| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akina Harada, Nidhi Kaushal, Kazunori Suzuki, Atsushi Nakatani, Konstantin Bobkov, John A Vekich, Joseph P Doyle, Haruhide Kimur. Balanced Activation of Striatal Output Pathways by Faster Off-Rate PDE10A Inhibitors Elicits Not Only Antipsychotic-Like Effects But Also Procognitive Effects in Rodents. The international journal of neuropsychopharmacology. vol 23. issue 2. 2020-11-25. PMID:31689714. |
we previously reported that the cyclic adenosine monophosphate concentration in dopamine d1 receptor-expressing medium spiny neurons (d1-msns) may be higher than that in d2-msns. |
2020-11-25 |
2023-08-13 |
Not clear |
| Sarah Zych, Christopher P For. Opioid-Induced Adaptations of cAMP Dynamics in the Nucleus Accumbens. Trends in pharmacological sciences. vol 41. issue 4. 2020-11-05. PMID:31964511. |
to investigate how opioid exposure alters dopamine (da) responses in medium spiny neurons (msns), muntean et al. |
2020-11-05 |
2023-08-13 |
Not clear |
| Renato Socodat. Dopamine D1 receptor signaling and endocannabinoid cooperate to fuel striatal plasticity: An Editorial Highlight for "Cyclic AMP-dependent protein kinase and D1 dopamine receptors regulate diacylglycerol lipase-α and synaptic 2-arachidonoyl glycerol signaling" on page 334. Journal of neurochemistry. vol 153. issue 3. 2020-11-04. PMID:32091130. |
this editorial highlights the study by shonesy et al., which presents evidence that activation of dopamine d1 receptor and its classical downstream target camp-dependent protein kinase (pka) are involved in increasing the synthesis of 2-ag in striatal medium spiny neurons (msn) to drive dse in the corticostriatal circuit, as schematically outlined in figure 1. |
2020-11-04 |
2023-08-13 |
Not clear |
| Sarah Thoeni, Michaël Loureiro, Eoin C O'Connor, Christian Lüsche. Depression of Accumbal to Lateral Hypothalamic Synapses Gates Overeating. Neuron. vol 107. issue 1. 2020-10-08. PMID:32333845. |
dopamine d1 receptor-expressing medium spiny neurons (d1-msns) of the nucleus accumbens shell (nacsh) project to the lateral hypothalamus (lh) to authorize feeding when inhibited. |
2020-10-08 |
2023-08-13 |
Not clear |
| Tom Macpherson, Takatoshi Hikid. Nucleus Accumbens Dopamine D1-Receptor-Expressing Neurons Control the Acquisition of Sign-Tracking to Conditioned Cues in Mice. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:29977188. |
however, currently, the possible roles of dorsal striatal subregions, as well as of the two major striatal neuron types, dopamine d1-/d2-expressing medium spiny neurons (msns), in controlling the development of conditioned responses is still unclear and warrants further study. |
2020-10-01 |
2023-08-13 |
mouse |
| Yasumasa Ueda, Ko Yamanaka, Atsushi Noritake, Kazuki Enomoto, Naoyuki Matsumoto, Hiroshi Yamada, Kazuyuki Samejima, Hitoshi Inokawa, Yukiko Hori, Kae Nakamura, Minoru Kimur. Distinct Functions of the Primate Putamen Direct and Indirect Pathways in Adaptive Outcome-Based Action Selection. Frontiers in neuroanatomy. vol 11. 2020-09-30. PMID:28824386. |
reinforcement learning models posit that action reward value is encoded by the firing activity of striatal medium spiny neurons (msns) and updated upon changing reinforcement contingencies by dopamine (da) signaling to these neurons. |
2020-09-30 |
2023-08-13 |
monkey |
| Karen Brami-Cherrier, Robert G Lewis, Marlene Cervantes, Yu Liu, Paola Tognini, Pierre Baldi, Paolo Sassone-Corsi, Emiliana Borrell. Cocaine-mediated circadian reprogramming in the striatum through dopamine D2R and PPARγ activation. Nature communications. vol 11. issue 1. 2020-09-30. PMID:32895370. |
pparγ reprogramming is altered in mice with cell-specific ablation of the dopamine d2 receptor (d2r) in the striatal medium spiny neurons (msns) (imsn-d2rko). |
2020-09-30 |
2023-08-13 |
mouse |
| Sara Schiavi, Daniela Iezzi, Antonia Manduca, Stefano Leone, Francesca Melancia, Carmen Carbone, Michele Petrella, Guido Mannaioni, Alessio Masi, Viviana Trezz. Reward-Related Behavioral, Neurochemical and Electrophysiological Changes in a Rat Model of Autism Based on Prenatal Exposure to Valproic Acid. Frontiers in cellular neuroscience. vol 13. 2020-09-29. PMID:31708750. |
in addition, vpa-exposed rats showed altered expression of dopamine receptors together with inherent hyperexcitability of medium spiny neurons (msns) in the nucleus accumbens (nac). |
2020-09-29 |
2023-08-13 |
rat |
| Manuela Ingallinesi, Benjamin Galet, Jonathan Pegon, Nicole Faucon Biguet, Anh Do Thi, Mark J Millan, Clotilde Mannoury la Cour, Rolando Melon. Knock-Down of GPR88 in the Dorsal Striatum Alters the Response of Medium Spiny Neurons to the Loss of Dopamine Input and L-3-4-Dyhydroxyphenylalanine. Frontiers in pharmacology. vol 10. 2020-09-29. PMID:31708775. |
knock-down of gpr88 in the dorsal striatum alters the response of medium spiny neurons to the loss of dopamine input and l-3-4-dyhydroxyphenylalanine. |
2020-09-29 |
2023-08-13 |
rat |
| Yasuhiro Funahashi, Anthony Ariza, Ryosuke Emi, Yifan Xu, Wei Shan, Ko Suzuki, Sachi Kozawa, Rijwan Uddin Ahammad, Mengya Wu, Tetsuya Takano, Yoshimitsu Yura, Keisuke Kuroda, Taku Nagai, Mutsuki Amano, Kiyofumi Yamada, Kozo Kaibuch. Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors. Cell reports. vol 29. issue 10. 2020-09-28. PMID:31801086. |
dopamine (da) activates mitogen-activated protein kinase (mapk) via protein kinase a (pka)/rap1 in medium spiny neurons (msns) expressing the dopamine d1 receptor (d1r) in the nucleus accumbens (nac), thereby regulating reward-related behavior. |
2020-09-28 |
2023-08-13 |
Not clear |
| Alessandra Porcu, Megan Vaughan, Anna Nilsson, Natsuko Arimoto, Katja Lamia, David K Wels. Vulnerability to helpless behavior is regulated by the circadian clock component CRYPTOCHROME in the mouse nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 24. 2020-09-14. PMID:32487727. |
in the nac of helpless mice, we found that higher expression of cry is associated with decreased activation of dopamine 1 receptor-expressing medium spiny neurons (d1r-msns). |
2020-09-14 |
2023-08-13 |
mouse |
| Zeng-Rui Zhang, Xing-Ru Zhang, Xiao-Qian Luan, Xin-Shi Wang, Wen-Wen Wang, Xiao-Yi Wang, Bei Shao, Cheng-Long Xi. Striatal overexpression of β-arrestin2 counteracts L-dopa-induced dyskinesia in 6-hydroxydopamine lesioned Parkinson's disease rats. Neurochemistry international. vol 131. 2020-09-03. PMID:31491493. |
accumulating evidence indicates that hyper-activation of the dopamine d1 receptor (d1r) and the camp signaling cascade in the medium spiny neurons (msns) of the striatum are involved in lid. |
2020-09-03 |
2023-08-13 |
rat |
| Johan Ruud, Jens Alber, Anna Tokarska, Linda Engström Ruud, Hendrik Nolte, Nasim Biglari, Rachel Lippert, Änne Lautenschlager, Przemysław E Cieślak, Łukasz Szumiec, Martin E Hess, Hella S Brönneke, Marcus Krüger, Hans Nissbrandt, Tatiana Korotkova, Gilad Silberberg, Jan Rodriguez Parkitna, Jens C Brünin. The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons. Cell reports. vol 27. issue 11. 2020-08-03. PMID:31189104. |
here, we report that fat mass and obesity-associated protein (fto) in dopamine d2 receptor-expressing medium spiny neurons (d2 msns) of mice regulate the excitability of these cells and control their striatopallidal globus pallidus external (gpe) projections. |
2020-08-03 |
2023-08-13 |
mouse |
| Tom Gilbertson, David Arkadir, J Douglas Steel. Opposing patterns of abnormal D1 and D2 receptor dependent cortico-striatal plasticity explain increased risk taking in patients with DYT1 dystonia. PloS one. vol 15. issue 5. 2020-07-23. PMID:32365120. |
as dopamine exerts opposing effects on cortico-striatal plasticity via different receptors expressed on medium spiny neurons (msn) of the direct (d1r dominant, dmsns) and indirect (d2r dominant, imsns) pathways, we tested whether abnormalities in cortico-striatal plasticity in one or both of these pathways could explain the patient's behaviour. |
2020-07-23 |
2023-08-13 |
Not clear |
| Benjamin N Greenwoo. The role of dopamine in overcoming aversion with exercise. Brain research. vol 1713. 2020-07-20. PMID:30171838. |
sensitized dopamine release in the striatum of physically active organisms shifts recruitment of striatal medium spiny neurons during aversive events from those expressing dopamine 2 (d2) receptors implicated in aversion and stress vulnerability, towards those expressing dopamine 1 (d1) receptors implicated in reward and stress resilience. |
2020-07-20 |
2023-08-13 |
Not clear |
| S Gallegos, B Muñoz, A Araya, L G Aguay. High ethanol sensitive glycine receptors regulate firing in D1 medium spiny neurons in the nucleus accumbens. Neuropharmacology. vol 160. 2020-07-08. PMID:31521620. |
one of the major types of neurons in the nac are the dopamine 1 receptor-expressing (d1+) medium spiny neurons (msns) that are activated when addictive drugs, like ethanol, are administrated. |
2020-07-08 |
2023-08-13 |
Not clear |
| T Chase Francis, Alison Gaynor, Ramesh Chandra, Megan E Fox, Mary Kay Lob. The Selective RhoA Inhibitor Rhosin Promotes Stress Resiliency Through Enhancing D1-Medium Spiny Neuron Plasticity and Reducing Hyperexcitability. Biological psychiatry. vol 85. issue 12. 2020-05-18. PMID:30955841. |
nucleus accumbens dopamine 1 receptor medium spiny neurons (d1-msns) play a critical role in the development of depression-like behavior in mice. |
2020-05-18 |
2023-08-13 |
mouse |
| Daniel M Kircher, Heather C Aziz, Regina A Mangieri, Richard A Morriset. Ethanol Experience Enhances Glutamatergic Ventral Hippocampal Inputs to D1 Receptor-Expressing Medium Spiny Neurons in the Nucleus Accumbens Shell. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 13. 2020-03-18. PMID:30692226. |
a key integrator of glutamatergic signaling in the reward circuit is the nucleus accumbens, more specifically, the dopamine d1 receptor-expressing medium spiny neurons (d1-msns) within this region, which have been implicated in the formation of dependence to many drugs of abuse including alcohol. |
2020-03-18 |
2023-08-13 |
mouse |
| Yifeng Cheng, Xuehua Wang, Xiaoyan Wei, Xueyi Xie, Sebastian Melo, Rajesh C Miranda, Jun Wan. Prenatal Exposure to Alcohol Induces Functional and Structural Plasticity in Dopamine D1 Receptor-Expressing Neurons of the Dorsomedial Striatum. Alcoholism, clinical and experimental research. 2020-03-06. PMID:29870053. |
excitation of dopamine d1 receptor-expressing medium spiny neurons (d1-msns) of the dorsomedial striatum (dms), a brain region that controls voluntary behavior, is known to induce hyperactivity in mice. |
2020-03-06 |
2023-08-13 |
mouse |
| Zhuangzhi Zhang, Song Wei, Heng Du, Zihao Su, Yan Wen, Zicong Shang, Xiaolei Song, Zhejun Xu, Yan You, Zhengang Yan. Zfhx3 is required for the differentiation of late born D1-type medium spiny neurons. Experimental neurology. vol 322. 2020-02-24. PMID:31491374. |
the striatal principal projection neurons are comprised of medium spiny neurons (msns) with two dopamine receptors: drd1 (d1 msns) and drd2 (d2 msns). |
2020-02-24 |
2023-08-13 |
Not clear |