| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xing-Hua Zhen, Ying-Chun Quan, Zhou Peng, Yan Han, Zhou-Jun Zheng, Li-Ping Gua. Design, Synthesis, and Potential Antidepressant-like Activity of 7-prenyloxy-2,3-dihydroflavanone Derivatives. Chemical biology & drug design. vol 87. issue 6. 2017-03-01. PMID:26705885. |
in addition, it was found that compounds 5j and 5k significantly increased the concentrations of the main neurotransmitters 5-ht and ne in the hippocampus, hypothalamus, and cortex. |
2017-03-01 |
2023-08-13 |
mouse |
| Xing-Hua Zhen, Ying-Chun Quan, Zhou Peng, Yan Han, Zhou-Jun Zheng, Li-Ping Gua. Design, Synthesis, and Potential Antidepressant-like Activity of 7-prenyloxy-2,3-dihydroflavanone Derivatives. Chemical biology & drug design. vol 87. issue 6. 2017-03-01. PMID:26705885. |
compounds 5j and 5k also significantly increased the contents of 5-hiaa in the hippocampus and cortex, shut down 5-ht metabolism compared with mice treated with stress vehicle. |
2017-03-01 |
2023-08-13 |
mouse |
| K Guo, G Yin, X H Zi, H X Zhu, Q Pa. Effect of selective serotonin reuptake inhibitors on expression of 5-HT1AR and neurotransmitters in rats with vascular dementia. Genetics and molecular research : GMR. vol 15. issue 4. 2017-03-01. PMID:27966748. |
this was accompanied by reductions in da, 5-ht, and ne levels in hippocampal tissues, as well as reduced cortical 5-ht and decreased 5-ht1ar mrna expression (p < 0.05). |
2017-03-01 |
2023-08-13 |
rat |
| K Guo, G Yin, X H Zi, H X Zhu, Q Pa. Effect of selective serotonin reuptake inhibitors on expression of 5-HT1AR and neurotransmitters in rats with vascular dementia. Genetics and molecular research : GMR. vol 15. issue 4. 2017-03-01. PMID:27966748. |
escitalopram treatments reduced escape latency, elevated platform crossing times, improved ca1 neuronal damage, increased da and 5-ht levels in hippocampal and cortical neurons, as well as elevated expression of 5-ht1ar mrna (p < 0.05). |
2017-03-01 |
2023-08-13 |
rat |
| Magdalena Jastrzębska-Więsek, Agata Siwek, Anna Partyka, Lucyna Antkiewicz-Michaluk, Jerzy Michaluk, Irena Romańska, Marcin Kołaczkowski, Anna Wesołowsk. Study of a mechanism responsible for potential antidepressant activity of EMD 386088, a 5-HT6 partial agonist in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 389. issue 8. 2017-02-21. PMID:27106213. |
the concentrations of monoamines (dopamine (da), noradrenaline (na), and serotonin (5-ht)) and the rate of their metabolism were measured ex vivo in the brain structures (hippocampus, nucleus accumbens, striatum) using high-performance liquid chromatography (hplc). |
2017-02-21 |
2023-08-13 |
rat |
| Y Chandrasekhar, E M Ramya, K Navya, G Phani Kumar, K R Anilakuma. Antidepressant like effects of hydrolysable tannins of Terminalia catappa leaf extract via modulation of hippocampal plasticity and regulation of monoamine neurotransmitters subjected to chronic mild stress (CMS). Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 86. 2017-02-08. PMID:28012396. |
moreover, tc administration significantly restored cms induced changes in concentrations of hippocampal neurotransmitters (5-ht, da and ne) as well as levels of acetyl cholinesterase, cortisol, monoamine oxidases (mao-a, mao-b), bdnf, creb, and p-creb. |
2017-02-08 |
2023-08-13 |
mouse |
| Peter Petschner, Gabriella Juhasz, Viola Tamasi, Csaba Adori, Laszlo Tothfalusi, Tomas Hökfelt, Gyorgy Bagd. Chronic venlafaxine treatment fails to alter the levels of galanin system transcripts in normal rats. Neuropeptides. vol 57. 2017-02-07. PMID:26891823. |
to answer this question we administered the selective serotonin and noradrenaline reuptake inhibitor (snri) venlafaxine (40mg/kg/day via osmotic minipumps) to normal rats and examined the levels of the transcripts for galanin and galr1-3 after a 3-week venlafaxine treatment in the dorsal raphe, hippocampus and frontal cortex. |
2017-02-07 |
2023-08-13 |
rat |
| A Ahnaou, W H I M Drinkenbur. Simultaneous Changes in Sleep, qEEG, Physiology, Behaviour and Neurochemistry in Rats Exposed to Repeated Social Defeat Stress. Neuropsychobiology. vol 73. issue 4. 2017-02-07. PMID:27287886. |
on day 5, prefrontal dopamine (da) and hippocampal serotonin (5-ht) as well as corticosterone were measured in submissive rats that had visual, acoustic, and olfactory (but no physical) contact with a dominant, resident conspecific rat. |
2017-02-07 |
2023-08-13 |
rat |
| A Ahnaou, W H I M Drinkenbur. Simultaneous Changes in Sleep, qEEG, Physiology, Behaviour and Neurochemistry in Rats Exposed to Repeated Social Defeat Stress. Neuropsychobiology. vol 73. issue 4. 2017-02-07. PMID:27287886. |
the increased levels of cortical da and hippocampal 5-ht during social threat may reflect a coping mechanism to promote alertness and psychological adaptation to provocative and threatening stimuli. |
2017-02-07 |
2023-08-13 |
rat |
| A V Sergutina, V I Rakhmanov. Differences in Monoamine Oxidase Activity in the Brain of Wistar and August Rats with High and Low Locomotor Activity: A Cytochemical Study. Bulletin of experimental biology and medicine. vol 161. issue 2. 2017-02-07. PMID:27383157. |
in august rats, enzyme activity (substrates tryptamine and serotonin) predominated in the hippocampus of animals with high motor activity. |
2017-02-07 |
2023-08-13 |
rat |
| A V Sergutina, V I Rakhmanov. Differences in Monoamine Oxidase Activity in the Brain of Wistar and August Rats with High and Low Locomotor Activity: A Cytochemical Study. Bulletin of experimental biology and medicine. vol 161. issue 2. 2017-02-07. PMID:27383157. |
animals demonstrating maximum differences in motor function) revealed significantly higher activity of the enzyme (substrates tryptamine and serotonin) in the hippocampus of wistar rats. |
2017-02-07 |
2023-08-13 |
rat |
| Luis García-García, Ahmed Anis Shiha, Pablo Bascuñana, Javier de Cristóbal, Rubén Fernández de la Rosa, Mercedes Delgado, Miguel A Poz. Serotonin Depletion Does not Modify the Short-Term Brain Hypometabolism and Hippocampal Neurodegeneration Induced by the Lithium-Pilocarpine Model of Status Epilepticus in Rats. Cellular and molecular neurobiology. vol 36. issue 4. 2017-02-06. PMID:26208805. |
serotonin depletion does not modify the short-term brain hypometabolism and hippocampal neurodegeneration induced by the lithium-pilocarpine model of status epilepticus in rats. |
2017-02-06 |
2023-08-13 |
rat |
| Carlos Borges Filho, Cristiano Ricardo Jesse, Franciele Donato, Lucian Del Fabbro, Marcelo Gomes de Gomes, André Tiago Rossito Goes, Leandro Cattelan Souza, Silvana Peterini Boeir. Chrysin promotes attenuation of depressive-like behavior and hippocampal dysfunction resulting from olfactory bulbectomy in mice. Chemico-biological interactions. vol 260. 2017-01-31. PMID:27818124. |
ob also caused the elevation of tumor necrosis factor-α, interferon-γ, interleukin-1β, interleukin-6, kynurenine (kyn) levels and indoleamine-2,3-dioxygenase activity, as well as occasioned the decrease of 5-hydroxytryptamine (5-ht) and brain-derived neurotrophic factor (bdnf) levels and increase kyn/tryptophan and 5-hydroxyindoleacetic acid/5-ht ratio in the hippocampus. |
2017-01-31 |
2023-08-13 |
mouse |
| Yung-Chih Kuo, Yin-Jung Le. Rescuing cholinergic neurons from apoptotic degeneration by targeting of serotonin modulator-and apolipoprotein E-conjugated liposomes to the hippocampus. International journal of nanomedicine. vol 11. 2017-01-31. PMID:28008255. |
rescuing cholinergic neurons from apoptotic degeneration by targeting of serotonin modulator-and apolipoprotein e-conjugated liposomes to the hippocampus. |
2017-01-31 |
2023-08-13 |
rat |
| Yung-Chih Kuo, Yin-Jung Le. Rescuing cholinergic neurons from apoptotic degeneration by targeting of serotonin modulator-and apolipoprotein E-conjugated liposomes to the hippocampus. International journal of nanomedicine. vol 11. 2017-01-31. PMID:28008255. |
β-amyloid (aβ)-targeting liposomes (lip) with surface serotonin modulator (sm) and apolipoprotein e (apoe) were utilized to facilitate the delivery of nerve growth factor (ngf) across the blood-brain barrier (bbb) for neuroprotection in the hippocampus. |
2017-01-31 |
2023-08-13 |
rat |
| Kanu Megha, Pravin S Deshmukh, Alok K Ravi, Ashok K Tripathi, Mahesh P Abegaonkar, Basu D Banerje. Effect of Low-Intensity Microwave Radiation on Monoamine Neurotransmitters and Their Key Regulating Enzymes in Rat Brain. Cell biochemistry and biophysics. vol 73. issue 1. 2017-01-18. PMID:25672490. |
dopamine (da), norepinephrine (ne), epinephrine (e) and serotonin (5-ht) were detected using lc-ms/ms in hippocampus of all experimental animals. |
2017-01-18 |
2023-08-13 |
human |
| Ning-Ning Song, Yun-Fang Jia, Lei Zhang, Qiong Zhang, Ying Huang, Xiao-Zhen Liu, Ling Hu, Wei Lan, Ling Chen, Klaus-Peter Lesch, Xiaoyan Chen, Lin Xu, Yu-Qiang Din. Reducing central serotonin in adulthood promotes hippocampal neurogenesis. Scientific reports. vol 6. 2017-01-16. PMID:26839004. |
reducing central serotonin in adulthood promotes hippocampal neurogenesis. |
2017-01-16 |
2023-08-13 |
mouse |
| Ning-Ning Song, Yun-Fang Jia, Lei Zhang, Qiong Zhang, Ying Huang, Xiao-Zhen Liu, Ling Hu, Wei Lan, Ling Chen, Klaus-Peter Lesch, Xiaoyan Chen, Lin Xu, Yu-Qiang Din. Reducing central serotonin in adulthood promotes hippocampal neurogenesis. Scientific reports. vol 6. 2017-01-16. PMID:26839004. |
chronic administration of selective serotonin reuptake inhibitors (ssris), which up-regulates central serotonin (5-ht) system function, enhances adult hippocampal neurogenesis. |
2017-01-16 |
2023-08-13 |
mouse |
| Ning-Ning Song, Yun-Fang Jia, Lei Zhang, Qiong Zhang, Ying Huang, Xiao-Zhen Liu, Ling Hu, Wei Lan, Ling Chen, Klaus-Peter Lesch, Xiaoyan Chen, Lin Xu, Yu-Qiang Din. Reducing central serotonin in adulthood promotes hippocampal neurogenesis. Scientific reports. vol 6. 2017-01-16. PMID:26839004. |
here, we report that lowering 5-ht level in adulthood is also able to enhance adult hippocampal neurogenesis. |
2017-01-16 |
2023-08-13 |
mouse |
| Ning-Ning Song, Yun-Fang Jia, Lei Zhang, Qiong Zhang, Ying Huang, Xiao-Zhen Liu, Ling Hu, Wei Lan, Ling Chen, Klaus-Peter Lesch, Xiaoyan Chen, Lin Xu, Yu-Qiang Din. Reducing central serotonin in adulthood promotes hippocampal neurogenesis. Scientific reports. vol 6. 2017-01-16. PMID:26839004. |
we used tamoxifen (tm)-induced cre in pet1-creer(t2) mice to either deplete central serotonergic (5-htergic) neurons or inactivate 5-ht synthesis in adulthood and explore the role of central 5-ht in adult hippocampal neurogenesis. |
2017-01-16 |
2023-08-13 |
mouse |