| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ahmed Draoui, Omar El Hiba, El Khiat Abdelaati, Abdellatif Abbaoui, Radouane El Fari, Mohamed Aitihya, Halima Gamran. Differential impairment of short working and spatial memories in a rat model of progressive Parkinson's disease onset: A focus on the prodromal stage. Brain research bulletin. vol 150. 2020-07-24. PMID:31228545. |
such deficit could arise from the loss of 5-ht innervation in bla and/or the astroglial morpho-functional changes within the hippocampus leading to possible neurophysiological disturbances of the different neighboring neuronal populations involved in short working memory. |
2020-07-24 |
2023-08-13 |
rat |
| Lokesh Agrawal, Sunil Kumar Vimal, Takashi Shig. Role of serotonin 4 receptor in the growth of hippocampal neurons during the embryonic development in mice. Neuropharmacology. vol 158. 2020-07-20. PMID:31325432. |
role of serotonin 4 receptor in the growth of hippocampal neurons during the embryonic development in mice. |
2020-07-20 |
2023-08-13 |
mouse |
| Per Plenge, Ara M Abramyan, Gunnar Sørensen, Arne Mørk, Pia Weikop, Ulrik Gether, Benny Bang-Andersen, Lei Shi, Claus J Lolan. The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter. Nature communications. vol 11. issue 1. 2020-07-17. PMID:32198394. |
the sert inhibition by lu af60097 is demonstrated by the potentiated imipramine binding and increased hippocampal serotonin level in rats. |
2020-07-17 |
2023-08-13 |
rat |
| Abdeslam Mouihate, Samah Kalakh, Rawan AlMutairi, Abdelrahman Alashqa. Prenatal Inflammation Dampens Neurogenesis and Enhances Serotonin Transporter Expression in the Hippocampus of Adult Female Rats. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. vol 28. issue 4. 2020-06-30. PMID:30884483. |
prenatal inflammation dampens neurogenesis and enhances serotonin transporter expression in the hippocampus of adult female rats. |
2020-06-30 |
2023-08-13 |
rat |
| Zhi-Long Zhang, Yu-Gang Gao, Pu Zang, Pei-Pei Gu, Yan Zhao, Zhong-Mei He, Hong-Yan Zh. [Research progress on mechanism of gastrodin and p-hydroxybenzyl alcohol on central nervous system]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 2. 2020-06-23. PMID:32237313. |
they alleviate hippocampal neuronal toxicity mainly by regulating a variety of neurotransmitters, such as acetylcholine, glutamic acid(glu), γ-aminobutyric acid(gaba), serotonin(5-ht), dopamine(da), norepinephrine(ne), 5-indoleacetic acid(5-hiaa), high vanillic acid(hva) and dihydroxyphenylacetic acid(dopac), pro-inflammatory cell growth factors, such as il-1β, il-6 and tnf-α and relevant receptor functions, and exert neuropharmacological effects by effectively increasing mrna expressions of brain neurotrophic factors, such as bdnf and gdnf, and further inhibiting the apoptosis of damaged neurons. |
2020-06-23 |
2023-08-13 |
Not clear |
| Juliane Zemdegs, Hugo Martin, Hiranya Pintana, Sebastien Bullich, Stella Manta, Marie A Marqués, Cédric Moro, Sophie Layé, Fabien Ducrocq, Nipon Chattipakorn, Siriporn C Chattipakorn, Claire Rampon, Luc Pénicaud, Xavier Fioramonti, Bruno P Guiar. Metformin Promotes Anxiolytic and Antidepressant-Like Responses in Insulin-Resistant Mice by Decreasing Circulating Branched-Chain Amino Acids. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 30. 2020-06-17. PMID:31160539. |
our results indicated that hfd-fed mice displayed impairment in the electrical activity of dorsal raphe 5-ht neurons, attenuated hippocampal extracellular 5-ht concentrations and anxiety, one of the most visible and early symptoms of depression. |
2020-06-17 |
2023-08-13 |
mouse |
| Pollyana C Leal, José Marcos M Bispo, Rovena C G J Engelberth, Kayo Diogenes de A Silva, Ywlliane R Meurer, Alessandra M Ribeiro, Regina H Silva, Murilo Marchioro, José R Santo. Serotonergic dysfunction in a model of parkinsonism induced by reserpine. Journal of chemical neuroanatomy. vol 96. 2020-06-15. PMID:30597197. |
after st, 5-ht immunoreactivity decreased in hippocampal subareas (ca1 and ca3) and medial prefrontal cortex (mpfc) compared to vehicle. |
2020-06-15 |
2023-08-13 |
rat |
| Jiacheng Lin, Zejia Song, Xiaolei Chen, Riji Zhao, Jiawen Chen, Huifeng Chen, Xiaodan Yang, Zhongping W. Trans-cinnamaldehyde shows anti-depression effect in the forced swimming test and possible involvement of the endocannabinoid system. Biochemical and biophysical research communications. vol 518. issue 2. 2020-06-15. PMID:31421826. |
moreover, tca elevated the level of 5-ht and decreased the ratio of glu/gaba in mice hippocampus. |
2020-06-15 |
2023-08-13 |
mouse |
| Abdelaati El Khiat, Lahcen Tamegart, Ahmed Draoui, Radouane El Fari, Souad Sellami, Hanane Rais, Omar El Hiba, Halima Gamran. Kinetic deterioration of short memory in rat with acute hepatic encephalopathy: Involvement of astroglial and neuronal dysfunctions. Behavioural brain research. vol 367. 2020-06-08. PMID:30928460. |
while for the behavioral study, we used t-maze test to assess short working memory using the percentage of alternation behavior, together with an immunohistochemical analysis of the glial fibrillary acidic protein (gfap) as the key marker of astrocytes in the hippocampus, as well as serotonin (5-ht) for 5-htergic neurons within the dorsal raphe nucleus (drn). |
2020-06-08 |
2023-08-13 |
rat |
| Bombi Lee, Mijung Yeom, Insop Shim, Hyejung Lee, Dae-Hyun Hah. Umbelliferone modulates depression-like symptoms by altering monoamines in a rat post-traumatic stress disorder model. Journal of natural medicines. vol 74. issue 2. 2020-06-05. PMID:31755013. |
umb treatment attenuated the sps-induced decrease in serotonin (5-ht) concentrations in the hippocampus and amygdala. |
2020-06-05 |
2023-08-13 |
rat |
| Bombi Lee, Mijung Yeom, Insop Shim, Hyejung Lee, Dae-Hyun Hah. Umbelliferone modulates depression-like symptoms by altering monoamines in a rat post-traumatic stress disorder model. Journal of natural medicines. vol 74. issue 2. 2020-06-05. PMID:31755013. |
the increased 5-ht concentration during umb treatment was partially due to a decrease in the ratio of 5-hydroxyindoleacetic acid/5-ht in the hippocampus of rats with ptsd. |
2020-06-05 |
2023-08-13 |
rat |
| Christine Gebhardt, Valentina Mosienko, Natalia Alenina, Doris Albrech. Priming of LTP in amygdala and hippocampus by prior paired pulse facilitation paradigm in mice lacking brain serotonin. Hippocampus. vol 29. issue 7. 2020-06-01. PMID:30457189. |
priming of ltp in amygdala and hippocampus by prior paired pulse facilitation paradigm in mice lacking brain serotonin. |
2020-06-01 |
2023-08-13 |
mouse |
| Huanhuan Li, Yutong Liu, Xiaoqing Gao, Lifen Liu, Siyiti Amuti, Dandan Wu, Fen Jiang, Liang Huang, Geying Wang, Jiujiang Zeng, Bin Ma, Qionglan Yua. Neuroplastin 65 modulates anxiety- and depression-like behavior likely through adult hippocampal neurogenesis and central 5-HT activity. The FEBS journal. vol 286. issue 17. 2020-05-26. PMID:31034748. |
neuroplastin 65 modulates anxiety- and depression-like behavior likely through adult hippocampal neurogenesis and central 5-ht activity. |
2020-05-26 |
2023-08-13 |
mouse |
| Huanhuan Li, Yutong Liu, Xiaoqing Gao, Lifen Liu, Siyiti Amuti, Dandan Wu, Fen Jiang, Liang Huang, Geying Wang, Jiujiang Zeng, Bin Ma, Qionglan Yua. Neuroplastin 65 modulates anxiety- and depression-like behavior likely through adult hippocampal neurogenesis and central 5-HT activity. The FEBS journal. vol 286. issue 17. 2020-05-26. PMID:31034748. |
in addition, the level of 5-hydroxytryptamine (5-ht) in the hippocampus was reduced. |
2020-05-26 |
2023-08-13 |
mouse |
| Debapriya Garabadu, Neha Srivastava, Yogesh Murt. Calotropis procera attenuates chronic unpredictable mild stress-induced depression in experimental animals. Metabolic brain disease. vol 34. issue 6. 2020-05-14. PMID:31346860. |
further, ecp (200 mg/kg) mitigated cums-induced decrease in serotonin (5-ht), increase in 5-hydroxy indole acetic acid (5-hiaa) and increase in the ratio of 5-hiaa/5-ht in hippocampus and pre-frontal cortex. |
2020-05-14 |
2023-08-13 |
rat |
| Vishnu N Thakare, Rajesh R Patil, Anupama A Suralkar, Valmik D Dhakane, Bhoomika M Pate. Protocatechuic acid attenuate depressive-like behavior in olfactory bulbectomized rat model: behavioral and neurobiochemical investigations. Metabolic brain disease. vol 34. issue 3. 2020-05-11. PMID:30848471. |
behavioral (ambulatory and rearing activity and immobility time), neurochemical [serotonin (5-ht), dopamine (da), norepinephrine (ne) and brain derived neurotrophic factor (bdnf) expression], biochemical (mda formation, il-6, tnf-α and antioxidants) changes in hippocampus and cerebral cortex along with serum corticosterone were investigated. |
2020-05-11 |
2023-08-13 |
rat |
| Vishnu N Thakare, Rajesh R Patil, Anupama A Suralkar, Valmik D Dhakane, Bhoomika M Pate. Protocatechuic acid attenuate depressive-like behavior in olfactory bulbectomized rat model: behavioral and neurobiochemical investigations. Metabolic brain disease. vol 34. issue 3. 2020-05-11. PMID:30848471. |
experimental findings reveals that obx subjected rats showed alteration in behaviors like, increase in immobility time, ambulatory and rearing behaviors significantly, reduced bdnf level, 5-ht, da,ne and antioxidant parameters along with increased serum corticosterone, mda formation, il-6, and tnf-α in hippocampus and cerebral cortex compared to sham operated rats. |
2020-05-11 |
2023-08-13 |
rat |
| Vishnu N Thakare, Rajesh R Patil, Anupama A Suralkar, Valmik D Dhakane, Bhoomika M Pate. Protocatechuic acid attenuate depressive-like behavior in olfactory bulbectomized rat model: behavioral and neurobiochemical investigations. Metabolic brain disease. vol 34. issue 3. 2020-05-11. PMID:30848471. |
administration of pca significantly attenuated behavioral and neurobiochemical alterations, thus, its antidepressant-like activity is largely mediated through modulation of neurotransmitter, endocrine and immunologic systems, mainly by improvements of bdnf, 5-ht, da, ne, reduced mda, il-6, and tnf-α in hippocampus and cerebral cortex. |
2020-05-11 |
2023-08-13 |
rat |
| Naif E Al Omairi, Ashraf Y Al-Brakati, Rami B Kassab, Maha S Lokman, Ehab Kotb Elmahallawy, Hatem K Amin, Ahmed E Abdel Monei. Soursop fruit extract mitigates scopolamine-induced amnesia and oxidative stress via activating cholinergic and Nrf2/HO-1 pathways. Metabolic brain disease. vol 34. issue 3. 2020-05-11. PMID:30919246. |
sco-treatment increased acetylcholine esterase activity and decreased hippocampal levels of acetylcholine, serotonin, dopamine, norepinephrine, and histamine. |
2020-05-11 |
2023-08-13 |
rat |
| Rubén García-Cabrerizo, M Julia García-Fuste. Methamphetamine binge administration dose-dependently enhanced negative affect and voluntary drug consumption in rats following prolonged withdrawal: role of hippocampal FADD. Addiction biology. vol 24. issue 2. 2020-05-08. PMID:29282816. |
in particular, rats treated repeatedly with methamphetamine (7.5 mg/kg) showed (1) enhanced negative affect-increased anhedonia associated with behavioral despair, (2) increased voluntary methamphetamine consumption, (3) enhanced neurotoxicity-decreased dopamine and metabolites in striatum and decreased serotonin in hippocampus, (4) altered neuroplasticity markers-decreased fadd protein and increased p-fadd/fadd balance selectively in hippocampus and (5) higher consumption rates of methamphetamine that were associated with lower fadd content in hippocampus. |
2020-05-08 |
2023-08-13 |
rat |