| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jieyun Sun, Xiong Zhang, Chen Wang, Zhipeng Teng, Yu L. Curcumin Decreases Hyperphosphorylation of Tau by Down-Regulating Caveolin-1/GSK-3β in N2a/APP695swe Cells and APP/PS1 Double Transgenic Alzheimer's Disease Mice. The American journal of Chinese medicine. vol 45. issue 8. 2018-02-14. PMID:29132216. |
curcumin decreases hyperphosphorylation of tau by down-regulating caveolin-1/gsk-3β in n2a/app695swe cells and app/ps1 double transgenic alzheimer's disease mice. |
2018-02-14 |
2023-08-13 |
mouse |
| Jieyun Sun, Xiong Zhang, Chen Wang, Zhipeng Teng, Yu L. Curcumin Decreases Hyperphosphorylation of Tau by Down-Regulating Caveolin-1/GSK-3β in N2a/APP695swe Cells and APP/PS1 Double Transgenic Alzheimer's Disease Mice. The American journal of Chinese medicine. vol 45. issue 8. 2018-02-14. PMID:29132216. |
in our previous studies, curcumin has been confirmed to play a neuroprotective role in alzheimer's disease (ad), but its effects on caveolin-1, tau and their correlation, and the mechanism is still unknown. |
2018-02-14 |
2023-08-13 |
mouse |
| T Nishikawa, T Takahashi, M Nakamori, N Hosomi, H Maruyama, Y Miyazaki, Y Izumi, M Matsumot. The identification of raft-derived tau-associated vesicles that are incorporated into immature tangles and paired helical filaments. Neuropathology and applied neurobiology. vol 42. issue 7. 2018-02-12. PMID:26501932. |
neurofibrillary tangles (nfts), a cardinal pathological feature of neurodegenerative disorders, such as alzheimer's disease (ad) are primarily composed of hyper-phosphorylated tau protein. |
2018-02-12 |
2023-08-13 |
Not clear |
| Mari Kim, Manivannan Subramanian, Yun-Ho Cho, Gye-Hyeong Kim, Eunil Lee, Joong-Jean Par. Short-term exposure to dim light at night disrupts rhythmic behaviors and causes neurodegeneration in fly models of tauopathy and Alzheimer's disease. Biochemical and biophysical research communications. vol 495. issue 2. 2018-02-12. PMID:29217196. |
the accumulation and aggregation of phosphorylated tau proteins in the brain are the hallmarks for the onset of alzheimer's disease (ad). |
2018-02-12 |
2023-08-13 |
human |
| Saima Zafar, Neelam Younas, Susana Correia, Mohsin Shafiq, Waqas Tahir, Matthias Schmitz, Isidre Ferrer, Olivier Andréoletti, Inga Zer. Strain-Specific Altered Regulatory Response of Rab7a and Tau in Creutzfeldt-Jakob Disease and Alzheimer's Disease. Molecular neurobiology. vol 54. issue 1. 2018-02-08. PMID:26768426. |
strain-specific altered regulatory response of rab7a and tau in creutzfeldt-jakob disease and alzheimer's disease. |
2018-02-08 |
2023-08-13 |
Not clear |
| Lary C Walker, Mathias Jucke. The Exceptional Vulnerability of Humans to Alzheimer's Disease. Trends in molecular medicine. vol 23. issue 6. 2018-02-08. PMID:28483344. |
nevertheless, the complete behavioral and pathologic phenotype of alzheimer's disease, including aβ plaques, neurofibrillary (tau) tangles, and dementia, has not yet been identified in a non-human species. |
2018-02-08 |
2023-08-13 |
monkey |
| Roberto Piacentini, Domenica Donatella Li Puma, Marco Mainardi, Giacomo Lazzarino, Barbara Tavazzi, Ottavio Arancio, Claudio Grass. Reduced gliotransmitter release from astrocytes mediates tau-induced synaptic dysfunction in cultured hippocampal neurons. Glia. vol 65. issue 8. 2018-02-02. PMID:28519902. |
in alzheimer's disease (ad) misfolded tau accumulates intraneuronally and leads to axonal degeneration. |
2018-02-02 |
2023-08-13 |
Not clear |
| Sarah L DeVos, Rebecca L Miller, Kathleen M Schoch, Brandon B Holmes, Carey S Kebodeaux, Amy J Wegener, Guo Chen, Tao Shen, Hien Tran, Brandon Nichols, Tom A Zanardi, Holly B Kordasiewicz, Eric E Swayze, C Frank Bennett, Marc I Diamond, Timothy M Mille. Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy. Science translational medicine. vol 9. issue 374. 2018-02-01. PMID:28123067. |
accumulation of hyperphosphorylated tau directly correlates with cognitive decline in alzheimer's disease and other primary tauopathies. |
2018-02-01 |
2023-08-13 |
mouse |
| Eleanor K Pickett, Christopher M Henstridge, Elizabeth Allison, Rose Pitstick, Amy Pooler, Susanne Wegmann, George Carlson, Bradley T Hyman, Tara L Spires-Jone. Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease. Synapse (New York, N.Y.). vol 71. issue 6. 2018-02-01. PMID:28196395. |
spread of tau down neural circuits precedes synapse and neuronal loss in the rtgtauec mouse model of early alzheimer's disease. |
2018-02-01 |
2023-08-13 |
mouse |
| Eleanor K Pickett, Christopher M Henstridge, Elizabeth Allison, Rose Pitstick, Amy Pooler, Susanne Wegmann, George Carlson, Bradley T Hyman, Tara L Spires-Jone. Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease. Synapse (New York, N.Y.). vol 71. issue 6. 2018-02-01. PMID:28196395. |
synaptic dysfunction and loss is the strongest pathological correlate of cognitive decline in alzheimer's disease (ad) with increasing evidence implicating neuropathological tau protein in this process. |
2018-02-01 |
2023-08-13 |
mouse |
| Marie Sarazin, Julien Lagarde, Michel Bottlaende. Distinct tau PET imaging patterns in typical and atypical Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 5. 2018-01-31. PMID:27189580. |
distinct tau pet imaging patterns in typical and atypical alzheimer's disease. |
2018-01-31 |
2023-08-13 |
Not clear |
| Zhongyun Chen, Chunyan Liu, Jie Zhang, Norman Relkin, Yan Xing, Yanfeng L. Cerebrospinal fluid Aβ42, t-tau, and p-tau levels in the differential diagnosis of idiopathic normal-pressure hydrocephalus: a systematic review and meta-analysis. Fluids and barriers of the CNS. vol 14. issue 1. 2018-01-31. PMID:28486988. |
the purpose of this systematic review and meta-analysis was to evaluate the performance of cerebrospinal fluid (csf) beta amyloid 42 (aβ42), total tau (t-tau), and phosphorylated tau (p-tau) as potential diagnostic biomarkers for idiopathic normal-pressure hydrocephalus (inph) and to assess their utility indistinguishing patients with inph from those with alzheimer disease (ad) and healthy normal controls. |
2018-01-31 |
2023-08-13 |
Not clear |
| Andrew J Doig, Maria P Del Castillo-Frias, Olivia Berthoumieu, Bogdan Tarus, Jessica Nasica-Labouze, Fabio Sterpone, Phuong H Nguyen, Nigel M Hooper, Peter Faller, Philippe Derreumau. Why Is Research on Amyloid-β Failing to Give New Drugs for Alzheimer's Disease? ACS chemical neuroscience. vol 8. issue 7. 2018-01-30. PMID:28586203. |
the two hallmarks of alzheimer's disease (ad) are the presence of neurofibrillary tangles (nft) made of aggregates of the hyperphosphorylated tau protein and of amyloid plaques composed of amyloid-β (aβ) peptides, primarily aβ1-40 and aβ1-42. |
2018-01-30 |
2023-08-13 |
Not clear |
| Sulana Schroeder, Aurelie Joly-Amado, Ahlam Soliman, Urmi Sengupta, Rakiz Kayed, Marcia N Gordon, David Morga. Oligomeric tau-targeted immunotherapy in Tg4510 mice. Alzheimer's research & therapy. vol 9. issue 1. 2018-01-30. PMID:28655349. |
finding ways to reverse or prevent the consequences of pathogenic tau in the brain is of considerable importance for treatment of alzheimer's disease and other tauopathies. |
2018-01-30 |
2023-08-13 |
mouse |
| Gloria Biella, Federica Fusco, Emanuele Nardo, Ottavia Bernocchi, Alessio Colombo, Stefan F Lichtenthaler, Gianluigi Forloni, Diego Alban. Sirtuin 2 Inhibition Improves Cognitive Performance and Acts on Amyloid-β Protein Precursor Processing in Two Alzheimer's Disease Mouse Models. Journal of Alzheimer's disease : JAD. vol 53. issue 3. 2018-01-29. PMID:27372638. |
the neuropathological hallmarks of alzheimer's disease (ad) are extracellular plaques built up by the accumulation of the amyloid-β protein precursor (aβpp)-derived peptide β (aβ), and intracellular tangles of hyperphosphorylated tau protein. |
2018-01-29 |
2023-08-13 |
mouse |
| Carl-Henrik Andersson, Oskar Hansson, Lennart Minthon, Niels Andreasen, Kaj Blennow, Henrik Zetterberg, Ingmar Skoog, Anders Wallin, Staffan Nilsson, Petronella Kettune. A Genetic Variant of the Sortilin 1 Gene is Associated with Reduced Risk of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 53. issue 4. 2018-01-29. PMID:27392867. |
alzheimer's disease (ad) is a neurodegenerative disorder represented by the accumulation of intracellular tau protein and extracellular deposits of amyloid-β (aβ) in the brain. |
2018-01-29 |
2023-08-13 |
Not clear |
| Charles B Malpas, Lucy Vivash, Sila Genc, Michael M Saling, Patricia Desmond, Christopher Steward, Rodney J Hicks, Jason Callahan, Amy Brodtmann, Steven Collins, Stephen Macfarlane, Niall M Corcoran, Christopher M Hovens, Dennis Velakoulis, Terence J O'Brie. A Phase IIa Randomized Control Trial of VEL015 (Sodium Selenate) in Mild-Moderate Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 54. issue 1. 2018-01-29. PMID:27447428. |
there is increasing interest in targeting hyperphosphorylated tau (h-tau) as a disease modifying approach for alzheimer's disease (ad). |
2018-01-29 |
2023-08-13 |
Not clear |
| Charisse Somers, Hanne Struyfs, Joery Goossens, Ellis Niemantsverdriet, Jill Luyckx, Naomi De Roeck, Ellen De Roeck, Bart De Vil, Patrick Cras, Jean-Jacques Martin, Peter-Paul De Deyn, Maria Bjerke, Sebastiaan Engelborgh. A Decade of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Belgium. Journal of Alzheimer's disease : JAD. vol 54. issue 1. 2018-01-29. PMID:27567807. |
during the past ten years, over 5,000 cerebrospinal fluid (csf) samples were analyzed at the reference center for biological markers of dementia (biodem), uantwerp, for core alzheimer's disease (ad) csf biomarkers: amyloid-β peptide of 42 amino acids (aβ1-42), total tau protein (t-tau), and tau phosphorylated at threonine 181 (p-tau181p). |
2018-01-29 |
2023-08-13 |
human |
| Ana Laura Calderon-Garcidueñas, Charles Duyckaert. Alzheimer disease. Handbook of clinical neurology. vol 145. 2018-01-29. PMID:28987180. |
alzheimer disease neuropathology is characterized by the extracellular accumulation of aβ peptide and intracellular aggregation of hyperphosphorylated tau. |
2018-01-29 |
2023-08-13 |
Not clear |
| Eleanor K Pickett, Robert M Koffie, Susanne Wegmann, Christopher M Henstridge, Abigail G Herrmann, Marti Colom-Cadena, Alberto Lleo, Kevin R Kay, Melissa Vaught, Roy Soberman, Dominic M Walsh, Bradley T Hyman, Tara L Spires-Jone. Non-Fibrillar Oligomeric Amyloid-β within Synapses. Journal of Alzheimer's disease : JAD. vol 53. issue 3. 2018-01-26. PMID:27258414. |
alzheimer's disease (ad) is characterized by memory loss, insidious cognitive decline, profound neurodegeneration, and the extracellular accumulation of amyloid-β (aβ) peptide in senile plaques and intracellular accumulation of tau in neurofibrillary tangles. |
2018-01-26 |
2023-08-13 |
mouse |