| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Edem Ekpenyong Edem, Uyi Emmanuel Okhonmina, Kate Eberechukwu Nebo, Elizabeth Toyin Akinluyi, Daniel Akinwale Ikuelogbon, Adedamola Adediran Fafure, Ayodeji Augustine Olabiyi, Mujeeb Adekunle Adedoku. Combined Exposure to Chronic Sleep Deprivation and Caffeine Potentiates Behavioural Deficits by Altering Neurochemical Profile and Synaptophysin Expression in Long-Evans Rats. Neurotoxicity research. 2022-11-26. PMID:36434357. |
the combination of chronic sleep deprivation and high-dose caffeine treatment produced varying degrees of behavioural impairments, depletion of antioxidants, serotonin, and an upregulation of acetylcholinesterase (ache) activity in the prefrontal cortex. |
2022-11-26 |
2023-08-14 |
rat |
| Lauren Allen McKibben, Yogesh Dwived. MicroRNA Regulates Early-Life Stress-Induced Depressive Behavior via Serotonin Signaling in a Sex-Dependent Manner in the Prefrontal Cortex of Rats. Biological psychiatry global open science. vol 1. issue 3. 2022-11-03. PMID:36325302. |
microrna regulates early-life stress-induced depressive behavior via serotonin signaling in a sex-dependent manner in the prefrontal cortex of rats. |
2022-11-03 |
2023-08-14 |
rat |
| Esther Silk, Mustansir Diwan, Thallita Rabelo, Hailey Katzman, Ana Carolina P Campos, Flavia Venetucci Gouveia, Peter Giacobbe, Nir Lipsman, Clement Haman. Serotonin 5-HT Psychopharmacology. 2022-10-25. PMID:36282287. |
serotonin 5-ht deep brain stimulation (dbs) delivered to the ventromedial prefrontal cortex (vmpfc) induces antidepressant- and anxiolytic-like responses in various animal models. |
2022-10-25 |
2023-08-14 |
Not clear |
| Barbara Dos Anjos Rosário, Maria de Fátima SantanaNazaré, Daniel Vitor de Souza, Luciana Le Sueur-Maluf, Débora Estadella, Daniel Araki Ribeiro, Milena de Barros Vian. The influence of sex and reproductive cycle on cocaine-induced behavioral and neurobiological alterations: a review. Experimental brain research. 2022-10-20. PMID:36264315. |
these observations are related to the direct effects played by ovarian hormones (in particularly estradiol), in dopamine, but also in serotonin neurons, and in brain regions such as the tegmental area, the nucleus accumbens, the hypothalamus, the amygdala and the prefrontal cortex. |
2022-10-20 |
2023-08-14 |
Not clear |
| Alice Taddeucci, Guendalina Olivero, Alessandra Roggeri, Claudio Milanese, Francesco Paolo Di Giorgio, Massimo Grilli, Mario Marchi, Beatrice Garrone, Anna Pittalug. Presynaptic 5-HT Cells. vol 11. issue 19. 2022-10-14. PMID:36230998. |
presynaptic 5-ht the glutamatergic nerve endings of a rat prefrontal cortex (pfc) possess presynaptic 5-ht |
2022-10-14 |
2023-08-14 |
rat |
| Maria Becker, Karin Abaev, Elena Shmerkin, Liza Weinstein-Fudim, Albert Pinhasov, Asher Orno. Prenatal SAMe Treatment Induces Changes in Brain Monoamines and in the Expression of Genes Related to Monoamine Metabolism in a Mouse Model of Social Hierarchy and Depression, Probably via an Epigenetic Mechanism. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36233200. |
same increased the levels of serotonin in the pfc of female sub mice but not in males. |
2022-10-14 |
2023-08-14 |
mouse |
| Paolo Tucci, Maria Bove, Vladyslav Sikora, Stefania Dimonte, Maria Grazia Morgese, Stefania Schiavone, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Luigia Trabac. Glucoraphanin Triggers Rapid Antidepressant Responses in a Rat Model of Beta Amyloid-Induced Depressive-like Behaviour. Pharmaceuticals (Basel, Switzerland). vol 15. issue 9. 2022-09-23. PMID:36145275. |
behavioural analyses were accompanied by neurochemical and biochemical measurements in the prefrontal cortex (pfc), such as serotonin (5-ht), noradrenaline (na), kynurenine (kyn), tryptophan (trp), reactive oxygen species (ros) and the transcription nuclear factor kappa b (nf-kb) levels. |
2022-09-23 |
2023-08-14 |
rat |
| Paolo Tucci, Maria Bove, Vladyslav Sikora, Stefania Dimonte, Maria Grazia Morgese, Stefania Schiavone, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Luigia Trabac. Glucoraphanin Triggers Rapid Antidepressant Responses in a Rat Model of Beta Amyloid-Induced Depressive-like Behaviour. Pharmaceuticals (Basel, Switzerland). vol 15. issue 9. 2022-09-23. PMID:36145275. |
we reported that gra administration in naïve rats at the dose of 50 mg/kg reduced the immobility frequency in the fst and increased 5-ht and na levels in the pfc compared to controls. |
2022-09-23 |
2023-08-14 |
rat |
| Paolo Tucci, Maria Bove, Vladyslav Sikora, Stefania Dimonte, Maria Grazia Morgese, Stefania Schiavone, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Luigia Trabac. Glucoraphanin Triggers Rapid Antidepressant Responses in a Rat Model of Beta Amyloid-Induced Depressive-like Behaviour. Pharmaceuticals (Basel, Switzerland). vol 15. issue 9. 2022-09-23. PMID:36145275. |
at the same dose, gra reverted depressive-like effects of saβ 1-42 administration, restored the 5-ht levels and reduced nf-kb, kyn and ros levels in pfc. |
2022-09-23 |
2023-08-14 |
rat |
| Bernardo Lopez-Torres, Irma Ares, Marta Martínez, Jorge-Enrique Maximiliano, María-Rosa Martínez-Larrañaga, Arturo Anadón, María-Aránzazu Martíne. Neurotoxicity induced by the pyrethroid lambda-cyhalothrin: Alterations in monoaminergic systems and dopaminergic and serotoninergic pathways in the rat brain. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-09-20. PMID:36126889. |
the effects of type ii pyrethroid lambda-cyhalothrin on dopamine (da) and serotonin (5-ht) synthesis in rat brain regions (striatum, hippocampus, prefrontal cortex, hypothalamus and midbrain) were studied. |
2022-09-20 |
2023-08-14 |
rat |
| Bernardo Lopez-Torres, Irma Ares, Marta Martínez, Jorge-Enrique Maximiliano, María-Rosa Martínez-Larrañaga, Arturo Anadón, María-Aránzazu Martíne. Neurotoxicity induced by the pyrethroid lambda-cyhalothrin: Alterations in monoaminergic systems and dopaminergic and serotoninergic pathways in the rat brain. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-09-20. PMID:36126889. |
the major decreases in da and 5-ht contents were observed in hippocampus and prefrontal cortex tissues. |
2022-09-20 |
2023-08-14 |
rat |
| Bernardo Lopez-Torres, Irma Ares, Marta Martínez, Jorge-Enrique Maximiliano, María-Rosa Martínez-Larrañaga, Arturo Anadón, María-Aránzazu Martíne. Neurotoxicity induced by the pyrethroid lambda-cyhalothrin: Alterations in monoaminergic systems and dopaminergic and serotoninergic pathways in the rat brain. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-09-20. PMID:36126889. |
this research study also showed in hippocampus and prefrontal cortex, that lambda-cyhalothrin modified the mrna levels of da transporter gene (dat1 up-regulation), 5-ht transporter gene (sert down-regulation), da receptor genes (drd1and drd2 down-regulation), 5-ht receptor genes (5-ht1a and 5-ht2a down-regulation/up-regulation), da synthesis gene (th down-regulation), 5-ht synthesis gene (tph2 down-regulation), da and 5-ht degradation genes (maoa and maob up-regulation). |
2022-09-20 |
2023-08-14 |
rat |
| Diana Serra, Joana F Henriques, Fábio J Sousa, Mariana Laranjo, Rosa Resende, Marisa Ferreira-Marques, Victor de Freitas, Gabriela Silva, João Peça, Teresa C P Dinis, Leonor M Almeid. Attenuation of Autism-like Behaviors by an Anthocyanin-Rich Extract from Portuguese Blueberries via Microbiota-Gut-Brain Axis Modulation in a Valproic Acid Mouse Model. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012528. |
our data suggested that the are treatment alleviated autism-like behaviors in in utero vpa-exposed mice and, at the same time, decreased both neuroinflammation and gut inflammation, modulated the gut microbiota composition, increased serotonin levels in cerebral prefrontal cortex and gut, and reduced the synaptic dysfunction verified in autistic mice. |
2022-08-26 |
2023-08-14 |
mouse |
| Takahiro Maekawa, Naoyoshi Sakitani, Youngjae Ryu, Atsushi Takashima, Shuhei Murase, Julius Fink, Motoshi Nagao, Toru Ogata, Masahiro Shinohara, Yasuhiro Sawad. Application of Passive Head Motion to Generate Defined Accelerations at the Heads of Rodents. Journal of visualized experiments : JoVE. issue 185. 2022-08-08. PMID:35938802. |
by using this system, it was demonstrated that phm recapitulates the serotonin (5-hydroxytryptamine, hereafter referred to as 5-ht) receptor subtype 2a (5-ht2a) signaling in the prefrontal cortex (pfc) neurons of mice. |
2022-08-08 |
2023-08-14 |
mouse |
| Yongxiang Li, Shuqing Zhu, Kailai Xie, Xiajie Feng, Lvshuang Chen, Xin Wu, Zhonghua Sun, Gang Shu, Songbo Wang, Canjun Zhu, Ping Gao, Qingyan Jiang, Lina Wan. TLR4 in Tph2 neurons modulates anxiety-related behaviors in a sex-dependent manner. Neuropharmacology. 2022-07-05. PMID:35787402. |
tph2 is a rate-limiting enzyme for 5-ht biosynthesis that is expressed at high levels in the drn, which includes the main 5-ht projection to the hippocampus and prefrontal cortex and regulates anxiety disorder. |
2022-07-05 |
2023-08-14 |
mouse |
| Khurshid Jalal, Faisal Khan, Shazia Nawaz, Rushda Afroz, Kanwal Khan, Sadia Basharat Ali, Liangliang Hao, Saeed Ahmad Khan, Mohsin Kazi, Reaz Uddin, Darakhshan Jabeen Halee. Anxiolytic, anti-nociceptive and body weight reducing effects of L-lysine in rats: Relationship with brain serotonin an In-Vivo and In-Silico study. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 152. 2022-06-13. PMID:35696944. |
5-hydroxytryptamine (5-ht, serotonin) metabolism, and tryptophan (trp) levels in the midbrain (mb), hippocampus (hp), and prefrontal cortex (pfc) were also determined. |
2022-06-13 |
2023-08-14 |
rat |
| Khurshid Jalal, Faisal Khan, Shazia Nawaz, Rushda Afroz, Kanwal Khan, Sadia Basharat Ali, Liangliang Hao, Saeed Ahmad Khan, Mohsin Kazi, Reaz Uddin, Darakhshan Jabeen Halee. Anxiolytic, anti-nociceptive and body weight reducing effects of L-lysine in rats: Relationship with brain serotonin an In-Vivo and In-Silico study. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 152. 2022-06-13. PMID:35696944. |
repeated administration of l-lys increased 5-ht levels in the pfc and hp. |
2022-06-13 |
2023-08-14 |
rat |
| Khurshid Jalal, Faisal Khan, Shazia Nawaz, Rushda Afroz, Kanwal Khan, Sadia Basharat Ali, Liangliang Hao, Saeed Ahmad Khan, Mohsin Kazi, Reaz Uddin, Darakhshan Jabeen Halee. Anxiolytic, anti-nociceptive and body weight reducing effects of L-lysine in rats: Relationship with brain serotonin an In-Vivo and In-Silico study. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 152. 2022-06-13. PMID:35696944. |
trp, the precourser of 5-ht, decreased in the pfc. |
2022-06-13 |
2023-08-14 |
rat |
| Khurshid Jalal, Faisal Khan, Shazia Nawaz, Rushda Afroz, Kanwal Khan, Sadia Basharat Ali, Liangliang Hao, Saeed Ahmad Khan, Mohsin Kazi, Reaz Uddin, Darakhshan Jabeen Halee. Anxiolytic, anti-nociceptive and body weight reducing effects of L-lysine in rats: Relationship with brain serotonin an In-Vivo and In-Silico study. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 152. 2022-06-13. PMID:35696944. |
these beneficial effects were associated with an increase in 5-ht levels in the pfc and hp. |
2022-06-13 |
2023-08-14 |
rat |
| Tingting Yang, Yue Li, Hui Wang, Peng Shi, Liu Teng, Haibo Guo, Xiaohua Tu, Xinyu Ya. The 5-HT and PLC Signaling Pathways Regulate the Secretion of IL-1 Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-05-23. PMID:35600957. |
the co-localization of ng2 cells and 5-ht in rat prefrontal cortex was determined using immunofluorescence. |
2022-05-23 |
2023-08-13 |
rat |