| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giuseppe Fanciulli, Rosaria M Ruggeri, Erika Grossrubatscher, Fabio Lo Calzo, Troy D Wood, Antongiulio Faggiano, Andrea Isidori, Annamaria Cola. Serotonin pathway in carcinoid syndrome: Clinical, diagnostic, prognostic and therapeutic implications. Reviews in endocrine & metabolic disorders. vol 21. issue 4. 2021-09-27. PMID:32152781. |
serotonin pathway is complex, resulting in production of biologically active molecules such as serotonin and melatonin, as well as of different intermediate molecules and final metabolites. |
2021-09-27 |
2023-08-13 |
Not clear |
| Pragathi Balakrishna, Sagila George, Hassan Hatoum, Sarbajit Mukherje. Serotonin Pathway in Cancer. International journal of molecular sciences. vol 22. issue 3. 2021-09-08. PMID:33525332. |
this review article describes serotonin's role in cancer pathogenesis and the utility of the serotonin pathway as a potential therapeutic target in cancer treatment. |
2021-09-08 |
2023-08-13 |
Not clear |
| S V Larsen, K Köhler-Forsberg, V H Dam, A S Poulsen, C Svarer, P S Jensen, G M Knudsen, P M Fisher, B Ozenne, V G Frokjae. Oral contraceptives and the serotonin 4 receptor: a molecular brain imaging study in healthy women. Acta psychiatrica Scandinavica. vol 142. issue 4. 2021-08-18. PMID:33314049. |
here, we investigate whether use of ocs in healthy women is associated with a marker of the serotonin system in terms of serotonin 4 receptor (5-ht4r) brain imaging. |
2021-08-18 |
2023-08-13 |
Not clear |
| Jun-Qi Yao, Chang Liu, Zeng-Liang Jin, Yan-Qin Liu, Yong-Yu Yin, Xin-Xin Fang, Yu-Hua Ran, Li-Ming Zhang, Yun-Feng L. Serotonergic transmission is required for the anxiolytic-like behavioral effects of YL-IPA08, a selective ligand targeting TSPO. Neuropharmacology. vol 178. 2021-08-12. PMID:32693005. |
since 5-ht is one of the most comprehensively studied neurotransmitter systems in the anxiety field, in the present study, we want to investigate whether 5-ht system is involved in the anxiolytic-like effects of yl-ipa08, a novel tspo ligand designed and synthesized at our institute. |
2021-08-12 |
2023-08-13 |
mouse |
| Zhicheng Jin, Jianer Ling, Jing Yu, Mengzi He, Pingping Ni, Fang Zhang, Yizhen Wan. Serotonin 2A receptor function and depression-like behavior in rats model of hypothyroidism. Experimental brain research. vol 239. issue 8. 2021-08-12. PMID:34106297. |
in conclusion, our results suggest that hypothyroidism induces depressive behaviors through the influence of the serotonin system, and the decreased expression of the 5-ht[formula: see text] receptor is an important cause of the depressive behaviors in hypothyroidism. |
2021-08-12 |
2023-08-13 |
rat |
| Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. |
this study aims to evaluate maternal hfd effects, during pregnancy and lactation, upon dams/mice offspring nutritional status, protein and gene expression of inflammatory pathway (jnk, pjnk and tnf-α), serotonin system molecules (tryptophan hydroxylase 2 (tph2), key-enzyme of serotonin synthesis, serotonin transporter (sert); 5-ht1a serotonergic receptor (5-ht1a)) and brain derived neurotrophic factor (bdnf) on recently weaned mice offspring hippocampus. |
2021-08-11 |
2023-08-13 |
mouse |
| Mauricio Sepulveda, Elizabeth E Manning, Andrea Gogos, Matthew Hale, Maarten van den Buus. Long-term effects of young-adult methamphetamine on dorsal raphe serotonin systems in mice: Role of brain-derived neurotrophic factor. Brain research. vol 1762. 2021-08-11. PMID:33737066. |
to assess the long-term effects of chronic adolescent methamphetamine (meth) treatment on the serotonin system in the brain, we used serotonin-1a receptor (5-ht |
2021-08-11 |
2023-08-13 |
mouse |
| Vinicius Kannen, Michael Bader, Juliana Y Sakita, Sergio A Uyemura, Jeremy A Squir. The Dual Role of Serotonin in Colorectal Cancer. Trends in endocrinology and metabolism: TEM. vol 31. issue 8. 2021-08-09. PMID:32439105. |
here, we review the diverse roles of 5-ht in intestinal homeostasis and in crc and discuss how improved understanding of the modulation of the 5-ht pathway could be helpful for the design of novel anticancer therapies. |
2021-08-09 |
2023-08-13 |
Not clear |
| Frederick S Barrett, Clifford I Workman, Haris I Sair, Alena V Savonenko, Michael A Kraut, Devin J Sodums, Jin J Joo, Najlla Nassery, Christopher M Marano, Cynthia A Munro, Jason Brandt, Yun Zhou, Dean F Wong, Gwenn S Smit. Association between serotonin denervation and resting-state functional connectivity in mild cognitive impairment. Human brain mapping. vol 38. issue 7. 2021-07-03. PMID:28379618. |
serotonin neurodegeneration has been observed in mci and ad and is associated with cognitive deficits and neuropsychiatric symptoms, but the role of the serotonin system in relation to brain network dysfunction has not been a major focus of investigation. |
2021-07-03 |
2023-08-13 |
human |
| Max Andersson, Ämma Tangen, Lars Farde, Sven Bölte, Christer Halldin, Jacqueline Borg, Johan Lundber. Serotonin transporter availability in adults with autism-a positron emission tomography study. Molecular psychiatry. vol 26. issue 5. 2021-06-11. PMID:32848204. |
reuptake through the 5-ht transporter (5-htt) is the main pathway decreasing extracellular 5-ht in the brain and a marker for the 5-ht system, but in vivo investigations of the 5-htt and the 5-ht system in asd are scarce and so far inconclusive. |
2021-06-11 |
2023-08-13 |
Not clear |
| Andrea Forero, Hsing-Ping Ku, Ana Belén Malpartida, Sina Wäldchen, Judit Alhama-Riba, Christina Kulka, Benjamin Aboagye, William H J Norton, Andrew M J Young, Yu-Qiang Ding, Robert Blum, Markus Sauer, Olga Rivero, Klaus-Peter Lesc. Serotonin (5-HT) neuron-specific inactivation of Cadherin-13 impacts 5-HT system formation and cognitive function. Neuropharmacology. vol 168. 2021-05-27. PMID:32113967. |
serotonin (5-ht) neuron-specific inactivation of cadherin-13 impacts 5-ht system formation and cognitive function. |
2021-05-27 |
2023-08-13 |
mouse |
| Andrea Forero, Hsing-Ping Ku, Ana Belén Malpartida, Sina Wäldchen, Judit Alhama-Riba, Christina Kulka, Benjamin Aboagye, William H J Norton, Andrew M J Young, Yu-Qiang Ding, Robert Blum, Markus Sauer, Olga Rivero, Klaus-Peter Lesc. Serotonin (5-HT) neuron-specific inactivation of Cadherin-13 impacts 5-HT system formation and cognitive function. Neuropharmacology. vol 168. 2021-05-27. PMID:32113967. |
here, we dissect the specific impact of cdh13 on 5-ht system development and function using a 5-ht neuron-specific cdh13 knockout mouse model (conditional cdh13 knockout, cdh13 cko). |
2021-05-27 |
2023-08-13 |
mouse |
| Yen-Chen Chiu, Bang-Hung Yang, Kai-Chin Yang, Mu-N Liu, Li-Yu Hu, Ying-Jay Liou, Li-Yi Chan, Yuan-Hwa Cho. A study of tryptophan, kynurenine and serotonin transporter in first-episode drug-naïve major depressive disorder. Psychiatry research. Neuroimaging. vol 312. 2021-05-20. PMID:33945927. |
the serotonin system is mainly modulated by the serotonin transporter (sert) which regulates serotonin uptake and the metabolism of its precursor, tryptophan and following kynurenine pathway. |
2021-05-20 |
2023-08-13 |
Not clear |
| Dan Wang, Hui-Ling Tian, Xia Cui, Qian Wang, Fan Guo, Wen Zhang, Qi-Sheng Tan. Effects of Jian-Pi-Zhi-Dong Decoction on the Expression of 5-HT and Its Receptor in a Rat Model of Tourette Syndrome and Comorbid Anxiety. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-13. PMID:32738135. |
conclusions jpzdd alleviated both tic and anxiety symptoms and the mechanism may be via reducing the expression of 5-ht2c mrna in the striatum, increasing the concentration of 5-ht, and enhancing the activity of the 5-ht system, which in turn exerts neuro-inhibition. |
2021-05-13 |
2023-08-13 |
rat |
| Katarzyna Wicha-Komsta, Robert Skibiński, Tomasz Kocki, Waldemar A Turski, Łukasz Komst. HPLC Gradient Retention of Tryptophan and its Metabolites on Three Stationary Phases in Context of Lipophilicity Assessment. Journal of chromatographic science. vol 59. issue 1. 2021-05-03. PMID:33107556. |
this paper is a continuation of lipophilicity research on 14 compounds (tryptophan, kynurenine pathway products, auxin pathway products, serotonin pathway products, tryptamine, as well as two synthetic auxin analogs): indole-2-acetic acid sodium salt (iaa), serotonin, 5-hydroxy-l-tryptophan, tryptamine, l-tryptophan, l-kynurenine (kyn), kynurenic acid (kya), 3-hydroxy-dl-kynurenine, naphtyl-1-acetamide, indole-3-propionic acid (ipa), naphthalene-1-acetic acid (naa), indole-3-butyric acid (iba), indole-3-pyruvic acid (ipv), as well as melatonin. |
2021-05-03 |
2023-08-13 |
Not clear |
| József Bódis, Endre Sulyok, Ákos Várnagy, Miklós Koppán, Gábor Kovács . Investigations of follicular fluid biomarkers in patients undergoing Orvosi hetilap. vol 162. issue 14. 2021-04-02. PMID:33784245. |
it was confirmed that the autocrine/paracrine serotonin system is functional already at the earliest stage of development and both maternal serum and follicular fluid serotonin levels were positively related to the number of mature oocytes (β = 0.447, p = 0.015 and β = 0.443, p = 0.016, respectively) and clinical pregnancy (β = 1.028, p = 0.047). |
2021-04-02 |
2023-08-13 |
Not clear |
| Rajapillai L I Pillai, Elizabeth A Bartlett, Mala R Ananth, Chencan Zhu, Jie Yang, Greg Hajcak, Ramin V Parsey, Christine DeLorenz. Examining the underpinnings of loudness dependence of auditory evoked potentials with positron emission tomography. NeuroImage. vol 213. 2021-02-15. PMID:32169543. |
to examine ldaep's relationship with the serotonin system, we performed pet using serotonin-1a (5-ht |
2021-02-15 |
2023-08-13 |
Not clear |
| Philippe De Deurwaerdère, Giuseppe Di Giovann. Serotonin in Health and Disease. International journal of molecular sciences. vol 21. issue 10. 2021-02-12. PMID:32429111. |
the recent progress made on the function and dysfunction of the 5-ht system will certainly increase the understanding of the widespread role of 5-ht ultimately leading to better apprehend its targeting in human diseases. |
2021-02-12 |
2023-08-13 |
human |
| Ana M Martins, Andreia Ascenso, Helena Margarida Ribeiro, Joana Mart. Current and Future Therapies for Psoriasis with a Focus on Serotonergic Drugs. Molecular neurobiology. vol 57. issue 5. 2021-02-03. PMID:32062841. |
finally, we discuss the role of the serotonin system in psoriasis, and summarize what is known about the effects of antidepressants, in particular specific serotonin reuptake inhibitors, on the physical symptoms of this disease. |
2021-02-03 |
2023-08-13 |
Not clear |
| Karin Hrovatin, Tanja Kunej, Vita Dolža. Genetic variability of serotonin pathway associated with schizophrenia onset, progression, and treatment. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 183. issue 2. 2021-01-04. PMID:31674148. |
genes associated with sz are present on all levels of serotonin pathway: serotonin synthesis, transport, receptor binding, intracellular signaling, and reuptake; however, regulatory genes are poorly researched. |
2021-01-04 |
2023-08-13 |
Not clear |