| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helen M Collins, L Sophie Gullino, Dersu Ozdemir, Caroline Lazarenco, Yulia Sudarikova, Elizabeth Daly, Fuencisla Pilar Cuéllar, Raquel Pinacho, David M Bannerman, Trevor Shar. Rebound activation of 5-HT neurons following SSRI discontinuation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-04-12. PMID:38609530. |
next, immunohistochemistry experiments found that paroxetine discontinuation increased c-fos expression in midbrain 5-ht (tph2 positive) neurons, adding further evidence for a hyperexcitable 5-ht system. |
2024-04-12 |
2024-04-15 |
mouse |
| b' Paola Giuliano, Giuliana La Rosa, Serena Capozzi, Emanuele Cassano, Simona Damiano, Francesco Habetswallner, Rosa Iodice, Maurizio Marra, Luigi Michele Pavone, Mario Quarantelli, Giuseppe Vitelli, Mariarosaria Santillo, Roberto Patern\\xc3\\xb. A Blood Test for the Diagnosis of Multiple Sclerosis. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338973.' |
in this study, since there is evidence connecting the serotonin pathway to ms, we used an elisa (enzyme-linked immunosorbent assay) to detect serum ms-specific auto-antibodies (auto-ab) against the extracellular loop 1 (ecl-1) of the 5-hydroxytryptamine (5-ht) receptor subtype 2a (5-ht2a). |
2024-02-10 |
2024-02-12 |
Not clear |
| Koshiro Mitsui, Aki Takahash. Aggression modulator: Understanding the multifaceted role of the dorsal raphe nucleus. BioEssays : news and reviews in molecular, cellular and developmental biology. 2024-02-05. PMID:38314963. |
however, recent studies challenge this 5-ht deficiency model, revealing a more complex role for the drn 5-ht system in aggression. |
2024-02-05 |
2024-02-09 |
Not clear |
| Lihua Ma, Yifan Yang, Shu Li, Bibhuti Upreti, Shuang Liu, Xiangyu Wang, Ru Bai, Yuqi Cheng, Jian X. Interaction of 5-HTTLPR and SLE disease status on resting-state brain function. Arthritis research & therapy. vol 26. issue 1. 2024-01-31. PMID:38297395. |
serotonin transporter gene-linked polymorphic region (5-httlpr) is an essential element of the 5-ht system gene polymorphism and is directly related to the control of 5-hydroxytryptamine transporter (5-htt)gene expression. |
2024-01-31 |
2024-02-03 |
Not clear |
| Cheng Zhang, Yanyao Li, Haibo Yu, Tian Li, Limin Ye, Xiaotian Zhang, Chi Wang, Pengju Li, Hong Ji, Qinfeng Gao, Shuanglin Don. Co-exposure of nanoplastics and arsenic causes neurotoxicity in zebrafish (Danio rerio) through disrupting homeostasis of microbiota-intestine-brain axis. The Science of the total environment. 2023-12-22. PMID:38135083. |
intestine, the primary source of 5-ht, its impaired health (aggravation in oxidative stress, mitochondrial damage and histopathological alterations) induced the dysregulation in the 5-ht system, which may be induced by the increased accumulation of as in the intestine by the co-exposure. |
2023-12-22 |
2023-12-25 |
zebrafish |
| Sneha Sivaramakrishnan, Vettriselvi Venkatesan, Sampath Kumar Paranthaman, R Sathianathan, Swetha Raghavan, Priyadarshee Pradha. Impact of Serotonin Pathway Gene Polymorphisms and Serotonin Levels in Suicidal Behavior. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 2023-09-17. PMID:37717578. |
impact of serotonin pathway gene polymorphisms and serotonin levels in suicidal behavior. |
2023-09-17 |
2023-10-07 |
Not clear |
| Gunild M Vulpius, Kristin Köhler-Forsberg, Brice Ozenne, Søren V Larsen, Arafat Nasser, Claus Svarer, Nic Gillings, Sune H Keller, Martin B Jørgensen, Gitte M Knudsen, Vibe G Frokjae. Stress hormone dynamics are coupled to brain serotonin 4 receptor availability in unmedicated patients with Major Depressive Disorder - a NeuroPharm study. The international journal of neuropsychopharmacology. 2023-08-05. PMID:37542733. |
an interesting feature of the cerebral serotonin system is the serotonin 4 receptor (5-ht4r), which is lower in depressed relative to healthy individuals, and also has been highlighted as a promising novel antidepressant target. |
2023-08-05 |
2023-08-14 |
Not clear |
| HaiXiang Ma, LeYuan Gu, YuLing Wang, Qing Xu, Yuanli Zhang, WeiHui Shao, Qian Yu, XiTing Lian, Lu Liu, JiaXuan Gu, Na Ji, XiaoLing Liu, Kazuki Nagayasu, HongHai Zhan. The States of Different 5-HT Receptors Located in the Dorsal Raphe Nucleus Are Crucial for Regulating the Awakening During General Anesthesia. Molecular neurobiology. 2023-07-29. PMID:37516665. |
our data showed that exogenous administration of 5-hydroxytryptophan (5-htp) and optogenetic activation of 5-ht neurons in the dorsal raphe nucleus (dr) could significantly shorten the emergence time of sevoflurane anesthesia in mice, suggesting that regulation of the 5-ht system using both endogenous and exogenous approaches could mediate delayed emergence. |
2023-07-29 |
2023-08-14 |
mouse |
| Alexander Ya Rodnyy, Elena M Kondaurova, Anton S Tsybko, Nina K Popova, Dmitry A Kudlay, Vladimir S Naumenk. The brain serotonin system in autism. Reviews in the neurosciences. 2023-07-07. PMID:37415576. |
in this review, we summarize existing data on the participation of all members of the brain 5-ht system, namely, 5-ht transporter, tryptophan hydroxylase 2, maoa, and 5-ht receptors, in autism in human and various animal models. |
2023-07-07 |
2023-08-14 |
human |
| Marcela Konjevod, Katherina B Sreter, Sanja Popovic-Grle, Marina Lampalo, Lucija Tudor, Irena Jukic, Gordana Nedic Erjavec, Jasna Bingulac-Popovic, Hana Safic Stanic, Matea Nikolac Perkovic, Jasenka Markeljevic, Miroslav Samarzija, Nela Pivac, Dubravka Svob Stra. Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and Biomolecules. vol 13. issue 5. 2023-05-27. PMID:37238670. |
platelet serotonin (5-ht) concentration, platelet monoamine oxidase b (mao-b) activity and the complex role of the serotonin system in respiratory function and inflammatory diseases such as asthma is unclear. |
2023-05-27 |
2023-08-14 |
Not clear |
| Julia Sacher, Rachel G Zsido, Claudia Barth, Franziska Zientek, Michael Rullmann, Julia Luthardt, Marianne Patt, Georg A Becker, Pablo Rusjan, A Veronica Witte, Ralf Regenthal, Abhay Koushik, Juergen Kratzsch, Beate Decker, Petra Jogschies, Arno Villringer, Swen Hesse, Osama Sabr. Increase in Serotonin Transporter Binding in Patients With Premenstrual Dysphoric Disorder Across the Menstrual Cycle: A Case-Control Longitudinal Neuroreceptor Ligand Positron Emission Tomography Imaging Study. Biological psychiatry. 2023-03-30. PMID:36997451. |
here, we tested whether a heightened sensitivity of the serotonin system to menstrual cycle phase underlies pmdd, assessing the relationship of serotonin transporter (5-htt) changes with symptom severity across the menstrual cycle. |
2023-03-30 |
2023-08-14 |
Not clear |
| Akihiro Mouri, Masaya Hasegawa, Kazuo Kunisawa, Kuniaki Saito, Toshitaka Nabeshim. [Diagnoses and new therapeutic strategy focused on physiological alteration of tryptophan metabolism]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 2023-03-29. PMID:36990795. |
indoleamine 2,3-dioxygenase 1 (ido1) is the first metabolizing enzyme in the trp-kyn pathway which is inducible by pro-inflammatory cytokines, involved depression-like behavior via 5-ht depletion due to decreased level of trp in the 5-ht pathway. |
2023-03-29 |
2023-08-14 |
Not clear |
| Ana Salomé Correia, Isabel Silva, Henrique Reguengo, José Carlos Oliveira, Francisco Vasques-Nóvoa, Armando Cardoso, Nuno Val. The Effect of the Stress Induced by Hydrogen Peroxide and Corticosterone on Tryptophan Metabolism, Using Human Neuroblastoma Cell Line (SH-SY5Y). International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36901819. |
it is important in processes such as mood and stress response, the 5-ht pathway begins with the conversion of l-trp to 5-hydroxytryptophan (5-htp), that is metabolized into 5-ht, converted to melatonin or to 5-hydroxyindoleacetic acid (5-hiaa). |
2023-03-11 |
2023-08-14 |
human |
| Xiaoxia Lin, Liang Huang, Huifang Huang, Zhongling Ke, Yanhui Che. Disturbed relationship between glucocorticoid receptor and 5-HT1AR/5-HT2AR in ADHD rats: A correlation study. Frontiers in neuroscience. vol 16. 2023-01-26. PMID:36699537. |
this work is to investigate the alterations of the central 5-hydroxytryptamine (5-ht) system in spontaneously hypertensive rats (shr) and the correlation with the behaviors of shr, and to explore the effects of glucocorticoid intervention on the central 5-ht system and shr behaviors. |
2023-01-26 |
2023-08-14 |
rat |
| Chor Hong Lim, Tomoko Soga, Ishwar S Parha. Social stress-induced serotonin dysfunction activates spexin in male Nile tilapia ( Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 3. 2023-01-09. PMID:36623187. |
since dysfunction of the serotonin (5-hydroxytryptamine, 5-ht) system is associated with social stress and the pathophysiology of depression, the present study investigated the regulatory relationship between the central 5-ht system and spx1a in the male teleost, nile tilapia ( |
2023-01-09 |
2023-08-14 |
Not clear |
| Andrew J Newell, Victoria A Kapps, Yuheng Cai, Mani Ratnam Rai, Genevieve St Armour, Brian M Horman, Kylie D Rock, Shannah K Witchey, Alon Greenbaum, Heather B Patisau. Maternal Organophosphate Flame Retardant Exposure Alters the Developing Mesencephalic Dopamine System in Fetal Rat. Toxicological sciences : an official journal of the Society of Toxicology. 2022-12-23. PMID:36562574. |
the development of the serotonin and dopamine systems occur in parallel and interact, therefore, we first sought to enhance our prior 5-ht work by first examining the ascending 5-ht system on embryonic day 14 using whole mount clearing of fetal heads and 3d brain imaging. |
2022-12-23 |
2023-08-14 |
human |
| Niklas Reich, Christian Hölsche. Beyond Appetite: Acylated Ghrelin As A Learning, Memory and Fear Behavior-modulating Hormone. Neuroscience and biobehavioral reviews. 2022-11-11. PMID:36368526. |
as such, in this review, we i) evaluate what specific stages and forms of memory, as well as which respective brain areas are affected by acylated ghrelin, ii) illustrate the plasticity-associated signaling pathways of ag in the hippocampus, also involving memory resolution-enhancing neurogenesis, iii) elucidate how the peptide modulates neurotransmitter systems (glutamate, γ-aminobutyric acid, dopamine, serotonin), iv) clarify the role of ag in conditioned taste aversion, novelty learning and the formation of spatial, recognition, auditory fear, contextual fear and passive avoidance memories in the hippocampus and amygdala as well as v) solve the mystery behind ag, its impact on the 5-ht system, the recently established link to post-traumatic stress disorder and the either fear-suppressing or fear-potentiating effects under neutral and acutely stressed conditions or chronic stress, respectively. |
2022-11-11 |
2023-08-14 |
Not clear |
| Abdulla Abu-Bakr Badaw. Tryptophan metabolism and disposition in cancer biology and immunotherapy. Bioscience reports. 2022-10-26. PMID:36286592. |
tumors down-regulate enzymes of serotonin synthesis, thereby removing competition for trp from the serotonin pathway. |
2022-10-26 |
2023-08-14 |
Not clear |
| Saida Oubraim, Ruixiang Wang, Kathryn Hausknecht, Martin Kaczocha, Roh-Yu Shen, Samir Haj-Dahman. Prenatal ethanol exposure causes anxiety-like phenotype and alters synaptic nitric oxide and endocannabinoid signaling in dorsal raphe nucleus of adult male rats. Translational psychiatry. vol 12. issue 1. 2022-10-10. PMID:36216807. |
while pe is known to disrupt the development of the 5-ht system, the cellular mechanisms by which it alters the function of dorsal raphe nucleus (drn) 5-ht neurons and their synaptic inputs remain unknown. |
2022-10-10 |
2023-08-14 |
rat |
| Qi Li, Baijian Jiang, Zhiqiang Zhang, Yongxiong Huang, Zhou Xu, Xinjin Chen, Xitan Hou, Jia Cai, Yu Huang, Jichang Jia. Serotonin system is partially involved in immunomodulation of Nile tilapia ( Frontiers in immunology. vol 13. 2022-08-15. PMID:35967362. |
serotonin system is partially involved in immunomodulation of nile tilapia ( serotonin (5-hydroxytryptamine) is a well-known neurotransmitter affecting emotion, behavior, and cognition. |
2022-08-15 |
2023-08-14 |
Not clear |