| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ekaterina Y Bazhenova, Nadezhda A Sinyakova, Elizabeth A Kulikova, Irina A Kazarinova, Daria V Bazovkina, Raul R Gainetdinov, Alexander V Kuliko. No effect of C1473G polymorphism in the tryptophan hydroxylase 2 gene on the response of the brain serotonin system to chronic fluoxetine treatment in mice. Neuroscience letters. vol 653. 2018-04-27. PMID:28579486. |
fluoxetine significantly attenuated 5-ht levels in the cortex and striatum, 5-hiaa concentrations in the cortex, hippocampus, striatum and midbrain, and tph2 gene expression in the midbrain. |
2018-04-27 |
2023-08-13 |
mouse |
| Minmin Luo, Yi Li, Weixin Zhon. Do dorsal raphe 5-HT neurons encode "beneficialness"? Neurobiology of learning and memory. vol 135. 2018-02-09. PMID:27544850. |
the dorsal raphe nucleus (drn) in the midbrain provides a majority of 5-ht for the forebrain. |
2018-02-09 |
2023-08-13 |
Not clear |
| Chandni Sheth, Teri M Furlong, Kristen A Keefe, Sharif A Tah. The lateral hypothalamus to lateral habenula projection, but not the ventral pallidum to lateral habenula projection, regulates voluntary ethanol consumption. Behavioural brain research. vol 328. 2018-02-07. PMID:28432009. |
the lateral habenula (lhb) is an epithalamic brain region implicated in aversive processing via negative modulation of midbrain dopamine (da) and serotonin (5-ht) systems. |
2018-02-07 |
2023-08-13 |
Not clear |
| Matthew Brodsky, Alec W Gibson, Denis Smirnov, Sunila G Nair, John F Neumaie. Striatal 5-HT6 Receptors Regulate Cocaine Reinforcement in a Pathway-Selective Manner. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 9. 2018-01-09. PMID:27032690. |
the nucleus accumbens (nac) in the ventral striatum integrates many neurochemical inputs including dopamine and serotonin projections from midbrain nuclei to modulate drug reward. |
2018-01-09 |
2023-08-13 |
rat |
| Christopher L Muller, Allison Mj Anacker, Tiffany D Rogers, Nick Goeden, Elizabeth H Keller, C Gunnar Forsberg, Travis M Kerr, Carly LA Wender, George M Anderson, Gregg D Stanwood, Randy D Blakely, Alexandre Bonnin, Jeremy Veenstra-VanderWeel. Impact of Maternal Serotonin Transporter Genotype on Placental Serotonin, Fetal Forebrain Serotonin, and Neurodevelopment. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 2. 2018-01-05. PMID:27550733. |
early in gestation, before midbrain 5-ht projections have reached the cortex, peripheral sources supply 5-ht to the forebrain, suggesting that altered maternal or placenta 5-ht system function could impact the developing embryo. |
2018-01-05 |
2023-08-13 |
mouse |
| Christopher L Muller, Allison Mj Anacker, Tiffany D Rogers, Nick Goeden, Elizabeth H Keller, C Gunnar Forsberg, Travis M Kerr, Carly LA Wender, George M Anderson, Gregg D Stanwood, Randy D Blakely, Alexandre Bonnin, Jeremy Veenstra-VanderWeel. Impact of Maternal Serotonin Transporter Genotype on Placental Serotonin, Fetal Forebrain Serotonin, and Neurodevelopment. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 2. 2018-01-05. PMID:27550733. |
we therefore used different combinations of maternal and embryo sert ala56 genotypes to examine effects on blood, placenta and embryo serotonin levels and neurodevelopment at embryonic day e14.5, when peripheral sources of 5-ht predominate, and e18.5, when midbrain 5-ht projections have reached the forebrain. |
2018-01-05 |
2023-08-13 |
mouse |
| Jessica L Hanson, Laura M Hurle. Serotonin, estrus, and social context influence c-Fos immunoreactivity in the inferior colliculus. Behavioral neuroscience. vol 130. issue 6. 2017-11-16. PMID:27657308. |
in the mouse inferior colliculus (ic), a midbrain auditory region, the neuromodulator serotonin increases in females interacting with courting males, but events downstream of serotonin release have not been investigated. |
2017-11-16 |
2023-08-13 |
mouse |
| b' J Gasull-Cam\\xc3\\xb3s, M Tarr\\xc3\\xa9s-Gatius, F Artigas, A Casta\\xc3\\xb1\\xc3\\xa. Glial GLT-1 blockade in infralimbic cortex as a new strategy to evoke rapid antidepressant-like effects in rats. Translational psychiatry. vol 7. issue 2. 2017-11-16. PMID:28221365.' |
the dhk-evoked antidepressant-like responses appear to be mediated by an ampa-r-driven enhancement of serotonergic activity, as (i) they were prevented by nbqx 2,3-dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt) and mimicked by s-ampa; (ii) dhk and s-ampa elevated similarly extracellular glutamate in il and prl, although extracellular 5-ht and c-fos expression in the midbrain dorsal raphe increased only when these agents were applied in il; and (iii) dhk antidepressant-like responses were prevented by 5-ht synthesis inhibition and mimicked by citalopram microinfusion in il. |
2017-11-16 |
2023-08-13 |
rat |
| Noreen Samad, Farzana Yasmin, Darakhshan Jabeen Halee. Co-treatment with imipramine averted haloperidol-instigated tardive dyskinesia: Association with serotonin in brain regions. Pakistan journal of pharmaceutical sciences. vol 29. issue 6 Suppl. 2017-11-03. PMID:28167465. |
8-oh-dpat-instigated low 5-hydroxytryptamine (5-ht; serotonin) metabolism was higher in saline+ haloperidol treated rats when compare to imi+ haloperidol treated rats in both regions of brain (striatum and midbrain). |
2017-11-03 |
2023-08-13 |
rat |
| Kaitlin S Carlson, Meredith S Whitney, Marie A Gadziola, Evan S Deneris, Daniel W Wesso. Preservation of Essential Odor-Guided Behaviors and Odor-Based Reversal Learning after Targeting Adult Brain Serotonin Synthesis. eNeuro. vol 3. issue 5. 2017-10-31. PMID:27896310. |
the olfactory system is innervated by midbrain 5-ht neurons into both its primary and secondary odor-processing stages. |
2017-10-31 |
2023-08-13 |
Not clear |
| Vincent van de Ven, Marleen Wingen, Kim P C Kuypers, Johannes G Ramaekers, Elia Formisan. Escitalopram Decreases Cross-Regional Functional Connectivity within the Default-Mode Network. PloS one. vol 8. issue 6. 2017-10-11. PMID:23826388. |
the serotonergic (5-ht) neurotransmitter system projects to dmn regions from midbrain efferents, and manipulation of this system could thus reveal insights into the neurobiological mechanisms of dmn functioning. |
2017-10-11 |
2023-08-12 |
human |
| Sebastian Pablo Fernandez, Bruno Cauli, Carolina Cabezas, Aude Muzerelle, Jean-Christophe Poncer, Patricia Gaspa. Multiscale single-cell analysis reveals unique phenotypes of raphe 5-HT neurons projecting to the forebrain. Brain structure & function. vol 221. issue 8. 2017-10-10. PMID:26608830. |
overall, these findings allow to define correlated anatomical and physiological identities of serotonin raphe neurons that help understanding how discrete raphe cells subpopulations account for the heterogeneous activities of the midbrain serotonergic system. |
2017-10-10 |
2023-08-13 |
mouse |
| Cynthia L Bethea, Kevin Mueller, Arubala P Reddy, Steven G Kohama, Henryk F Urbansk. Effects of obesogenic diet and estradiol on dorsal raphe gene expression in old female macaques. PloS one. vol 12. issue 6. 2017-09-19. PMID:28628658. |
compared to old ovx macaques on primate chow and treated with placebo or e, the wsd-fed monkeys exhibited greater individual variance and blunted responses to e-treatment in the expression of genes related to serotonin neurotransmission, crh components in the midbrain, synapse assembly, dna repair, protein folding, ubiquitylation, transport and neurodegeneration. |
2017-09-19 |
2023-08-13 |
human |
| Ayesha Sengupta, Marco Bocchio, David M Bannerman, Trevor Sharp, Marco Capogn. Control of Amygdala Circuits by 5-HT Neurons via 5-HT and Glutamate Cotransmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 7. 2017-08-18. PMID:28087766. |
therefore, elucidating the physiological mechanisms through which midbrain 5-ht neurons modulate amygdala circuits could be pivotal in understanding emotional regulation in health and disease. |
2017-08-18 |
2023-08-13 |
mouse |
| Chih-Hsing Wu, Chin-Sung Chang, Yen Kuang Yang, Lie-Hang Shen, Wei-Jen Ya. Comparison of brain serotonin transporter using [I-123]-ADAM between obese and non-obese young adults without an eating disorder. PloS one. vol 12. issue 2. 2017-08-15. PMID:28182708. |
no significant difference in sert availability in the midbrain between morbidly obese and non-obese young adults without an eating disorder indicates an unmet need for investigating the role of cerebral serotonin in obesity. |
2017-08-15 |
2023-08-13 |
human |
| N N Kudryavtseva, D A Smagin, I L Kovalenko, A G Galyamina, G B Vishnivetskaya, V N Babenko, Yu L Orlo. [Serotonergic genes in the development of anxiety/depression-like state and pathology of aggressive behavior in male mice: RNA-seq data]. Molekuliarnaia biologiia. vol 51. issue 2. 2017-08-14. PMID:28537235. |
using the data of whole transcriptome analysis (rna-seq), the changes in the expression of serotonergic genes involved in the synthesis, inactivation, and reception of serotonin, as well as of the creb1 (transcription factor) gene and the bdnf (brain-derived neurotrophic factor) gene were detected in the striatum (str), ventral tegmental area (vta), midbrain raphe nuclei (mrn), hypothalamus (hyp), and hippocampus (hip) of defeated and aggressive male mice. |
2017-08-14 |
2023-08-13 |
mouse |
| A V Kulikov, E Y Bazhenova, E A Kulikova, D V Fursenko, L I Trapezova, E E Terenina, P Mormede, N K Popova, O V Trapezo. Interplay between aggression, brain monoamines and fur color mutation in the American mink. Genes, brain, and behavior. vol 15. issue 8. 2017-06-28. PMID:27489198. |
significant interaction effects were found between the hedlund mutation and aggressive behavior on serotonin metabolism in the substantia nigra (p < 0.001), dopamine level in the midbrain (p < 0.01) and its metabolism in the striatum (p < 0.05). |
2017-06-28 |
2023-08-13 |
Not clear |
| Pascal Seyer, Franck Vandermoere, Elisabeth Cassier, Joël Bockaert, Philippe Mari. Physical and functional interactions between the serotonin transporter and the neutral amino acid transporter ASCT2. The Biochemical journal. vol 473. issue 13. 2017-05-15. PMID:27143784. |
conversely, depletion of cellular asct2 by rnai enhances 5-ht uptake in both hek-293 cells and primary cultured mesencephalon neurons. |
2017-05-15 |
2023-08-13 |
human |
| Maria A Oquendo, Hanga Galfalvy, Gregory M Sullivan, Jeffrey M Miller, Matthew M Milak, M Elizabeth Sublette, Sebastian Cisneros-Trujillo, Ainsley K Burke, Ramin V Parsey, J John Man. Positron Emission Tomographic Imaging of the Serotonergic System and Prediction of Risk and Lethality of Future Suicidal Behavior. JAMA psychiatry. vol 73. issue 10. 2017-05-01. PMID:27463606. |
in cross-sectional studies, individuals with depression who attempt suicide have lower midbrain serotonin transporter binding potential compared with those who do not attempt suicide, and higher serotonin1a binding potential in the raphe nuclei (rn) is associated with greater lethality of past suicide attempts and suicidal intent and ideation. |
2017-05-01 |
2023-08-13 |
Not clear |
| Ilya Ayzenberg, Ilias Nastos, Katrin Strassburger-Krogias, Mark Obermann, Ralf Gold, Christos Krogia. Hypoechogenicity of brainstem raphe nuclei is associated with increased attack frequency in episodic migraine. Cephalalgia : an international journal of headache. vol 36. issue 8. 2017-03-02. PMID:26566936. |
postulating that migraine may constitute a "chronic low serotonin syndrome," we aimed to evaluate the echogenicity of midbrain structures, including serotonergic brn in episodic migraine. |
2017-03-02 |
2023-08-13 |
Not clear |