| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ran Ye, Meagan A Quinlan, Hideki Iwamoto, Hsiao-Huei Wu, Noah H Green, Christopher S Jetter, Douglas G McMahon, Jeremy Veestra-VanderWeele, Pat Levitt, Randy D Blakel. Physical Interactions and Functional Relationships of Neuroligin 2 and Midbrain Serotonin Transporters. Frontiers in synaptic neuroscience. vol 7. 2016-01-21. PMID:26793096. |
physical interactions and functional relationships of neuroligin 2 and midbrain serotonin transporters. |
2016-01-21 |
2023-08-13 |
mouse |
| H C Tsai, S-H Lin, P S Chen, H H Chang, I H Lee, T L Yeh, K C Chen, N T Chiu, W J Yao, M-H Liao, Y K Yan. Quantifying midbrain serotonin transporter in depression: a preliminary study of diagnosis and naturalistic treatment outcome. Pharmacopsychiatry. vol 48. issue 2. 2016-01-18. PMID:25626060. |
quantifying midbrain serotonin transporter in depression: a preliminary study of diagnosis and naturalistic treatment outcome. |
2016-01-18 |
2023-08-13 |
Not clear |
| Lan-Ting Lee, Hsin Chun Tsai, Mei Hung Chi, Wei Hung Chang, Kao Chin Chen, I Hui Lee, Po See Chen, Wei Jen Yao, Nan Tsing Chiu, Yen Kuang Yan. Lower availability of striatal dopamine transporter in generalized anxiety disorder: a preliminary two-ligand SPECT study. International clinical psychopharmacology. vol 30. issue 3. 2016-01-15. PMID:25647452. |
the aims of this study were to examine the availabilities of the striatal dopamine transporter (dat) and the midbrain serotonin transporter (sert) in patients with gad. |
2016-01-15 |
2023-08-13 |
human |
| Dasiel O Borroto-Escuela, Mileidys Pérez-Alea, Manuel Narvaez, Alexander O Tarakanov, Giuseppa Mudó, Antonio Jiménez-Beristain, Luigi F Agnati, Francisco Ciruela, Natale Belluardo, Kjell Fux. Enhancement of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems. Relevance for neuroplasticity and depression. Biochemical and biophysical research communications. vol 463. issue 3. 2015-09-10. PMID:25957476. |
enhancement of the fgfr1 signaling in the fgfr1-5-ht1a heteroreceptor complex in midbrain raphe 5-ht neuron systems. |
2015-09-10 |
2023-08-13 |
rat |
| Dasiel O Borroto-Escuela, Mileidys Pérez-Alea, Manuel Narvaez, Alexander O Tarakanov, Giuseppa Mudó, Antonio Jiménez-Beristain, Luigi F Agnati, Francisco Ciruela, Natale Belluardo, Kjell Fux. Enhancement of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems. Relevance for neuroplasticity and depression. Biochemical and biophysical research communications. vol 463. issue 3. 2015-09-10. PMID:25957476. |
new findings show existence of fgfr1-5-ht1a heteroreceptor complexes in 5-ht nerve cells of the dorsal and median raphe nuclei of the rat midbrain and hippocampus. |
2015-09-10 |
2023-08-13 |
rat |
| Dasiel O Borroto-Escuela, Mileidys Pérez-Alea, Manuel Narvaez, Alexander O Tarakanov, Giuseppa Mudó, Antonio Jiménez-Beristain, Luigi F Agnati, Francisco Ciruela, Natale Belluardo, Kjell Fux. Enhancement of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems. Relevance for neuroplasticity and depression. Biochemical and biophysical research communications. vol 463. issue 3. 2015-09-10. PMID:25957476. |
the existence of fgfr1-5-ht1a heteroreceptor complexes also in midbrain raphe 5-ht nerve cells open up the possibility that antidepressant drugs by increasing extracellular 5-ht levels can cause an activation of the fgf-2/fgfr1 mechanism in these nerve cells as well. |
2015-09-10 |
2023-08-13 |
rat |
| Dasiel O Borroto-Escuela, Mileidys Pérez-Alea, Manuel Narvaez, Alexander O Tarakanov, Giuseppa Mudó, Antonio Jiménez-Beristain, Luigi F Agnati, Francisco Ciruela, Natale Belluardo, Kjell Fux. Enhancement of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems. Relevance for neuroplasticity and depression. Biochemical and biophysical research communications. vol 463. issue 3. 2015-09-10. PMID:25957476. |
therefore, the agonist modulation of the fgfr1-5-ht1a heteroreceptor complexes and their specific role is now determined in rat medullary raphe rn33b cells and in the caudal midline raphe area of the midbrain rich in 5-ht nerve cells. |
2015-09-10 |
2023-08-13 |
rat |
| Dasiel O Borroto-Escuela, Mileidys Pérez-Alea, Manuel Narvaez, Alexander O Tarakanov, Giuseppa Mudó, Antonio Jiménez-Beristain, Luigi F Agnati, Francisco Ciruela, Natale Belluardo, Kjell Fux. Enhancement of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems. Relevance for neuroplasticity and depression. Biochemical and biophysical research communications. vol 463. issue 3. 2015-09-10. PMID:25957476. |
taken together, the 5-ht1a autoreceptors by being part of a fgfr1-5-ht1a heteroreceptor complex in the midbrain raphe 5-ht nerve cells appears to have also a trophic role in the central 5-ht neuron systems besides playing a key role in reducing the firing of these neurons. |
2015-09-10 |
2023-08-13 |
rat |
| Alan E Stewart, Kathryn A Roecklein, Susan Tanner, Michael G Kimli. Possible contributions of skin pigmentation and vitamin D in a polyfactorial model of seasonal affective disorder. Medical hypotheses. vol 83. issue 5. 2015-08-18. PMID:25270233. |
there are several reasons for this position: 1. vitamin d levels fluctuate in the body seasonally, with a lag, in direct relation to seasonally-available sunlight; 2. lower vitamin d levels have been observed in depressed patients (as well as in patients with other psychiatric disorders) compared to controls; 3. vitamin d levels in the central nervous system affect the production of both serotonin and dopamine; and 4. vitamin d and vitamin d responsive elements are found throughout the midbrain regions and are especially concentrated in the hypothalamus, a region that encompasses the circadian timing systems and much of its neural circuitry. |
2015-08-18 |
2023-08-13 |
Not clear |
| Phuong V Tran, Vishwajit S Chowdhury, Mao Nagasawa, Mitsuhiro Furus. Changes in free amino acid and monoamine concentrations in the chick brain associated with feeding behavior. SpringerPlus. vol 4. 2015-07-20. PMID:26191470. |
as for monoamines, serotonin and norepinephrine were significantly lower in the mesencephalon of the hungry group compared with the satiated group, but 5 hydroxyindolacetic acid (5-hiaa) was higher. |
2015-07-20 |
2023-08-13 |
chicken |
| Kayoko W Miyazaki, Katsuhiko Miyazaki, Kenji F Tanaka, Akihiro Yamanaka, Aki Takahashi, Sawako Tabuchi, Kenji Doy. Optogenetic activation of dorsal raphe serotonin neurons enhances patience for future rewards. Current biology : CB. vol 24. issue 17. 2015-05-20. PMID:25155504. |
previous recording studies of the midbrain dorsal raphe nucleus (drn) revealed that the activation of putative serotonin neurons correlates with the levels of behavioral arousal [1], rhythmic motor outputs [2], salient sensory stimuli [3-6], reward, and conditioned cues [5-8]. |
2015-05-20 |
2023-08-13 |
mouse |
| P C Hsieh, K C Chen, T L Yeh, I H Lee, P S Chen, W J Yao, N-T Chiu, C-C Chen, M-H Liao, Y K Yan. Lower availability of midbrain serotonin transporter between healthy subjects with and without a family history of major depressive disorder - a preliminary two-ligand SPECT study. European psychiatry : the journal of the Association of European Psychiatrists. vol 29. issue 7. 2015-05-15. PMID:24439516. |
lower availability of midbrain serotonin transporter between healthy subjects with and without a family history of major depressive disorder - a preliminary two-ligand spect study. |
2015-05-15 |
2023-08-12 |
human |
| Dietmar Hestermann, Yasin Temel, Arjan Blokland, Lee Wei Li. Acute serotonergic treatment changes the relation between anxiety and HPA-axis functioning and periaqueductal gray activation. Behavioural brain research. vol 273. 2015-05-11. PMID:25043730. |
interestingly, the periaqueductal gray (pag), a midbrain structure which regulates anxiety behavior - has robust 5-ht fibers and reciprocal connections with the hypothalamic-pituitary-adrenal (hpa) axis. |
2015-05-11 |
2023-08-13 |
Not clear |
| Dasiel O Borroto-Escuela, Manuel Narvaez, Mileidys Pérez-Alea, Alexander O Tarakanov, Antonio Jiménez-Beristain, Giuseppa Mudó, Luigi F Agnati, Francisco Ciruela, Natale Belluardo, Kjell Fux. Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system. Biochemical and biophysical research communications. vol 456. issue 1. 2015-03-10. PMID:25485703. |
the ascending midbrain 5-ht neurons known to contain 5-ht1a autoreceptors may be dysregulated in depression due to a reduced trophic support. |
2015-03-10 |
2023-08-13 |
rat |
| Dasiel O Borroto-Escuela, Manuel Narvaez, Mileidys Pérez-Alea, Alexander O Tarakanov, Antonio Jiménez-Beristain, Giuseppa Mudó, Luigi F Agnati, Francisco Ciruela, Natale Belluardo, Kjell Fux. Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system. Biochemical and biophysical research communications. vol 456. issue 1. 2015-03-10. PMID:25485703. |
with in situ proximity ligation assay (pla) and supported by co-location of the fgfr1 and 5-ht1a immunoreactivities in midbrain raphe 5-ht cells, evidence for the existence of fgfr1-5-ht1a heteroreceptor complexes were obtained in the dorsal and median raphe nuclei of the sprague-dawley rat. |
2015-03-10 |
2023-08-13 |
rat |
| Dasiel O Borroto-Escuela, Manuel Narvaez, Mileidys Pérez-Alea, Alexander O Tarakanov, Antonio Jiménez-Beristain, Giuseppa Mudó, Luigi F Agnati, Francisco Ciruela, Natale Belluardo, Kjell Fux. Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system. Biochemical and biophysical research communications. vol 456. issue 1. 2015-03-10. PMID:25485703. |
taken together, the 5-ht1a autoreceptors by being recruited into a fgfr1-5-ht1a heteroreceptor complex in the midbrain raphe 5-ht nerve cells may develop a novel function, namely a trophic role in many midbrain 5-ht neuron systems originating from the dorsal and medianus raphe nuclei. |
2015-03-10 |
2023-08-13 |
rat |
| Vladimir S Naumenko, Elena M Kondaurova, Daria V Bazovkina, Anton S Tsybko, Tatyana V Il'chibaeva, Nina K Popov. On the role of 5-HT(1A) receptor gene in behavioral effect of brain-derived neurotrophic factor. Journal of neuroscience research. vol 92. issue 8. 2015-02-21. PMID:24706292. |
functional activity of 5-ht2a receptors and 5-ht(2a) receptor mrna levels in the midbrain and hippocampus of 76c mice were decreased compared with akr mice. |
2015-02-21 |
2023-08-13 |
mouse |
| Vladimir S Naumenko, Elena M Kondaurova, Daria V Bazovkina, Anton S Tsybko, Tatyana V Il'chibaeva, Nina K Popov. On the role of 5-HT(1A) receptor gene in behavioral effect of brain-derived neurotrophic factor. Journal of neuroscience research. vol 92. issue 8. 2015-02-21. PMID:24706292. |
reduced 5-ht1a and 5-ht(2a) receptor mrna levels in the frontal cortex and tph-2 mrna level in the midbrain of akr mice. |
2015-02-21 |
2023-08-13 |
mouse |
| Alonzo Whyte, Tammy Jessen, Seth Varney, Ana M D Carneir. Serotonin transporter and integrin beta 3 genes interact to modulate serotonin uptake in mouse brain. Neurochemistry international. vol 73. 2015-02-02. PMID:24083985. |
itgb3 single heterozygous mice displayed significant reductions in 5-ht vmax, with no changes in km, in midbrain preparations. |
2015-02-02 |
2023-08-12 |
mouse |
| Alonzo Whyte, Tammy Jessen, Seth Varney, Ana M D Carneir. Serotonin transporter and integrin beta 3 genes interact to modulate serotonin uptake in mouse brain. Neurochemistry international. vol 73. 2015-02-02. PMID:24083985. |
however, in the presence of both itgb3 and slc6a4 heterozygozity, 5-ht uptake was similar to wild-type levels, revealing a significant slc6a4 by itgb3 genetic interaction in the midbrain. |
2015-02-02 |
2023-08-12 |
mouse |