| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sadayuki Hashioka, Youn-Hee Han, Shunsuke Fujii, Takahiro Kato, Akira Monji, Hideo Utsumi, Makoto Sawada, Hiroshi Nakanishi, Shigenobu Kanb. Phospholipids modulate superoxide and nitric oxide production by lipopolysaccharide and phorbol 12-myristate-13-acetate-activated microglia. Neurochemistry international. vol 50. issue 3. 2007-04-10. PMID:17126953. |
phospholipids modulate superoxide and nitric oxide production by lipopolysaccharide and phorbol 12-myristate-13-acetate-activated microglia. |
2007-04-10 |
2023-08-12 |
Not clear |
| Sadayuki Hashioka, Youn-Hee Han, Shunsuke Fujii, Takahiro Kato, Akira Monji, Hideo Utsumi, Makoto Sawada, Hiroshi Nakanishi, Shigenobu Kanb. Phospholipids modulate superoxide and nitric oxide production by lipopolysaccharide and phorbol 12-myristate-13-acetate-activated microglia. Neurochemistry international. vol 50. issue 3. 2007-04-10. PMID:17126953. |
recently, peroxynitrite (onoo(-)), the reaction product of superoxide (o(2)(-)) and nitric oxide (no) both of which can be generated by activated microglia, has been demonstrated to act as a major mediator in the neurotoxicity induced by activated microglia. |
2007-04-10 |
2023-08-12 |
Not clear |
| Cindy X Zhang-Gandhi, Paul D Dre. Liver X receptor and retinoid X receptor agonists inhibit inflammatory responses of microglia and astrocytes. Journal of neuroimmunology. vol 183. issue 1-2. 2007-04-05. PMID:17175031. |
our studies demonstrated for the first time that lxr agonists inhibited the production of nitric oxide, the pro-inflammatory cytokines il-1beta and il-6 and the chemokine mcp-1 from lps-stimulated microglia and astrocytes. |
2007-04-05 |
2023-08-12 |
mouse |
| Xi-Jin Wang, Zhi-Qiang Yan, Guo-Qiang Lu, Smith Stuart, Sheng-Di Che. Parkinson disease IgG and C5a-induced synergistic dopaminergic neurotoxicity: role of microglia. Neurochemistry international. vol 50. issue 1. 2007-03-20. PMID:16971022. |
through immunocytochemistry analysis and assay of proinflammatory factors, we observed that each of the four pdiggs (60microg/ml) and c5a (0.1nm) synergistically induced microglia activation and production of superoxide and nitric oxide (no) in neuron-glia cultures. |
2007-03-20 |
2023-08-12 |
human |
| Yuan-Yuan Tian, Li-Jia An, Lan Jiang, Yan-Long Duan, Jun Chen, Bo Jian. Catalpol protects dopaminergic neurons from LPS-induced neurotoxicity in mesencephalic neuron-glia cultures. Life sciences. vol 80. issue 3. 2007-02-02. PMID:17049947. |
activated microglia can induce expression of inducible nitric-oxide synthase (inos) and release significant amounts of nitric oxide (no) and tnf-alpha, which can damage the dopaminergic neurons. |
2007-02-02 |
2023-08-12 |
Not clear |
| Vikas Kaushal, Paulo D Koeberle, Yimin Wang, Lyanne C Schlichte. The Ca2+-activated K+ channel KCNN4/KCa3.1 contributes to microglia activation and nitric oxide-dependent neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 1. 2007-01-29. PMID:17202491. |
kca3.1 channels contributed to microglia activation, inducible nitric oxide synthase upregulation, production of nitric oxide and peroxynitrite, and to consequent neurotoxicity, protein tyrosine nitration, and caspase 3 activation in the target neurons. |
2007-01-29 |
2023-08-12 |
rat |
| Agnieszka Kinsner, Monica Boveri, Lars Hareng, Guy C Brown, Sandra Coecke, Thomas Hartung, Anna Bal-Pric. Highly purified lipoteichoic acid induced pro-inflammatory signalling in primary culture of rat microglia through Toll-like receptor 2: selective potentiation of nitric oxide production by muramyl dipeptide. Journal of neurochemistry. vol 99. issue 2. 2007-01-08. PMID:16879708. |
highly purified lipoteichoic acid induced pro-inflammatory signalling in primary culture of rat microglia through toll-like receptor 2: selective potentiation of nitric oxide production by muramyl dipeptide. |
2007-01-08 |
2023-08-12 |
mouse |
| Agnieszka Kinsner, Monica Boveri, Lars Hareng, Guy C Brown, Sandra Coecke, Thomas Hartung, Anna Bal-Pric. Highly purified lipoteichoic acid induced pro-inflammatory signalling in primary culture of rat microglia through Toll-like receptor 2: selective potentiation of nitric oxide production by muramyl dipeptide. Journal of neurochemistry. vol 99. issue 2. 2007-01-08. PMID:16879708. |
as bacterial components are recognised by the innate immunity through toll-like receptors (tlrs) we showed that lipoteichoic acid was recognised in microglia by the tlr2 and lipopolysaccharide by the tlr4, as cells isolated from mice lacking tlr2 or tlr4 did not produce pro-inflammatory cytokines and nitric oxide upon lipoteichoic acid or lipopolysaccharide stimulation, respectively. |
2007-01-08 |
2023-08-12 |
mouse |
| Sun Ae Lyu, Seung Yeon Lee, Song Jin Lee, Sung Woo Son, Mun Ok Kim, Gi-Young Kim, Young Hee Kim, Hwa Jung Yoon, Hoon Kim, Dong Il Park, Woo Shin K. Seungma-galgeun-tang attenuates proinflammatory activities through the inhibition of NF-kappaB signal pathway in the BV-2 microglial cells. Journal of ethnopharmacology. vol 107. issue 1. 2006-12-05. PMID:16546335. |
since nitric oxide (no) is one of the major inflammatory parameters, we first studied the effects of sgt on no production in lipopolysaccharide (lps)-stimulated bv-2 microglia. |
2006-12-05 |
2023-08-12 |
Not clear |
| Hong Sook Kim, Sang-Kyu Ye, Ik Hyun Cho, Joo Eun Jung, Dong-Hyun Kim, Seongwon Choi, Yong-Sik Kim, Chung-Gyu Park, Tae-Yoon Kim, Jung Weon Lee, Myung-Hee Chun. 8-hydroxydeoxyguanosine suppresses NO production and COX-2 activity via Rac1/STATs signaling in LPS-induced brain microglia. Free radical biology & medicine. vol 41. issue 9. 2006-12-05. PMID:17023266. |
we demonstrate here for the first time that oh(8)dg inhibits lipopolysaccharide (lps)-induced nitric oxide (no) production and cyclooxygenase-2 (cox-2) activity, and both gene transcriptions in microglia. |
2006-12-05 |
2023-08-12 |
Not clear |
| Yun-Jung Kim, So-Young Hwang, Eok-Soo Oh, Seikwan Oh, Inn-Oc Ha. IL-1beta, an immediate early protein secreted by activated microglia, induces iNOS/NO in C6 astrocytoma cells through p38 MAPK and NF-kappaB pathways. Journal of neuroscience research. vol 84. issue 5. 2006-11-28. PMID:16881054. |
in the present study we sought to examine cell-cell interactions by investigating the effects of factors released by stimulated microglia on inducible nitric oxide (no) synthase (inos) induction in astrocytoma cells. |
2006-11-28 |
2023-08-12 |
Not clear |
| Katrin Färber, Helmut Kettenman. Purinergic signaling and microglia. Pflugers Archiv : European journal of physiology. vol 452. issue 5. 2006-11-20. PMID:16791619. |
the purinoreceptors also modulate the release of substances from microglia, such as cytokines, nitric oxide, or superoxide, which are important in the context of a pathologic response. |
2006-11-20 |
2023-08-12 |
Not clear |
| Ki Kyung Jung, Hae Sung Lee, Jae Youl Cho, Won Cheol Shin, Man Hee Rhee, Tae Gyun Kim, Ju Hye Kang, Seung Hee Kim, Sungyoul Hong, Seog Youn Kan. Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia. Life sciences. vol 79. issue 21. 2006-11-20. PMID:16934299. |
inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia. |
2006-11-20 |
2023-08-12 |
rat |
| Toshio Matsuda, Takayuki Nagano, Motohiko Takemura, Akemichi Bab. Topics on the Na+/Ca2+ exchanger: responses of Na+/Ca2+ exchanger to interferon-gamma and nitric oxide in cultured microglia. Journal of pharmacological sciences. vol 102. issue 1. 2006-11-14. PMID:16960424. |
topics on the na+/ca2+ exchanger: responses of na+/ca2+ exchanger to interferon-gamma and nitric oxide in cultured microglia. |
2006-11-14 |
2023-08-12 |
Not clear |
| Toshio Matsuda, Takayuki Nagano, Motohiko Takemura, Akemichi Bab. Topics on the Na+/Ca2+ exchanger: responses of Na+/Ca2+ exchanger to interferon-gamma and nitric oxide in cultured microglia. Journal of pharmacological sciences. vol 102. issue 1. 2006-11-14. PMID:16960424. |
to clarify the role of ncx in microglia, we studied the responses of ncx to pathological conditions such as interferon-gamma or nitric oxide (no) exposure. |
2006-11-14 |
2023-08-12 |
Not clear |
| Luisa Franco, Nicoletta Bodrato, Iliana Moreschi, Cesare Usai, Santina Bruzzone, Sonia Scarf ì, Elena Zocchi, Antonio De Flor. Cyclic ADP-ribose is a second messenger in the lipopolysaccharide-stimulated activation of murine N9 microglial cell line. Journal of neurochemistry. vol 99. issue 1. 2006-11-14. PMID:16987244. |
the activation pathway triggered by lipopolysaccharide in microglia involves enhanced basal levels of intracellular calcium ([ca2+]i) and terminates with increased generation of cytokines/chemokines and nitric oxide. |
2006-11-14 |
2023-08-12 |
Not clear |
| Li Qian, Michelle L Block, Sung-Jen Wei, Chiou-Feng Lin, Jeffrey Reece, Hao Pang, Belinda Wilson, Jau-Shyong Hong, Patrick M Floo. Interleukin-10 protects lipopolysaccharide-induced neurotoxicity in primary midbrain cultures by inhibiting the function of NADPH oxidase. The Journal of pharmacology and experimental therapeutics. vol 319. issue 1. 2006-11-02. PMID:16807359. |
il-10 significantly inhibited lps-induced production of tumor necrosis factor-alpha, nitric oxide, and extracellular superoxide in microglia cells. |
2006-11-02 |
2023-08-12 |
mouse |
| Ming Hong Lee, Jae Yeon Kim, Jeong Hoon Yoon, Hyo Jin Lim, Tae Hee Kim, Changbae Jin, Wie-Jong Kwak, Chang-Kyun Han, Jae-Ha Ry. Inhibition of nitric oxide synthase expression in activated microglia and peroxynitrite scavenging activity by Opuntia ficus indica var. saboten. Phytotherapy research : PTR. vol 20. issue 9. 2006-11-02. PMID:16807879. |
activated microglia by neuronal injury or inflammatory stimulation overproduce nitric oxide (no) by inducible nitric oxide synthase (inos) and reactive oxygen species (ros) such as superoxide anion, resulting in neurodegenerative diseases. |
2006-11-02 |
2023-08-12 |
Not clear |
| L Zecca, F A Zucca, A Albertini, E Rizzio, R G Fariell. A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease. Neurology. vol 67. issue 7 Suppl 2. 2006-10-30. PMID:17030740. |
these in turn activate microglia, causing release of nitric oxide, interleukin-6 and tumor necrosis factor-alpha, thus becoming an important determinant of disease aggravation. |
2006-10-30 |
2023-08-12 |
human |
| L Qian, J S Hong, P M Floo. Role of microglia in inflammation-mediated degeneration of dopaminergic neurons: neuroprotective effect of interleukin 10. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017555. |
inflammation-mediated neurodegeneration involves activation of the brain's resident immune cells, the microglia, which produce proinflammatory and neurotoxic factors including cytokines, reactive oxygen species (ros), nitric oxide, and eicosanoids that directly or indirectly cause neurodegeneration. |
2006-10-24 |
2023-08-12 |
rat |