| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jens H van Dalfsen, C Rob Marku. The serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the sleep-promoting effects of tryptophan: A randomized placebo-controlled crossover study. Journal of psychopharmacology (Oxford, England). vol 33. issue 8. 2020-07-27. PMID:31237183. |
the low-expressive short (s) allele of a functional polymorphism (5-httlpr) within the serotonin (5-hydroxytriptamine; 5-ht) transporter gene (slc6a4) has been associated with a reduced functioning of the brain 5-ht system relative to the long (l) allele. |
2020-07-27 |
2023-08-13 |
Not clear |
| Zsombor Szoke-Kovacs, Csaba More, Rita Szoke-Kovacs, Endre Mathe, Ede Frecsk. Selective Inhibition of the Serotonin Transporter in the Treatment of Depression: Sertraline, Fluoxetine and Citalopram. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 22. issue 1. 2020-07-09. PMID:32329748. |
drugs from this class alter the functioning of the serotonin system by the potentiation of serotonin through the negative allosteric modulation of its neuronal uptake by the human serotonin transporter. |
2020-07-09 |
2023-08-13 |
human |
| Kevin J Cummings, Matthew R Hodge. The serotonergic system and the control of breathing during development. Respiratory physiology & neurobiology. vol 270. 2020-06-01. PMID:31362064. |
this review focuses on what is known about the developmental roles for the 5-ht system, which we define as the neurons producing 5-ht along with pre-and post-synaptic receptors, in a vital homeostatic motor behavior - the control of breathing. |
2020-06-01 |
2023-08-13 |
human |
| Kevin J Cummings, Matthew R Hodge. The serotonergic system and the control of breathing during development. Respiratory physiology & neurobiology. vol 270. 2020-06-01. PMID:31362064. |
we will cover what is known about the embryonic origins and fate specification of 5-ht neurons, and how the 5-ht system influences pre- and post-natal maturation of the ventilatory control system. |
2020-06-01 |
2023-08-13 |
human |
| Yu L L Luo, Keith M Welker, Baldwin Way, Nathan DeWall, Brad J Bushman, Tim Wildschut, Constantine Sedikide. 5-HTTLPR polymorphism is associated with nostalgia proneness: The role of neuroticism. Social neuroscience. vol 14. issue 2. 2020-04-27. PMID:29210327. |
we focused on a polymorphism in the promoter of the serotonin transporter gene (5-httlpr) as a possible biological basis of nostalgia proneness, because the serotonin system has been associated with sensitivity to negative experience. |
2020-04-27 |
2023-08-13 |
human |
| Joseph S Lonstei. The dynamic serotonin system of the maternal brain. Archives of women's mental health. vol 22. issue 2. 2020-04-27. PMID:30032323. |
more information about the normative and stress-derailed changes in the maternal central serotonin system is essential for understanding how serotonin is involved in the etiology of, and the best use of ssris for potentially treating, affective disorders in the pregnant and postpartum populations. |
2020-04-27 |
2023-08-13 |
Not clear |
| Le Wang, Yanming Zhang, Xia Du, Teng Ding, Weiling Gong, Feng Li. Review of antidepressants in clinic and active ingredients of traditional Chinese medicine targeting 5-HT1A receptors. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 120. 2020-04-21. PMID:31541883. |
the 5-ht1a receptor is a key protein in the brain serotonin system, modulating the release of 5-ht and other neurotransmitters. |
2020-04-21 |
2023-08-13 |
Not clear |
| J John Mann, Allison V Metts, R Todd Ogden, Chester A Mathis, Harry Rubin-Falcone, Zhiqun Gong, Wayne C Drevets, Jamie Zelazny, David A Bren. Quantification of 5-HT Archives of suicide research : official journal of the International Academy for Suicide Research. vol 23. issue 1. 2020-04-16. PMID:29281590. |
quantification of 5-ht to determine serotonin system abnormalities related to major depression or previous suicidal behavior. |
2020-04-16 |
2023-08-13 |
Not clear |
| Magnus Sjögren, Anna Skovgaard Møller Nielsen, Katharina Collin Hasselbalch, Maria Wøllo, Jitka Stilund Hanse. A systematic review of blood-based serotonergic biomarkers in Bulimia Nervosa. Psychiatry research. vol 279. 2020-03-31. PMID:30878305. |
bn deviate from healthy controls in terms of 5-ht biomarkers in blood supporting an abnormal 5-ht system in bn. |
2020-03-31 |
2023-08-13 |
Not clear |
| Nina K Popova, Vladimir S Naumenk. Neuronal and behavioral plasticity: the role of serotonin and BDNF systems tandem. Expert opinion on therapeutic targets. vol 23. issue 3. 2020-03-06. PMID:30661441. |
this review describes (1) different 5-ht functioning in the embryonic (as neurotrophin) and adult brain (as a neurotransmitter); (2) bdnf as a modulator of 5-ht system and vice versa; (3) the prolonged positive effect of bdnf on genetically and epigenetically defined central nervous system disorders; (4) the 5-ht-bdnf interplay contribution to aggressive behavior, depression, drug addiction, suicide, and stress response; and (5) the role of common second messengers for 5-ht and bdnf signaling in the 5-ht-bdnf interaction. |
2020-03-06 |
2023-08-13 |
Not clear |
| Jodi L Pawluski, Ming Li, Joseph S Lonstei. Serotonin and motherhood: From molecules to mood. Frontiers in neuroendocrinology. vol 53. 2020-01-02. PMID:30878665. |
therefore, the main goals of this review are to detail: (1) how the serotonin system of the female brain changes across pregnancy and postpartum; (2) the role of the central serotonergic system in maternal caregiving and maternal aggression; and (3) how the serotonin system and selective serotonin reuptake inhibitor medications (ssris) are involved in the treatment of maternal mental illness. |
2020-01-02 |
2023-08-13 |
Not clear |
| K.R. Powell, M.J. Picker, L.A. Dykstr. Serotonin involvement in the discriminative stimulus effects of mu and kappa opioids in rats. Behavioural pharmacology. vol 5. issue 3. 2019-11-20. PMID:11224275. |
these results suggest that the 5-ht system is involved in the discriminative stimulus effects of both morphine and u50,488, although the exact nature of this 5-ht involvement is not clear. |
2019-11-20 |
2023-08-12 |
rat |
| Klaus Peter Lesch, Armin Heil. Serotonergic gene transcriptional control regions: targets for antidepressant drug development? The international journal of neuropsychopharmacology. vol 3. issue 1. 2019-11-20. PMID:11343581. |
given the fact that the 5-ht system continues to be an important target for large-scale drug development and production, novel strategies aiming toward the modification of 5-ht function at the level of gene expression are likely to be exploited by enterprises participating actively in the introduction of alternative therapeutic approaches. |
2019-11-20 |
2023-08-12 |
Not clear |
| Ashwin A. Patkar, Wade H. Berrettini, Margaret Hoehe, Kevin P. Hill, Robert C. Sterling, Edward Gottheil, Stephen P. Weinstei. Serotonin transporter (5-HTT) gene polymorphisms and susceptibility to cocaine dependence among African-American individuals. Addiction biology. vol 6. issue 4. 2019-11-20. PMID:11900612. |
studies indicate that the serotonin system, particularly the serotonin transporter (5-htt), may modulate the central effects of cocaine. |
2019-11-20 |
2023-08-12 |
human |
| Feng C Zhou, Youssef Sari, Ting-Kai Li, Charles Goodlett, Efrain C Azmiti. Deviations in brain early serotonergic development as a result of fetal alcohol exposure. Neurotoxicity research. vol 4. issue 4. 2019-11-20. PMID:12829423. |
since 5-ht is a signal for development of many forebrain neurons, the deviation of 5-ht in early life may have consequences on brain development that extend beyond those seen in the 5-ht system. |
2019-11-20 |
2023-08-12 |
mouse |
| Elyse C Dankoski, Susan Carroll, Robert Mark Wightma. Acute selective serotonin reuptake inhibitors regulate the dorsal raphe nucleus causing amplification of terminal serotonin release. Journal of neurochemistry. vol 136. issue 6. 2019-11-20. PMID:26749030. |
the onset of antidepressant effects also coincides with desensitization of somatodendritic serotonin autoreceptors in the dorsal raphe nucleus (drn), suggesting that disrupting inhibitory feedback within the serotonin system may contribute to the therapeutic effects of ssris. |
2019-11-20 |
2023-08-13 |
mouse |
| Ayesha Sengupta, Andrew Holme. A Discrete Dorsal Raphe to Basal Amygdala 5-HT Circuit Calibrates Aversive Memory. Neuron. vol 103. issue 3. 2019-10-31. PMID:31204082. |
although fear recruits 5-ht and vglut3 co-expressing drn neurons, the fear-potentiating influence of the drn→ba 5-ht pathway requires signaling at ba 5-ht1a/2a receptors. |
2019-10-31 |
2023-08-13 |
Not clear |
| Sahel Kumar, Zsofia Gal, Xenia Gonda, Robin J Huse, Gabriella Juhasz, Gyorgy Bagdy, Peter Petschne. Transcriptomic changes following chronic administration of selective serotonin reuptake inhibitors: a review of animal studies. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 21. issue 1. 2019-04-26. PMID:30962407. |
in spite of some measurable changes in serotonin system mrna expression, serotonin transporter levels remained mostly unaltered following various treatment protocols. |
2019-04-26 |
2023-08-13 |
Not clear |
| Danilo De Gregorio, Justine P Enns, Nicolas A Nuñez, Luca Posa, Gabriella Gobb. d-Lysergic acid diethylamide, psilocybin, and other classic hallucinogens: Mechanism of action and potential therapeutic applications in mood disorders. Progress in brain research. vol 242. 2019-03-29. PMID:30471683. |
lsd, belonging to the category of "classic halluginogens," interacts with the 5-ht system through 5ht |
2019-03-29 |
2023-08-13 |
Not clear |
| Agnete Overgaard, Stephanie E Lieblich, Robin Richardson, Liisa A M Galea, Vibe G Frokjae. Paroxetine blunts the corticosterone response to swim-induced stress and increases depressive-like behavior in a rat model of postpartum depression. Psychoneuroendocrinology. vol 89. 2018-12-31. PMID:29146408. |
the serotonin system is sensitive to such hormone fluctuations, and serotonin reuptake inhibitors (ssris) are used to treat pnd, although treatment is suboptimal and it is not known at which peripartum time-point ssri treatment may be most efficacious. |
2018-12-31 |
2023-08-13 |
rat |