| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Ju Liu, Hai-Juan Wang, Xiao-Yu Wang, Yin-Xia Ning, Jie Ga. GABABR1 in DRN mediated GABA to regulate 5-HT expression in multiple brain regions in male rats with high and low aggressive behavior. Neurochemistry international. vol 150. 2021-11-11. PMID:34509561. |
after microinjection of baclofen into the drn, the 5-ht contents in the pfc, hypothalamus and hippocampus of rats in each group decreased significantly. |
2021-11-11 |
2023-08-13 |
rat |
| Xiao-Ju Liu, Hai-Juan Wang, Xiao-Yu Wang, Yin-Xia Ning, Jie Ga. GABABR1 in DRN mediated GABA to regulate 5-HT expression in multiple brain regions in male rats with high and low aggressive behavior. Neurochemistry international. vol 150. 2021-11-11. PMID:34509561. |
in contrast, the 5-ht contents in the pfc, hypothalamus and hippocampus of rats in each group increased significantly after injection with cgp35348. |
2021-11-11 |
2023-08-13 |
rat |
| Xiao-Ju Liu, Hai-Juan Wang, Xiao-Yu Wang, Yin-Xia Ning, Jie Ga. GABABR1 in DRN mediated GABA to regulate 5-HT expression in multiple brain regions in male rats with high and low aggressive behavior. Neurochemistry international. vol 150. 2021-11-11. PMID:34509561. |
the significant increase in gaba in the drn combined with the significant increase in gb1 in the drn further mediated the synaptic inhibition effect, which reduced the 5-ht level of 5-ht neurons in the drn, resulting in a significant decrease in 5-ht levels in the pfc, hypothalamus and hippocampus. |
2021-11-11 |
2023-08-13 |
rat |
| Xiao-Ju Liu, Hai-Juan Wang, Xiao-Yu Wang, Yin-Xia Ning, Jie Ga. GABABR1 in DRN mediated GABA to regulate 5-HT expression in multiple brain regions in male rats with high and low aggressive behavior. Neurochemistry international. vol 150. 2021-11-11. PMID:34509561. |
therefore, gb1-mediated gaba regulation of 5-ht levels in the pfc, hypothalamus and hippocampus is one of the mechanisms of highly and less aggressive behavior originating in the drn. |
2021-11-11 |
2023-08-13 |
rat |
| Francisco J Flores-Ramirez, Anapaula Themann, Jorge A Sierra-Fonseca, Israel Garcia-Carachure, Samuel A Castillo, Minerva Rodriguez, Omar Lira, Joshua Preciado-Piña, Brandon L Warren, Alfred J Robison, Sergio D Iñigue. Adolescent fluoxetine treatment mediates a persistent anxiety-like outcome in female C57BL/6 mice that is ameliorated by fluoxetine re-exposure in adulthood. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:33833356. |
an additional goal was to assess the impact of adolescent flx pretreatment, and its re-exposure in adulthood, on serotonin transporters (5-htt) and brain-derived-neurotrophic-factor (bdnf)-related signaling markers (trkb-erk1/2-creb-probdnf-mbdnf) within the hippocampus and prefrontal cortex. |
2021-11-08 |
2023-08-13 |
mouse |
| Zhen Yan, Benjamin Rei. Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications. Molecular psychiatry. 2021-11-05. PMID:33875802. |
the efficacy of synaptic signaling in the pfc network is profundedly influenced by monoaminergic inputs via the activation of dopamine, adrenergic, or serotonin receptors. |
2021-11-05 |
2023-08-13 |
human |
| Marwa E El-Shamarka, Hesham A Eliwa, Maha A E Ahme. Inhibition of boldenone-induced aggression in rats by curcumin: Targeting TLR4/MyD88/TRAF-6/NF-κB pathway. Journal of biochemical and molecular toxicology. 2021-11-01. PMID:34719837. |
the prefrontal cortex was used to assess serotonin level, oxidative stress markers, and mrna expression of myeloid differentiation primary response gene (myd88), tnfr-associated factor 6 (traf-6), tumor necrosis factor α (tnf-α), interleukin-1β (il-1β), protein expression of toll-like receptor 4 (tlr4), and phosphorylated nuclear factor-κb transcription factor (nf-κb p65). |
2021-11-01 |
2023-08-13 |
rat |
| Ana Agustí, Isabel Campillo, Tiziano Balzano, Alfonso Benítez-Páez, Inmaculada López-Almela, Marina Romaní-Pérez, Jerónimo Forteza, Vicente Felipo, Nicole M Avena, Yolanda San. Bacteroides uniformis CECT 7771 Modulates the Brain Reward Response to Reduce Binge Eating and Anxiety-Like Behavior in Rat. Molecular neurobiology. vol 58. issue 10. 2021-10-30. PMID:34228269. |
these effects are mediated, at least in part, by changes in the levels of dopamine, serotonin, and noradrenaline in the nucleus accumbens and in the expression of dopamine d1 and d2 receptors in the prefrontal cortex and intestine. |
2021-10-30 |
2023-08-13 |
rat |
| Jeong-Hee Kim, Young-Don Son, Hang-Keun Kim, Jong-Hoon Ki. Association Between Lack of Insight and Prefrontal Serotonin Transporter Availability in Antipsychotic-Free Patients with Schizophrenia: A High-Resolution PET Study with [ Neuropsychiatric disease and treatment. vol 17. 2021-10-30. PMID:34707358. |
in this study, we examined the relationship between serotonin transporter (sert) availability in regions of the prefrontal cortex (dorsolateral, ventrolateral, ventromedial, and orbitofrontal cortices) and insight deficits in antipsychotic-free patients with schizophrenia using high-resolution positron emission tomography (pet) with [ |
2021-10-30 |
2023-08-13 |
Not clear |
| Lu Xiao, Junyan Yan, Ting Yang, Jiang Zhu, Tingyu Li, Hong Wei, Jie Che. Fecal Microbiome Transplantation from Children with Autism Spectrum Disorder Modulates Tryptophan and Serotonergic Synapse Metabolism and Induces Altered Behaviors in Germ-Free Mice. mSystems. vol 6. issue 2. 2021-10-28. PMID:33824200. |
western blotting detected the protein expression levels of tryptophan hydroxylase 1 (tph1), serotonin transporter (sert), and serotonin 1a receptor (5-ht1ar) in the colon and tph2, sert, and 5-ht1ar in the prefrontal cortex of mice. |
2021-10-28 |
2023-08-13 |
mouse |
| Amar Sarkar, Siobhán Harty, Katerina V-A Johnson, Andrew H Moeller, Rachel N Carmody, Soili M Lehto, Susan E Erdman, Robin I M Dunbar, Philip W J Burne. The role of the microbiome in the neurobiology of social behaviour. Biological reviews of the Cambridge Philosophical Society. vol 95. issue 5. 2021-10-25. PMID:32383208. |
these include the structure and function of regions of the 'social' brain (the amygdala, the prefrontal cortex, and the hippocampus) and the regulation of 'social' signalling molecules (glucocorticoids including corticosterone and cortisol, sex hormones including testosterone, oestrogens, and progestogens, neuropeptide hormones such as oxytocin and arginine vasopressin, and monoamine neurotransmitters such as serotonin and dopamine). |
2021-10-25 |
2023-08-13 |
human |
| Wankupar Wankhar, Donkupar Syiem, Careen Liza Pakyntein, Daiahun Thabah, Shelareen Ediemi Sun. Effect of 5-HT Behavioural brain research. vol 393. 2021-10-25. PMID:32579979. |
using this animal model, we have attempted to understand the serotonergic system in the hippocampus and prefrontal cortex, while using the 5-ht |
2021-10-25 |
2023-08-13 |
Not clear |
| Scott A Bullock, Marc N Potenz. Pathological Gambling: Neuropsychopharmacology and Treatment. Current psychopharmacology. vol 1. issue 1. 2021-10-21. PMID:24349964. |
cortico-limbic circuitry involving the ventral striatum, ventromedial prefrontal cortex, anterior cingulate cortex, and dorsolateral prefrontal cortex are discussed as are the neurotransmitters norepinephrine, serotonin, dopamine, opioids, glutamate, and gamma-aminobutyric acid (gaba). |
2021-10-21 |
2023-08-12 |
Not clear |
| Dongju Seo, Christopher J Patrick, Patrick J Kenneal. Role of Serotonin and Dopamine System Interactions in the Neurobiology of Impulsive Aggression and its Comorbidity with other Clinical Disorders. Aggression and violent behavior. vol 13. issue 5. 2021-10-20. PMID:19802333. |
the review suggests that dysfunctional interactions between serotonin and dopamine systems in the prefrontal cortex may be an important mechanism underlying the link between impulsive aggression and its comorbid disorders. |
2021-10-20 |
2023-08-12 |
Not clear |
| Eliane Proulx, Edwin J Young, Lucy R Osborne, Evelyn K Lamb. Enhanced prefrontal serotonin 5-HT(1A) currents in a mouse model of Williams-Beuren syndrome with low innate anxiety. Journal of neurodevelopmental disorders. vol 2. issue 2. 2021-10-20. PMID:20585377. |
here, we investigated the inhibitory effects of serotonin (5-ht) on the major output neurons of the prefrontal cortex in gtf2ird1(-/-) mice and their wildtype (wt) siblings. |
2021-10-20 |
2023-08-12 |
mouse |
| Eliane Proulx, Edwin J Young, Lucy R Osborne, Evelyn K Lamb. Enhanced prefrontal serotonin 5-HT(1A) currents in a mouse model of Williams-Beuren syndrome with low innate anxiety. Journal of neurodevelopmental disorders. vol 2. issue 2. 2021-10-20. PMID:20585377. |
prefrontal 5-ht receptors are known to modulate anxiety-like behaviors, and the gtf2ird1(-/-) mice have altered 5-ht metabolism in prefrontal cortex. |
2021-10-20 |
2023-08-12 |
mouse |
| Eliane Proulx, Edwin J Young, Lucy R Osborne, Evelyn K Lamb. Enhanced prefrontal serotonin 5-HT(1A) currents in a mouse model of Williams-Beuren syndrome with low innate anxiety. Journal of neurodevelopmental disorders. vol 2. issue 2. 2021-10-20. PMID:20585377. |
using whole cell recording from layer v neurons in acute brain slices of prefrontal cortex, we found that 5-ht elicited significantly larger inhibitory, outward currents in gtf2ird1(-/-) mice than in wt controls. |
2021-10-20 |
2023-08-12 |
mouse |
| Lu Lu, Jeffrey A Mills, Hailong Li, Heidi K Schroeder, Sarah A Mossman, Sara T Varney, Kim M Cecil, Xiaoqi Huang, Qiyong Gong, Laura B Ramsey, Melissa P DelBello, John A Sweeney, Jeffrey R Straw. Acute Neurofunctional Effects of Escitalopram in Pediatric Anxiety: A Double-Blind, Placebo-Controlled Trial. Journal of the American Academy of Child and Adolescent Psychiatry. vol 60. issue 10. 2021-10-20. PMID:33548492. |
amygdala-ventrolateral prefrontal cortex (vlpfc) circuitry is disrupted in pediatric anxiety disorders, yet how selective serotonin reuptake inhibitors (ssris) affect this circuitry is unknown. |
2021-10-20 |
2023-08-13 |
Not clear |
| Xiwen Geng, Hongyun Wu, Zifa Li, Chuanfen Li, Dan Chen, Jiancheng Zong, Zimin Liu, Sheng Wei, Wei Pen. Jie-Yu-He-Huan Capsule Ameliorates Anxiety-Like Behaviours in Rats Exposed to Chronic Restraint Stress via the cAMP/PKA/CREB/BDNF Signalling Pathway. Oxidative medicine and cellular longevity. vol 2021. 2021-10-15. PMID:34646421. |
in the hippocampus and prefrontal cortex, concentrations of 5-ht and its metabolite 5-hydroxyindoleacetic acid, as well as monoamine oxidase a, glucocorticoid receptor, and 5-ht1a receptor expression levels, were measured. |
2021-10-15 |
2023-08-13 |
rat |
| Ning Jiang, Lv Jingwei, Haixia Wang, Hong Huang, Qiong Wang, Guirong Zeng, Shanshan Li, Xinmin Li. Ginsenoside 20(S)-protopanaxadiol attenuates depressive-like behaviour and neuroinflammation in chronic unpredictable mild stress-induced depressive rats. Behavioural brain research. vol 393. 2021-10-04. PMID:32464121. |
in addition, ppd decreased the elevated levels of cort and proinflammatory cytokines (il-6, il-1β and tnf-α) in the serum and neurotransmitters (5-ht and ne) in the hippocampus and pfc induced by cums. |
2021-10-04 |
2023-08-13 |
rat |