| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qi Li, Baijian Jiang, Zhiqiang Zhang, Yongxiong Huang, Zhou Xu, Xinjin Chen, Xitan Hou, Jia Cai, Yu Huang, Jichang Jia. Serotonin system is partially involved in immunomodulation of Nile tilapia ( Frontiers in immunology. vol 13. 2022-08-15. PMID:35967362. |
serotonin system is partially involved in immunomodulation of nile tilapia ( serotonin (5-hydroxytryptamine) is a well-known neurotransmitter affecting emotion, behavior, and cognition. |
2022-08-15 |
2023-08-14 |
Not clear |
| Basile Coutens, Antoine Yrondi, Claire Rampon, Bruno P Guiar. Psychopharmacological properties and therapeutic profile of the antidepressant venlafaxine. Psychopharmacology. 2022-08-10. PMID:35947166. |
currently, the first-line treatment for md targets the serotonin system but these drugs, notably the selective serotonin reuptake inhibitors, usually need 4 to 6 weeks before the benefit is felt and a significant proportion of patients shows an unsatisfactory response. |
2022-08-10 |
2023-08-14 |
Not clear |
| Howard M Lazarus, Jill Denning, Stephen Wring, Michelle Palacios, Sidra Hoffman, Katelyn Crizer, Watiri Kamau-Kelley, William Symonds, Jeremy Feldma. A trial design to maximize knowledge of the effects of rodatristat ethyl in the treatment of pulmonary arterial hypertension (ELEVATE 2). Pulmonary circulation. vol 12. issue 2. 2022-07-07. PMID:35795492. |
targeting the serotonin pathway via inhibition of peripheral serotonin and local production in diseased tissues, rather than individual receptor-mediated or receptor-independent mechanisms, may result in the ability to halt or reverse pulmonary vascular remodeling. |
2022-07-07 |
2023-08-14 |
human |
| Danna Wang, Jianbin Wu, Peilin Zhu, Hanqi Xie, Lianxiao Lu, Wanting Bai, Weixi Pan, Renjie Shi, Jin Ye, Bing Xia, Zhenting Zhao, Yutang Wang, Xuebo Liu, Beita Zha. Tryptophan-rich diet ameliorates chronic unpredictable mild stress induced depression- and anxiety-like behavior in mice: The potential involvement of gut-brain axis. Food research international (Ottawa, Ont.). vol 157. 2022-06-28. PMID:35761597. |
besides, cums also enhanced the kynurenine pathway, but repressed the serotonin pathway and indole pathway of tryptophan metabolism, leading to a decrease in 5-ht and indole in serum, whereas tryptophan supplementation might shift the tryptophan metabolism more toward the serotonin pathway in cums-treated mice. |
2022-06-28 |
2023-08-14 |
mouse |
| Hayet Kouchi, Michaël Ogier, Gabriel Dieuset, Anne Morales, Béatrice Georges, Jean-Louis Rouanet, Benoît Martin, Philippe Ryvlin, Sylvain Rheims, Laurent Bezi. Respiratory dysfunction in two rodent models of chronic epilepsy and acute seizures and its link with the brainstem serotonin system. Scientific reports. vol 12. issue 1. 2022-06-17. PMID:35715469. |
as the brainstem 5-ht system is a prominent modulator of respiratory function, this study aimed at determining whether epilepsy is associated with alterations in both the respiratory function and brainstem serotonin (5-ht) system in rats. |
2022-06-17 |
2023-08-14 |
mouse |
| Kevin A Hope, Alexys R Berman, Randall T Peterson, Clement Y Cho. An in vivo drug repurposing screen and transcriptional analyses reveals the serotonin pathway and GSK3 as major therapeutic targets for NGLY1 deficiency. PLoS genetics. vol 18. issue 6. 2022-06-02. PMID:35653343. |
this study reveals the importance of the serotonin pathway in ngly1 deficiency, and serotonin modulators or gsk3 inhibitors may be effective therapeutics for this rare disease. |
2022-06-02 |
2023-08-14 |
drosophila_melanogaster |
| Elizabeth A Bartlett, Francesca Zanderigo, Denise Shieh, Jeffrey Miller, Patrick Hurley, Harry Rubin-Falcone, Maria A Oquendo, M Elizabeth Sublette, R Todd Ogden, J John Man. Serotonin transporter binding in major depressive disorder: impact of serotonin system anatomy. Molecular psychiatry. 2022-04-29. PMID:35487966. |
serotonin transporter binding in major depressive disorder: impact of serotonin system anatomy. |
2022-04-29 |
2023-08-13 |
Not clear |
| F Bavato, S Stamatakos, C M Yde Ohki, E Seifritz, P Romualdi, E Grünblatt, B B Quedno. Brain-derived neurotrophic factor protects serotonergic neurons against 3,4-methylenedioxymethamphetamine ("Ecstasy") induced cytoskeletal damage. Journal of neural transmission (Vienna, Austria : 1996). 2022-04-14. PMID:35420371. |
our findings confirmed that bdnf levels can influence mdma-induced 5-ht damage, and support bdnf to be a crucial target for neuroprotective interventions of the 5-ht system. |
2022-04-14 |
2023-08-13 |
human |
| Runlong Zhao, Yalin Zhou, Hanxu Shi, Wanyun Ye, Ying Lyu, Zhang Wen, Rui Li, Yajun X. Effect of Gestational Diabetes on Postpartum Depression-like Behavior in Rats and Its Mechanism. Nutrients. vol 14. issue 6. 2022-03-26. PMID:35334886. |
the hpa axis hormone did not show the typical stress state of depression, but the level of 5-ht decreased significantly in serum, prefrontal cortex and hippocampus, and the kyn/trp ratio increased significantly in serum and prefrontal cortex, implying the switch of the tryptophan (trp) metabolism from the 5-ht pathway to the kynurenine (kyn) pathway. |
2022-03-26 |
2023-08-13 |
rat |
| Lluis Miquel-Rio, Diana Alarcón-Arís, María Torres-López, Valentín Cóppola-Segovia, Rubén Pavia-Collado, Verónica Paz, Esther Ruiz-Bronchal, Leticia Campa, Carme Casal, Andrés Montefeltro, Miquel Vila, Francesc Artigas, Raquel Revilla, Analia Bortolozz. Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapy. Translational psychiatry. vol 12. issue 1. 2022-02-25. PMID:35210396. |
we showed that adeno-associated virus (aav5)-induced overexpression of wild-type human α-syn (h-α-syn) in raphe 5-ht neurons triggers progressive accumulation, phosphorylation, and aggregation of h-α-syn protein in the 5-ht system. |
2022-02-25 |
2023-08-13 |
mouse |
| Lluís Fabà, Nienke de Groot, Guillermo Ramis, Carolina G Cabrera-Gómez, John Doelma. Serotonin receptors and their association with the immune system in the gastrointestinal tract of weaning piglets. Porcine health management. vol 8. issue 1. 2022-01-29. PMID:35090573. |
a disruption of the 5-ht system post-weaning with transcriptional upregulation of 5-ht receptors may be linked to increased cytokine mrna abundance and immune system activation. |
2022-01-29 |
2023-08-13 |
Not clear |
| Qi Wang, Ya-Nan Sun, Chun-Ming Zou, Te-Li Zhang, Zhu Li, Min Liu, Bi-Ying Shi, Shan-Shan Shi, Chun-Yue Yu, Tai-Ming We. Regulation of the kynurenine/serotonin pathway by berberine and the underlying effect in the hippocampus of the chronic unpredictable mild stress mice. Behavioural brain research. 2022-01-20. PMID:35051489. |
this study was to investigate the hypothesis that bbr treats depressive-like behavior by shifting the balance of the kynurenine (kyn)/serotonin (5-ht) pathway toward the 5-ht pathway through downregulated indoleamine 2,3-dioxygenase 1 (ido1), monoamine oxidase a (maoa) and upregulated dopamine decarboxylase (ddc) in hippocampus. |
2022-01-20 |
2023-08-13 |
mouse |
| Vijayakumar Mavanji, Brianna Pomonis, Catherine M Kot. Orexin, serotonin, and energy balance. WIREs mechanisms of disease. vol 14. issue 1. 2022-01-13. PMID:35023323. |
in addition, we discuss possible brain areas involved in orexin-serotonin cross-talk; the role of serotonin receptors, transporters and uptake-inhibitors in the pathogenesis and treatment of obesity; animal models of obesity with impaired serotonin-function; single-nucleotide polymorphisms in the serotonin system and obesity; and future directions in the orexin-serotonin field. |
2022-01-13 |
2023-08-13 |
Not clear |
| Faranak Vahid-Ansari, Paul R Alber. Rewiring of the Serotonin System in Major Depression. Frontiers in psychiatry. vol 12. 2022-01-03. PMID:34975594. |
the 5-ht neurons have the unusual capacity to regrow and reinnervate brain regions following insults such as brain injury, chronic stress, or altered development that result in disconnection of the 5-ht system and often cause depression, anxiety, and cognitive impairment. |
2022-01-03 |
2023-08-13 |
Not clear |
| Faranak Vahid-Ansari, Paul R Alber. Rewiring of the Serotonin System in Major Depression. Frontiers in psychiatry. vol 12. 2022-01-03. PMID:34975594. |
chronic treatment with antidepressants that amplify 5-ht action, such as selective serotonin reuptake inhibitors (ssris), appears to accelerate the rewiring of the 5-ht system by mechanisms that may be critical to the behavioral and cognitive improvements induced in these models. |
2022-01-03 |
2023-08-13 |
Not clear |
| De-Wei Yang, Jie Su. [Correlation of lifelong premature ejaculation with 5-HT system gene polymorphism]. Zhonghua nan ke xue = National journal of andrology. vol 27. issue 8. 2021-12-16. PMID:34914250. |
the pathogenesis of lpe has not been clarified, but it is believed to be related to the regulation of 5-ht and the 5-ht1a and 5-ht2c receptors from the perspective of the theory of 5-ht system neurotransmitter disorder. |
2021-12-16 |
2023-08-13 |
Not clear |
| Nirupa Goel, Tristan J Philippe, Judy Chang, Maya E Koblanski, Victor Via. Cellular and serotonergic correlates of habituated neuroendocrine responses in male and female rats. Psychoneuroendocrinology. vol 136. 2021-12-10. PMID:34891046. |
serotonin staining in the dorsal raphe and terminal profiles in the forebrain continued to reflect a higher pre-synaptic capacity for the 5-ht system in females. |
2021-12-10 |
2023-08-13 |
rat |
| Rezvan Yaghoubfar, Ava Behrouzi, Ehsan Zare Banadkoki, Fatemeh Ashrafian, Arezou Lari, Farzam Vaziri, Seyed Ali Nojoumi, Abolfazl Fateh, Shohreh Khatami, Seyed Davar Siada. Effect of Akkermansia muciniphila, Faecalibacterium prausnitzii, and Their Extracellular Vesicles on the Serotonin System in Intestinal Epithelial Cells. Probiotics and antimicrobial proteins. vol 13. issue 6. 2021-12-09. PMID:33852147. |
our findings showed that a. muciniphila and f. prausnitzii along with their evs could modulate serotonin system-related genes; hence, they may be useful in microbiota modulation therapies to maintain the homeostasis of the serotonin system. |
2021-12-09 |
2023-08-13 |
human |
| Paul Andrews, Jay Amsterda. A hormetic approach to understanding antidepressant effectiveness and the development of antidepressant tolerance - A conceptual view. Psychiatria polska. vol 54. issue 6. 2021-09-29. PMID:33740797. |
specifically, the serotonin system adapts to ssris by suppressing the firing of serotonergic neurons, inhibiting the synthesis of serotonin, and reducing the overall content of serotonin in the brain. |
2021-09-29 |
2023-08-13 |
Not clear |
| Cláudia Teixeira, Pedro Rodrigues, Paula Serrão, Luís Figueira, Laura Guimarães, Luís Oliva Teles, Helena Peres, António Paulo Carvalh. Dietary tryptophan supplementation does not affect growth but increases brain serotonin level and modulates the expression of some liver genes in zebrafish (Danio rerio). Fish physiology and biochemistry. vol 47. issue 5. 2021-09-29. PMID:34370152. |
this study aimed at assessing the effects of the dietary tryptophan (trp) supplementation on growth and feed utilization, brain serotonin content, and expression of selected liver genes (involved in the liver serotonin pathway, protein synthesis degradation, and antioxidant activity) in zebrafish. |
2021-09-29 |
2023-08-13 |
zebrafish |