| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Brodat. The use of THA for Alzheimer's disease. The Medical journal of Australia. vol 152. issue 11. 1990-07-11. PMID:2348794. |
the use of tha for alzheimer's disease. |
1990-07-11 |
2023-08-11 |
Not clear |
| D J Ames, P S Bhathal, B M Davies, J R Fraser, P R Gibson, S Robert. Heterogeneity of adverse hepatic reactions to tetrahydroaminoacridine. Australian and New Zealand journal of medicine. vol 20. issue 2. 1990-06-26. PMID:2344330. |
of 14 patients taking tetrahydroaminoacridine (tha) for the trial treatment of alzheimer's disease, five developed mildly abnormal liver function tests. |
1990-06-26 |
2023-08-11 |
human |
| D J Ames, P S Bhathal, B M Davies, J R Fraser, P R Gibson, S Robert. Heterogeneity of adverse hepatic reactions to tetrahydroaminoacridine. Australian and New Zealand journal of medicine. vol 20. issue 2. 1990-06-26. PMID:2344330. |
patients receiving tha for treatment of alzheimer's disease need regular monitoring of liver function. |
1990-06-26 |
2023-08-11 |
human |
| S Gauthier, R Bouchard, A Lamontagne, P Bailey, H Bergman, J Ratner, Y Tesfaye, M Saint-Martin, Y Bacher, L Carrie. Tetrahydroaminoacridine-lecithin combination treatment in patients with intermediate-stage Alzheimer's disease. Results of a Canadian double-blind, crossover, multicenter study. The New England journal of medicine. vol 322. issue 18. 1990-05-24. PMID:2183056. |
we studied the efficacy and safety of oral tetrahydroaminoacridine (tha) combined with lecithin in 52 patients with alzheimer's disease. |
1990-05-24 |
2023-08-11 |
Not clear |
| G Chatellier, L Lacomble. Tacrine (tetrahydroaminoacridine; THA) and lecithin in senile dementia of the Alzheimer type: a multicentre trial. Groupe Français d'Etude de la Tetrahydroaminoacridine. BMJ (Clinical research ed.). vol 300. issue 6723. 1990-05-10. PMID:2107926. |
tacrine (tetrahydroaminoacridine; tha) and lecithin in senile dementia of the alzheimer type: a multicentre trial. |
1990-05-10 |
2023-08-11 |
Not clear |
| G Chatellier, L Lacomble. Tacrine (tetrahydroaminoacridine; THA) and lecithin in senile dementia of the Alzheimer type: a multicentre trial. Groupe Français d'Etude de la Tetrahydroaminoacridine. BMJ (Clinical research ed.). vol 300. issue 6723. 1990-05-10. PMID:2107926. |
to see whether combined treatment with oral tacrine (tetrahydroaminoacridine; tha) and lecithin improves the symptoms of patients with alzheimer's disease. |
1990-05-10 |
2023-08-11 |
Not clear |
| A Adem, S S Jossan, L Orelan. Tetrahydroaminoacridine inhibits human and rat brain monoamine oxidase. Neuroscience letters. vol 107. issue 1-3. 1990-03-14. PMID:2616041. |
thus it is possible that inhibition of mao may be involved in the therapeutic action of tha in alzheimer's disease. |
1990-03-14 |
2023-08-11 |
human |
| W K Summers, K H Tachiki, A Klin. Tacrine in the treatment of Alzheimer's disease. A clinical update and recent pharmacologic studies. European neurology. vol 29 Suppl 3. 1990-03-05. PMID:2693104. |
the initial report of the effectiveness of tacrine or tetrahydroaminoacridine (tha) in the treatment of some patients with alzheimer's disease has been confirmed by further study of additional subjects and by preliminary reports from other investigators. |
1990-03-05 |
2023-08-11 |
human |
| L J Fitten, K M Perryman, P L Gross, H Fine, J Cummins, C Marshal. Treatment of Alzheimer's disease with short- and long-term oral THA and lecithin: a double-blind study. The American journal of psychiatry. vol 147. issue 2. 1990-03-02. PMID:2405720. |
treatment of alzheimer's disease with short- and long-term oral tha and lecithin: a double-blind study. |
1990-03-02 |
2023-08-11 |
Not clear |
| L J Fitten, K M Perryman, P L Gross, H Fine, J Cummins, C Marshal. Treatment of Alzheimer's disease with short- and long-term oral THA and lecithin: a double-blind study. The American journal of psychiatry. vol 147. issue 2. 1990-03-02. PMID:2405720. |
ten alzheimer's disease patients underwent a trial of oral tetrahydroaminoacridine (tha) and lecithin. |
1990-03-02 |
2023-08-11 |
Not clear |
| J A Nielsen, E E Mena, I H Williams, M R Nocerini, D Listo. Correlation of brain levels of 9-amino-1,2,3,4-tetrahydroacridine (THA) with neurochemical and behavioral changes. European journal of pharmacology. vol 173. issue 1. 1990-02-22. PMID:2606156. |
9-amino-1,2,3,4-tetrahydroacridine (tha) has been reported to cause improvement in patients with senile dementia of the alzheimer's type. |
1990-02-22 |
2023-08-11 |
mouse |
| J A Nielsen, E E Mena, I H Williams, M R Nocerini, D Listo. Correlation of brain levels of 9-amino-1,2,3,4-tetrahydroacridine (THA) with neurochemical and behavioral changes. European journal of pharmacology. vol 173. issue 1. 1990-02-22. PMID:2606156. |
we conclude that brain ache inhibition by tha is sufficient to explain its purported therapeutic activity in alzheimer's disease and that its favorable brain/plasma distribution in vivo may account for its central cholinergic action without inducing the severe peripheral cholinergic effects typically seen with other ache inhibitors. |
1990-02-22 |
2023-08-11 |
mouse |
| A Nordberg, L Nilsson-Håkansson, A Adem, Z Lai, B Winbla. Multiple actions of THA on cholinergic neurotransmission in Alzheimer brains. Progress in clinical and biological research. vol 317. 1990-01-31. PMID:2557636. |
multiple actions of tha on cholinergic neurotransmission in alzheimer brains. |
1990-01-31 |
2023-08-11 |
human |
| A Nordberg, L Nilsson-Håkansson, A Adem, Z Lai, B Winbla. Multiple actions of THA on cholinergic neurotransmission in Alzheimer brains. Progress in clinical and biological research. vol 317. 1990-01-31. PMID:2557636. |
1,2,3,4-tetrahydro-9-aminoacridine (tha) is a cholinesterase inhibitor presently under investigation in clinical trials for treatment of alzheimer's disease, senile dementia of alzheimer type (ad/sdat). |
1990-01-31 |
2023-08-11 |
human |
| K A Sherman, E Messamor. Cholinesterase inhibitor therapy for Alzheimer dementia: what do animal models tell us? Progress in clinical and biological research. vol 317. 1990-01-31. PMID:2602408. |
despite a strong rationale for the use of cholinesterase (che) inhibitors and related drugs to augment cholinergic function as palliative treatment for alzheimer dementia, this approach met with limited and variable success until the striking results recently reported with tacrine (tha). |
1990-01-31 |
2023-08-11 |
mouse |
| V Kumar, R E Becke. Clinical pharmacology of tetrahydroaminoacridine: a possible therapeutic agent Alzheimer's disease. International journal of clinical pharmacology, therapy, and toxicology. vol 27. issue 10. 1990-01-04. PMID:2684868. |
tetrahydroaminoacridine (tha) was administered to a small number of patients with alzheimer's disease. |
1990-01-04 |
2023-08-11 |
Not clear |
| F Boller, F Forett. Alzheimer's disease and THA: a review of the cholinergic theory and of preliminary results. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 43. issue 7. 1989-12-28. PMID:2684292. |
alzheimer's disease and tha: a review of the cholinergic theory and of preliminary results. |
1989-12-28 |
2023-08-11 |
Not clear |
| G Fredj, F Dietlin, D Fredj, L Schwarzenberg, C Jasmin, P Meyer, J L Misse. Tetrahydroaminoacridine in HIV infections. The THA Study Group. International journal of clinical pharmacology, therapy, and toxicology. vol 27. issue 8. 1989-11-06. PMID:2793276. |
on the basis of a similarity between certain neurological symptoms of aids and alzheimer's disease, the authors studied the effects of tetrahydroaminoacridine (tha) in 9 patients with hiv infection. |
1989-11-06 |
2023-08-11 |
Not clear |
| P L Moriearty, W Kenny, V Kuma. Estimation of plasma tacrine concentrations using an in vitro cholinesterase inhibition assay. Alzheimer disease and associated disorders. vol 3. issue 3. 1989-11-02. PMID:2789791. |
tha (9-amino, 1,2,3,4-tetrahydroacridine; tacrine) is currently under study as a cholinesterase (che) inhibitor in alzheimer disease. |
1989-11-02 |
2023-08-11 |
human |
| D Grossi, O L Lopez, A J Martine. Mamillary bodies in Alzheimer's disease. Acta neurologica Scandinavica. vol 80. issue 1. 1989-10-23. PMID:2506728. |
the number of senile (neuritic) plaques (sp) and neurofibrillary tangles (nft) in mamillary bodies (mb) and in the dorsomedial nucleus of the thalamus (dmnt) were assessed in 25 cases of definite alzheimer's disease. |
1989-10-23 |
2023-08-11 |
Not clear |