| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sita N Shah, Maria-Eleni Dounavi, Paresh A Malhotra, Brian Lawlor, Lorina Naci, Ivan Koychev, Craig W Ritchie, Karen Ritchie, John T O'Brie. Dementia risk and thalamic nuclei volumetry in healthy midlife adults: the PREVENT Dementia study. Brain communications. vol 6. issue 2. 2024-03-06. PMID:38444908. |
a reduction in the volume of the thalamus and its nuclei has been reported in alzheimer's disease, mild cognitive impairment and asymptomatic individuals with risk factors for early-onset alzheimer's disease. |
2024-03-06 |
2024-03-08 |
human |
| Niels Okkels, Michel J Grothe, John-Paul Taylor, Steen Gregers Hasselbalch, Tatyana D Fedorova, Karoline Knudsen, Sygrid van der Zee, Teus van Laar, Nicolaas Bohnen, Per Borghammer, Jacob Horsage. Cholinergic changes in Lewy body disease: implications for presentation, progression and subtypes. Brain : a journal of neurology. 2024-03-04. PMID:38437860. |
in patients with alzheimer's disease, the thalamus is variably affected, suggesting a different sequential involvement of cholinergic cell groups in alzheimer's disease compared to lewy body disease. |
2024-03-04 |
2024-03-07 |
Not clear |
| Susanna Lopez, Harald Hampel, Patrizia Andrea Chiesa, Claudio Del Percio, Giuseppe Noce, Roberta Lizio, Stefan J Teipel, Martin Dyrba, Gabriel González-Escamilla, Hovagim Bakardjian, Enrica Cavedo, Simone Lista, Andrea Vergallo, Pablo Lemercier, Giuseppe Spinelli, Michel J Grothe, Marie-Claude Potier, Fabrizio Stocchi, Raffaele Ferri, Marie-Odile Habert, Bruno Dubois, Claudio Babilon. The association between posterior resting-state EEG alpha rhythms and functional MRI connectivity in older adults with subjective memory complaint. Neurobiology of aging. vol 137. 2024-03-03. PMID:38431999. |
these results suggest that in smc persons, early alzheimer's disease amyloidosis may contrast the beneficial effects of cognitive reserve on neurophysiological oscillatory mechanisms at alpha frequencies and connectivity between the thalamus and visual cortical networks. |
2024-03-03 |
2024-03-06 |
human |
| Yuta Saito, Sora Sato, Yoshitaka Nishikawa, Fumiya Oguro, Nobuaki Moriyama, Keiichiro Sato, Yurie Kobashi, Toyoaki Sawano, Akihiko Ozaki, Takeo Nakayama, Masaharu Tsubokura, Seiji Yasumura, Shohei Saka. Outpatient rehabilitation for an older couple in a repopulated village 10 years after the Fukushima nuclear disaster:An embedded case study. Fukushima journal of medical science. 2023-11-12. PMID:37952979. |
here, we report the case of an older couple living in an area repopulated after the fukushima nuclear disaster of 2011 who received outpatient rehabilitation.case presentationan 84-year-old woman underwent total hip arthroplasty (tha) after she fell and sustained a trochanteric fracture while caring for her husband with alzheimer's disease. |
2023-11-12 |
2023-11-20 |
Not clear |
| Natallia Makarava, Olga Mychko, Kara Molesworth, Jennifer Chen-Yu Chang, Rebecca J Henry, Natalya Tsymbalyuk, Volodymyr Gerzanich, J Marc Simard, David J Loane, Ilia V Baskako. Region-Specific Homeostatic Identity of Astrocytes Is Essential for Defining Their Response to Pathological Insults. Cells. vol 12. issue 17. 2023-09-08. PMID:37681904. |
to address this question, region-specific gene expression profiling was performed for four brain regions (cortex, hippocampus, thalamus, and hypothalamus) in mice using a custom nanostring panel consisting of selected sets of genes associated with astrocyte functions and their reactivity for five conditions: prion disease, traumatic brain injury, brain ischemia, 5xfad alzheimer's disease model and normal aging. |
2023-09-08 |
2023-10-07 |
mouse |
| Julia Schumacher, Nicola J Ray, Calum A Hamilton, Maurizio Bergamino, Paul C Donaghy, Michael Firbank, Rosie Watson, Gemma Roberts, Louise Allan, Nicola Barnett, John T O'Brien, Alan J Thomas, John-Paul Taylo. Free water imaging of the cholinergic system in dementia with Lewy bodies and Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-03-15. PMID:36919460. |
degeneration of cortical cholinergic projections from the nucleus basalis of meynert (nbm) is characteristic of dementia with lewy bodies (dlb) and alzheimer's disease (ad), whereas involvement of cholinergic projections from the pedunculopontine nucleus (ppn) to the thalamus is less clear. |
2023-03-15 |
2023-08-14 |
Not clear |
| Puck C Reeders, M Vanessa Rivera Núñez, Robert P Vertes, Aaron T Mattfeld, Timothy A Alle. Identifying the midline thalamus in humans in vivo. Brain structure & function. 2023-01-04. PMID:36598561. |
the midline thalamus is critical for flexible cognition, memory, and stress regulation in humans and its dysfunction is associated with several neurological and psychiatric disorders, including alzheimer's disease, schizophrenia, and depression. |
2023-01-04 |
2023-08-14 |
human |
| Jiaojiao Tian, Miao Ren, Peilin Zhao, Shukang Luo, Yingying Chen, Xiaofeng Xu, Tao Jiang, Qingtao Sun, Anan Li, Hui Gong, Xiangning Li, Qingming Lu. Dissection of the long-range projections of specific neurons at the synaptic level in the whole mouse brain. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 40. 2022-09-26. PMID:36161898. |
with three-dimensional reconstruction in the targeted areas, we found that synaptic degeneration was inconsistent with the accumulation of amyloid-β plaques but was preferred in memory-related circuits, such as hippocampal formation and thalamus, but not in most hypothalamic nuclei in 8-month-old mice with five familial alzheimer's disease mutations. |
2022-09-26 |
2023-08-14 |
mouse |
| Fumi Katsuki, Dmitry Gerashchenko, Ritchie E Brow. Alterations of sleep oscillations in Alzheimer's Disease: A potential role for GABAergic neurons in the cortex, hippocampus, and thalamus. Brain research bulletin. 2022-07-19. PMID:35850189. |
alterations of sleep oscillations in alzheimer's disease: a potential role for gabaergic neurons in the cortex, hippocampus, and thalamus. |
2022-07-19 |
2023-08-14 |
mouse |
| Yun-Long Xu, Lin Zhu, Zi-Jun Chen, Xiao-Fei Deng, Pei-Dong Liu, Shan Li, Bing-Chun Lin, Chuan-Zhong Yang, Wei Xu, Kui-Kui Zhou, Ying-Jie Zh. Release of Endogenous Brain-derived Neurotrophic Factor into the Lateral Entorhinal Cortex from the Paraventricular Thalamus Ameliorates Social Memory Deficits in a Mouse Model of Alzheimer's Disease. Neuroscience bulletin. 2022-06-28. PMID:35764752. |
release of endogenous brain-derived neurotrophic factor into the lateral entorhinal cortex from the paraventricular thalamus ameliorates social memory deficits in a mouse model of alzheimer's disease. |
2022-06-28 |
2023-08-14 |
mouse |
| Laurens Ansem van de Mortel, Rajat Mani Thomas, Guido Alexander van Winge. Grey Matter Loss at Different Stages of Cognitive Decline: A Role for the Thalamus in Developing Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 83. issue 2. 2021-11-18. PMID:34366336. |
grey matter loss at different stages of cognitive decline: a role for the thalamus in developing alzheimer's disease. |
2021-11-18 |
2023-08-13 |
Not clear |
| Enmanuelle Pardilla-Delgado, Heirangi Torrico-Teave, Justin S Sanchez, Liliana A Ramirez-Gomez, Ana Baena, Yamile Bocanegra, Clara Vila-Castelar, Joshua T Fox-Fuller, Edmarie Guzmán-Vélez, Jairo Martínez, Sergio Alvarez, Martin Ochoa-Escudero, Francisco Lopera, Yakeel T Quiro. Associations between subregional thalamic volume and brain pathology in autosomal dominant Alzheimer's disease. Brain communications. vol 3. issue 2. 2021-06-08. PMID:34095834. |
histopathological reports suggest that subregions of the thalamus, which regulates multiple physiological and cognitive processes, are not uniformly affected by alzheimer's disease. |
2021-06-08 |
2023-08-13 |
Not clear |
| Oishi, Mochizuki, Takas. Regional differences in cerebrovascular reactivity to acetazolamide in Alzheimer's disease. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 6. issue 5. 2019-11-20. PMID:10844775. |
the blood flows in the frontal lobe, parietal lobe and temporal lobe were reduced but the blood flows in the caudate nucleus, putamen and thalamus were normal in the alzheimer's disease group. |
2019-11-20 |
2023-08-12 |
human |
| S. J. Marsh, A. Hubbard, D. A. Brow. Some Actions of 9-Amino-1,2,3,4-Tetrahydroacridine (THA) on Cholinergic Transmission and Membrane Currents in Rat Sympathetic Ganglia. The European journal of neuroscience. vol 2. issue 12. 2019-11-20. PMID:12106073. |
tha (tacrine) is an anticholinesterase drug reported to alleviate cognitive deficit in alzheimer's disease. |
2019-11-20 |
2023-08-12 |
rat |
| F Feng, B Zhou, L Wang, H X Yao, Y E Guo, N Y An, L N Wang, X Zhan. [The correlation of functional connectivity and structural connectivity between hippocampus and thalamus in Alzheimer's disease and amnestic mild cognitive impairment]. Zhonghua nei ke za zhi. vol 58. issue 9. 2019-09-05. PMID:31461817. |
[the correlation of functional connectivity and structural connectivity between hippocampus and thalamus in alzheimer's disease and amnestic mild cognitive impairment]. |
2019-09-05 |
2023-08-13 |
Not clear |
| Martina Kaniakova, Lenka Kleteckova, Katarina Lichnerova, Kristina Holubova, Kristyna Skrenkova, Miloslav Korinek, Jan Krusek, Tereza Smejkalova, Jan Korabecny, Karel Vales, Ondrej Soukup, Martin Hora. 7-Methoxyderivative of tacrine is a 'foot-in-the-door' open-channel blocker of GluN1/GluN2 and GluN1/GluN3 NMDA receptors with neuroprotective activity in vivo. Neuropharmacology. vol 140. 2019-02-20. PMID:30099049. |
1,2,3,4-tetrahydro-9-aminoacridine (tacrine; tha) was the first approved drug for alzheimer's disease (ad) treatment. |
2019-02-20 |
2023-08-13 |
rat |
| Eva Mezeiova, Jan Korabecny, Vendula Sepsova, Martina Hrabinova, Petr Jost, Lubica Muckova, Tomas Kucera, Rafael Dolezal, Jan Misik, Katarina Spilovska, Ngoc Lam Pham, Lucia Pokrievkova, Jaroslav Roh, Daniel Jun, Ondrej Soukup, Daniel Kaping, Kamil Kuc. Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy. Molecules (Basel, Switzerland). vol 22. issue 8. 2018-04-23. PMID:28788095. |
tacrine (tha), the first clinically effective acetylcholinesterase (ache) inhibitor and the first approved drug for the treatment of alzheimer's disease (ad), was withdrawn from the market due to its side effects, particularly its hepatotoxicity. |
2018-04-23 |
2023-08-13 |
human |
| Gwenn S Smith, Frederick S Barrett, Jin Hui Joo, Najlla Nassery, Alena Savonenko, Devin J Sodums, Christopher M Marano, Cynthia A Munro, Jason Brandt, Michael A Kraut, Yun Zhou, Dean F Wong, Clifford I Workma. Molecular imaging of serotonin degeneration in mild cognitive impairment. Neurobiology of disease. vol 105. 2018-04-18. PMID:28511918. |
reduced serotonin transporter availability was observed in mild cognitive impairment compared to controls in cortical and limbic areas typically affected by alzheimer's disease pathology, as well as in sensory and motor areas, striatum and thalamus that are relatively spared in alzheimer's disease. |
2018-04-18 |
2023-08-13 |
human |
| Ahmed A Moustafa, Ryan D McMullan, Bjorn Rostron, Doaa H Hewedi, Harry H Haladjia. The thalamus as a relay station and gatekeeper: relevance to brain disorders. Reviews in the neurosciences. vol 28. issue 2. 2018-01-02. PMID:28085677. |
we further discuss neuropsychological and brain disorders associated with thalamus function, including parkinson's disease, alzheimer's disease, korsakoff's syndrome, and sleep disorders. |
2018-01-02 |
2023-08-13 |
Not clear |
| Tiina Annus, Liam R Wilson, Julio Acosta-Cabronero, Arturo Cardenas-Blanco, Young T Hong, Tim D Fryer, Jonathan P Coles, David K Menon, Shahid H Zaman, Anthony J Holland, Peter J Nesto. The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis. Neurobiology of aging. vol 53. 2017-11-16. PMID:28192686. |
in the presence of amyloid neuropathology, the ds brains demonstrated a strikingly similar pattern of posterior dominant cortical thinning and subcortical atrophy in the hippocampus, thalamus, and striatum, to that observed in non-ds alzheimer's disease. |
2017-11-16 |
2023-08-13 |
Not clear |