| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| James W Bales, Hong Q Yan, Xiecheng Ma, Youming Li, Ranmal Samarasinghe, C Edward Dixo. The dopamine and cAMP regulated phosphoprotein, 32 kDa (DARPP-32) signaling pathway: a novel therapeutic target in traumatic brain injury. Experimental neurology. vol 229. issue 2. 2011-08-05. PMID:21376040. |
dopamine and camp regulated phosphoprotein 32 (darpp-32) is expressed within striatal medium spiny neurons and regulates striatal function. |
2011-08-05 |
2023-08-12 |
rat |
| b' Marco Orru, Jana Bake\\xc5\\xa1ov\\xc3\\xa1, Marc Brugarolas, C\\xc3\\xa9sar Quiroz, Vahri Beaumont, Steven R Goldberg, Carme Llu\\xc3\\xads, Antoni Cort\\xc3\\xa9s, Rafael Franco, Vicent Casad\\xc3\\xb3, Enric I Canela, Sergi Ferr\\xc3\\xa. Striatal pre- and postsynaptic profile of adenosine A(2A) receptor antagonists. PloS one. vol 6. issue 1. 2011-08-02. PMID:21264319.' |
striatal adenosine a(2a) receptors (a(2a)rs) are highly expressed in medium spiny neurons (msns) of the indirect efferent pathway, where they heteromerize with dopamine d(2) receptors (d(2)rs). |
2011-08-02 |
2023-08-12 |
Not clear |
| A F Ramlackhansingh, S K Bose, I Ahmed, F E Turkheimer, N Pavese, D J Brook. Adenosine 2A receptor availability in dyskinetic and nondyskinetic patients with Parkinson disease. Neurology. vol 76. issue 21. 2011-07-22. PMID:21606452. |
a2a receptors are expressed on the bodies of indirect pathway medium spiny striatal neurons and on dopamine terminals and play a role in modulating dopamine transmission. |
2011-07-22 |
2023-08-12 |
Not clear |
| John M Burkhardt, Xin Jin, Rui M Cost. Dissociable effects of dopamine on neuronal firing rate and synchrony in the dorsal striatum. Frontiers in integrative neuroscience. vol 3. 2011-07-14. PMID:19949467. |
since dopamine d1 and d2 receptors are preferentially expressed in striatonigral and striatopallidal medium spiny neurons, respectively, we investigated the relative contribution of lack of d1 and/or d2-type receptor activation to the changes in striatal firing rate and synchrony observed after dopamine depletion. |
2011-07-14 |
2023-08-12 |
mouse |
| John M Burkhardt, Xin Jin, Rui M Cost. Dissociable effects of dopamine on neuronal firing rate and synchrony in the dorsal striatum. Frontiers in integrative neuroscience. vol 3. 2011-07-14. PMID:19949467. |
our results suggest that the changes in rate and entrainment to the lfp observed in medium spiny neurons after dopamine depletion are somewhat dissociable, and that lack of d1- or d2-type receptor activation can exert independent yet interactive pathological effects during the progression of parkinson's disease. |
2011-07-14 |
2023-08-12 |
mouse |
| Rosa M Villalba, Yoland Smit. Striatal spine plasticity in Parkinson's disease. Frontiers in neuroanatomy. vol 4. 2011-07-14. PMID:21179580. |
striatal dopamine (da) denervation results in a significant loss of dendritic spines on medium spiny projection neurons in parkinson's disease. |
2011-07-14 |
2023-08-12 |
monkey |
| Melissa L Perreault, Ahmed Hasbi, Brian F O'Dowd, Susan R Georg. The dopamine d1-d2 receptor heteromer in striatal medium spiny neurons: evidence for a third distinct neuronal pathway in Basal Ganglia. Frontiers in neuroanatomy. vol 5. 2011-07-14. PMID:21747759. |
the dopamine d1-d2 receptor heteromer in striatal medium spiny neurons: evidence for a third distinct neuronal pathway in basal ganglia. |
2011-07-14 |
2023-08-12 |
Not clear |
| Lisa R Beutler, Matthew J Wanat, Albert Quintana, Elisenda Sanz, Nigel S Bamford, Larry S Zweifel, Richard D Palmite. Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 10. 2011-05-26. PMID:21368124. |
balanced nmda receptor activity in dopamine d1 receptor (d1r)- and d2r-expressing medium spiny neurons is required for amphetamine sensitization. |
2011-05-26 |
2023-08-12 |
Not clear |
| Mariela F Perez, Kerstin A Ford, Ivan Goussakov, Grace E Stutzmann, Xiu-Ti H. Repeated cocaine exposure decreases dopamine D₂-like receptor modulation of Ca(2+) homeostasis in rat nucleus accumbens neurons. Synapse (New York, N.Y.). vol 65. issue 2. 2011-04-01. PMID:20665696. |
dopamine modulates activity of medium spiny neurons (msns) in the nac. |
2011-04-01 |
2023-08-12 |
rat |
| Alessandro Tozzi, Antonio de Iure, Massimiliano Di Filippo, Michela Tantucci, Cinzia Costa, Franco Borsini, Veronica Ghiglieri, Carmen Giampà, Francesca Romana Fusco, Barbara Picconi, Paolo Calabres. The distinct role of medium spiny neurons and cholinergic interneurons in the D₂/A₂A receptor interaction in the striatum: implications for Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 5. 2011-04-01. PMID:21289195. |
a functional antagonism exists between a(2a) adenosine and d(2) dopamine (da) receptors that are coexpressed in striatal medium spiny neurons (msns) of the indirect pathway. |
2011-04-01 |
2023-08-12 |
Not clear |
| Nao Chuhma, Kenji F Tanaka, René Hen, Stephen Raypor. Functional connectome of the striatal medium spiny neuron. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 4. 2011-03-30. PMID:21273403. |
in the substantia nigra, medium spiny neurons connected strongly with gaba, but not with dopamine neurons. |
2011-03-30 |
2023-08-12 |
mouse |
| Yunmin Ding, Lisa Won, Jonathan P Britt, Sean Austin O Lim, Daniel S McGehee, Un Jung Kan. Enhanced striatal cholinergic neuronal activity mediates L-DOPA-induced dyskinesia in parkinsonian mice. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 2. 2011-02-24. PMID:21187382. |
using two pd models, the traditional 6-hydroxydopamine toxic lesion and a genetic model with nigrostriatal dopaminergic deficits, we found that acute dopamine challenge induces erk activation in medium spiny neurons in denervated striatum. |
2011-02-24 |
2023-08-12 |
mouse |
| I González-Burgos, S García-Martínez, D A Velázquez-Zamora, R Ponce-Roló. Cytoarchitectural impairments in the medium spiny neurons of the Nucleus Accumbens core of hyperactive juvenile rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 28. issue 6. 2011-01-11. PMID:20600788. |
in this work, a golgi study was carried out to investigate the effects of dopamine depletion on the cytoarchitecture of dendritic spines of nucleus accumbens core medium spiny neurons. |
2011-01-11 |
2023-08-12 |
rat |
| I González-Burgos, S García-Martínez, D A Velázquez-Zamora, R Ponce-Roló. Cytoarchitectural impairments in the medium spiny neurons of the Nucleus Accumbens core of hyperactive juvenile rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 28. issue 6. 2011-01-11. PMID:20600788. |
together, the present findings suggest an alteration to the excitatory/inhibitory balance on dendritic spines of medium spiny neurons of the nucleus accumbens core in hyperactive juvenile rats following early dopamine depletion. |
2011-01-11 |
2023-08-12 |
rat |
| Saturnino Spiga, Alessandra Lintas, Michele Migliore, Marco Dian. Altered architecture and functional consequences of the mesolimbic dopamine system in cannabis dependence. Addiction biology. vol 15. issue 3. 2010-11-02. PMID:20477755. |
cannabinoid withdrawal produces a hypofunction of mesencephalic dopamine neurons that impinge upon medium spiny neurons (msn) of the forebrain. |
2010-11-02 |
2023-08-12 |
rat |
| Jeremy Celver, Meenakshi Sharma, Abraham Kovoo. RGS9-2 mediates specific inhibition of agonist-induced internalization of D2-dopamine receptors. Journal of neurochemistry. vol 114. issue 3. 2010-10-06. PMID:20477943. |
rgs9-2 can be found co-localized with d(2)-class dopamine receptors in medium spiny striatal neurons and altered functioning of both rgs9-2 and d(2)-like dopamine receptors have been implicated in schizophrenia, movement disorders and reward responses. |
2010-10-06 |
2023-08-12 |
Not clear |
| Alexxai V Kravitz, Benjamin S Freeze, Philip R L Parker, Kenneth Kay, Myo T Thwin, Karl Deisseroth, Anatol C Kreitze. Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry. Nature. vol 466. issue 7306. 2010-09-21. PMID:20613723. |
here we report direct activation of basal ganglia circuitry in vivo, using optogenetic control of direct- and indirect-pathway medium spiny projection neurons (msns), achieved through cre-dependent viral expression of channelrhodopsin-2 in the striatum of bacterial artificial chromosome transgenic mice expressing cre recombinase under control of regulatory elements for the dopamine d1 or d2 receptor. |
2010-09-21 |
2023-08-12 |
mouse |
| Anne Schaefer, Heh-In Im, Morten T Venø, Christie D Fowler, Alice Min, Adam Intrator, Jørgen Kjems, Paul J Kenny, Donal O'Carroll, Paul Greengar. Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction. The Journal of experimental medicine. vol 207. issue 9. 2010-09-16. PMID:20643829. |
cocaine is a highly addictive drug that exerts its effects by increasing the levels of released dopamine in the striatum, followed by stable changes in gene transcription, mrna translation, and metabolism within medium spiny neurons in the striatum. |
2010-09-16 |
2023-08-12 |
mouse |
| David T S Lin, Pascale Fretier, Cindy Jiang, Steven R Vincen. Nitric oxide signaling via cGMP-stimulated phosphodiesterase in striatal neurons. Synapse (New York, N.Y.). vol 64. issue 6. 2010-07-19. PMID:20175220. |
together, these observations indicate that striatal no producing interneurons can act via the pde2a in the medium spiny neurons to regulate the camp response to dopamine stimulation. |
2010-07-19 |
2023-08-12 |
Not clear |
| V Santhakumar, R T Jones, I Mod. Developmental regulation and neuroprotective effects of striatal tonic GABAA currents. Neuroscience. vol 167. issue 3. 2010-06-29. PMID:20206233. |
striatal projection neurons, or medium spiny neurons (msns), are divided into two classes: msns containing the dopamine d1 receptor (d1-msns) form the direct pathway to the substantia nigra and facilitate movement while msns expressing the dopamine d2 receptor (d2-msns) form the pallidal pathway that inhibits movement. |
2010-06-29 |
2023-08-12 |
mouse |