| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L H Parsons, J B Justic. Serotonin and dopamine sensitization in the nucleus accumbens, ventral tegmental area, and dorsal raphe nucleus following repeated cocaine administration. Journal of neurochemistry. vol 61. issue 5. 1993-11-29. PMID:7693863. |
on day 11, baseline dialysate levels of da, 5-ht, dihydroxyphenylacetic acid, and 5-hydroxyindoleacetic acid were obtained from either the n acc and vta or the n acc and drn, followed by a 10 mg/kg i.p. |
1993-11-29 |
2023-08-12 |
rat |
| L H Parsons, J B Justic. Serotonin and dopamine sensitization in the nucleus accumbens, ventral tegmental area, and dorsal raphe nucleus following repeated cocaine administration. Journal of neurochemistry. vol 61. issue 5. 1993-11-29. PMID:7693863. |
the percent baseline increases of both 5-ht and da were significantly higher in the n acc, vta, and drn of animals that received daily injections of cocaine compared with saline controls (p < 0.05, in each region). |
1993-11-29 |
2023-08-12 |
rat |
| L H Parsons, J B Justic. Serotonin and dopamine sensitization in the nucleus accumbens, ventral tegmental area, and dorsal raphe nucleus following repeated cocaine administration. Journal of neurochemistry. vol 61. issue 5. 1993-11-29. PMID:7693863. |
maximum dialysate 5-ht concentrations after cocaine challenge were significantly higher in the n acc and vta (p < 0.05) and drn (p < 0.01) of chronically treated animals compared with saline controls. |
1993-11-29 |
2023-08-12 |
rat |
| W J McBride, J M Murphy, G J Gatto, A D Levy, L Lumeng, T K L. Serotonin and dopamine systems regulating alcohol intake. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. vol 1. 1993-10-07. PMID:1726986. |
overall the data suggest the involvement of certain vta da and dorsal raphe nucleus 5-ht pathways in regulating high alcohol drinking behavior. |
1993-10-07 |
2023-08-11 |
rat |
| D F Fiorino, A Coury, H C Fibiger, A G Phillip. Electrical stimulation of reward sites in the ventral tegmental area increases dopamine transmission in the nucleus accumbens of the rat. Behavioural brain research. vol 55. issue 2. 1993-09-30. PMID:7689319. |
5-hiaa concentrations also increased during icss but these changes were not correlated with either icss rate or current intensity, suggesting that changes in serotonin metabolism were unlikely to subserve brain stimulation reward in the vta. |
1993-09-30 |
2023-08-12 |
rat |
| S Ferré, F Artiga. Dopamine D2 receptor-mediated regulation of serotonin extracellular concentration in the dorsal raphe nucleus of freely moving rats. Journal of neurochemistry. vol 61. issue 2. 1993-08-24. PMID:7687663. |
it is postulated that da, either from projections from the substantia nigra or the ventral tegmental area or from the da-containing neurons of the drn, may increase 5-ht release in the drn, which, through autoreceptor stimulation, can profoundly influence the activity of ascending serotoninergic neurons. |
1993-08-24 |
2023-08-12 |
rat |
| M G Feenstra, A Kalsbeek, H van Gale. Neonatal lesions of the ventral tegmental area affect monoaminergic responses to stress in the medial prefrontal cortex and other dopamine projection areas in adulthood. Brain research. vol 596. issue 1-2. 1993-01-28. PMID:1334776. |
a mean decrease of dopamine (da) to 20% and serotonin to 25-30% of control levels was found in the medial prefrontal cortex (mpfc) and amygdala/piriform cortex (a/pc) of adult rats with neonatal lesions of the ventral tegmental area (vta). |
1993-01-28 |
2023-08-11 |
rat |
| A J Stoessl, E Szczutkowski, B Glenn, I Watso. Behavioural effects of selective tachykinin agonists in midbrain dopamine regions. Brain research. vol 565. issue 2. 1993-01-19. PMID:1668812. |
these findings suggest that (i) dopamine-mediated behavioural responses seen following tachykinin administration into the midbrain are dependent upon stimulation of nk-3 tachykinin receptors, (ii) tachykinin-induced grooming is mediated by stimulation of nk-1 receptors and (iii) some of the previously described 5-ht mediated behaviours seen following administration of nk-3 tachykinin agonists are probably generated by stimulation of 5-ht cell bodies in the ventral tegmental area. |
1993-01-19 |
2023-08-11 |
rat |
| P A Broderic. Distinguishing effects of cocaine i.v. and SC on mesoaccumbens dopamineand serotonin release with chloral hydrate anesthesia. Pharmacology, biochemistry, and behavior. vol 43. issue 3. 1992-12-30. PMID:1448488. |
in further in vivo voltammetric studies, the effects of sc cocaine on synaptic concentrations of da and 5-ht were studied in the chloral hydrate-anesthetized paradigm in two neuroanatomic substrates, nacc and mesoaccumbens somatodendrites, the ventral tegmental area (vta-a10), in a dose-response fashion (10, 20, and 40 mg/kg) in six separate studies. |
1992-12-30 |
2023-08-11 |
rat |
| P A Broderic. Distinguishing effects of cocaine i.v. and SC on mesoaccumbens dopamineand serotonin release with chloral hydrate anesthesia. Pharmacology, biochemistry, and behavior. vol 43. issue 3. 1992-12-30. PMID:1448488. |
on the other hand, sc cocaine concurrently and significantly decreased da and 5-ht release in nacc (p < 0.0001) and vta (p < 0.0001) at each separate dose tested. |
1992-12-30 |
2023-08-11 |
rat |
| J P Tassi. NE/DA interactions in prefrontal cortex and their possible roles as neuromodulators in schizophrenia. Journal of neural transmission. Supplementum. vol 36. 1992-10-22. PMID:1356142. |
the monoaminergic innervation of the rat prefrontal cortex arises from well-defined mesencephalic nuclei, with noradrenergic (ne) neurons located in the locus coeruleus, dopaminergic (da) neurons located in the ventral tegmental area, and serotonergic (5-ht) neurons originating in the raphe nuclei. |
1992-10-22 |
2023-08-11 |
rat |
| P A Broderic. Cocaine's colocalized effects on synaptic serotonin and dopamine in ventral tegmentum in a reinforcement paradigm. Pharmacology, biochemistry, and behavior. vol 42. issue 4. 1992-09-25. PMID:1513872. |
the effect of subcutaneous (sc) cocaine (20 mg/kg) on synaptic concentrations of the biogenic amines, dopamine (da), and serotonin (5-ht) in ventral tegmental area, (vta-[a10]) was studied in freely moving and behaving rats (rattus norvegicus) with in vivo voltammetry (in vivo electrochemistry). |
1992-09-25 |
2023-08-11 |
rat |
| P A Broderic. Cocaine's colocalized effects on synaptic serotonin and dopamine in ventral tegmentum in a reinforcement paradigm. Pharmacology, biochemistry, and behavior. vol 42. issue 4. 1992-09-25. PMID:1513872. |
the results show that cocaine concurrently and significantly increased synaptic concentrations of da (p less than 0.0001) and 5-ht (p less than 0.004) in vta. |
1992-09-25 |
2023-08-11 |
rat |
| P A Broderic. Cocaine's colocalized effects on synaptic serotonin and dopamine in ventral tegmentum in a reinforcement paradigm. Pharmacology, biochemistry, and behavior. vol 42. issue 4. 1992-09-25. PMID:1513872. |
importantly, da and 5-ht changes in vta were significantly and positively correlated (p less than 0.01). |
1992-09-25 |
2023-08-11 |
rat |
| G Battaglia, J Sharkey, M J Kuhar, E B de Souz. Neuroanatomic specificity and time course of alterations in rat brain serotonergic pathways induced by MDMA (3,4-methylenedioxymethamphetamine): assessment using quantitative autoradiography. Synapse (New York, N.Y.). vol 8. issue 4. 1991-11-14. PMID:1681594. |
regions which demonstrated no significant reduction in 5-ht uptake sites included the dorsal and median raphe nuclei, ventral tegmental area, central grey, interpeduncular nucleus, locus coerulus, pontine reticular formation and cerebellum. |
1991-11-14 |
2023-08-11 |
rat |
| G Bonvento, P Lacombe, E T MacKenzie, D Fage, J Benavides, L Rouquier, B Scatto. Evidence for differing origins of the serotonergic innervation of major cerebral arteries and small pial vessels in the rat. Journal of neurochemistry. vol 56. issue 2. 1991-02-26. PMID:1703222. |
destruction of the ascending serotonergic pathways (via local administration of 5,7-dihydroxytryptamine into the ventral tegmental area) produced a dramatic fall in 5-ht and 5-hiaa concentrations in both vascular compartments. |
1991-02-26 |
2023-08-11 |
rat |
| F E Pontieri, A M Crane, L S Seiden, M S Kleven, L J Porrin. Metabolic mapping of the effects of intravenous methamphetamine administration in freely moving rats. Psychopharmacology. vol 102. issue 2. 1991-02-26. PMID:1980372. |
dopamine and serotonin are depleted in these regions, as well as in the ventral tegmental area where glucose utilization was also increased, following chronic treatment with high doses of methamphetamine. |
1991-02-26 |
2023-08-11 |
rat |
| F Darchen, Y Masuo, M Vial, W Rostene, D Scherma. Quantitative autoradiography of the rat brain vesicular monoamine transporter using the binding of [3H]dihydrotetrabenazine and 7-amino-8-[125I]iodoketanserin. Neuroscience. vol 33. issue 2. 1990-03-28. PMID:2622531. |
cell bodies were also labelled in the substantia nigra and ventral tegmental area (dopamine), in locus coeruleus (noradrenaline) and in raphe nucleus (serotonin). |
1990-03-28 |
2023-08-11 |
rat |
| L Cervo, G Grignaschi, E Nowakowska, R Samani. 1-(3-Trifluoromethylphenyl) piperazine (TFMPP) in the ventral tegmental area reduces the effect of desipramine in the forced swimming test in rats: possible role of serotonin receptors. European journal of pharmacology. vol 171. issue 1. 1990-03-12. PMID:2533079. |
1-(3-trifluoromethylphenyl) piperazine (tfmpp) in the ventral tegmental area reduces the effect of desipramine in the forced swimming test in rats: possible role of serotonin receptors. |
1990-03-12 |
2023-08-11 |
rat |
| X M Guan, W J McBrid. Serotonin microinfusion into the ventral tegmental area increases accumbens dopamine release. Brain research bulletin. vol 23. issue 6. 1990-03-08. PMID:2575444. |
serotonin microinfusion into the ventral tegmental area increases accumbens dopamine release. |
1990-03-08 |
2023-08-11 |
rat |