| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chang-Hong Wang, Cong Liu, En-Zhao Cong, Gai-Ling Xu, Ting-Ting Lv, Ying-Li Zhang, Qiu-Fen Ning, Ji-Kang Wang, Hui-Yao Nie, Yan L. Association of tryptophan hydroxylase-2 polymorphisms with oppositional defiant disorder in a Chinese Han population. Behavioral and brain functions : BBF. vol 12. issue 1. 2017-01-23. PMID:27871272. |
the enzyme tryptophan hydroxylase-2 (tph-2) synthesizes 5-ht in serotonergic neurons of the midbrain raphe. |
2017-01-23 |
2023-08-13 |
Not clear |
| Alan C Jackso. Diabolical effects of rabies encephalitis. Journal of neurovirology. vol 22. issue 1. 2016-10-14. PMID:25994917. |
heavy accumulation of rabv antigen was found in the midbrain raphe nuclei, indicating that impaired serotonin neurotransmission from the brainstem may account for the aggressive behavior. |
2016-10-14 |
2023-08-13 |
Not clear |
| Dasiel O Borroto-Escuela, Alexander O Tarakanov, Kjell Fux. FGFR1-5-HT1A Heteroreceptor Complexes: Implications for Understanding and Treating Major Depression. Trends in neurosciences. vol 39. issue 1. 2016-10-07. PMID:26687454. |
they were first described in the hippocampus and later in midbrain 5-ht neurons, where these heterocomplexes are enriched in 5-ht1a autoreceptors. |
2016-10-07 |
2023-08-13 |
Not clear |
| Deepali Gupta, Devadoss Thangaraj, Mahesh Radhakrishna. A novel 5HT3 antagonist 4i (N-(3-chloro-2-methylphenyl)quinoxalin-2-carboxamide) prevents diabetes-induced depressive phenotypes in mice: Modulation of serotonergic system. Behavioural brain research. vol 297. 2016-09-15. PMID:26454237. |
for 4-weeks and subjected to neurobehavioral assays, followed by biochemical estimation of serotonin levels in midbrain, prefrontal-cortex and cerebellum. |
2016-09-15 |
2023-08-13 |
mouse |
| Claudia Böhm, Maria Pangalos, Dietmar Schmitz, Jochen Wintere. Serotonin Attenuates Feedback Excitation onto O-LM Interneurons. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 11. 2016-07-18. PMID:26021702. |
in the hippocampus, serotonin (5-ht) is released by ascending serotonergic fibers from the midbrain raphe nuclei, thereby mediating numerous modulatory functions on various neuronal subtypes. |
2016-07-18 |
2023-08-13 |
rat |
| J L Rodríguez, I Ares, V Castellano, M Martínez, M R Martínez-Larrañaga, A Anadón, M A Martíne. Effects of exposure to pyrethroid cyfluthrin on serotonin and dopamine levels in brain regions of male rats. Environmental research. vol 146. 2016-06-27. PMID:26826775. |
after last dose of cyfluthrin, dopamine (da) and serotonin (5-ht) and its metabolites levels were determined in brain regions hypothalamus, midbrain, hippocampus, striatum and prefrontal cortex by hplc. |
2016-06-27 |
2023-08-13 |
rat |
| J L Rodríguez, I Ares, V Castellano, M Martínez, M R Martínez-Larrañaga, A Anadón, M A Martíne. Effects of exposure to pyrethroid cyfluthrin on serotonin and dopamine levels in brain regions of male rats. Environmental research. vol 146. 2016-06-27. PMID:26826775. |
moreover, cyfluthrin (20mg/kg bw, orally 6 days) evoked a statistically significant increase in 5-ht turnover in striatum and midbrain, and in da turnover in striatum and prefrontal cortex. |
2016-06-27 |
2023-08-13 |
rat |
| Galina T Shishkina, Tatyana S Kalinina, Veta V Bulygina, Dmitry A Lanshakov, Ekaterina V Babluk, Nikolay N Dygal. Anti-Apoptotic Protein Bcl-xL Expression in the Midbrain Raphe Region Is Sensitive to Stress and Glucocorticoids. PloS one. vol 10. issue 12. 2016-06-20. PMID:26624017. |
in order to determine whether stressful events may influence the expression of anti-apoptotic protein bcl-xl in the midbrain and specifically in the midbrain serotonergic (5-ht) neurons involved in neurobehavioral responses to adverse stimuli, adult male rats were subjected to short-term or chronic forced swim stress. |
2016-06-20 |
2023-08-13 |
rat |
| Galina T Shishkina, Tatyana S Kalinina, Veta V Bulygina, Dmitry A Lanshakov, Ekaterina V Babluk, Nikolay N Dygal. Anti-Apoptotic Protein Bcl-xL Expression in the Midbrain Raphe Region Is Sensitive to Stress and Glucocorticoids. PloS one. vol 10. issue 12. 2016-06-20. PMID:26624017. |
a short-term stress rapidly increased the midbrain bcl-xl mrna levels and significantly elevated bcl-xl immunoreactivity in the midbrain 5-ht cells. |
2016-06-20 |
2023-08-13 |
rat |
| Galina T Shishkina, Tatyana S Kalinina, Veta V Bulygina, Dmitry A Lanshakov, Ekaterina V Babluk, Nikolay N Dygal. Anti-Apoptotic Protein Bcl-xL Expression in the Midbrain Raphe Region Is Sensitive to Stress and Glucocorticoids. PloS one. vol 10. issue 12. 2016-06-20. PMID:26624017. |
forced swim repeated daily for 2 weeks led to a decrease in bcl-xl mrna in the midbrain without any effects on the bcl-xl protein expression in the 5-ht neurons. |
2016-06-20 |
2023-08-13 |
rat |
| Galina T Shishkina, Tatyana S Kalinina, Veta V Bulygina, Dmitry A Lanshakov, Ekaterina V Babluk, Nikolay N Dygal. Anti-Apoptotic Protein Bcl-xL Expression in the Midbrain Raphe Region Is Sensitive to Stress and Glucocorticoids. PloS one. vol 10. issue 12. 2016-06-20. PMID:26624017. |
our findings are the first to demonstrate that both short-term stress and acute glucocorticoid exposures induce bcl-xl protein expression in the midbrain 5-ht neurons concomitantly with the activation of the 5-ht synthesis pathway in these neurons. |
2016-06-20 |
2023-08-13 |
rat |
| Sylvia Navailles, Karine Guillem, Caroline Vouillac-Mendoza, Serge H Ahme. Coordinated Recruitment of Cortical-Subcortical Circuits and Ascending Dopamine and Serotonin Neurons During Inhibitory Control of Cocaine Seeking in Rats. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 9. 2016-05-10. PMID:24872521. |
overall, we found that effective inhibitory control of cocaine seeking is associated with the coordinated recruitment of different top-down cortical-striatal circuits originating from different pfc territories, and of different bottom-up dopamine (da) and serotonin (5-ht) midbrain subsystems that normally modulate activity in these circuits. |
2016-05-10 |
2023-08-13 |
rat |
| Essam Ezzeldin, Wafaa A H Souror, Toqa El-Nahhas, Abdel Nasser M M Soudi, Abdelaaty A Shaha. Biochemical and neurotransmitters changes associated with tramadol in streptozotocin-induced diabetes in rats. BioMed research international. vol 2014. 2016-05-02. PMID:24971322. |
the levels of da, ne, and 5-ht in cerebral cortex, thalamus/hypothalamus, midbrain, and brainstem were evaluated in rats. |
2016-05-02 |
2023-08-13 |
rat |
| Noah H Green, Chad R Jackson, Hideki Iwamoto, Michael C Tackenberg, Douglas G McMaho. Photoperiod programs dorsal raphe serotonergic neurons and affective behaviors. Current biology : CB. vol 25. issue 10. 2016-04-21. PMID:25959961. |
the serotonergic raphe nuclei of the midbrain are principal centers from which serotonin neurons project to innervate cortical and sub-cortical structures. |
2016-04-21 |
2023-08-13 |
mouse |
| Noah H Green, Chad R Jackson, Hideki Iwamoto, Michael C Tackenberg, Douglas G McMaho. Photoperiod programs dorsal raphe serotonergic neurons and affective behaviors. Current biology : CB. vol 25. issue 10. 2016-04-21. PMID:25959961. |
here, we demonstrate that day length (photoperiod) during development induces enduring changes in mouse dorsal raphe serotonin neurons—programming their firing rate, responsiveness to noradrenergic stimulation, intrinsic electrical properties, serotonin and norepinephrine content in the midbrain, and depression/anxiety-related behavior in a melatonin receptor 1 (mt1)-dependent manner. |
2016-04-21 |
2023-08-13 |
mouse |
| Julia T Brouard, Judith V Schweimer, Rachel Houlton, Katherine E Burnham, Philip Quérée, Trevor Shar. Pharmacological Evidence for 5-HT6 Receptor Modulation of 5-HT Neuron Firing in Vivo. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25837696. |
5-hydroxytryptamine (5-ht) neurons in the midbrain dorsal raphe nucleus (drn) are implicated in the drug treatment and pathophysiology of a wide variety of neuropsychiatric disorders. |
2016-04-19 |
2023-08-13 |
rat |
| Tillmann Weber, Miriam A Vogt, Sarah E Gartside, Stefan M Berger, Rafael Lujan, Thorsten Lau, Elke Herrmann, Rolf Sprengel, Dusan Bartsch, Peter Gas. Adult AMPA GLUA1 receptor subunit loss in 5-HT neurons results in a specific anxiety-phenotype with evidence for dysregulation of 5-HT neuronal activity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 6. 2016-03-29. PMID:25547714. |
descending cortical glutamatergic neurons regulate 5-ht neuronal activity in the midbrain raphe nuclei through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) and n-methyl-d-aspartate (nmda) receptors. |
2016-03-29 |
2023-08-13 |
mouse |
| Jillon S Vander Wa. The Treatment of Night Eating Syndrome: A Review and Theoretical Model. Current obesity reports. vol 3. issue 1. 2016-03-12. PMID:26626475. |
the biobehavioral model proposes that a genetic predisposition, coupled with stress, enhances midbrain serotonin transporter (sert) binding, which results in lower post-synaptic serotonin, dysregulating circadian rhythms and decreasing satiety. |
2016-03-12 |
2023-08-13 |
Not clear |
| Matthew Mazalouskas, Tammy Jessen, Seth Varney, James S Sutcliffe, Jeremy Veenstra-VanderWeele, Edwin H Cook, Ana M D Carneir. Integrin β3 Haploinsufficiency Modulates Serotonin Transport and Antidepressant-Sensitive Behavior in Mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 8. 2016-03-08. PMID:25684064. |
notably, we establish that loss of a single allele of itgb3 in murine neurons is sufficient to decrease 5-ht uptake by sert in midbrain synaptosomes. |
2016-03-08 |
2023-08-13 |
mouse |
| Matthew Mazalouskas, Tammy Jessen, Seth Varney, James S Sutcliffe, Jeremy Veenstra-VanderWeele, Edwin H Cook, Ana M D Carneir. Integrin β3 Haploinsufficiency Modulates Serotonin Transport and Antidepressant-Sensitive Behavior in Mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 8. 2016-03-08. PMID:25684064. |
these data are consistent with the existence of a subpopulation of serts that are tightly modulated by integrin αvβ3 and significantly contribute to global sert function at 5-ht synapses in the midbrain. |
2016-03-08 |
2023-08-13 |
mouse |