| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T B Thompson, G Meisl, T P J Knowles, A Goriel. The role of clearance mechanisms in the kinetics of pathological protein aggregation involved in neurodegenerative diseases. The Journal of chemical physics. vol 154. issue 12. 2021-07-19. PMID:33810689. |
in alzheimer's disease, the formation of amyloid-β plaques and neurofibrillary tangles of the tau protein is associated with the appearance of symptoms and pathology. |
2021-07-19 |
2023-08-13 |
Not clear |
| Julia Neitzel, Nicolai Franzmeier, Anna Rubinski, Martin Dichgans, Matthias Brendel, Rainer Malik, Michael Ewer. KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease. Nature communications. vol 12. issue 1. 2021-07-19. PMID:34158479. |
kl-vs heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in alzheimer's disease. |
2021-07-19 |
2023-08-13 |
Not clear |
| Jack Hashem, Mei Hu, Jian Zhang, Fei Gao, Chu Che. Inhibition of 2-Arachidonoylglycerol Metabolism Alleviates Neuropathology and Improves Cognitive Function in a Tau Mouse Model of Alzheimer's Disease. Molecular neurobiology. vol 58. issue 8. 2021-07-17. PMID:33939165. |
inhibition of 2-arachidonoylglycerol metabolism alleviates neuropathology and improves cognitive function in a tau mouse model of alzheimer's disease. |
2021-07-17 |
2023-08-13 |
mouse |
| Antonio Valencia, Veronica L Reinhart Bieber, Bekim Bajrami, Galina Marsh, Stefan Hamann, Ru Wei, Karen Ling, Frank Rigo, H Moore Arnold, Olga Golonzhka, Heike Herin. Antisense Oligonucleotide-Mediated Reduction of HDAC6 Does Not Reduce Tau Pathology in P301S Tau Transgenic Mice. Frontiers in neurology. vol 12. 2021-07-16. PMID:34262517. |
acetylation of tau protein is dysregulated in alzheimer's disease (ad). |
2021-07-16 |
2023-08-13 |
mouse |
| Ming-Jang Chiu, Ta-Fu Chen, Chaur-Jong Hu, Sui-Hing Yan, Yu Sun, Bing-Hsien Liu, Yun-Tsui Chang, Che-Chuan Yang, Shieh-Yueh Yan. Nanoparticle-based immunomagnetic assay of plasma biomarkers for differentiating dementia and prodromal states of Alzheimer's disease - A cross-validation study. Nanomedicine : nanotechnology, biology, and medicine. vol 28. 2021-07-15. PMID:32222476. |
blood-based biomarker assays of plasma β-amyloid (aβ) and tau have the advantages of cost-effective and less invasive for the diagnosis of alzheimer's disease (ad). |
2021-07-15 |
2023-08-13 |
human |
| Qing Xia, XinYu Yang, JiaBin Shi, ZiJie Liu, YaHui Peng, WenJing Wang, BoWen Li, Yu Zhao, JiaYing Xiao, Lei Huang, DaYong Wang, Xu Ga. The Protective A673T Mutation of Amyloid Precursor Protein (APP) in Alzheimer's Disease. Molecular neurobiology. vol 58. issue 8. 2021-07-15. PMID:33914267. |
alzheimer's disease is a progressive neurodegenerative disorder characterized by extracellular amyloid beta peptides and neurofibrillary tangles consisted of intracellular hyperphosphorylated tau in the hippocampus and cerebral cortex. |
2021-07-15 |
2023-08-13 |
Not clear |
| Meiting Li, Nan Cai, Liang Gu, Lijun Yao, Decheng Bi, Weishan Fang, Zhijian Lin, Yan Wu, Hong Xu, Hui Li, Zhangli Hu, Xu X. Genipin Attenuates Tau Phosphorylation and Aβ Levels in Cellular Models of Alzheimer's Disease. Molecular neurobiology. vol 58. issue 8. 2021-07-15. PMID:33948899. |
genipin attenuates tau phosphorylation and aβ levels in cellular models of alzheimer's disease. |
2021-07-15 |
2023-08-13 |
Not clear |
| Sarah Gourmaud, David A Stewart, David J Irwin, Nicholas Roberts, Aaron J Barbour, Grace Eberwine, William T O'Brien, Robert Vassar, Delia M Talos, Frances E Jense. The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease. Brain : a journal of neurology. 2021-07-15. PMID:34264340. |
to elucidate our proposed bidirectional relationship between alzheimer's disease and seizures, we studied alzheimer's disease human brain samples (n = 34) and found that patients with a history of seizures (n = 14) had increased β-amyloid and tau pathology, and upregulation of the mechanistic target of rapamycin (mtor) pathway compared to cases without known seizure history (n = 20). |
2021-07-15 |
2023-08-13 |
mouse |
| Shi-Dong Chen, Yu-Yuan Huang, Xue-Ning Shen, Yu Guo, Lan Tan, Qiang Dong, Jin-Tai Y. Longitudinal plasma phosphorylated tau 181 tracks disease progression in Alzheimer's disease. Translational psychiatry. vol 11. issue 1. 2021-07-14. PMID:34120152. |
longitudinal plasma phosphorylated tau 181 tracks disease progression in alzheimer's disease. |
2021-07-14 |
2023-08-13 |
human |
| Feng Xing, Tao Meng, Joseph Therriault, Jing Luo, Hua Zhan. Apolipoprotein E ε4 and ε3 alleles associate with cerebrospinal fluid tau and cognition in the presence of amyloid-β in mild cognitive impairment but not in Alzheimer's disease. Journal of integrative neuroscience. vol 20. issue 2. 2021-07-14. PMID:34258926. |
apolipoprotein e ε4 and ε3 alleles associate with cerebrospinal fluid tau and cognition in the presence of amyloid-β in mild cognitive impairment but not in alzheimer's disease. |
2021-07-14 |
2023-08-13 |
human |
| Feng Xing, Tao Meng, Joseph Therriault, Jing Luo, Hua Zhan. Apolipoprotein E ε4 and ε3 alleles associate with cerebrospinal fluid tau and cognition in the presence of amyloid-β in mild cognitive impairment but not in Alzheimer's disease. Journal of integrative neuroscience. vol 20. issue 2. 2021-07-14. PMID:34258926. |
the associations of apolipoprotein e ε4 and ε3 with total tau (t-tau), phosphorylated tau (p-tau), and alzheimer's disease assessment scale was significantly substantial among participants with significant amyloid-β deposition. |
2021-07-14 |
2023-08-13 |
human |
| Feng Xing, Tao Meng, Joseph Therriault, Jing Luo, Hua Zhan. Apolipoprotein E ε4 and ε3 alleles associate with cerebrospinal fluid tau and cognition in the presence of amyloid-β in mild cognitive impairment but not in Alzheimer's disease. Journal of integrative neuroscience. vol 20. issue 2. 2021-07-14. PMID:34258926. |
our study shows that the presence of apolipoprotein e ε4 and ε3 alleles is related to tau pathology and cognitive impairment in the presence of amyloid-β in mild cognitive impairment, but not in alzheimer's disease. |
2021-07-14 |
2023-08-13 |
human |
| Joana B Pereira, Shorena Janelidze, Ruben Smith, Niklas Mattsson-Carlgren, Sebastian Palmqvist, Charlotte E Teunissen, Henrik Zetterberg, Erik Stomrud, Nicholas J Ashton, Kaj Blennow, Oskar Hansso. Plasma GFAP is an early marker of amyloid-β but not tau pathology in Alzheimer's disease. Brain : a journal of neurology. 2021-07-14. PMID:34259835. |
plasma gfap is an early marker of amyloid-β but not tau pathology in alzheimer's disease. |
2021-07-14 |
2023-08-13 |
human |
| Severin Mairinger, Thomas Filip, Michael Sauberer, Stefanie Flunkert, Thomas Wanek, Johann Stanek, Sara Furtner, Birgit Hutter-Paier, Nobuyuki Okamura, Claudia Kuntne. Plasma pharmacokinetic and metabolism of [ Nuclear medicine and biology. vol 84-85. 2021-07-13. PMID:31981857. |
plasma pharmacokinetic and metabolism of [ tau deposition is one of the hallmarks of alzheimer's disease (ad) and can be visualized and quantified using [ |
2021-07-13 |
2023-08-13 |
Not clear |
| Te-Hsien Lin, Ya-Jen Chiu, Chih-Hsin Lin, Chung-Yin Lin, Chih-Ying Chao, Yu-Chieh Chen, Shu-Mei Yang, Wenwei Lin, Hsiu Mei Hsieh-Li, Yih-Ru Wu, Kuo-Hsuan Chang, Guey-Jen Lee-Chen, Chiung-Mei Che. Exploration of multi-target effects of 3-benzoyl-5-hydroxychromen-2-one in Alzheimer's disease cell and mouse models. Aging cell. vol 19. issue 7. 2021-07-13. PMID:32496635. |
abnormal tau phosphorylation and aggregation are a common pathogenic hallmark in alzheimer's disease (ad). |
2021-07-13 |
2023-08-13 |
mouse |
| Le Yu, Guanghua Wen, Shoufeng Zhu, Xianwen Hu, Chunxia Huang, Yan Yan. Abnormal phosphorylation of tau protein and neuroinflammation induced by laparotomy in an animal model of postoperative delirium. Experimental brain research. vol 239. issue 3. 2021-07-13. PMID:33409674. |
neuroinflammation and abnormal tau phosphorylation that commonly presenting in alzheimer's disease (ad) may contribute to the progression and duration of pod. |
2021-07-13 |
2023-08-13 |
mouse |
| Xulong Ding, Shuting Zhang, Lijun Jiang, Lu Wang, Tao Li, Peng Le. Ultrasensitive assays for detection of plasma tau and phosphorylated tau 181 in Alzheimer's disease: a systematic review and meta-analysis. Translational neurodegeneration. vol 10. issue 1. 2021-07-13. PMID:33712071. |
ultrasensitive assays for detection of plasma tau and phosphorylated tau 181 in alzheimer's disease: a systematic review and meta-analysis. |
2021-07-13 |
2023-08-13 |
Not clear |
| Rajib Das, Abdur Rauf, Saima Akhter, Mohammad Nazmul Islam, Talha Bin Emran, Saikat Mitra, Ishaq N Khan, Mohammad S Mubara. Role of Withaferin A and Its Derivatives in the Management of Alzheimer's Disease: Recent Trends and Future Perspectives. Molecules (Basel, Switzerland). vol 26. issue 12. 2021-07-13. PMID:34204308. |
globally, alzheimer's disease (ad) is one of the most prevalent age-related neurodegenerative disorders associated with cognitive decline and memory deficits due to beta-amyloid deposition (aβ) and tau protein hyperphosphorylation. |
2021-07-13 |
2023-08-13 |
Not clear |
| M A Berezutsky, N A Durnova, L E Sigarev. [Neurobiological effects of tenuigenin and the opportunity of it's using in the therapy of Alzheimer's and Parkinson's diseases (literature review).] Advances in gerontology = Uspekhi gerontologii. vol 34. issue 2. 2021-07-13. PMID:34245502. |
it was noted, that the capacities of the tenuigenin to decrease the secretion of beta amyloid and to protect of neurons from damage by already made beta ameloids, to inhibit the processes of the tau proteins` hyperphosphorylation and inflammations in microglia, as well as increase the main synaptic transmission can be used by the development of effective therapeutic drugs aimed to reduce the pathogenesis of alzheimer`s disease. |
2021-07-13 |
2023-08-13 |
Not clear |
| Xiaomin Yin, Chenhao Zhao, Yanyan Qiu, Zheng Zhou, Junze Bao, Wei Qia. Dendritic/Post-synaptic Tau and Early Pathology of Alzheimer's Disease. Frontiers in molecular neuroscience. vol 14. 2021-07-13. PMID:34248498. |
dendritic/post-synaptic tau and early pathology of alzheimer's disease. |
2021-07-13 |
2023-08-13 |
Not clear |