| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Allison Costello, Katrina Linning-Duffy, Carleigh Vandenbrook, Joseph S Lonstein, Lily Ya. Daytime Light Deficiency Leads to Sex- and Brain Region-Specific Neuroinflammatory Responses in a Diurnal Rodent. Cellular and molecular neurobiology. 2022-07-21. PMID:35864429. |
after 4 weeks, microglia markers iba-1 and cd11b, as well as pro-inflammatory cytokines tnf-α and il-6, were examined in the anterior cingulate cortex (acc), basolateral amygdala (bla), and dorsal hippocampus (dhipp). |
2022-07-21 |
2023-08-14 |
rat |
| Yiping Chen, Chongyao Hao, Wenjie Chen, Wenjing Cheng, Peng Li, Junliang Shen, Tao Tong, Simin Yan, Shuqiong Huang, Tianwei He, Zhiyong Huang, Xianjun Men. Anti-depressant Effects of Acupuncture: the Insights from NLRP3 mediated Pyroptosis and Inflammation. Neuroscience letters. 2022-07-12. PMID:35820551. |
results showed that acupuncture significantly improved the depression-like behavior of cums rat, suppressed the expressions of nlrp3, asc, caspase-1, gsdmd, il-1β, il-18, hmgb1, ifn-γ, il-6 and tnf-α in the serum and hippocampus, restored the %area of microglia, astrocytes and neuronal cells in the hippocampus. |
2022-07-12 |
2023-08-14 |
rat |
| b' Marcella Massimini, Benedetta Bachetti, Elena Dalle Vedove, Alessia Benvenga, Francesco Di Pierro, Nicola Bernab\\xc3\\xb. A Set of Dysregulated Target Genes to Reduce Neuroinflammation at Molecular Level. International journal of molecular sciences. vol 23. issue 13. 2022-07-09. PMID:35806178.' |
considering the important role of microglia in neurodegeneration, a murine co-culture of hippocampal cells and inflamed microglia cells was set up. |
2022-07-09 |
2023-08-14 |
human |
| Kesem Nahum, Doron Todder, Joseph Zohar, Hagit Cohe. The Role of Microglia in the (Mal)adaptive Response to Traumatic Experience in an Animal Model of PTSD. International journal of molecular sciences. vol 23. issue 13. 2022-07-09. PMID:35806185. |
these data indicate that pss-induced microglia activation in the hippocampus serves as a critical mechanistic link between the hpa-axis and pss-induced impairment in behavioral responses. |
2022-07-09 |
2023-08-14 |
rat |
| Xiao Ke, Manfei Deng, Zhuoze Wu, Hongyan Yu, Dian Yu, Hao Li, Youming Lu, Kai Shu, Lei Pe. miR-34b-3p Inhibition of eIF4E Causes Post-stroke Depression in Adult Mice. Neuroscience bulletin. 2022-07-08. PMID:35802246. |
together, our data demonstrated that insufficient mir34b-3p after stroke cannot inhibit eif4e translation, which causes psd by the activation of microglia in the hippocampus. |
2022-07-08 |
2023-08-14 |
mouse |
| Yuanyuan Wang, Changli Wang, Dan Zhang, Liping Wang, Huihui Wang, Baoji Hu, Lulong B. Methane-rich saline protects against sepsis-associated cognitive deficits in mice. Brain research. 2022-07-05. PMID:35780865. |
a physiological mechanistic investigation revealed that microglia in the hippocampus are largely activated, coupled with the production of inflammatory cytokines and reactive oxygen species (ros). |
2022-07-05 |
2023-08-14 |
mouse |
| Yuanyuan Wang, Changli Wang, Dan Zhang, Liping Wang, Huihui Wang, Baoji Hu, Lulong B. Methane-rich saline protects against sepsis-associated cognitive deficits in mice. Brain research. 2022-07-05. PMID:35780865. |
notably, methane inhibited the activation of microglia in the hippocampus, reduced the severity of inflammation, diminished the generation of ros, and ultimately alleviated behavioral impairment in septic mice. |
2022-07-05 |
2023-08-14 |
mouse |
| Qing Li, Xianjie Zhang, Siyuan Li, Wen Li, Yunpeng Teng, Yukai Zhou, Hongfei Xion. Carnosol alleviates sevoflurane-induced cognitive dysfunction by mediating NF-κB pathway in aged rats. Drug development research. 2022-07-05. PMID:35781309. |
the effects of carnosol on the expression of inflammatory factors in rat hippocampus mediated by sev were determined by enzyme-linked immunoassay and polymerase chain reaction experiments; the effects of carnosol on the expressions of iba-1 and glial fibrillary acidic protein after sev-mediated activation of rat microglia were clarified by immunofluorescence and western blotting (wb); the effects of carnosol on sev-mediated neuronal apoptosis were studied by terminal deoxynucleotidyl transferase dutp nick end labeling and wb; the specific signaling pathways regulated by carnosol were elucidated by wb. |
2022-07-05 |
2023-08-14 |
rat |
| Tao Yu, Liang Huo, Jie Lei, Jing-Jing Sun, Hua Wan. Modulation of Microglia M2 Polarization and Alleviation of Hippocampal Neuron Injury By MiR-106b-5p/RGMa in a Mouse Model of Status Epilepticus. Inflammation. 2022-07-05. PMID:35789312. |
modulation of microglia m2 polarization and alleviation of hippocampal neuron injury by mir-106b-5p/rgma in a mouse model of status epilepticus. |
2022-07-05 |
2023-08-14 |
mouse |
| Wenxin Zhang, Mingqian Yu, Qiyue Zhang, Zhuo Yang, Tao Zhan. DFO treatment protects against depression-like behaviors and cognitive impairment in CUMS mice. Brain research bulletin. 2022-07-02. PMID:35779818. |
additionally, cums exposure significantly decreased the expression of hippocampal synapse related proteins and the spine density of neurons in the dg region, accompanied by increasing the expression of hippocampal inflammatory cytokines, and promoted the activation of microglia in the hippocampus. |
2022-07-02 |
2023-08-14 |
mouse |
| Miao-Miao Hong, En-Cong Zhao, Li-Min Chen, Feng Wang, Wan-Qing Guo, Xue-Hua Zheng, Lan Lin, Chang-Zheng Li, Wei-Guo Don. [Effect of electroacupuncture on complement C1q and microglia phagocytosis in hippocampus of SAMP8 mice]. Zhen ci yan jiu = Acupuncture research. vol 47. issue 6. 2022-06-28. PMID:35764513. |
[effect of electroacupuncture on complement c1q and microglia phagocytosis in hippocampus of samp8 mice]. |
2022-06-28 |
2023-08-14 |
mouse |
| Jing Li, Peilin Zhu, Yue Li, Kai Xiao, Jing Tang, Xin Liang, Yanmin Luo, Jin Wang, Yuhui Deng, Lin Jiang, Qian Xiao, Yijing Guo, Yong Tang, Chunxia Huan. The liver X receptors agonist GW3965 attenuates depressive-like behaviors and suppresses microglial activation and neuroinflammation in hippocampal subregions in a mouse depression model. The Journal of comparative neurology. 2022-06-27. PMID:35758275. |
hippocampal neuroinflammation and impairment of the normal structure and function of microglia are closely associated with depression. |
2022-06-27 |
2023-08-14 |
mouse |
| Jing Li, Peilin Zhu, Yue Li, Kai Xiao, Jing Tang, Xin Liang, Yanmin Luo, Jin Wang, Yuhui Deng, Lin Jiang, Qian Xiao, Yijing Guo, Yong Tang, Chunxia Huan. The liver X receptors agonist GW3965 attenuates depressive-like behaviors and suppresses microglial activation and neuroinflammation in hippocampal subregions in a mouse depression model. The Journal of comparative neurology. 2022-06-27. PMID:35758275. |
to investigate the effects of lxrs agonist (gw3965) on neuroinflammation and microglia in the hippocampal formation of mice with chronic unpredictable stress (cus)-induced depression, depressive-like behaviors were evaluated by behavioral tests, hippocampal lxrs gene expression were evaluated by qrt-pcr, the protein expression levels of interleukin-1β, tumor necrosis factor-α, inducible nitric oxide synthase, nuclear factor kappa b, and cluster of differentiation 206 were estimated by western blotting, modern stereological methods were used to precisely quantify the total number of microglia in each hippocampal subregion, and immunofluorescence was used to detect the density of activated microglia and the morphology of microglia. |
2022-06-27 |
2023-08-14 |
mouse |
| Jing Li, Peilin Zhu, Yue Li, Kai Xiao, Jing Tang, Xin Liang, Yanmin Luo, Jin Wang, Yuhui Deng, Lin Jiang, Qian Xiao, Yijing Guo, Yong Tang, Chunxia Huan. The liver X receptors agonist GW3965 attenuates depressive-like behaviors and suppresses microglial activation and neuroinflammation in hippocampal subregions in a mouse depression model. The Journal of comparative neurology. 2022-06-27. PMID:35758275. |
these findings suggest that regulating the number, activated state, and morphology of microglia in hippocampal subregions might be an important basis for the antidepressant effects of lxrs. |
2022-06-27 |
2023-08-14 |
mouse |
| Benjamin J Bell, Kristen R Hollinger, Pragney Deme, Shinji Sakamoto, Yuto Hasegawa, David Volsky, Atsushi Kamiya, Norman Haughey, Xiaolei Zhu, Barbara S Slushe. Glutamine antagonist JHU083 improves psychosocial behavior and sleep deficits in EcoHIV-infected mice. Brain, behavior, & immunity - health. vol 23. 2022-06-23. PMID:35734753. |
to explore potential mechanisms underlying this effect, hippocampal microglia were isolated for rna sequencing. |
2022-06-23 |
2023-08-14 |
mouse |
| Benjamin J Bell, Kristen R Hollinger, Pragney Deme, Shinji Sakamoto, Yuto Hasegawa, David Volsky, Atsushi Kamiya, Norman Haughey, Xiaolei Zhu, Barbara S Slushe. Glutamine antagonist JHU083 improves psychosocial behavior and sleep deficits in EcoHIV-infected mice. Brain, behavior, & immunity - health. vol 23. 2022-06-23. PMID:35734753. |
the dysregulated genes and pathways in ecohiv-infected hippocampal microglia pointed to disruptions in immune functions of these cells, which were partially restored by jhu083 treatment. |
2022-06-23 |
2023-08-14 |
mouse |
| Kazue Hisaoka-Nakashima, Kazuto Ohata, Natsuki Yoshimoto, Shintarou Tokuda, Nanako Yoshii, Yoki Nakamura, Dengli Wang, Keyue Liu, Hidenori Wake, Takayuki Yoshida, Yukio Ago, Kouichi Hashimoto, Masahiro Nishibori, Norimitsu Moriok. High-mobility group box 1-mediated hippocampal microglial activation induces cognitive impairment in mice with neuropathic pain. Experimental neurology. 2022-06-23. PMID:35738416. |
furthermore, two weeks after psnl, significant microglia activation was observed in hippocampus. |
2022-06-23 |
2023-08-14 |
mouse |
| Kazue Hisaoka-Nakashima, Kazuto Ohata, Natsuki Yoshimoto, Shintarou Tokuda, Nanako Yoshii, Yoki Nakamura, Dengli Wang, Keyue Liu, Hidenori Wake, Takayuki Yoshida, Yukio Ago, Kouichi Hashimoto, Masahiro Nishibori, Norimitsu Moriok. High-mobility group box 1-mediated hippocampal microglial activation induces cognitive impairment in mice with neuropathic pain. Experimental neurology. 2022-06-23. PMID:35738416. |
inhibition of microglial activation with minocycline, local hippocampal microglia depletion with clodronate liposome, or blockade of hmgb1 with either glycyrrhizic acid (gza) or anti-hmgb1 antibody in psnl mice reduced hippocampal microglia activation and ameliorated cognitive impairment. |
2022-06-23 |
2023-08-14 |
mouse |
| Yachun Li, Meng Mao, Lanyue Zhu, Qiang Sun, Jianhua Tong, Zhiqiang Zho. IL-17A drives cognitive aging probably via inducing neuroinflammation and theta oscillation disruption in the hippocampus. International immunopharmacology. vol 108. 2022-06-22. PMID:35729833. |
both young mice receiving il-17a and aging mice showed impaired memory, increased blood-brain barrier permeability, overactivated microglia and increased inflammatory mediators in the hippocampus. |
2022-06-22 |
2023-08-14 |
mouse |
| Shizhan Ma, Wenkai Bi, Xueying Liu, Shangbin Li, Yaxin Qiu, Chengcheng Huang, Renjun Lv, Qingqing Yi. Single-Cell Sequencing Analysis of the db/db Mouse Hippocampus Reveals Cell-Type-Specific Insights Into the Pathobiology of Diabetes-Associated Cognitive Dysfunction. Frontiers in endocrinology. vol 13. 2022-06-20. PMID:35721719. |
compared with db/m mouse, experiments at the protein level supported the activation of microglia, increased expression of inflammatory factors and oxidative stress damage in the hippocampus of db/db mouse. |
2022-06-20 |
2023-08-14 |
mouse |