| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Danielle M Bailey, Mackenzie A Catron, Oleg Kovtun, Robert L Macdonald, Qi Zhang, Sandra J Rosentha. Single Quantum Dot Tracking Reveals Serotonin Transporter Diffusion Dynamics are Correlated with Cholesterol-Sensitive Threonine 276 Phosphorylation Status in Primary Midbrain Neurons. ACS chemical neuroscience. vol 9. issue 11. 2019-12-23. PMID:29787674. |
single quantum dot tracking reveals serotonin transporter diffusion dynamics are correlated with cholesterol-sensitive threonine 276 phosphorylation status in primary midbrain neurons. |
2019-12-23 |
2023-08-13 |
rat |
| Ekaterina Y Bazhenova, Dariya V Fursenko, Elizabeth A Kulikova, Nikita V Khotskin, Nadezhda A Sinyakova, Alexander A Kuliko. Effect of photoperiodic alterations on depression-like behavior and the brain serotonin system in mice genetically different in tryptophan hydroxylase 2 activity. Neuroscience letters. vol 699. 2019-12-17. PMID:30685409. |
at the same time, photoperiod alterations affected depressive-like immobility in the forced swim test, the 5-ht, 5-hydroxyindoleacetic acid (5-hiaa) levels, 5-hiaa/5-ht ratio and the htr2a mrna level in hippocampus and midbrain. |
2019-12-17 |
2023-08-13 |
mouse |
| P.J. Fletche. Effects of 8-OH-DPAT, 5-CT and muscimol on behaviour maintained by a DRL20 schedule of reinforcement, following microinjection into the dorsal or median raphe nuclei. Behavioural pharmacology. vol 5. issue 3. 2019-11-20. PMID:11224282. |
experiments were performed to investigate the effects of microinjections of the 5-ht(1a) agonist 8- hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat), the non-selective 5-ht(1) agonist 5-carboxamidotryptamine (5-ct) and the gaba(a) agonist muscimol into the midbrain raphe nuclei, on behaviour maintained by a differential reinforcement of low rate (drl) 20 schedule of food reinforcement. |
2019-11-20 |
2023-08-12 |
rat |
| Pau Celada, M. Victoria Puig, Raúl Martín-Ruiz, Josep M. Casanovas, Francesc Artiga. Control of the serotonergic system by the medial prefrontal cortex: potential role in the etiology of PTSD and depressive disorders. Neurotoxicity research. vol 4. issue 5-6. 2019-11-20. PMID:12754155. |
serotonergic neurons of the midbrain rapbe nuclei innervate the prefrontal cortex and are the cellular target for drugs used to treat mood disorders such as the selective serotonin (5-ht) reuptake inhibitors. |
2019-11-20 |
2023-08-12 |
Not clear |
| Satoko Hattori, Keizo Takao, Hiroshi Funakoshi, Tsuyoshi Miyakaw. Comprehensive behavioral analysis of tryptophan 2,3-dioxygenase (Tdo2) knockout mice. Neuropsychopharmacology reports. vol 38. issue 2. 2019-09-18. PMID:30106261. |
it has been reported that targeted deletion of the tdo2 gene in mice resulted in reduced anxiety-like behavior, enhanced exploratory activity and cognitive performance, and increased levels of trp and 5-ht in the hippocampus and midbrain. |
2019-09-18 |
2023-08-13 |
mouse |
| María-Aránzazu Martínez, Irma Ares, José-Luis Rodríguez, Marta Martínez, María-Rosa Martínez-Larrañaga, Arturo Anadó. Neurotransmitter changes in rat brain regions following glyphosate exposure. Environmental research. vol 161. 2019-08-28. PMID:29156344. |
after last dose of glyphosate, serotonin (5-ht), dopamine (da) and norepinephrine (ne) and its metabolites levels were determined in the brain regions striatum, hippocampus, prefrontal, cortex, hypothalamus and midbrain, by hplc. |
2019-08-28 |
2023-08-13 |
rat |
| Sarah M Keesom, Mitchell D Morningstar, Rebecca Sandlain, Bradley M Wise, Laura M Hurle. Social isolation reduces serotonergic fiber density in the inferior colliculus of female, but not male, mice. Brain research. vol 1694. 2019-07-11. PMID:29763575. |
here, we assess whether 4 weeks of post-weaning individual housing alters serotonergic fiber density in the inferior colliculus (ic), an auditory midbrain nucleus in which serotonin alters auditory-evoked activity. |
2019-07-11 |
2023-08-13 |
mouse |
| Athanasios Metaxas, Ramanan Vaitheeswaran, Katrine T Jensen, Camilla Thygesen, Laura Ilkjaer, Sultan Darvesh, Bente Finse. Reduced Serotonin Transporter Levels and Inflammation in the Midbrain Raphe of 12 Month Old APPswe/PSEN1dE9 Mice. Current Alzheimer research. vol 15. issue 5. 2019-05-13. PMID:28982335. |
reduced serotonin transporter levels and inflammation in the midbrain raphe of 12 month old appswe/psen1de9 mice. |
2019-05-13 |
2023-08-13 |
mouse |
| Enaam Chleilat, Lena Skatulla, Belal Rahhal, Manal T Hussein, Melanie Feuerstein, Kerstin Krieglstein, Eleni Rouss. TGF-β Signaling Regulates Development of Midbrain Dopaminergic and Hindbrain Serotonergic Neuron Subgroups. Neuroscience. vol 381. 2019-04-05. PMID:29689292. |
molecular and functional diversity within midbrain dopaminergic (mda) and hindbrain serotonergic (5-ht) neurons has emerged as a relevant feature that could underlie selective vulnerability of neurons in clinical disorders. |
2019-04-05 |
2023-08-13 |
Not clear |
| Meng-Meng Wang, Xiao-Hua Yu, Wei Geng, Hua-Feng Cui, Chang-Chun Wang, Jing Han, Dian-Hui Yan. [Manual Acupuncture Stimulation Regulates Expression of Receptor Activity-modifying Protein 1 and 5-HT 1 D Receptor Proteins and Genes in Migraine Rats]. Zhen ci yan jiu = Acupuncture research. vol 43. issue 7. 2019-04-05. PMID:30094981. |
to observe the effect of liver-soothing and mental-activity-regulating (lsmar) needling on the expression of receptor activity-modifying protein 1 (ramp 1, receptor of calcitonin gene-related peptide), 5-hydroxytryptamine 1 d receptor(5-ht 1 dr) in the spinal trigeminal nucleus (stn) and midbrain in migraine rats, so as to explore its underlying mechanism in relieving migraine. |
2019-04-05 |
2023-08-13 |
rat |
| Limei Zhang, Vito S Hernández, Jerome D Swinny, Anil K Verma, Torsten Giesecke, Andrew C Emery, Kerim Mutig, Luis M Garcia-Segura, Lee E Eide. A GABAergic cell type in the lateral habenula links hypothalamic homeostatic and midbrain motivation circuits with sex steroid signaling. Translational psychiatry. vol 8. issue 1. 2018-12-12. PMID:29479060. |
here, we report a cell type in the medial division of the lhb (lhbm) in male rats that is distinguished by: (1) a molecular signature for gabaergic neurotransmission (slc32a1/vgat) and estrogen receptor (esr1/erα) expression, at both mrna and protein levels, as well as the mrna for vesicular glutamate transporter slc17a6/vglut2, which we term the gabaergic estrogen-receptive neuron (gern); (2) its axonal projection patterns, identified by in vivo juxtacellular labeling, to both local lhb and to midbrain modulatory systems; and (3) its somatic expression of receptors for vasopressin, serotonin and dopamine, and mrna for orexin receptor 2. |
2018-12-12 |
2023-08-13 |
rat |
| Limei Zhang, Vito S Hernández, Jerome D Swinny, Anil K Verma, Torsten Giesecke, Andrew C Emery, Kerim Mutig, Luis M Garcia-Segura, Lee E Eide. A GABAergic cell type in the lateral habenula links hypothalamic homeostatic and midbrain motivation circuits with sex steroid signaling. Translational psychiatry. vol 8. issue 1. 2018-12-12. PMID:29479060. |
this cell type is anatomically located to receive afferents from midbrain reward (dopamine and serotonin) and hypothalamic water and energy homeostasis (vasopressin and orexin) circuits. |
2018-12-12 |
2023-08-13 |
rat |
| A S Tsybko, T V Ilchibaeva, D V Bazovkina, V S Naumenk. [Functional Responses to the Chronic Activation of 5-HT1A Receptors in Mice with Genetic Predisposition to Catalepsy]. Molekuliarnaia biologiia. vol 52. issue 2. 2018-12-11. PMID:29695693. |
the chronic activation of 5-ht1a receptor downregulated 5-ht1a gene expression, as well as the expression of the gene that encodes tryptophan hydroxylase 2, a key enzyme of 5-ht biosynthesis, in the midbrain and the expression of the gene that encodes the 5-ht2a receptor in the frontal cortex of cba, but not c57bl/6 mice. |
2018-12-11 |
2023-08-13 |
mouse |
| M Allie Holschbach, Erika M Vitale, Joseph S Lonstei. Serotonin-specific lesions of the dorsal raphe disrupt maternal aggression and caregiving in postpartum rats. Behavioural brain research. vol 348. 2018-11-05. PMID:29653128. |
these findings suggest that drdm serotonin projecting to the ah is particularly critical for maternal aggression, but that more widespread disruption of midbrain raphe serotonin is necessary to greatly impair maternal caregiving. |
2018-11-05 |
2023-08-13 |
rat |
| Saiful Alom Siddique, Thangavel Tamilselvan, Manikkannan Vishnupriya, Elumalai Balamuruga. Evaluation of Neurotransmitter Alterations in Four Distinct Brain Regions After Rapid Eye Movement Sleep Deprivation (REMSD) Induced Mania-Like Behaviour in Swiss Albino Mice. Neurochemical research. vol 43. issue 6. 2018-10-15. PMID:29671235. |
quantitative determinations of da, 5-ht, ne and gaba concentrations in four distinct brain regions (cerebral cortex, hippocampus, midbrain, and pons) were determined by the spectrofluorimetric method. |
2018-10-15 |
2023-08-13 |
mouse |
| Ryan P Vetreno, Yesha Patel, Urvi Patel, T Jordan Walter, Fulton T Crew. Adolescent intermittent ethanol reduces serotonin expression in the adult raphe nucleus and upregulates innate immune expression that is prevented by exercise. Brain, behavior, and immunity. vol 60. 2018-08-16. PMID:27647531. |
tryptophan hydroxylase 2, the rate-limiting 5-ht synthesizing enzyme, and vesicular monoamine transporter 2, which packages 5-ht into synaptic vesicles, were also reduced in the young adult midbrain following aie treatment. |
2018-08-16 |
2023-08-13 |
human |
| Takeya Kitta, Takahiko Mitsui, Yukiko Kanno, Hiroki Chiba, Kimihiko Moriya, Mitsuhiro Yoshioka, Nobuo Shinohar. Differences in neurotransmitter systems of ventrolateral periaqueductal gray between the micturition reflex and nociceptive regulation: An in vivo microdialysis study. International journal of urology : official journal of the Japanese Urological Association. vol 23. issue 7. 2018-08-07. PMID:27062256. |
to elucidate the possible involvement of glutamate and serotonin (5-hydroxytryptamine) neurons in the ventrolateral midbrain periaqueductal gray during noxious stimulation. |
2018-08-07 |
2023-08-13 |
Not clear |
| Christopher L Petersen, Laura M Hurle. Putting it in Context: Linking Auditory Processing with Social Behavior Circuits in the Vertebrate Brain. Integrative and comparative biology. vol 57. issue 4. 2018-05-04. PMID:28985384. |
serotonin fluctuates in the mouse inferior colliculus (ic), an auditory midbrain region important for species-specific vocalizations, during specific social and non-social contexts. |
2018-05-04 |
2023-08-13 |
mouse |
| Takayuki Ishiwata, Hiroshi Hasegawa, Benjamin N Greenwoo. Involvement of serotonin in the ventral tegmental area in thermoregulation of freely moving rats. Neuroscience letters. vol 653. 2018-04-30. PMID:28527719. |
we have recently reported that the serotonin (5-ht) projections from the midbrain's raphe nuclei that contains 5-ht cell bodies may play a role both in heat production and in heat loss. |
2018-04-30 |
2023-08-13 |
rat |
| Grazyna Rajkowska, Gouri Mahajan, Beata Legutko, Lavanya Challagundla, Michael Griswold, Paul R Albert, Mireille Daigle, Jose J Miguel-Hidalgo, Mark C Austin, Randy D Blakely, David C Steffens, Craig A Stockmeie. Length of axons expressing the serotonin transporter in orbitofrontal cortex is lower with age in depression. Neuroscience. vol 359. 2018-04-30. PMID:28711621. |
studies of major depressive disorder (mdd) in postmortem brain tissue report enhanced binding to inhibitory serotonin-1a autoreceptors in midbrain dorsal raphe and reductions in length of axons expressing the serotonin transporter (sert) in dorsolateral prefrontal cortex. |
2018-04-30 |
2023-08-13 |
human |