| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Rogawsk. Tetrahydroaminoacridine blocks voltage-dependent ion channels in hippocampal neurons. European journal of pharmacology. vol 142. issue 1. 1988-02-20. PMID:2446884. |
tetrahydroaminoacridine (tha) is a centrally active anticholinesterase that may produce functional improvement in patients with alzheimer's disease. |
1988-02-20 |
2023-08-11 |
Not clear |
| L Nilsson, A Adem, J Hardy, B Winblad, A Nordber. Do tetrahydroaminoacridine (THA) and physostigmine restore acetylcholine release in Alzheimer brains via nicotinic receptors? Journal of neural transmission. vol 70. issue 3-4. 1988-01-20. PMID:3681290. |
do tetrahydroaminoacridine (tha) and physostigmine restore acetylcholine release in alzheimer brains via nicotinic receptors? |
1988-01-20 |
2023-08-11 |
Not clear |
| L J Fitten, J F Flood, C F Baxter, K H Tachiki, K Perryma. Long-term oral administration of memory-enhancing doses of tacrine in mice: a study of potential toxicity and side effects. Journal of gerontology. vol 42. issue 6. 1987-12-30. PMID:3680887. |
recently, tacrine (1, 2, 3, 4-tetrahydro-9-aminoacridine; tha; tac) has received international attention as an oral agent capable of relieving some of the cognitive symptoms accompanying alzheimer's disease (ad). |
1987-12-30 |
2023-08-11 |
mouse |
| B Drukarch, K S Kits, E G Van der Meer, J C Lodder, J C Stoo. 9-Amino-1,2,3,4-tetrahydroacridine (THA), an alleged drug for the treatment of Alzheimer's disease, inhibits acetylcholinesterase activity and slow outward K+ current. European journal of pharmacology. vol 141. issue 1. 1987-12-14. PMID:2444444. |
9-amino-1,2,3,4-tetrahydroacridine (tha), an alleged drug for the treatment of alzheimer's disease, inhibits acetylcholinesterase activity and slow outward k+ current. |
1987-12-14 |
2023-08-11 |
rat |
| B Drukarch, K S Kits, E G Van der Meer, J C Lodder, J C Stoo. 9-Amino-1,2,3,4-tetrahydroacridine (THA), an alleged drug for the treatment of Alzheimer's disease, inhibits acetylcholinesterase activity and slow outward K+ current. European journal of pharmacology. vol 141. issue 1. 1987-12-14. PMID:2444444. |
it is discussed that both effects of tha possibly contribute to its reported effect in the treatment of patients with alzheimer's disease. |
1987-12-14 |
2023-08-11 |
rat |
| J Moossy, A J Martinez, I Hanin, G Rao, H Yonas, F Bolle. Thalamic and subcortical gliosis with dementia. Archives of neurology. vol 44. issue 5. 1987-05-28. PMID:3579662. |
these cases offer further evidence that subcortical lesions, especially in the thalamus, may produce a dementia that is not always clinically distinguishable from alzheimer's disease and other "cortical" dementias. |
1987-05-28 |
2023-08-11 |
Not clear |
| W K Summers, L V Majovski, G M Marsh, K Tachiki, A Klin. Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type. The New England journal of medicine. vol 315. issue 20. 1986-12-04. PMID:2430180. |
we treated 17 patients who had moderate to severe alzheimer's disease with oral tetrahydroaminoacridine (tha), a centrally active anticholinesterase, in a three-phase study. |
1986-12-04 |
2023-08-11 |
human |
| W K Summers, L V Majovski, G M Marsh, K Tachiki, A Klin. Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type. The New England journal of medicine. vol 315. issue 20. 1986-12-04. PMID:2430180. |
among the 14 subjects completing phase ii, tha treatment produced significantly better results than placebo on the global assessment (p = 0.003), the orientation test (p = 0.004), the alzheimer's deficit scale (p = 0.003), and the names learning test (p = 0.001). |
1986-12-04 |
2023-08-11 |
human |
| W K Summers, L V Majovski, G M Marsh, K Tachiki, A Klin. Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type. The New England journal of medicine. vol 315. issue 20. 1986-12-04. PMID:2430180. |
these encouraging initial results suggest that tha may be at least temporarily useful in the long-term palliative treatment of patients with alzheimer's disease. |
1986-12-04 |
2023-08-11 |
human |
| S Jenni-Eiermann, H P von Hahn, C G Honegger, J Ulric. Studies on neurotransmitter binding in senile dementia. Comparison of Alzheimer's and mixed vascular-Alzheimer's dementias. Gerontology. vol 30. issue 6. 1985-03-11. PMID:6151534. |
binding of 3h-labeled agonists and antagonists to muscarinic-cholinergic, alpha- and beta-adrenergic, dopaminergic, serotoninergic, and opiate receptors was studied in four regions of the neocortex and in hippocampus, thalamus, putamen, and caudatus in autoptic material from patients with senile dementia of alzheimer type and of mixed vascular-alzheimer pathogenesis. |
1985-03-11 |
2023-08-12 |
Not clear |
| T McDuff, S M Sum. Subcortical degeneration in Alzheimer's disease. Neurology. vol 35. issue 1. 1985-02-05. PMID:3917560. |
in 28 patients with progressive dementia and pathologically confirmed alzheimer's disease, we found senile (neuritic) plaques and neurofibrillary tangles in the thalamus in 25 patients, in the hypothalamus in 22, and in the mamillary body in 17. |
1985-02-05 |
2023-08-11 |
Not clear |
| D G Brownstein, E A Johnson, A L Smit. Spontaneous Reye's-like syndrome in BALB/cByJ mice. Laboratory investigation; a journal of technical methods and pathology. vol 51. issue 4. 1984-11-13. PMID:6482384. |
necropsy findings included swollen, diffusely pale yellow livers with panlobular microvesicular fatty change, pale renal cortices with epithelial fat droplets of the proximal convoluted tubules, and alzheimer type ii astrocytosis of the neocortex, corpus striatum, hippocampus, and thalamus. |
1984-11-13 |
2023-08-12 |
mouse |
| D E Kuh. Imaging local brain function with emission computed tomography. Radiology. vol 150. issue 3. 1984-03-23. PMID:6607481. |
the fdg scan appears normal in the depressed patient, studded with multiple metabolic defects in patients with multiple infarct dementia, and in the patients with alzheimer disease, metabolism is particularly reduced in the parietal cortex, but only slightly reduced in the caudate and thalamus. |
1984-03-23 |
2023-08-12 |
human |
| H Ishino, S Otsuk. Distribution of Alzheimer's neurofibrillary tangles in the basal ganglia and brain stem of progressive supranuclear palsy and Alzheimer's disease. Folia psychiatrica et neurologica japonica. vol 29. issue 2. 1975-12-28. PMID:1176072. |
in two cases with alzheimer's disease, neurofibrillary tangles were found most numerously in the nucleus mamilloinfundibularis, nucleus basilaris, nucleus dorsalis raphe, nucleus centralis superior, and next in order came the thalamus. |
1975-12-28 |
2023-08-11 |
Not clear |