| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Braak, E Braa. Alzheimer's disease affects limbic nuclei of the thalamus. Acta neuropathologica. vol 81. issue 3. 1991-07-26. PMID:1711755. |
sensitive silver techniques for amyloid and neurofibrillary changes were applied to examine the pathological changes revealed by limbic nuclei of the thalamus in alzheimer's disease. |
1991-07-26 |
2023-08-11 |
Not clear |
| H Braak, E Braa. Alzheimer's disease affects limbic nuclei of the thalamus. Acta neuropathologica. vol 81. issue 3. 1991-07-26. PMID:1711755. |
at first glance, the thalamus appeared to be only mildly affected by alzheimer's disease. |
1991-07-26 |
2023-08-11 |
Not clear |
| J H Xuereb, J M Candy, E K Perry, R H Perry, E Marshall, J R Bonha. Distribution of neurofibrillary tangle formation and [3H]-D-aspartate receptor binding in the thalamus in the normal elderly brain, in Alzheimer's disease and in Parkinson's disease. Neuropathology and applied neurobiology. vol 16. issue 6. 1991-07-15. PMID:1965733. |
distribution of neurofibrillary tangle formation and [3h]-d-aspartate receptor binding in the thalamus in the normal elderly brain, in alzheimer's disease and in parkinson's disease. |
1991-07-15 |
2023-08-11 |
Not clear |
| N Hershkowitz, M A Rogawsk. Tetrahydroaminoacridine block of N-methyl-D-aspartate-activated cation channels in cultured hippocampal neurons. Molecular pharmacology. vol 39. issue 5. 1991-06-21. PMID:1709720. |
the action of tetrahydroaminoacridine (tha), a centrally active cholinesterase inhibitor that may provide symptomatic benefit in alzheimer's disease, was studied on responses to the excitatory amino acid n-methyl-d-aspartate (nmda) in cultured hippocampal neurons, using whole-cell voltage-clamp and single-channel recording techniques. |
1991-06-21 |
2023-08-11 |
Not clear |
| H C Weinstein, S Teunisse, W A van Goo. Tetrahydroaminoacridine and lecithin in the treatment of Alzheimer's disease. Effect on cognition, functioning in daily life, behavioural disturbances and burden experienced by the carers. Journal of neurology. vol 238. issue 1. 1991-06-17. PMID:2030370. |
in 12 ambulant patients with a clinical diagnosis of probable alzheimer's disease, a 12-week, double-blind, placebo-controlled study with 100 mg/day tetrahydroaminoacridine (tha) and 10 g/day lecithin is reported. |
1991-06-17 |
2023-08-11 |
Not clear |
| E E Mena, M C Desa. High-affinity [3H]THA (tetrahydroaminoacridine) binding sites in rat brain. Pharmaceutical research. vol 8. issue 2. 1991-05-31. PMID:2023867. |
tetrahydroaminoacridine (tha), an acetylcholinesterase inhibitor that is reported to have significant effects on cognition and memory in alzheimer's disease patients, binds to rat brain membranes in a saturable and reversible manner. |
1991-05-31 |
2023-08-11 |
rat |
| K M Parks, J E Sugar, V Haroutunian, L Bierer, D Perl, W C Wallac. Reduced in vitro phosphorylation of synapsin I (site 1) in Alzheimer's disease postmortem tissues. Brain research. Molecular brain research. vol 9. issue 1-2. 1991-05-21. PMID:1850067. |
the reductions were not observed in either cerebellum or thalamus of alzheimer's disease brain. |
1991-05-21 |
2023-08-11 |
Not clear |
| J H Xuereb, E K Perry, J M Candy, J R Bonham, R H Perry, E Marshal. Parameters of cholinergic neurotransmission in the thalamus in Parkinson's disease and Alzheimer's disease. Journal of the neurological sciences. vol 99. issue 2-3. 1991-05-21. PMID:1964958. |
parameters of cholinergic neurotransmission in the thalamus in parkinson's disease and alzheimer's disease. |
1991-05-21 |
2023-08-11 |
Not clear |
| A K Mohammed, G Wahlström, T Archer, A Nordber. Learning deficits in aged rats pretreated chronically with barbital and tested late in abstinence: alleviation by tetrahydroaminoacridine. Journal of neural transmission. Parkinson's disease and dementia section. vol 2. issue 4. 1991-05-01. PMID:2078308. |
physostigmine and tetrahydroaminoacridine (tha) have been reported to improve cognitive function in patients with alzheimer's disease. |
1991-05-01 |
2023-08-11 |
rat |
| R S Hsu, G M Shutske, E M Dileo, S M Chesson, A R Linville, R C Alle. Identification of the urinary metabolites of tacrine in the rat. Drug metabolism and disposition: the biological fate of chemicals. vol 18. issue 5. 1991-04-25. PMID:1981736. |
tacrine (tha) is a potent cholinesterase inhibitor being studied for the treatment of alzheimer's disease. |
1991-04-25 |
2023-08-11 |
rat |
| D W Molloy, G H Guyatt, D B Wilson, R Duke, L Rees, J Singe. Effect of tetrahydroaminoacridine on cognition, function and behaviour in Alzheimer's disease. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. vol 144. issue 1. 1991-02-04. PMID:1984813. |
to determine the efficacy of tetrahydroaminoacridine (tha) in alzheimer's disease. |
1991-02-04 |
2023-08-11 |
Not clear |
| A Adem, A K Mohammed, B Winbla. Multiple effects of tetrahydroaminoacridine on the cholinergic system: biochemical and behavioural aspects. Journal of neural transmission. Parkinson's disease and dementia section. vol 2. issue 2. 1990-12-13. PMID:2222779. |
9-amino-1,2,3,4-tetrahydroaminoacridine (tha) in combination with lecithin has been reported to improve the memory of alzheimer's disease patients. |
1990-12-13 |
2023-08-11 |
human |
| A Adem, A K Mohammed, B Winbla. Multiple effects of tetrahydroaminoacridine on the cholinergic system: biochemical and behavioural aspects. Journal of neural transmission. Parkinson's disease and dementia section. vol 2. issue 2. 1990-12-13. PMID:2222779. |
moreover, tha showed similar affinity for temporal cortices muscarinic receptors from alzheimer and non-alzheimer (control) brains. |
1990-12-13 |
2023-08-11 |
human |
| C Peterso. Tetrahydroaminoacridine increases acetylcholine synthesis and glucose oxidation by mouse brain slices in vitro. Neuroscience letters. vol 115. issue 2-3. 1990-12-12. PMID:2234505. |
1,2,3,4-tetrahydro-5-aminoacridine (tha; tacrine) reportedly improves cognitive deficits in certain individuals with alzheimer's disease. |
1990-12-12 |
2023-08-11 |
mouse |
| C Peterso. Tetrahydroaminoacridine increases acetylcholine synthesis and glucose oxidation by mouse brain slices in vitro. Neuroscience letters. vol 115. issue 2-3. 1990-12-12. PMID:2234505. |
thus the efficacy of tha treatment on alzheimer patients may be partially related to increased ach synthesis and oxidative metabolism. |
1990-12-12 |
2023-08-11 |
mouse |
| L J Tha. THA, a putative drug in the treatment of Alzheimer's disease? Acta neurologica Scandinavica. Supplementum. vol 129. 1990-11-06. PMID:2220321. |
tha, a putative drug in the treatment of alzheimer's disease? |
1990-11-06 |
2023-08-11 |
Not clear |
| P Cumming, P B Reiner, S R Vincen. Inhibition of rat brain histamine-N-methyltransferase by 9-amino-1,2,3,4-tetrahydroacridine (THA). Biochemical pharmacology. vol 40. issue 6. 1990-10-22. PMID:2403387. |
9-amino-1,2,3,4-tetrahydroacridine (tha), an inhibitor of acetylcholinesterase, has been proposed as a treatment for alzheimer's disease on the basis of its ability to increase cerebral levels of acetylcholine. |
1990-10-22 |
2023-08-11 |
rat |
| D A Butterfield, D A Palmier. Spin-labelling studies of the interaction of 9-amino-1,2,3,4-tetrahydroacridine (THA), a proposed drug for the treatment of Alzheimer's disease, with erythrocyte membranes. Free radical research communications. vol 9. issue 3-6. 1990-09-25. PMID:2167274. |
spin-labelling studies of the interaction of 9-amino-1,2,3,4-tetrahydroacridine (tha), a proposed drug for the treatment of alzheimer's disease, with erythrocyte membranes. |
1990-09-25 |
2023-08-11 |
human |
| D A Butterfield, D A Palmier. Spin-labelling studies of the interaction of 9-amino-1,2,3,4-tetrahydroacridine (THA), a proposed drug for the treatment of Alzheimer's disease, with erythrocyte membranes. Free radical research communications. vol 9. issue 3-6. 1990-09-25. PMID:2167274. |
these results are discussed in relation to possible interaction sites of tha in erythrocyte ghosts and to potential mechanisms by which tha reportedly increases mental function of victims of alzheimer's disease. |
1990-09-25 |
2023-08-11 |
human |
| D A Palmieri, D A Butterfiel. Structure-activity investigation of the alteration of the physical state of the skeletal network of proteins in human erythrocyte membranes induced by 9-amino-1,2,3,4-tetrahydroacridine. Biochimica et biophysica acta. vol 1024. issue 2. 1990-07-26. PMID:2354181. |
the oral administration of 9-amino-1,2,3,4-tetrahydroacridine (tha) is purported to increase the mental function of alzheimer's disease patients (summers et al. |
1990-07-26 |
2023-08-11 |
human |