| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rui Peng, Wen Dai, Di Li, Yan L. Gonadal hormone trigger the dynamic microglial alterations through Traf6/TAK1 axis that correlate with depressive behaviors. Journal of psychiatric research. vol 152. 2022-06-20. PMID:35724494. |
activating microglia in mice exposed to 7 days of castration subsequently suppressed the proliferation of microglia, such that their numbers in hippocampus and cortex were lower than the numbers in sham-operated mice after 30 days of castration. |
2022-06-20 |
2023-08-14 |
mouse |
| Liangyu Peng, Shuai Liu, Jiyan Xu, Wenjia Xie, Xin Fang, Tianjiao Xia, Xiaoping G. Metformin alleviates prolonged isoflurane inhalation induced cognitive decline via reducing neuroinflammation in adult mice. International immunopharmacology. vol 109. 2022-06-16. PMID:35709590. |
prolonged sub-mac isoflurane exposure also triggered typically reactive microglia and a1-like astrocytes in the hippocampus of adult mice on day 3 after anesthesia. |
2022-06-16 |
2023-08-14 |
mouse |
| Liangyu Peng, Shuai Liu, Jiyan Xu, Wenjia Xie, Xin Fang, Tianjiao Xia, Xiaoping G. Metformin alleviates prolonged isoflurane inhalation induced cognitive decline via reducing neuroinflammation in adult mice. International immunopharmacology. vol 109. 2022-06-16. PMID:35709590. |
the positive cellular modifications promoted by metformin pretreatment included the inhibition of reactive microglia and a1-like astrocytes and the polarization of microglia into m2 phenotype in the hippocampus of adult mice. |
2022-06-16 |
2023-08-14 |
mouse |
| Liangyu Peng, Shuai Liu, Jiyan Xu, Wenjia Xie, Xin Fang, Tianjiao Xia, Xiaoping G. Metformin alleviates prolonged isoflurane inhalation induced cognitive decline via reducing neuroinflammation in adult mice. International immunopharmacology. vol 109. 2022-06-16. PMID:35709590. |
in conclusion, prolonged sub-mac isoflurane exposure triggered significant hippocampal neuroinflammation and cognitive decline in adult mice which can be alleviated by metformin pretreatment via inhibiting reactive microglia and a1-like astrocytes and promoting microglia polarization toward anti-inflammatory phenotype in the hippocampus. |
2022-06-16 |
2023-08-14 |
mouse |
| Kata Tóth, Tamás Oroszi, Eddy A van der Zee, Csaba Nyakas, Regien G Schoemake. The effects of exercise training on heart, brain and behavior, in the isoproterenol-induced cardiac infarct model in middle-aged female rats. Scientific reports. vol 12. issue 1. 2022-06-16. PMID:35710575. |
actually, hippocampal microglia hyper-ramification was observed after iso. |
2022-06-16 |
2023-08-14 |
rat |
| Maryam Ardalan, Tetyana Chumak, Alexandra Quist, Seyedeh Marziyeh Jabbari Shiadeh, Anna-Jean Mallard, Ali Hoseinpoor Rafati, Carina Mallar. Sex dependent glio-vascular interface abnormality in the hippocampus following postnatal immune activation in mice. Developmental neuroscience. 2022-06-15. PMID:35705008. |
brains were collected at p12 and morphological quantifications of hippocampal fibrillary glial acid protein (gfap+) astrocytes and ionized calcium binding adaptor molecule 1 (iba1+) microglia were performed by using 3-d image analysis together with measuring the length of cd31+ and aquaporin-4 (aqp4+) vessels. |
2022-06-15 |
2023-08-14 |
mouse |
| Xue Mi, Gui-Rong Zeng, Jie-Qing Liu, Zhou-Song Luo, Ling Zhang, Xiao-Man Dai, Wen-Ting Fang, Jing Zhang, Xiao-Chun Che. Ganoderma Lucidum Triterpenoids Improve Maternal Separation-Induced Anxiety- and Depression-like Behaviors in Mice by Mitigating Inflammation in the Periphery and Brain. Nutrients. vol 14. issue 11. 2022-06-10. PMID:35684068. |
maternal separation up-regulated the pro-inflammatory markers in the periphery and brain, and activated microglia in the prefrontal cortex and hippocampus. |
2022-06-10 |
2023-08-14 |
mouse |
| Shanshan Zhang, Juntao Hu, Guixue Liu, Haoran Wu, Meihui Li, Chenye Shi, Qiong Liu, Wensheng L. Chronic clomipramine treatment increases hippocampal volume in rats exposed to chronic unpredictable mild stress. Translational psychiatry. vol 12. issue 1. 2022-06-10. PMID:35688836. |
rats exhibited defective behavior and hippocampal neuroinflammation after 12 weeks of cms, which included elevated expression of cleaved interleukin-1β (il-1β) and nlrp3 inflammasome together with the activation of microglia. |
2022-06-10 |
2023-08-14 |
rat |
| Shanshan Zhang, Juntao Hu, Guixue Liu, Haoran Wu, Meihui Li, Chenye Shi, Qiong Liu, Wensheng L. Chronic clomipramine treatment increases hippocampal volume in rats exposed to chronic unpredictable mild stress. Translational psychiatry. vol 12. issue 1. 2022-06-10. PMID:35688836. |
all these results indicate that the nlrp3 inflammasome of microglia in the hippocampus is related to the antidepressant effects of clomipramine and cms-induced depressive-like behavior in rats. |
2022-06-10 |
2023-08-14 |
rat |
| Yuka Okusha, Benjamin J Lang, Ayesha Murshid, Thiago J Borges, Kristina M Holton, Joanne Clark-Matott, Sachin Doshi, Tsuneya Ikezu, Stuart K Calderwoo. Extracellular Hsp90α stimulates a unique innate gene profile in microglial cells with simultaneous activation of Nrf2 and protection from oxidative stress. Cell stress & chaperones. 2022-06-10. PMID:35689138. |
using a co-culture system of microglia and hippocampal neuronal cell line ht22 cells separated by a chamber insert, the neurotoxicity of medium conditioned by microglia treated with faβ was reduced when ehsp90α was also added. |
2022-06-10 |
2023-08-14 |
Not clear |
| Ana-Karina Aguilar-Peralta, Alejandro Gonzalez-Vazquez, Constantino Tomas-Sanchez, Victor-Manuel Blanco-Alvarez, Daniel Martinez-Fong, Juan-Antonio Gonzalez-Barrios, Ilhuicamina Daniel Limon, Lourdes Millán-Perez Peña, Gonzalo Flores, Guadalupe Soto-Rodriguez, Eduardo Brambila, Jorge Cebada, Viridiana Vargas-Castro, Bertha Alicia Leon-Chave. Prophylactic Zinc Administration Combined with Swimming Exercise Prevents Cognitive-Emotional Disturbances and Tissue Injury following a Transient Hypoxic-Ischemic Insult in the Rat. Behavioural neurology. vol 2022. 2022-05-31. PMID:35637877. |
nissl staining evaluated hippocampus cytoarchitecture and iba-1 immunohistochemistry activated the microglia. |
2022-05-31 |
2023-08-13 |
rat |
| Zhiquan Zhang, Qing Ma, Ravikanth Velagapudi, William E Barclay, Ramona M Rodriguiz, William C Wetsel, Ting Yang, Mari L Shinohara, Niccolò Terrand. Annexin-A1 Tripeptide Attenuates Surgery-Induced Neuroinflammation and Memory Deficits Through Regulation the NLRP3 Inflammasome. Frontiers in immunology. vol 13. 2022-05-23. PMID:35603196. |
surgery triggered asc specks formation in ca1 hippocampal microglia, but without inducing significant morphological changes in nlrp3 and asc knockout mice. |
2022-05-23 |
2023-08-13 |
mouse |
| Amira A Sallam, Mohammed A El-Magd, Mona M Ahmed, Heba I Ghamry, Mohammad Y Alshahrani, Rabab A Hegazy, Ahmed Magdy, Magdy F Abou El-Foto. Quercetin alleviated multi-walled carbon nanotubes-induced neurotoxicity in mice through inhibition of oxidation, inflammation, and pyroptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 151. 2022-05-23. PMID:35605300. |
however, treatment with que ameliorated mwcnts-induced neurotoxicity as revealed by 1) elevated acetylcholinesterase (ache) activity, 2) reduced lipid peroxidation biomarker malondialdehyde (mda), 3) improved antioxidant status as indicated by increased levels of reduced glutathione (gsh) and activities of superoxide dismutase (sod), catalase (cat), as well as upregulated expression of nuclear factor erythroid 2-related factor 2 (nrf2) and heme oxygenase-1 (ho-1) genes, 4) decreased levels and expression of inflammatory biomarkers [nitric oxide (no), interleukin 1 beta (il1ß), tumor necrosis factor-alpha (tnfα), and nuclear factor kappa b (nf-κb)], 5) downregulated expression of pyroptosis-related genes [nod-like receptor protein inflammasome 3 (nlrp3) and caspase 1 (casp1)] but with no effect on the apoptotic casp3 gene, 6) minimized axonal degeneration and number of microglia in the cerebral medulla, and 7) diminished the number of degenerated neurons in hippocampus and cerebellum. |
2022-05-23 |
2023-08-13 |
mouse |
| Sahithi Attaluri, Raghavendra Upadhya, Maheedhar Kodali, Leelavathi N Madhu, Dinesh Upadhya, Bing Shuai, Ashok K Shett. Brain-Specific Increase in Leukotriene Signaling Accompanies Chronic Neuroinflammation and Cognitive Impairment in a Model of Gulf War Illness. Frontiers in immunology. vol 13. 2022-05-16. PMID:35572589. |
cyslt and ltb4 concentrations were elevated in the hippocampus and the cerebral cortex, along with enhanced 5-lox expression in neurons and microglia. |
2022-05-16 |
2023-08-13 |
mouse |
| Haiyang Zhang, Jibin Wang, Chuqian Ruan, Zhicheng Gao, Qiuxiang Zhu, Shoujun L. Co-exposure of chronic stress and alumina nanoparticles aggravates hippocampal microglia pyroptosis by activating cathepsin B/NLRP3 signaling pathway. Journal of hazardous materials. vol 436. 2022-05-15. PMID:35569374. |
co-exposure of chronic stress and alumina nanoparticles aggravates hippocampal microglia pyroptosis by activating cathepsin b/nlrp3 signaling pathway. |
2022-05-15 |
2023-08-13 |
rat |
| Haiyang Zhang, Jibin Wang, Chuqian Ruan, Zhicheng Gao, Qiuxiang Zhu, Shoujun L. Co-exposure of chronic stress and alumina nanoparticles aggravates hippocampal microglia pyroptosis by activating cathepsin B/NLRP3 signaling pathway. Journal of hazardous materials. vol 436. 2022-05-15. PMID:35569374. |
this study aimed to investigate the effect and mechanism of co-exposure to chronic stress and alnps on hippocampal microglia pyroptosis. |
2022-05-15 |
2023-08-13 |
rat |
| Haiyang Zhang, Jibin Wang, Chuqian Ruan, Zhicheng Gao, Qiuxiang Zhu, Shoujun L. Co-exposure of chronic stress and alumina nanoparticles aggravates hippocampal microglia pyroptosis by activating cathepsin B/NLRP3 signaling pathway. Journal of hazardous materials. vol 436. 2022-05-15. PMID:35569374. |
in this study, chronic restraint stress (crs) alone caused nlrp3-mediated hippocampal microglia pyroptosis, but alnps did not. |
2022-05-15 |
2023-08-13 |
rat |
| Haiyang Zhang, Jibin Wang, Chuqian Ruan, Zhicheng Gao, Qiuxiang Zhu, Shoujun L. Co-exposure of chronic stress and alumina nanoparticles aggravates hippocampal microglia pyroptosis by activating cathepsin B/NLRP3 signaling pathway. Journal of hazardous materials. vol 436. 2022-05-15. PMID:35569374. |
moreover, co-exposure to crs and alnps exacerbated hippocampal microglia pyroptosis, resulting in more severe hippocampal damage and behavioral deficits in rats. |
2022-05-15 |
2023-08-13 |
rat |
| Haiyang Zhang, Jibin Wang, Chuqian Ruan, Zhicheng Gao, Qiuxiang Zhu, Shoujun L. Co-exposure of chronic stress and alumina nanoparticles aggravates hippocampal microglia pyroptosis by activating cathepsin B/NLRP3 signaling pathway. Journal of hazardous materials. vol 436. 2022-05-15. PMID:35569374. |
whereas, caspase-1 inhibitor vx-765 alleviated hippocampal microglia pyroptosis and behavioral deficits in rats. |
2022-05-15 |
2023-08-13 |
rat |
| Haiyang Zhang, Jibin Wang, Chuqian Ruan, Zhicheng Gao, Qiuxiang Zhu, Shoujun L. Co-exposure of chronic stress and alumina nanoparticles aggravates hippocampal microglia pyroptosis by activating cathepsin B/NLRP3 signaling pathway. Journal of hazardous materials. vol 436. 2022-05-15. PMID:35569374. |
these results demonstrated that co-exposure to chronic stress and alnps could aggravate hippocampal microglia pyroptosis by activating cathepsin b/nlrp3 signaling pathway, resulting in hippocampal damage and behavioral deficits. |
2022-05-15 |
2023-08-13 |
rat |