| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kathryn Hausknecht, Samir Haj-Dahmane, Roh-Yu She. Prenatal stress exposure increases the excitation of dopamine neurons in the ventral tegmental area and alters their reponses to psychostimulants. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 2. 2013-10-17. PMID:22948974. |
the reversal effect on vta da neuron in pse animals represents an actual increase in the impulse activity. |
2013-10-17 |
2023-08-12 |
rat |
| L Lahti, K Achim, J Partane. Molecular regulation of GABAergic neuron differentiation and diversity in the developing midbrain. Acta physiologica (Oxford, England). vol 207. issue 4. 2013-09-25. PMID:23297792. |
recent studies have also highlighted importance of the gabaergic neurones associated with the ventral tegmental area for the control of da neuron activity and motivated behaviours. |
2013-09-25 |
2023-08-12 |
Not clear |
| H De Brito Gariepy, S Talbot, J Sénécal, R Coutur. Brain kinin B₁ receptor contributes to the onset of stereotypic nocifensive behavior in rat. Behavioural brain research. vol 241. 2013-07-01. PMID:23219968. |
b(1)r was detected on da neuron of the ventral tegmental area in shr. |
2013-07-01 |
2023-08-12 |
rat |
| Miriam Melis, Anna Lisa Muntoni, Marco Pisti. Endocannabinoids and the processing of value-related signals. Frontiers in pharmacology. vol 3. 2012-10-02. PMID:22347186. |
endocannabinoids, by regulating different forms of synaptic plasticity in the vta, provide a critical modulation of the da neuron output and, ultimately, of the systems driving and regulating motivated behaviors. |
2012-10-02 |
2023-08-12 |
Not clear |
| Ornella Valenti, Kathryn M Gill, Anthony A Grac. Different stressors produce excitation or inhibition of mesolimbic dopamine neuron activity: response alteration by stress pre-exposure. The European journal of neuroscience. vol 35. issue 8. 2012-08-27. PMID:22512259. |
we have previously shown that 2-week exposure to cold, a comparatively mild inescapable stressor, induced a pronounced reduction in ventral tegmental area (vta) dopamine (da) neuron activity, whereas restraint stress increases da neuron activity. |
2012-08-27 |
2023-08-12 |
rat |
| Ornella Valenti, Kathryn M Gill, Anthony A Grac. Different stressors produce excitation or inhibition of mesolimbic dopamine neuron activity: response alteration by stress pre-exposure. The European journal of neuroscience. vol 35. issue 8. 2012-08-27. PMID:22512259. |
however, it is not known if these stressors differentially impact the vta in a region-specific manner, if they differentially impact behavioral responses, or whether the effects of such different stressors are additive or antagonistic with regard to their impact on da neuron firing. |
2012-08-27 |
2023-08-12 |
rat |
| David W Allison, Rebecca S Wilcox, Kyle L Ellefsen, Caitlin E Askew, David M Hansen, Jeffrey D Wilcox, Stephanie S Sandoval, Dennis L Eggett, Yuchio Yanagawa, Scott C Steffense. Mefloquine effects on ventral tegmental area dopamine and GABA neuron inhibition: a physiologic role for connexin-36 GAP junctions. Synapse (New York, N.Y.). vol 65. issue 8. 2011-10-18. PMID:21218452. |
the aim of this study was to determine the effect mefloquine (mfq) has on midbrain da and gaba neuron inhibition, and the role cx36 gjs play in regulating midbrain vta da neuron activity in mice. |
2011-10-18 |
2023-08-12 |
mouse |
| David W Allison, Rebecca S Wilcox, Kyle L Ellefsen, Caitlin E Askew, David M Hansen, Jeffrey D Wilcox, Stephanie S Sandoval, Dennis L Eggett, Yuchio Yanagawa, Scott C Steffense. Mefloquine effects on ventral tegmental area dopamine and GABA neuron inhibition: a physiologic role for connexin-36 GAP junctions. Synapse (New York, N.Y.). vol 65. issue 8. 2011-10-18. PMID:21218452. |
in brain slices from adolescent wild-type (wt) mice the cx36-selective gj blocker mefloquine (mfq, 25 μm) increased vta da neuron sipsc frequency sixfold, and mipsc frequency threefold. |
2011-10-18 |
2023-08-12 |
mouse |
| David W Allison, Rebecca S Wilcox, Kyle L Ellefsen, Caitlin E Askew, David M Hansen, Jeffrey D Wilcox, Stephanie S Sandoval, Dennis L Eggett, Yuchio Yanagawa, Scott C Steffense. Mefloquine effects on ventral tegmental area dopamine and GABA neuron inhibition: a physiologic role for connexin-36 GAP junctions. Synapse (New York, N.Y.). vol 65. issue 8. 2011-10-18. PMID:21218452. |
we also examined mfq effects on vta da neuron firing rate and current-evoked spiking in wt and cx36 ko mice, and found that mfq decreased wt da neuron firing rate and current-evoked spiking, but did not alter these measures in cx36 ko mice. |
2011-10-18 |
2023-08-12 |
mouse |
| David W Allison, Rebecca S Wilcox, Kyle L Ellefsen, Caitlin E Askew, David M Hansen, Jeffrey D Wilcox, Stephanie S Sandoval, Dennis L Eggett, Yuchio Yanagawa, Scott C Steffense. Mefloquine effects on ventral tegmental area dopamine and GABA neuron inhibition: a physiologic role for connexin-36 GAP junctions. Synapse (New York, N.Y.). vol 65. issue 8. 2011-10-18. PMID:21218452. |
taken together these findings suggest that blocking cx36 gjs increases vta da neuron inhibition, and that gjs play in key role in regulating inhibition of vta da neurons. |
2011-10-18 |
2023-08-12 |
mouse |
| Maria Razzoli, Michela Andreoli, Francesca Michielin, Davide Quarta, David M Soka. Increased phasic activity of VTA dopamine neurons in mice 3 weeks after repeated social defeat. Behavioural brain research. vol 218. issue 1. 2011-05-25. PMID:21129410. |
prior defeat induced social avoidance and hyperphagia and increased ventral tegmental area (vta) da neuron bursting activity. |
2011-05-25 |
2023-08-12 |
mouse |
| Maria Razzoli, Michela Andreoli, Francesca Michielin, Davide Quarta, David M Soka. Increased phasic activity of VTA dopamine neurons in mice 3 weeks after repeated social defeat. Behavioural brain research. vol 218. issue 1. 2011-05-25. PMID:21129410. |
these data extend previous studies and suggest that increased phasic da neuron firing in the vta could be considered amongst the features defining the lasting imprint of social defeat stress. |
2011-05-25 |
2023-08-12 |
mouse |
| Ting Y Chen, Andrei Dragomir, Die Zhang, Yasemin Akay, Metin Aka. Prefrontal cortex deletion affects the dopaminergic neural firing complexity in nicotine-treated ventral tegmental area. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2010. 2011-03-29. PMID:21095787. |
in this study, we tested the hypothesis that systemic exposure to nicotine significantly increases the vta da neuron's complexity of firing. |
2011-03-29 |
2023-08-12 |
human |
| Cecilia Gotti, Stefania Guiducci, Vincenzo Tedesco, Silvia Corbioli, Lara Zanetti, Milena Moretti, Alessio Zanardi, Roberto Rimondini, Manolo Mugnaini, Francesco Clementi, Christian Chiamulera, Michele Zol. Nicotinic acetylcholine receptors in the mesolimbic pathway: primary role of ventral tegmental area alpha6beta2* receptors in mediating systemic nicotine effects on dopamine release, locomotion, and reinforcement. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 15. 2010-05-14. PMID:20392953. |
overall, the results of these experiments show that the alpha6beta2* nachrs expressed in the vta are necessary for the effects of systemic nicotine on da neuron activity and da-dependent behaviors such as locomotion and reinforcement, and suggest that alpha6beta2*-selective compounds capable of crossing the blood-brain barrier may affect the addictive properties of nicotine and therefore be useful in the treatment of tobacco dependence. |
2010-05-14 |
2023-08-12 |
rat |
| Arthur C Riegel, Agustin Zapata, Toni S Shippenberg, Edward D Frenc. The abused inhalant toluene increases dopamine release in the nucleus accumbens by directly stimulating ventral tegmental area neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 7. 2007-08-31. PMID:17213847. |
moreover, unlike non-da neurons, the magnitude of vta da neuron firing does not decline during longer exposures designed to emulate 'huffing'. |
2007-08-31 |
2023-08-12 |
Not clear |
| Elyssa B Margolis, Hagar Lock, Gregory O Hjelmstad, Howard L Field. The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons? The Journal of physiology. vol 577. issue Pt 3. 2007-03-09. PMID:16959856. |
we conclude that reliable physiological criteria for vta da neuron identification have yet to be determined, and that the criteria currently being used are unreliable. |
2007-03-09 |
2023-08-12 |
Not clear |
| Roh-Yu Shen, Kar-Chan Choong, Alexis C Thompso. Long-term reduction in ventral tegmental area dopamine neuron population activity following repeated stimulant or ethanol treatment. Biological psychiatry. vol 61. issue 1. 2007-02-20. PMID:16697354. |
few studies have investigated the long-term adaptations in ventral tegmental area (vta) da neuron activity after repeated exposure to drugs of abuse. |
2007-02-20 |
2023-08-12 |
Not clear |
| Jue Wang, Samir Haj-Dahmane, Roh-Yu She. Effects of prenatal ethanol exposure on the excitability of ventral tegmental area dopamine neurons in vitro. The Journal of pharmacology and experimental therapeutics. vol 319. issue 2. 2006-12-04. PMID:16905687. |
prenatal ethanol exposure leads to a persistent reduction in the number of spontaneously active dopaminergic (da) neurons (da neuron population activity) in the ventral tegmental area (vta) in developing and adult animals. |
2006-12-04 |
2023-08-12 |
Not clear |
| Jue Wang, Samir Haj-Dahmane, Roh-Yu She. Effects of prenatal ethanol exposure on the excitability of ventral tegmental area dopamine neurons in vitro. The Journal of pharmacology and experimental therapeutics. vol 319. issue 2. 2006-12-04. PMID:16905687. |
to characterize the underlying cellular mechanism for prenatal ethanol exposure-induced reduction in vta da neuron population activity, we used the whole-cell patch-clamp technique to study the membrane properties of putative vta da neurons in brain slices in 2- to 3-week-old control and prenatal ethanol-exposed animals. |
2006-12-04 |
2023-08-12 |
Not clear |
| Jue Wang, Samir Haj-Dahmane, Roh-Yu She. Effects of prenatal ethanol exposure on the excitability of ventral tegmental area dopamine neurons in vitro. The Journal of pharmacology and experimental therapeutics. vol 319. issue 2. 2006-12-04. PMID:16905687. |
however, they do not seem to play a role in reduced vta da neuron population activity in vivo, an effect thought to be mediated by excessive excitation leading to depolarization inactivation. |
2006-12-04 |
2023-08-12 |
Not clear |