| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julio David Vega-Torres, Perla Ontiveros-Angel, Esmeralda Terrones, Erwin C Stuffle, Sara Solak, Emma Tyner, Marie Oropeza, Ike Dela Peña, Andre Obenaus, Byron D Ford, Johnny D Figuero. Short-term exposure to an obesogenic diet during adolescence elicits anxiety-related behavior and neuroinflammation: modulatory effects of exogenous neuregulin-1. Translational psychiatry. vol 12. issue 1. 2022-02-27. PMID:35220393. |
nrg1 administration reduced psd-95 protein expression (30%) and selectively reduced hippocampal cytokine levels (il-33, gm-csf, ccl-2, ifn-γ) while significantly impacting microglia morphology (increased span ratio and reduced circularity). |
2022-02-27 |
2023-08-13 |
rat |
| Julio David Vega-Torres, Perla Ontiveros-Angel, Esmeralda Terrones, Erwin C Stuffle, Sara Solak, Emma Tyner, Marie Oropeza, Ike Dela Peña, Andre Obenaus, Byron D Ford, Johnny D Figuero. Short-term exposure to an obesogenic diet during adolescence elicits anxiety-related behavior and neuroinflammation: modulatory effects of exogenous neuregulin-1. Translational psychiatry. vol 12. issue 1. 2022-02-27. PMID:35220393. |
wd rats exhibited reduced right hippocampal volume (7%), altered microglia morphology (reduced density and increased lacunarity), and increased levels of cytokines implicated in neuroinflammation (il-1α, tnf-α, il-6). |
2022-02-27 |
2023-08-13 |
rat |
| Michael Ratz, Leonie von Berlin, Ludvig Larsson, Marcel Martin, Jakub Orzechowski Westholm, Gioele La Manno, Joakim Lundeberg, Jonas Frisé. Clonal relations in the mouse brain revealed by single-cell and spatial transcriptomics. Nature neuroscience. 2022-02-25. PMID:35210624. |
by reconstructing thousands of clones, we discovered fate-restricted progenitor cells in the mouse hippocampal neuroepithelium and show that microglia are derived from few primitive myeloid precursors that massively expand to generate widely dispersed progeny. |
2022-02-25 |
2023-08-13 |
mouse |
| Tiantian Zhao, Dong Wu, Jingyi Du, Guowei Liu, Guangyu Ji, Zixiao Wang, Fan Peng, Lajie Man, Wenjuan Zhou, Aijun Ha. Folic Acid Attenuates Glial Activation in Neonatal Mice and Improves Adult Mood Disorders Through Epigenetic Regulation. Frontiers in pharmacology. vol 13. 2022-02-24. PMID:35197855. |
here, we investigated the roles of fa in a mouse model of pia, and found that fa treatment improved depressive- and anxiety-like behaviors in adults, accompanied by a decrease in the number of activated microglia and astrocytes, as well as a reduction in the inflammatory response in the cortex and hippocampus of neonatal mice. |
2022-02-24 |
2023-08-13 |
mouse |
| Lucas Taoro-González, Andrea Cabrera-Pastor, María Sancho-Alonso, Vicente Felip. Intracellular and extracelluar cyclic GMP in the brain and the hippocampus. Vitamins and hormones. vol 118. 2022-02-19. PMID:35180929. |
the mechanisms implicated are still unclear and might involve complex interactions between hippocampal neurons, astrocytes and microglia. |
2022-02-19 |
2023-08-13 |
rat |
| Kala N Nwachukwu, Dantae M King, Kati L Healey, H Scott Swartzwelder, S Alex Marshal. SEX-SPECIFIC Effects OF Adolescent Intermittent Ethanol Exposure-Induced Dysregulation OF Hippocampal Glial Cells In Adulthood. Alcohol (Fayetteville, N.Y.). 2022-02-19. PMID:35182671. |
in adulthood, immunohistochemical techniques were utilized to determine the effects of aie on astrocytes and microglia, and fluoro-jade c (fjc) was used to assess neurodegeneration in the hippocampus. |
2022-02-19 |
2023-08-13 |
rat |
| Licheng Yan, Jinghua Yang, Miao Yu, Wenchang Sun, Yarao Han, Xiaobo Lu, Cuihong Jin, Shengwen Wu, Yuan Ca. Lanthanum Impairs Learning and Memory by Activating Microglia in the Hippocampus of Mice. Biological trace element research. vol 200. issue 4. 2022-02-18. PMID:35178682. |
lanthanum impairs learning and memory by activating microglia in the hippocampus of mice. |
2022-02-18 |
2023-08-13 |
mouse |
| Ekaterina A Rudnitskaya, Alena O Burnyasheva, Tatiana A Kozlova, Daniil A Peunov, Nataliya G Kolosova, Natalia A Stefanov. Changes in Glial Support of the Hippocampus during the Development of an Alzheimer's Disease-like Pathology and Their Correction by Mitochondria-Targeted Antioxidant SkQ1. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163053. |
in summary, both astrocytes and microglia are more vulnerable to ad-associated neurodegeneration in the ca3 area than in other hippocampal areas; skq1 had an anti-inflammatory effect and is a promising modality for ad prevention and treatment. |
2022-02-15 |
2023-08-13 |
rat |
| Daniele Lana, Elisabetta Gerace, Giada Magni, Francesca Cialdai, Monica Monici, Guido Mannaioni, Maria Grazia Giovannin. Hypoxia/Ischemia-Induced Rod Microglia Phenotype in CA1 Hippocampal Slices. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163344. |
hypoxia/ischemia-induced rod microglia phenotype in ca1 hippocampal slices. |
2022-02-15 |
2023-08-13 |
rat |
| Daniele Lana, Elisabetta Gerace, Giada Magni, Francesca Cialdai, Monica Monici, Guido Mannaioni, Maria Grazia Giovannin. Hypoxia/Ischemia-Induced Rod Microglia Phenotype in CA1 Hippocampal Slices. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163344. |
we demonstrated that oxygen-glucose deprivation (ogd) induced rapid, time- and space-dependent phenotypic microglia modifications in ca1 stratum pyramidalis (sp) and stratum radiatum (sr) of rat organotypic hippocampal slices as well as the degeneration of pyramidal neurons, especially in the outer layer of sp. |
2022-02-15 |
2023-08-13 |
rat |
| Kun Ni, Jixiang Zhu, Xuan Xu, Yue Liu, Shuai Yang, Yulin Huang, Rui Xu, Li Jiang, Juan Zhang, Wei Zhang, Zhengliang M. Hippocampal Activated Microglia May Contribute to Blood-Brain Barrier Impairment and Cognitive Dysfunction in Post-Traumatic Stress Disorder-Like Rats. Journal of molecular neuroscience : MN. 2022-02-15. PMID:35167061. |
hippocampal activated microglia may contribute to blood-brain barrier impairment and cognitive dysfunction in post-traumatic stress disorder-like rats. |
2022-02-15 |
2023-08-13 |
rat |
| Kun Ni, Jixiang Zhu, Xuan Xu, Yue Liu, Shuai Yang, Yulin Huang, Rui Xu, Li Jiang, Juan Zhang, Wei Zhang, Zhengliang M. Hippocampal Activated Microglia May Contribute to Blood-Brain Barrier Impairment and Cognitive Dysfunction in Post-Traumatic Stress Disorder-Like Rats. Journal of molecular neuroscience : MN. 2022-02-15. PMID:35167061. |
hence, we established an animal model of ptsd, single prolonged stress (sps), and investigated permeability changes in the hippocampus and further explored the effects of microglia on bbb remodeling. |
2022-02-15 |
2023-08-13 |
rat |
| Kevin Sanchez, Jeffrey S Darling, Reha Kakkar, Sienna L Wu, Andrew Zentay, Christopher A Lowry, Laura K Fonke. Mycobacterium vaccae immunization in rats ameliorates features of age-associated microglia activation in the amygdala and hippocampus. Scientific reports. vol 12. issue 1. 2022-02-10. PMID:35140249. |
mycobacterium vaccae immunization in rats ameliorates features of age-associated microglia activation in the amygdala and hippocampus. |
2022-02-10 |
2023-08-13 |
rat |
| Kevin Sanchez, Jeffrey S Darling, Reha Kakkar, Sienna L Wu, Andrew Zentay, Christopher A Lowry, Laura K Fonke. Mycobacterium vaccae immunization in rats ameliorates features of age-associated microglia activation in the amygdala and hippocampus. Scientific reports. vol 12. issue 1. 2022-02-10. PMID:35140249. |
aging led to elevated iba1 immunoreactivity, microglial density, and deramification of microglia processes in the hippocampus and amygdala but not other brain regions. |
2022-02-10 |
2023-08-13 |
rat |
| Kevin Sanchez, Jeffrey S Darling, Reha Kakkar, Sienna L Wu, Andrew Zentay, Christopher A Lowry, Laura K Fonke. Mycobacterium vaccae immunization in rats ameliorates features of age-associated microglia activation in the amygdala and hippocampus. Scientific reports. vol 12. issue 1. 2022-02-10. PMID:35140249. |
notably, m. vaccae treatment ameliorated indicators of microglia activation in both the amygdala and hippocampus. |
2022-02-10 |
2023-08-13 |
rat |
| Juan R Perea, Esther García, Laura Vallés-Saiz, Raquel Cuadros, Félix Hernández, Marta Bolós, Jesús Avil. p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model. Scientific reports. vol 12. issue 1. 2022-02-09. PMID:35136118. |
using the p301s tauopathy mouse model, here we show that p38 activation increases during aging and that this occurs mainly in microglia of the hippocampus rather than in neurons. |
2022-02-09 |
2023-08-13 |
mouse |
| Chunyan Fu, Qincui Shuang, Yonghui Liu, Li Zeng, Wen S. Baihe Extracts Reduce the Activation and Apoptosis of Microglia in the Hippocampus of Mice with Depression-like Behaviors by Downregulating MYC. ACS chemical neuroscience. 2022-02-09. PMID:35139304. |
baihe extracts reduce the activation and apoptosis of microglia in the hippocampus of mice with depression-like behaviors by downregulating myc. |
2022-02-09 |
2023-08-13 |
mouse |
| Huidan Zhang, Heng Fang, Yirong Wang, Jing Xu, Chunbo Che. [Mechanisms of sodium butyrate inhibition of microglia inflammatory activation in hippocampus via Toll-like receptor 4/nuclear factor-κB p65 pathway]. Zhonghua wei zhong bing ji jiu yi xue. vol 33. issue 12. 2022-02-08. PMID:35131015. |
[mechanisms of sodium butyrate inhibition of microglia inflammatory activation in hippocampus via toll-like receptor 4/nuclear factor-κb p65 pathway]. |
2022-02-08 |
2023-08-13 |
mouse |
| Huidan Zhang, Heng Fang, Yirong Wang, Jing Xu, Chunbo Che. [Mechanisms of sodium butyrate inhibition of microglia inflammatory activation in hippocampus via Toll-like receptor 4/nuclear factor-κB p65 pathway]. Zhonghua wei zhong bing ji jiu yi xue. vol 33. issue 12. 2022-02-08. PMID:35131015. |
to investigate the effects of sodium butyrate (nab) on long-term anxiety like behavior and inflammatory activation of microglia in the hippocampus of sepsis-associated encephalopathy (sae) mice. |
2022-02-08 |
2023-08-13 |
mouse |
| Isaac Vargas-Rodríguez, Luis Antonio Reyes-Castro, Gustavo Pacheco-López, Consuelo Lomas-Soria, Elena Zambrano, Araceli Díaz-Ruíz, Sofía Diaz-Cintr. POSTNATAL EXPOSURE TO LIPOPOLYSACCHARIDE COMBINED WITH HIGH-FAT DIET CONSUMPTION INDUCES IMMUNE TOLERANCE WITHOUT PREVENTION IN SPATIAL WORKING MEMORY IMPAIRMENT. Behavioural brain research. 2022-02-05. PMID:35120930. |
hfd exposure has a pro-inflammatory effect associated with microglial cell modifications in the hippocampus, a region involved in the working memory process. |
2022-02-05 |
2023-08-13 |
mouse |