| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robbie Schepers, C Robert Marku. The interaction between 5-HTTLPR genotype and ruminative thinking on BMI. The British journal of nutrition. vol 118. issue 8. 2017-10-30. PMID:28969722. |
a short (s) allele polymorphism in the serotonin transporter gene (5-httlpr) is associated with a less efficient functioning brain serotonin system and therefore higher stress vulnerability. |
2017-10-30 |
2023-08-13 |
Not clear |
| Renata Ferreira, Marcus Lira Brandão, Manoel Jorge Nobr. 5-HT1A receptors of the prelimbic cortex mediate the hormonal impact on learned fear expression in high-anxious female rats. Hormones and behavior. vol 84. 2017-10-03. PMID:27328163. |
furthermore, we investigate the role of the 5-ht system of the prl, particularly the 5-ht1a receptors, as a possible modulator of estrous cycle influence on the expression of learned fear through intra-prl microinjections of 5-ht itself or the full 5-ht1a agonist 8-oh-dpat (8-hydroxy-2-(di-n-propylamine)tetralin). |
2017-10-03 |
2023-08-13 |
human |
| Meredith Sorenson Whitney, Ashley M Shemery, Alexandra M Yaw, Lauren J Donovan, J David Glass, Evan S Deneri. Adult Brain Serotonin Deficiency Causes Hyperactivity, Circadian Disruption, and Elimination of Siestas. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 38. 2017-08-17. PMID:27656022. |
here, we have developed a genetic approach that reproducibly achieves near-complete elimination of 5-ht synthesis from the adult ascending 5-ht system by stereotaxic injection of an adeno-associated virus expressing cre recombinase (aav-cre) into the midbrain/pons of mice carrying a loxp-conditional tryptophan hydroxylase 2 (tph2) allele. |
2017-08-17 |
2023-08-13 |
mouse |
| Dong-Fang He, Yan-Ping Ren, Mei-Yan Li. Effects of Ginseng Fruit Saponins on Serotonin System in Sprague-Dawley Rats with Myocardial Infarction, Depression, and Myocardial Infarction Complicated with Depression. Chinese medical journal. vol 129. issue 24. 2017-03-13. PMID:27958222. |
our previous studies have demonstrated that the levels of 5-hydroxytryptamine (5-ht) and 5-ht 2a receptor (5-ht2ar) in serum and platelet were associated with depression and myocardial infarction (mi), and pretreatment with ginseng fruit saponins (gfs) before mi and depression had an effect on the 5-ht system. |
2017-03-13 |
2023-08-13 |
rat |
| Wenjuan Wang, Guangxia Cui, Biao Jin, Ke Wang, Xing Chen, Yu Sun, Lihua Qin, Wenpei Ba. Estradiol Valerate and Remifemin ameliorate ovariectomy-induced decrease in a serotonin dorsal raphe-preoptic hypothalamus pathway in rats. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. vol 208. 2017-02-07. PMID:27562857. |
we conclude that serotonin pathway is changed after ovariectomy, including the serotonin synthesis in dr and serotonin fibers in po/ah, both e and remifemin have an equivalent therapeutic effect on it. |
2017-02-07 |
2023-08-13 |
rat |
| In-Jee You, Sherie R Wright, Alvaro L Garcia-Garcia, Andrew R Tapper, Paul D Gardner, George F Koob, E David Leonardo, Laura M Bohn, Sunmee We. 5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 5. 2016-12-14. PMID:26324408. |
the 5-ht system in the brain is carefully controlled by a combined process of regulating 5-ht neuron firing through 5-ht autoreceptors, neurotransmitter release, enzymatic degradation, and reuptake by transporters. |
2016-12-14 |
2023-08-13 |
mouse |
| Inbar Zohar, Shai Shoham, Marta Weinstoc. Perinatal citalopram does not prevent the effect of prenatal stress on anxiety, depressive-like behaviour and serotonergic transmission in adult rat offspring. The European journal of neuroscience. vol 43. issue 4. 2016-12-13. PMID:26669896. |
it had adverse behavioural effects in the offspring of control rats, which, together with the lack of any change in prenatally-stressed rats, may be due to inhibition of the foetal serotonin transporter thereby preventing normal development of the serotonin system. |
2016-12-13 |
2023-08-13 |
rat |
| Koen Hogenelst, Anastasios Sarampalis, N Pontus Leander, Barbara C N Müller, Robert A Schoevers, Marije aan het Ro. The effects of acute tryptophan depletion on speech and behavioural mimicry in individuals at familial risk for depression. Journal of psychopharmacology (Oxford, England). vol 30. issue 3. 2016-12-13. PMID:26755543. |
mdd has also been associated with disturbances in the brain serotonin system, but the extent to which serotonin regulates speech and behavioural mimicry remains unclear. |
2016-12-13 |
2023-08-13 |
human |
| Wanhong Zuo, Yong Zhang, Guiqin Xie, Danielle Gregor, Alex Bekker, Jiang-Hong Y. Serotonin stimulates lateral habenula via activation of the post-synaptic serotonin 2/3 receptors and transient receptor potential channels. Neuropharmacology. vol 101. 2016-10-05. PMID:26471419. |
these results demonstrate that the reciprocal connection between the lhb and the 5-ht system highlights a key role for 5-ht stimulation of lhb neurons that may be important in the pathogenesis of depression. |
2016-10-05 |
2023-08-13 |
rat |
| Daan van Rooij, Catharina A Hartman, Marjolein M J van Donkelaar, Janita Bralten, Daniel von Rhein, Marina Hakobjan, Barbara Franke, Dirk J Heslenfeld, Jaap Oosterlaan, Nanda Rommelse, Jan K Buitelaar, Pieter J Hoekstr. Variation in serotonin neurotransmission genes affects neural activation during response inhibition in adolescents and young adults with ADHD and healthy controls. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 16. issue 8. 2016-09-21. PMID:26428549. |
given the role of serotonin in adhd and impulsivity, we postulated that genetic variants within the serotonin pathway might influence response inhibition. |
2016-09-21 |
2023-08-13 |
Not clear |
| Alberto Montalbano, Jonas Waider, Mario Barbieri, Ozan Baytas, Klaus-Peter Lesch, Renato Corradetti, Boris Mlina. Cellular resilience: 5-HT neurons in Tph2(-/-) mice retain normal firing behavior despite the lack of brain 5-HT. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 11. 2016-08-26. PMID:26409296. |
it is well established that the brain 5-ht system is under autoregulatory control by its principal transmitter 5-ht via its effects on activity and expression of 5-ht system-related proteins. |
2016-08-26 |
2023-08-13 |
mouse |
| M Kondo, Y Nakamura, Y Ishida, S Shimad. The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects. Molecular psychiatry. vol 20. issue 11. 2016-08-02. PMID:25403840. |
brain serotonin (5-hydroxytryptamine, 5-ht) levels increase following exercise, and the 5-ht system has been suggested to have an important role in these exercise-induced neuronal effects. |
2016-08-02 |
2023-08-13 |
mouse |
| Luis Rodrigo Cataldo, Víctor Antonio Cortés, José Eduardo Galgani, Pablo Roberto Olmos, José Luis Santo. [Role of peripheral serotonin in the insulin secretion and glucose homeostasis]. Nutricion hospitalaria. vol 30. issue 3. 2016-07-28. PMID:25238823. |
additionally, other tissues such as the endocrine pancreas, particularly β-cells, have its own serotonin system able to synthesize, secrete and respond to extracellular 5ht through cell surface receptors subtypes that have been grouped in 7 families (htr1-7). |
2016-07-28 |
2023-08-13 |
Not clear |
| Xiaoxia Zhu, Linlin Jing, Chun Chen, Meng Shao, Qin Fan, Jianxin Diao, Yuanliang Liu, Zhiping Lv, Xuegang Su. Danzhi Xiaoyao San ameliorates depressive-like behavior by shifting toward serotonin via the downregulation of hippocampal indoleamine 2,3-dioxygenase. Journal of ethnopharmacology. vol 160. 2016-05-23. PMID:25435286. |
this study is aimed to investigate the hypothesis that dxs treats depressive-like behavior by shifting the balance of the kynurenine (kyn)/serotonin (5-ht) pathway toward the 5-ht pathway through the downregulation of hippocampal indoleamine 2,3-dioxygenase (ido). |
2016-05-23 |
2023-08-13 |
Not clear |
| Markus Wöhr, Marcel M van Gaalen, Rainer K W Schwartin. Affective communication in rodents: serotonin and its modulating role in ultrasonic vocalizations. Behavioural pharmacology. vol 26. issue 6. 2016-05-05. PMID:26221830. |
consequently, the 5-ht system is implicated in various neuropsychiatric disorders, such as anxiety disorders and depression or autism spectrum disorders (asd), with selective 5-ht reuptake inhibitors being the frontline medication. |
2016-05-05 |
2023-08-13 |
mouse |
| Markus Wöhr, Marcel M van Gaalen, Rainer K W Schwartin. Affective communication in rodents: serotonin and its modulating role in ultrasonic vocalizations. Behavioural pharmacology. vol 26. issue 6. 2016-05-05. PMID:26221830. |
so far, little is known about the role of 5-ht in the production of interaction-induced usv in mice and appetitive 50-khz usv in rats, although recent findings also suggest a modulatory effect of the 5-ht system. |
2016-05-05 |
2023-08-13 |
mouse |
| Terrell Holloway, Javier González-Maes. Epigenetic Mechanisms of Serotonin Signaling. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25734378. |
the cardinal signal transduction mechanisms via serotonin and its receptors are well established, but fundamental questions regarding complex interactions between the serotonin system and heritable epigenetic modifications that exert control on gene function remain a topic of intense research and debate. |
2016-04-19 |
2023-08-13 |
Not clear |
| N K Popova, E G Ponimaskin, V S Naumenk. [CROSS-TALK BETWEEN 5-HT1A AND 5-HT7 RECEPTORS: ROLE IN THE AUTOREGULATION OF THE BRAIN SEROTONIN SYSTEM AND IN MECHANISM OF ANTIDEPRESSANTS ACTION]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 101. issue 11. 2016-04-08. PMID:26995955. |
the results described in the present review indicate that: i) dimerization and formation of mobile receptor complexes is a common feature for the members of g-protein coupled receptor superfamily; ii) 5-ht7 receptor appears to be a modulator for 5-ht1a receptor - the key autoregulator of the brain serotonin system; iii) 5-ht1a/5-ht7 receptor complexes formation is one of the mechanisms for inactivation and desensitization of the 5-htia receptors in the brain; iv) differences in the 5-ht7 receptor and 5-htia/5-ht7 heterodimers density define different sensitivity of pre- and postsynaptic 5-htla receptors to chronic treatment with selective serotonin reuptake inhibitors. |
2016-04-08 |
2023-08-13 |
Not clear |
| H G Westenber. Biological concepts of anxiety disorders. Acta neuropsychiatrica. vol 9. issue 2. 2016-03-14. PMID:26972132. |
the complexity of the 5-ht system in terms of receptor heterogeneity offers a dazzling opportunity to the development of new drugs affecting selective 5-ht functions, but it also precludes that firm conclusions can be drawn when less selective agents are being used. |
2016-03-14 |
2023-08-13 |
human |
| José-Ángel García-Pedraza, Mónica García, María-Luisa Martín, Asunción Morá. Pharmacological evidence that 5-HT1D activation induces renal vasodilation by NO pathway in rats. Clinical and experimental pharmacology & physiology. vol 42. issue 6. 2016-02-29. PMID:25854421. |
this study aimed to investigate whether, behind the predominant serotonergic vasoconstrictor action, the 5-ht system may exert renal vasodilator actions, and, if so, characterize the 5-ht receptors and possible indirect pathways. |
2016-02-29 |
2023-08-13 |
rat |