| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M V Podda, E Riccardi, M D'Ascenzo, G B Azzena, C Grass. Dopamine D1-like receptor activation depolarizes medium spiny neurons of the mouse nucleus accumbens by inhibiting inwardly rectifying K+ currents through a cAMP-dependent protein kinase A-independent mechanism. Neuroscience. vol 167. issue 3. 2010-06-29. PMID:20211700. |
dopamine d1-like receptor activation depolarizes medium spiny neurons of the mouse nucleus accumbens by inhibiting inwardly rectifying k+ currents through a camp-dependent protein kinase a-independent mechanism. |
2010-06-29 |
2023-08-12 |
mouse |
| Christopher Shaffer, Ming-Lei Guo, Eugene E Fibuch, Li-Min Mao, John Q Wan. Regulation of group I metabotropic glutamate receptor expression in the rat striatum and prefrontal cortex in response to amphetamine in vivo. Brain research. vol 1326. 2010-06-25. PMID:20193665. |
group i mglurs (mglur1 and mglur5 subtypes) are expressed in striatal medium spiny output neurons and are believed to play an important role in the modulation of cellular responses to dopamine stimulation with psychostimulants. |
2010-06-25 |
2023-08-12 |
rat |
| Xinyong Tian, Li Kai, Philip E Hockberger, David L Wokosin, D James Surmeie. MEF-2 regulates activity-dependent spine loss in striatopallidal medium spiny neurons. Molecular and cellular neurosciences. vol 44. issue 1. 2010-06-17. PMID:20197093. |
striatal dopamine depletion profoundly reduces the density of spines and corticostriatal glutamatergic synapses formed on d(2) dopamine receptor expressing striatopallidal medium spiny neurons, leaving d(1) receptor expressing striatonigral medium spiny neurons relatively intact. |
2010-06-17 |
2023-08-12 |
mouse |
| Katherine E Soderstrom, Jennifer A O'Malley, Nathan D Levine, Caryl E Sortwell, Timothy J Collier, Kathy Steece-Collie. Impact of dendritic spine preservation in medium spiny neurons on dopamine graft efficacy and the expression of dyskinesias in parkinsonian rats. The European journal of neuroscience. vol 31. issue 3. 2010-05-17. PMID:20105237. |
impact of dendritic spine preservation in medium spiny neurons on dopamine graft efficacy and the expression of dyskinesias in parkinsonian rats. |
2010-05-17 |
2023-08-12 |
rat |
| Katherine E Soderstrom, Jennifer A O'Malley, Nathan D Levine, Caryl E Sortwell, Timothy J Collier, Kathy Steece-Collie. Impact of dendritic spine preservation in medium spiny neurons on dopamine graft efficacy and the expression of dyskinesias in parkinsonian rats. The European journal of neuroscience. vol 31. issue 3. 2010-05-17. PMID:20105237. |
specifically, there is marked atrophy of dendrites and dendritic spines on striatal medium spiny neurons (msn), primary targets of inputs from nigral dopamine and cortical glutamate neurons, in advanced pd and rodent models of severe dopamine depletion. |
2010-05-17 |
2023-08-12 |
rat |
| Takashi Nakano, Tomokazu Doi, Junichiro Yoshimoto, Kenji Doy. A kinetic model of dopamine- and calcium-dependent striatal synaptic plasticity. PLoS computational biology. vol 6. issue 2. 2010-05-10. PMID:20169176. |
corticostriatal synapse plasticity of medium spiny neurons is regulated by glutamate input from the cortex and dopamine input from the substantia nigra. |
2010-05-10 |
2023-08-12 |
Not clear |
| Darren Goffin, Afia B Ali, Nazir Rampersaud, Alexander Harkavyi, Celine Fuchs, Peter S Whitton, Angus C Nairn, Jasmina N Jovanovi. Dopamine-dependent tuning of striatal inhibitory synaptogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 8. 2010-05-04. PMID:20181591. |
we demonstrate here that dopamine, by activating d(1)- and/or d(2)-dopamine receptors, decreases the number of functional gabaergic synapses formed between the embryonic precursors of the medium spiny neurons, the principal output neurons of the striatum, with associated changes in spontaneous synaptic activity. |
2010-05-04 |
2023-08-12 |
Not clear |
| Darren Goffin, Afia B Ali, Nazir Rampersaud, Alexander Harkavyi, Celine Fuchs, Peter S Whitton, Angus C Nairn, Jasmina N Jovanovi. Dopamine-dependent tuning of striatal inhibitory synaptogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 8. 2010-05-04. PMID:20181591. |
thus, tonic d(1)- and d(2)-receptor activity limits the extent of collateral inhibitory synaptogenesis between medium spiny neurons, revealing a novel role of dopamine in controlling the development of intrinsic striatal microcircuits. |
2010-05-04 |
2023-08-12 |
Not clear |
| Y Smith, R M Villalba, D V Raj. Striatal spine plasticity in Parkinson's disease: pathological or not? Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20082980. |
in parkinsonism, the striatal dopamine denervation induces major spine loss on medium spiny neurons and generates a significant remodeling of corticostriatal and thalamostriatal glutamatergic synapses, consistent with increased synaptic transmission. |
2010-03-31 |
2023-08-12 |
monkey |
| Jon-Eric VanLeeuwen, Giselle M Petzinger, John P Walsh, Garnik K Akopian, Marta Vuckovic, Michael W Jakowe. Altered AMPA receptor expression with treadmill exercise in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury. Journal of neuroscience research. vol 88. issue 3. 2010-03-30. PMID:19746427. |
dopamine depletion leads to impaired motor performance and increased glutamatergic-mediated hyperexcitability of medium spiny neurons in the basal ganglia. |
2010-03-30 |
2023-08-12 |
mouse |
| Karima Azdad, Marcelo Chàvez, Patrick Don Bischop, Pim Wetzelaer, Bart Marescau, Peter Paul De Deyn, David Gall, Serge N Schiffman. Homeostatic plasticity of striatal neurons intrinsic excitability following dopamine depletion. PloS one. vol 4. issue 9. 2010-02-01. PMID:19730738. |
neuronal activity of striatal medium spiny neurons (msn) is modulated by dopamine receptors. |
2010-02-01 |
2023-08-12 |
Not clear |
| Oscar Diaz-Ruiz, Agustin Zapata, Lufei Shan, YaJun Zhang, Andreas C Tomac, Nasir Malik, Fidel de la Cruz, Cristina M Bäckma. Selective deletion of PTEN in dopamine neurons leads to trophic effects and adaptation of striatal medium spiny projecting neurons. PloS one. vol 4. issue 9. 2010-02-01. PMID:19750226. |
selective deletion of pten in dopamine neurons leads to trophic effects and adaptation of striatal medium spiny projecting neurons. |
2010-02-01 |
2023-08-12 |
mouse |
| Jérémie Lavaur, Yann S Mineur, Marina R Picciott. The membrane cytoskeletal protein adducin is phosphorylated by protein kinase C in D1 neurons of the nucleus accumbens and dorsal striatum following cocaine administration. Journal of neurochemistry. vol 111. issue 5. 2009-12-11. PMID:19780900. |
our results demonstrate that adducin is phosphorylated by protein kinase c in medium spiny neurons that express the dopamine d1 receptor. |
2009-12-11 |
2023-08-12 |
Not clear |
| Jesus Bertran-Gonzalez, Kerstin Håkansson, Anders Borgkvist, Theano Irinopoulou, Karen Brami-Cherrier, Alessandro Usiello, Paul Greengard, Denis Hervé, Jean-Antoine Girault, Emmanuel Valjent, Gilberto Fison. Histone H3 phosphorylation is under the opposite tonic control of dopamine D2 and adenosine A2A receptors in striatopallidal neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 7. 2009-08-03. PMID:19158668. |
the antipsychotic agent haloperidol regulates gene transcription in striatal medium spiny neurons (msns) by blocking dopamine d2 receptors (d2rs). |
2009-08-03 |
2023-08-12 |
mouse |
| Amandine Berthet, Grégory Porras, Evelyne Doudnikoff, Holger Stark, Martine Cador, Erwan Bezard, Bertrand Bloc. Pharmacological analysis demonstrates dramatic alteration of D1 dopamine receptor neuronal distribution in the rat analog of L-DOPA-induced dyskinesia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 15. 2009-05-12. PMID:19369551. |
detailed analysis at the ultrastructural level demonstrates specific alterations of dopamine d(1) receptor (d(1)r) subcellular localization in striatal medium spiny neurons in l-dopa-treated 6-hydroxydopamine-lesioned rats with abnormal involuntary movements (aims). |
2009-05-12 |
2023-08-12 |
rat |
| Ariel Y Deutch, Roger J Colbran, Danny J Winde. Striatal plasticity and medium spiny neuron dendritic remodeling in parkinsonism. Parkinsonism & related disorders. vol 13 Suppl 3. 2009-04-01. PMID:18267246. |
in particular, the compensatory changes that occur in striatal medium spiny neurons (msns) that have lost their normal dopamine input remains poorly understood. |
2009-04-01 |
2023-08-12 |
Not clear |
| Thomas McAvoy, Ming-ming Zhou, Paul Greengard, Angus C Nair. Phosphorylation of Rap1GAP, a striatally enriched protein, by protein kinase A controls Rap1 activity and dendritic spine morphology. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 9. 2009-04-01. PMID:19218462. |
protein kinase a (pka)-dependent signaling cascades play an important role in mediating the effects of dopamine and other neurotransmitters in striatal medium spiny neurons. |
2009-04-01 |
2023-08-12 |
Not clear |
| Thomas McAvoy, Ming-ming Zhou, Paul Greengard, Angus C Nair. Phosphorylation of Rap1GAP, a striatally enriched protein, by protein kinase A controls Rap1 activity and dendritic spine morphology. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 9. 2009-04-01. PMID:19218462. |
although present throughout the brain, rap1gap is enriched in striatal medium spiny neurons and is phosphorylated by pka at ser-441 and ser-499 in response to activation of d1 dopamine receptors. |
2009-04-01 |
2023-08-12 |
Not clear |
| A J Saylor, J F McGint. Amphetamine-induced locomotion and gene expression are altered in BDNF heterozygous mice. Genes, brain, and behavior. vol 7. issue 8. 2009-02-27. PMID:18681898. |
administration of amphetamine overstimulates medium spiny neurons (msns) by releasing dopamine and glutamate from afferents in the striatum. |
2009-02-27 |
2023-08-12 |
mouse |
| Huaxia Tong, Alasdair J Gib. Dopamine D1 receptor inhibition of NMDA receptor currents mediated by tyrosine kinase-dependent receptor trafficking in neonatal rat striatum. The Journal of physiology. vol 586. issue 19. 2009-01-15. PMID:18703578. |
we therefore conclude that a tyrosine kinase-dependent alteration of nmda receptor trafficking underlies d1 dopamine receptor-mediated down-regulation of nmda receptor currents in medium spiny neurons of neonatal rat striatum. |
2009-01-15 |
2023-08-12 |
rat |