| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emanuela Santini, Emmanuel Valjent, Alessandro Usiello, Manolo Carta, Anders Borgkvist, Jean-Antoine Girault, Denis Hervé, Paul Greengard, Gilberto Fison. Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 26. 2007-08-01. PMID:17596448. |
we show that attenuation of camp signaling in the medium spiny neurons of the striatum, achieved by genetic inactivation of the dopamine and camp-regulated phosphoprotein of 32 kda (darpp-32), reduces lid. |
2007-08-01 |
2023-08-12 |
mouse |
| Soledad Cabeza de Vaca, Pavitra Kannan, Yan Pan, Nancy Jiang, Yanjie Sun, Kenneth D Car. The adenosine A2A receptor agonist, CGS-21680, blocks excessive rearing, acquisition of wheel running, and increases nucleus accumbens CREB phosphorylation in chronically food-restricted rats. Brain research. vol 1142. 2007-06-13. PMID:17292868. |
adenosine a(2a) receptors are preferentially expressed in rat striatum, where they are concentrated in dendritic spines of striatopallidal medium spiny neurons and exist in a heteromeric complex with d(2) dopamine (da) receptors. |
2007-06-13 |
2023-08-12 |
human |
| Kuei Y Tseng, Abigail Snyder-Keller, Patricio O'Donnel. Dopaminergic modulation of striatal plateau depolarizations in corticostriatal organotypic cocultures. Psychopharmacology. vol 191. issue 3. 2007-06-12. PMID:16758237. |
it has been proposed that dopamine (da) sustains up states in striatal medium spiny neurons (msn). |
2007-06-12 |
2023-08-12 |
Not clear |
| Marco Diana, Saturnino Spiga, Elio Acqua. Persistent and reversible morphine withdrawal-induced morphological changes in the nucleus accumbens. Annals of the New York Academy of Sciences. vol 1074. 2007-01-10. PMID:17105943. |
morphine withdrawal produces a hypofunction of mesencephalic dopamine (da) neurons which impinge upon medium spiny neurons (msn) of the forebrain. |
2007-01-10 |
2023-08-12 |
rat |
| Ubaldo Bonuccelli, Paolo Del Dott. New pharmacologic horizons in the treatment of Parkinson disease. Neurology. vol 67. issue 7 Suppl 2. 2006-10-30. PMID:17030738. |
the nonphysiologic pulsatile stimulation of striatal dopamine receptors, produced by the currently available dopaminergic drugs, may trigger a dysregulation of many neurotransmitter systems within the basal ganglia, mainly localized on medium spiny striatal neurons. |
2006-10-30 |
2023-08-12 |
Not clear |
| A Y Deutc. Striatal plasticity in parkinsonism: dystrophic changes in medium spiny neurons and progression in Parkinson's disease. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017511. |
most of these changes involve surviving dopamine neurons, but there are also changes in striatal medium spiny neurons (msns), which are the major target of dopamine axons. |
2006-10-24 |
2023-08-12 |
Not clear |
| J Ma, N Ye, B M Cohe. Typical and atypical antipsychotic drugs target dopamine and cyclic AMP-regulated phosphoprotein, 32 kDa and neurotensin-containing neurons, but not GABAergic interneurons in the shell of nucleus accumbens of ventral striatum. Neuroscience. vol 141. issue 3. 2006-10-18. PMID:16781818. |
we reported here that haloperidol- and clozapine-activated neurons showed the following features: 1) approximately 54-57% of them express dopamine and cyclic amp-regulated phosphoprotein, 32 kda (a marker for gabaergic medium spiny projection neurons), 2) they appear rarely to be gabaergic interneurons, marked by the calcium binding proteins, parvalbumin, calretinin or calbindin-d28k, 3) about 84-86% of them express the neuropeptide neurotensin (a neurotransmitter most often associated with projection neurons in the site tested). |
2006-10-18 |
2023-08-12 |
rat |
| Krisztián A Kovács, Myriam Steinmann, Pierre J Magistretti, Olivier Halfon, Jean-René Cardinau. C/EBPbeta couples dopamine signalling to substance P precursor gene expression in striatal neurones. Journal of neurochemistry. vol 98. issue 5. 2006-10-03. PMID:16771829. |
given that substance p is known to increase dopamine signalling in the striatum and, in turn, dopamine increases substance p expression in medium spiny neurones, our results implicate c/ebpbeta in a positive feedback loop, changes of which might contribute to the development of drug addiction. |
2006-10-03 |
2023-08-12 |
Not clear |
| Agnes Nadjar, Jonathan M Brotchie, Celine Guigoni, Qin Li, Shao-Bo Zhou, Gui-Jie Wang, Paula Ravenscroft, François Georges, Alan R Crossman, Erwan Bezar. Phenotype of striatofugal medium spiny neurons in parkinsonian and dyskinetic nonhuman primates: a call for a reappraisal of the functional organization of the basal ganglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 34. 2006-09-28. PMID:16928853. |
although many studies have investigated the pathophysiology of the basal ganglia after dopamine denervation and subsequent chronic levodopa (l-dopa) treatment, none has ever considered the possibility of plastic changes leading to profound reorganization and/or biochemical phenotype modifications of medium spiny neurons. |
2006-09-28 |
2023-08-12 |
Not clear |
| Alicia J Saylor, Gloria E Meredith, Michael S Vercillo, Daniel S Zahm, Jacqueline F McGint. BDNF heterozygous mice demonstrate age-related changes in striatal and nigral gene expression. Experimental neurology. vol 199. issue 2. 2006-08-11. PMID:16478623. |
trkb receptors mediate the effects of bdnf on striatal medium spiny neurons and mesencephalic dopamine neurons. |
2006-08-11 |
2023-08-12 |
mouse |
| Giselle M Petzinger, Beth Fisher, Elizabeth Hogg, Avery Abernathy, Pablo Arevalo, Kerry Nixon, Michael W Jakowe. Behavioral motor recovery in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned squirrel monkey (Saimiri sciureus): changes in striatal dopamine and expression of tyrosine hydroxylase and dopamine transporter proteins. Journal of neuroscience research. vol 83. issue 2. 2006-05-25. PMID:16385585. |
brain tissue was harvested at 6 weeks or 9 months after the last injection and analyzed for dopamine and its metabolites by high performance liquid chromatography (hplc), and by immunohistochemical staining and western immunoblotting for the expression of tyrosine hydroxylase (th), dopamine transporter (dat), and dopamine- and camp-responsive protein phosphatase of 32 kda (darpp-32), an effector molecule enriched in striatal medium spiny neurons. |
2006-05-25 |
2023-08-12 |
monkey |
| Ko-Woon Lee, Yong Kim, Amie M Kim, Kathryn Helmin, Angus C Nairn, Paul Greengar. Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 9. 2006-04-10. PMID:16492766. |
cocaine-induced dendritic spine formation in d1 and d2 dopamine receptor-containing medium spiny neurons in nucleus accumbens. |
2006-04-10 |
2023-08-12 |
mouse |
| Pamela J Voulalas, Lynne Holtzclaw, Jennifer Wolstenholme, James T Russell, Steven E Hyma. Metabotropic glutamate receptors and dopamine receptors cooperate to enhance extracellular signal-regulated kinase phosphorylation in striatal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 15. 2006-02-13. PMID:15829628. |
striatal medium spiny neurons are an important site of convergence for signaling mediated by the neurotransmitters dopamine and glutamate. |
2006-02-13 |
2023-08-12 |
Not clear |
| Ken Uematsu, Marie Futter, Linda C Hsieh-Wilson, Hideho Higashi, Hisao Maeda, Angus C Nairn, Paul Greengard, Akinori Nish. Regulation of spinophilin Ser94 phosphorylation in neostriatal neurons involves both DARPP-32-dependent and independent pathways. Journal of neurochemistry. vol 95. issue 6. 2006-01-20. PMID:16300646. |
activation of dopamine d1 receptors in striatonigral medium spiny neurons, and of adenosine a 2a receptors in striatopallidal medium spiny neurons increased, whereas activation of dopamine d2 receptors in striatopallidal neurons decreased, spinophilin ser94 phosphorylation. |
2006-01-20 |
2023-08-12 |
mouse |
| Saturnino Spiga, Maria Cristina Puddu, Milena Pisano, Marco Dian. Morphine withdrawal-induced morphological changes in the nucleus accumbens. The European journal of neuroscience. vol 22. issue 9. 2006-01-17. PMID:16262671. |
morphine withdrawal produces a hypofunction of mesencephalic dopamine neurons that impinge upon medium spiny neurons (msn) of the forebrain. |
2006-01-17 |
2023-08-12 |
rat |
| Irina N Krasnova, Bruce Ladenheim, Jean Lud Cade. Amphetamine induces apoptosis of medium spiny striatal projection neurons via the mitochondria-dependent pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 7. 2005-12-22. PMID:15731293. |
when taken together, these observations indicate that injections of doses of amph that are known to destroy striatal dopamine terminals can also cause apoptotic death of postsynaptic medium spiny projection neurons via mitochondria-dependent mechanisms. |
2005-12-22 |
2023-08-12 |
mouse |
| A J Lawrence, C L Parish, F Chen, D J Lodge, E V Krstew, K Card, D I Finkelstein, M K Horn. Chronic corticotropin-releasing factor type 1 receptor antagonism with antalarmin regulates the dopaminergic system of Fawn-Hooded rats. Journal of neurochemistry. vol 94. issue 6. 2005-10-27. PMID:16000149. |
receptor autoradiography indicated an up-regulation of dopamine d2, but no change in d1, binding in striatum, and golgi-cox analysis of striatal medium spiny neurones indicated that chronic antalarmin treatment increased spine density. |
2005-10-27 |
2023-08-12 |
rat |
| L-Y Ngai, J Herber. Glucocorticoid enhances the neurotoxic actions of quinolinic acid in the striatum in a cell-specific manner. Journal of neuroendocrinology. vol 17. issue 7. 2005-08-17. PMID:15946160. |
lesion volumes were measured on neuronal nuclei stained sections, dopamine and cyclic amp-regulated phosphoprotein 32 (darrp-32) was used to assess medium spiny neurone survival, nadph-diaphorase histochemistry to assess medium aspiny neurones and, finally, choline acetyltransferase to assess large aspiny neurones. |
2005-08-17 |
2023-08-12 |
rat |
| Nigel S Bamford, Siobhan Robinson, Richard D Palmiter, John A Joyce, Cynthia Moore, Charles K Meshu. Dopamine modulates release from corticostriatal terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 43. 2005-05-19. PMID:15509741. |
within the striatum, excitatory inputs from cortical glutamatergic neurons and modulatory inputs from midbrain dopamine neurons converge onto dendritic spines of medium spiny neurons. |
2005-05-19 |
2023-08-12 |
mouse |
| Nigel S Bamford, Siobhan Robinson, Richard D Palmiter, John A Joyce, Cynthia Moore, Charles K Meshu. Dopamine modulates release from corticostriatal terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 43. 2005-05-19. PMID:15509741. |
in addition to dopamine receptors on medium spiny neurons, d2 receptors are also present on corticostriatal terminals, where they act to dampen striatal excitation. |
2005-05-19 |
2023-08-12 |
mouse |