurons Reveal Multifaceted Roles in Cocaine Abuse. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 3. 2019-10-16. PMID:30446532. |
here, we targeted vta da neurons for bidirectional chemogenetic modulation during specific tests of cocaine reinforcement, demand, and relapse-related behaviors in male rats, querying the roles of da neuron inhibitory and excitatory g-protein signaling in these processes. |
2019-10-16 |
2023-08-13 |
rat |
| Millie Rincón-Cortés, Kimberly G Gagnon, Hannah K Dollish, Anthony A Grac. Diazepam reverses increased anxiety-like behavior, social behavior deficit, and dopamine dysregulation following withdrawal from acute amphetamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 12. 2019-03-11. PMID:29959439. |
the effects of diazepam, a drug commonly used to treat anxiety disorders, were tested on anxiety-like and social behavior as well as vta da neuron activity following acute amph withdrawal. |
2019-03-11 |
2023-08-13 |
rat |
| Maximilian Tufvesson-Alm, Lilly Schwieler, Robert Schwarcz, Michel Goiny, Sophie Erhardt, Göran Engber. Importance of kynurenine 3-monooxygenase for spontaneous firing and pharmacological responses of midbrain dopamine neurons: Relevance for schizophrenia. Neuropharmacology. vol 138. 2019-02-13. PMID:29879409. |
kmo k/o mice exhibited a marked increase in spontaneous vta da neuron activity as compared to wild-type (wt) mice. |
2019-02-13 |
2023-08-13 |
mouse |
| Sebastiano Bariselli, Hanna Hörnberg, Clément Prévost-Solié, Stefano Musardo, Laetitia Hatstatt-Burklé, Peter Scheiffele, Camilla Bellon. Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction. Nature communications. vol 9. issue 1. 2019-01-07. PMID:30093665. |
altogether, these findings link impaired exploration of nonfamiliar conspecifics to vta da neuron dysfunction in mice. |
2019-01-07 |
2023-08-13 |
mouse |
| Cecile Hryhorczuk, Zhenyu Sheng, Léa Décarie-Spain, Nicolas Giguère, Charles Ducrot, Louis-Éric Trudeau, Vanessa H Routh, Thierry Alquier, Stephanie Fulto. Oleic Acid in the Ventral Tegmental Area Inhibits Feeding, Food Reward, and Dopamine Tone. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 3. 2018-11-20. PMID:28857071. |
we investigated the impact of the monounsaturated fa oleate in the vta on feeding, locomotion, food reward, and da neuronal activity and da neuron expression of fa-handling proteins and fa uptake. |
2018-11-20 |
2023-08-13 |
mouse |
| Stefania Tolu, Fabio Marti, Carole Morel, Carole Perrier, Nicolas Torquet, Stephanie Pons, Renaud de Beaurepaire, Philippe Faur. Nicotine enhances alcohol intake and dopaminergic responses through β2* and β4* nicotinic acetylcholine receptors. Scientific reports. vol 7. 2018-11-14. PMID:28332590. |
simultaneous injections of the two drugs enhanced their responses on vta da neuron firing and chronic exposure to nicotine increased alcohol-induced da responses and alcohol intake. |
2018-11-14 |
2023-08-13 |
mouse |
| Jacob Nielsen, Kim Fejgin, Florence Sotty, Vibeke Nielsen, Arne Mørk, Claus T Christoffersen, Leonid Yavich, Jes B Lauridsen, Dorte Clausen, Peter H Larsen, Jan Egebjerg, Thomas M Werge, Pekka Kallunki, Kenneth V Christensen, Michael Didrikse. A mouse model of the schizophrenia-associated 1q21.1 microdeletion syndrome exhibits altered mesolimbic dopamine transmission. Translational psychiatry. vol 7. issue 11. 2018-07-10. PMID:29187755. |
electrophysiological characterization of da neuron firing in the ventral tegmental area revealed more spontaneously active da neurons and increased firing variability in df(h1q21)/+ mice, and decreased feedback reduction of da neuron firing in response to amphetamine. |
2018-07-10 |
2023-08-13 |
mouse |
| Sebastiano Bariselli, Camilla Bellon. VTA DA neuron excitatory synapses in Shank3 Δex Synapse (New York, N.Y.). vol 71. issue 6. 2018-02-01. PMID:28002633. |
vta da neuron excitatory synapses in shank3 Δex several mutations within shank3 gene have been identified in autism spectrum disorder patients and several studies have now started to show that those mutations could impact different brain circuits leading to the heterogeneity of the disease. |
2018-02-01 |
2023-08-13 |
mouse |