| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Benneth Ben-Azu, Olusegun G Adebayo, Emuesiri G Moke, Adrian I Omogbiya, Benjamin Oritsemuelebi, Emmanuel O Chidebe, Emuesiri Umukoro, Eze K Nwangwa, Emmanuel Etijoro, Emmanuel Umukoro, Elizabeth J Mamudu, Chineye Chukwum. Geraniol attenuates behavioral and neurochemical impairments by inhibitions of HPA-axis and oxido-inflammatory perturbations in mice exposed to post-traumatic stress disorder. Journal of psychiatric research. vol 168. 2023-11-01. PMID:37913743. |
geraniol also increased glutathione, superoxide-dismutase, and catalase levels as well as dopamine, serotonin concentrations and gabaergic glutamic acid decarboxylase enzyme activity in the striatum, prefrontal cortex and hippocampus in the ptsd-mice relative to sps control. |
2023-11-01 |
2023-11-08 |
mouse |
| Kaito Kurogi, Fuka Taniguchi, Ryohei Matsuo, Marina Shinozuka, Raiki Suzaki, Shinobu Yasu. Increased depression-like behaviors with altered brain dopamine metabolisms in male mice housed in large cages are alleviated by bupropion. European journal of pharmacology. 2023-10-20. PMID:37858834. |
in mice housed in large cages, sex-specific dysregulation of brain monoamine systems was observed; dopamine turnover to homovanillic acid or norepinephrine in the prefrontal cortex was elevated in males, while serotonin turnover to 5-hydroxyindoleacetic acid in the amygdala was increased in females. |
2023-10-20 |
2023-11-08 |
mouse |
| Mauritz Frederick Herselman, Larisa Bobrovskay. The Effects of Chronic Unpredictable Mild Stress and Semi-Pure Diets on the Brain, Gut and Adrenal Medulla in C57BL6 Mice. International journal of molecular sciences. vol 24. issue 19. 2023-10-14. PMID:37834073. |
cums induced anxiety-like behaviour, dysregulated the tryptophan and serotonin metabolic pathways in the hippocampus, prefrontal cortex, and colon, and altered the composition of the gut microbiota. |
2023-10-14 |
2023-10-15 |
mouse |
| Huijuan Guo, Xinxu Liu, Ti Chen, Xiaoping Wang, Xiaojie Zhan. Akkermansia muciniphila Improves Depressive-Like Symptoms by Modulating the Level of 5-HT Neurotransmitters in the Gut and Brain of Mice. Molecular neurobiology. 2023-09-05. PMID:37668965. |
more importantly, akk implantation significantly increased the level of 5-ht in the gut and pfc of both the alcohol exposure mice and the cums mice. |
2023-09-05 |
2023-09-07 |
mouse |
| Francesco Tortora, Abed L Hadipour, Simone Battaglia, Alessandra Falzone, Alessio Avenanti, Carmelo M Vicari. The Role of Serotonin in Fear Learning and Memory: A Systematic Review of Human Studies. Brain sciences. vol 13. issue 8. 2023-08-26. PMID:37626553. |
accumulating evidence from both animal and human studies suggests that brain regions involved in fc, such as the amygdala, hippocampus, and prefrontal cortex, possess a high density of 5-ht receptors, implicating the crucial involvement of serotonin in aversive learning. |
2023-08-26 |
2023-09-07 |
human |
| Kyung Hwa Lee, Jiyoon Shin, Jung Lee, Jae Hyun Yoo, Jae-Won Kim, David A Bren. Measures of Connectivity and Dorsolateral Prefrontal Cortex Volumes and Depressive Symptoms Following Treatment With Selective Serotonin Reuptake Inhibitors in Adolescents. JAMA network open. vol 6. issue 8. 2023-08-04. PMID:37540512. |
measures of connectivity and dorsolateral prefrontal cortex volumes and depressive symptoms following treatment with selective serotonin reuptake inhibitors in adolescents. |
2023-08-04 |
2023-08-14 |
Not clear |
| Ruixi Yang, Suzhen Ye, Shuping Zhang, Hanjin Huang, Yun Zhang, Yao Yang, Shu Xie, Lin He, Yuwei Yang, Jian Sh. Serotonin and dopamine depletion in distinct brain regions may cause anxiety in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice as a model of early Parkinson's disease. Neuroreport. vol 34. issue 11. 2023-06-29. PMID:37384936. |
in our murine model, mptp induced a decreased level of 5-hydroxytryptamine and its metabolite 5-hydroxyindoleacetic acid (5-hiaa) in the prefrontal cortex, hippocampus, and striatum (all p < 0.05); however, it only induced a decreased level of dopamine and its metabolite homovanillic acid (hva) in the striatum (both p < 0.001), with a negative correlation in the hippocampus and a positive correlation in the cortex and striatum. |
2023-06-29 |
2023-08-14 |
mouse |
| Fang Lin, Xinyuan Wang, Ruifang Luo, Binlin Yuan, Shasha Ye, Ting Yang, Lu Xiao, Jie Che. Maternal LPS Exposure Enhances the 5-HT Level in the Prefrontal Cortex of Autism-like Young Offspring. Brain sciences. vol 13. issue 6. 2023-06-28. PMID:37371436. |
maternal lps exposure enhances the 5-ht level in the prefrontal cortex of autism-like young offspring. |
2023-06-28 |
2023-08-14 |
rat |
| Fang Lin, Xinyuan Wang, Ruifang Luo, Binlin Yuan, Shasha Ye, Ting Yang, Lu Xiao, Jie Che. Maternal LPS Exposure Enhances the 5-HT Level in the Prefrontal Cortex of Autism-like Young Offspring. Brain sciences. vol 13. issue 6. 2023-06-28. PMID:37371436. |
the aim of this research is to investigate the changes in serotonin (5-ht) in the medial prefrontal cortex (pfc) of autism-like offspring induced by maternal lipopolysaccharide (lps) exposure. |
2023-06-28 |
2023-08-14 |
rat |
| Rosa Savino, Anna Nunzia Polito, Gabriella Marsala, Antonio Ventriglio, Melanie Di Salvatore, Maria Ida De Stefano, Anna Valenzano, Luigi Marinaccio, Antonello Bellomo, Giuseppe Cibelli, Marcellino Monda, Vincenzo Monda, Antonietta Messina, Rita Polito, Marco Carotenuto, Giovanni Messin. Agomelatine: A Potential Multitarget Compound for Neurodevelopmental Disorders. Brain sciences. vol 13. issue 5. 2023-05-27. PMID:37239206. |
agm is involved in the resynchronization of interrupted circadian rhythms, with beneficial effects on sleep patterns, while antagonism on serotonin receptors increases the availability of norepinephrine and dopamine in the prefrontal cortex, with an antidepressant and nootropic effect. |
2023-05-27 |
2023-08-14 |
Not clear |
| Xiaoju Liu, Haijuan Wang, Xiaoyu Wang, Yinxia Ning, Wei Liu, Jie Ga. Baixiangdan capsule and Shuyu capsule regulate anger-out and anger-in, respectively: GB1-mediated GABA can regulate 5-HT levels in multiple brain regions. Aging. vol 15. 2023-03-29. PMID:36988497. |
the improvement way is as follows: decreased abnormal increase of gaba and gb1 in the drn further mediated synaptic inhibition and increased 5-ht level in the drn, leading to increased 5-ht levels in the pfc, hypothalamus, and hippocampus. |
2023-03-29 |
2023-08-14 |
rat |
| Zhonghua An, Yifan Wang, Xiangbo Li, Hong Jin, Yanling Gon. Antifatigue effect of sea buckthorn seed oil on swimming fatigue in mice. Journal of food science. 2023-03-14. PMID:36916120. |
the sso treatment decreased hypothalamic 5-hydroxytryptamine content, lipid hydroperoxide level, nlrp3 inflammasome, and interleukin-1β protein expression in the prefrontal cortex. |
2023-03-14 |
2023-08-14 |
mouse |
| Elisa Giunti, Roberto Collu, Simona Dedoni, M Paola Castelli, Maria Scherma, Paola Fadd. Food restriction and hyperactivity induce changes in corticolimbic brain dopamine and serotonin levels in female rats. Behavioural brain research. 2023-03-02. PMID:36863461. |
we exposed female rats to the aba paradigm and measured the levels of da, 5-ht, and the metabolites 3,4-dihydroxyphenylacetic acid (dopac), homovanillic acid (hva), 5-hydroxyindoleacetic acid (5-hiaa), and dopaminergic type 2 (d2) receptors density in feeding- and reward-implicated brain regions (i.e., cerebral cortex, cx; prefrontal cortex, pfc; caudate putamen, cpu; nucleus accumbens, nacc; amygdala, amy; hypothalamus, hyp; hippocampus, hipp). |
2023-03-02 |
2023-08-14 |
rat |
| Elisa Giunti, Roberto Collu, Simona Dedoni, M Paola Castelli, Maria Scherma, Paola Fadd. Food restriction and hyperactivity induce changes in corticolimbic brain dopamine and serotonin levels in female rats. Behavioural brain research. 2023-03-02. PMID:36863461. |
da levels were significantly increased in the cx, pfc and nacc, while 5-ht was significantly enhanced in the nacc and hipp of aba rats. |
2023-03-02 |
2023-08-14 |
rat |
| M Maetzi Estévez-Cabrera, Fausto Sánchez-Muñoz, Gilberto Pérez-Sánchez, Lenin Pavón, Adrian Hernández-Díazcouder, J Luis Córtes Altamirano, C Soria-Fregoso, Alfonso Alfaro-Rodríguez, Herlinda Bonilla-Jaim. Therapeutic treatment with fluoxetine using the chronic unpredictable stress model induces changes in neurotransmitters and circulating miRNAs in extracellular vesicles. Heliyon. vol 9. issue 2. 2023-02-28. PMID:36852042. |
after cums, the rats performed the fst, and serum levels of cort and six micrornas (mir-16, -21, -144, -155, -146a, -223) were analyzed, as were levels of dopamine, noradrenaline, and serotonin in the prefrontal cortex, hippocampus, and hypothalamus. |
2023-02-28 |
2023-08-14 |
rat |
| Kinga Krzysztoforska, Agnieszka Piechal, Ewa Wojnar, Kamilla Blecharz-Klin, Justyna Pyrzanowska, Ilona Joniec-Maciejak, Jan Krzysztoforski, Ewa Widy-Tyszkiewic. Protocatechuic Acid Prevents Some of the Memory-Related Behavioural and Neurotransmitter Changes in a Pyrithiamine-Induced Thiamine Deficiency Model of Wernicke-Korsakoff Syndrome in Rats. Nutrients. vol 15. issue 3. 2023-02-11. PMID:36771332. |
compared to the control group, rats with wks showed reduced serotonin levels in the prefrontal cortex and changes in dopamine and/or norepinephrine metabolites in the prefrontal cortex, medulla oblongata and spinal cord. |
2023-02-11 |
2023-08-14 |
rat |
| Xia-Jing Zhang, Zhi-Bin Xiao, Jun-Xiang Gu, Kun Chen, Jian Wang, Sheng-Long Xu, Ke-Ke Xing, Tao Che. Investigating the molecular mechanisms of delirium-like neuropsychiatric disorder induced by electromagnetic pulse based on bioinformatics analysis. Molecular brain. vol 16. issue 1. 2023-02-08. PMID:36750928. |
lncrna aabr07042999.1 and mrna tph2, slc6a4, dbh and th were upregulated, and the contents of serotonin, dopamine and norepinephrine were increased in both pfc and hip after emp exposure. |
2023-02-08 |
2023-08-14 |
rat |
| R Janet, N Costes, I Mérida, E Derrington, J C Drehe. Relationships between serotonin availability and frontolimbic response to fearful and threatening faces. Scientific reports. vol 13. issue 1. 2023-01-27. PMID:36707612. |
although emotion processing is known to engage a corticolimbic circuit, including the amygdala and prefrontal cortex, exactly how this brain system is modulated by serotonin remains unclear. |
2023-01-27 |
2023-08-14 |
human |
| Guilherme Shigueto Vilar Higa, José Francis-Oliveira, Estevão Carlos-Lima, Alicia Moraes Tamais, Fernando da Silva Borges, Alexandre Hiroaki Kihara, Ianê Carvalho Shieh, Henning Ulrich, Silvana Chiavegatto, Roberto De Pasqual. 5-HT-dependent synaptic plasticity of the prefrontal cortex in postnatal development. Scientific reports. vol 12. issue 1. 2022-12-05. PMID:36470912. |
in the pfc, activated 5-ht receptors modify neuronal excitability and interact with intracellular signaling involved in synaptic modifications, thus suggesting that 5-ht might participate in early postnatal plasticity. |
2022-12-05 |
2023-08-14 |
rat |
| Guilherme Shigueto Vilar Higa, José Francis-Oliveira, Estevão Carlos-Lima, Alicia Moraes Tamais, Fernando da Silva Borges, Alexandre Hiroaki Kihara, Ianê Carvalho Shieh, Henning Ulrich, Silvana Chiavegatto, Roberto De Pasqual. 5-HT-dependent synaptic plasticity of the prefrontal cortex in postnatal development. Scientific reports. vol 12. issue 1. 2022-12-05. PMID:36470912. |
to test this hypothesis, we employed intracellular electrophysiological recordings of pfc layer 5 neurons to study the modulatory effects of 5-ht on plasticity induced by theta-burst stimulation (tbs) in two postnatal periods of rats. |
2022-12-05 |
2023-08-14 |
rat |