| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ethan D Smith, Robert McKenna, Mario Mietzsch, David R Borchelt, Stefan Prokop, Paramita Chakrabart. Hyperacetylation mimetics within the tau filament core inhibits prion-like propagation of misfolded tau. bioRxiv : the preprint server for biology. 2024-04-25. PMID:38659970. |
acetylation of key lysine residues characterizes aggregates of the microtubule-associated protein tau constituting the neuropathological hallmark of many neurodegenerative diseases, such as alzheimer's disease (ad) and progressive supranuclear palsy (psp). |
2024-04-25 |
2024-04-28 |
Not clear |
| Joanna M Cooper, Aurelien Lathuiliere, Enming J Su, Yuyu Song, Daniel Torrente, Youhwa Jo, Nicholas Weinrich, Jennifer Diaz Sales, Mary Migliorini, Thomas H Sisson, Daniel A Lawrence, Bradley T Hyman, Dudley K Stricklan. SORL1 is a receptor for tau that promotes tau seeding. The Journal of biological chemistry. 2024-04-24. PMID:38657864. |
finally, we demonstrate that the n1358s mutant of sorl1 significantly increases tau seeding when compared to wt sorl1, identifying for the first time a potential mechanism that connects this specific sorl1 mutation to alzheimer's disease. |
2024-04-24 |
2024-04-28 |
Not clear |
| Nathalie Kyalu Ngoie Zola, Clémence Balty, Didier Vertommen, Bernard Jimmy Hanseeu. [Specific modifications of the soluble tau protein distinguish Alzheimer's disease from other tauopathies]. Medecine sciences : M/S. vol 40. issue 4. 2024-04-23. PMID:38651955. |
[specific modifications of the soluble tau protein distinguish alzheimer's disease from other tauopathies]. |
2024-04-23 |
2024-04-26 |
Not clear |
| Bhanuranjan Das, Anurag Tk Baidya, Sourabh Chakrabarti, Deepak Chouhan, Banita Thakur, Taher Darreh-Shori, Gefei Chen, Vinod Tiwari, Rajnish Kuma. Synthesis and biological evaluation of Halogen-Substituted novel α-Ketoamides as potential protein aggregation modulators in Alzheimer's disease. Bioorganic chemistry. vol 147. 2024-04-23. PMID:38653149. |
the escalating prevalence of alzheimer's disease (ad) has prompted extensive research into potential therapeutic interventions, with a specific focus on molecular targets such as amyloid beta (aβ) and tau protein aggregation. |
2024-04-23 |
2024-04-26 |
Not clear |
| Mohsina Patwekar, Faheem Patwekar, Shahzad Khan, Rohit Sharma, Dileep Kuma. Navigating the Alzheimer's Treatment Landscape: Unraveling Amyloid-Beta Complexities and Pioneering Precision Medicine Approaches. Current topics in medicinal chemistry. 2024-04-22. PMID:38644708. |
combination therapies are becoming increasingly popular as a way to address the multifaceted pathology of alzheimer's by simultaneously attacking aβ plaques, tau tangles, neuroinflammation, and other factors. |
2024-04-22 |
2024-04-24 |
Not clear |
| Jonathan Hulse, Nicole Maphis, Julianne Peabody, Bryce Chackerian, Kiran Bhaska. Virus-like particle (VLP)-based vaccine targeting tau phosphorylated at Ser396/Ser404 (PHF1) site outperforms phosphorylated S199/S202 (AT8) site in reducing tau pathology and restoring cognitive deficits in the rTg4510 mouse model of tauopathy. bioRxiv : the preprint server for biology. 2024-04-22. PMID:38644999. |
tauopathies, including alzheimer's disease (ad) and frontotemporal dementia (ftd), are histopathologically defined by the aggregation of hyperphosphorylated pathological tau (ptau) as neurofibrillary tangles in the brain. |
2024-04-22 |
2024-04-24 |
mouse |
| Anthony J Griswold, Farid Rajabli, Tianjie Gu, Jamie Arvizu, Charles G Golightly, Patrice L Whitehead, Kara L Hamilton-Nelson, Larry D Adams, Jose Javier Sanchez, Pedro R Mena, Takiyah D Starks, Maryenela Illanes-Manrique, Concepcion Silva, William S Bush, Michael L Cuccaro, Jeffery M Vance, Mario R Cornejo-Olivas, Briseida E Feliciano-Astacio, Goldie S Byrd, Gary W Beecham, Jonathan L Haines, Margaret A Pericak-Vanc. Generalizability of Tau and Amyloid Plasma Biomarkers in Alzheimer's Disease Cohorts of Diverse Genetic Ancestries. medRxiv : the preprint server for health sciences. 2024-04-22. PMID:38645114. |
generalizability of tau and amyloid plasma biomarkers in alzheimer's disease cohorts of diverse genetic ancestries. |
2024-04-22 |
2024-04-24 |
Not clear |
| Anthony J Griswold, Farid Rajabli, Tianjie Gu, Jamie Arvizu, Charles G Golightly, Patrice L Whitehead, Kara L Hamilton-Nelson, Larry D Adams, Jose Javier Sanchez, Pedro R Mena, Takiyah D Starks, Maryenela Illanes-Manrique, Concepcion Silva, William S Bush, Michael L Cuccaro, Jeffery M Vance, Mario R Cornejo-Olivas, Briseida E Feliciano-Astacio, Goldie S Byrd, Gary W Beecham, Jonathan L Haines, Margaret A Pericak-Vanc. Generalizability of Tau and Amyloid Plasma Biomarkers in Alzheimer's Disease Cohorts of Diverse Genetic Ancestries. medRxiv : the preprint server for health sciences. 2024-04-22. PMID:38645114. |
plasma phosphorylated threonine-181 of tau and amyloid beta are biomarkers for differential diagnosis and preclinical detection of alzheimer disease (ad). |
2024-04-22 |
2024-04-24 |
Not clear |
| Gérard N Bischof, Elena Jaeger, Kathrin Giehl, Frank Jessen, Oezguer A Onur, Sid O'Bryant, Esra Kara, Peter H Weiss, Alexander Drzezg. Cortical Tau Aggregation Patterns associated with Apraxia in Alzheimer's Disease. medRxiv : the preprint server for health sciences. 2024-04-22. PMID:38645131. |
cortical tau aggregation patterns associated with apraxia in alzheimer's disease. |
2024-04-22 |
2024-04-24 |
Not clear |
| Gérard N Bischof, Elena Jaeger, Kathrin Giehl, Frank Jessen, Oezguer A Onur, Sid O'Bryant, Esra Kara, Peter H Weiss, Alexander Drzezg. Cortical Tau Aggregation Patterns associated with Apraxia in Alzheimer's Disease. medRxiv : the preprint server for health sciences. 2024-04-22. PMID:38645131. |
here, we systematically investigated apraxia profiles in a well-defined group of patients with alzheimer's disease (ad; n=32) who additionally underwent pet imaging with the second-generation tau pet tracer [18f]pi-2620. |
2024-04-22 |
2024-04-24 |
Not clear |
| Fang Frank Yu, James Rathnakar, Bryan Ryder, Brian Hitt, Omar M Kashmer, A Dean Sherry, Elena Vinogrado. Differentiation and characterization of healthy versus pathological tau using chemical exchange saturation transfer. NMR in biomedicine. 2024-04-22. PMID:38646677. |
neurofibrillary tangles of tau constitute one of the key biological hallmarks of alzheimer's disease. |
2024-04-22 |
2024-04-24 |
Not clear |
| Aditya Singh, Shubhrat Maheshwari, Jagat Pal Yadav, Aditya Prakash Varshney, Sudarshan Singh, Bhupendra G Prajapat. A Review on Tau Targeting Biomimetics Nano Formulations: Novel Approach for Targeting Alzheimer's Diseases. Central nervous system agents in medicinal chemistry. 2024-04-22. PMID:38646682. |
a review on tau targeting biomimetics nano formulations: novel approach for targeting alzheimer's diseases. |
2024-04-22 |
2024-04-24 |
Not clear |
| Aditya Singh, Shubhrat Maheshwari, Jagat Pal Yadav, Aditya Prakash Varshney, Sudarshan Singh, Bhupendra G Prajapat. A Review on Tau Targeting Biomimetics Nano Formulations: Novel Approach for Targeting Alzheimer's Diseases. Central nervous system agents in medicinal chemistry. 2024-04-22. PMID:38646682. |
recent research has revealed that tau pathology can occur independently of amyloid-β and is closely correlated with the clinical progression of alzheimer's symptoms. |
2024-04-22 |
2024-04-24 |
Not clear |
| Aditya Singh, Shubhrat Maheshwari, Jagat Pal Yadav, Aditya Prakash Varshney, Sudarshan Singh, Bhupendra G Prajapat. A Review on Tau Targeting Biomimetics Nano Formulations: Novel Approach for Targeting Alzheimer's Diseases. Central nervous system agents in medicinal chemistry. 2024-04-22. PMID:38646682. |
in alzheimer's disease, beta-amyloid plaques and neurofibrillary tau tangles hinder neuron transmission and function. |
2024-04-22 |
2024-04-24 |
Not clear |
| Hariharan Moorthy, Madhu Ramesh, Dikshaa Padhi, Prayasee Baruah, Thimmaiah Govindaraj. Polycatechols inhibit ferroptosis and modulate tau liquid-liquid phase separation to mitigate Alzheimer's disease. Materials horizons. 2024-04-22. PMID:38647314. |
polycatechols inhibit ferroptosis and modulate tau liquid-liquid phase separation to mitigate alzheimer's disease. |
2024-04-22 |
2024-04-26 |
Not clear |
| Daniel C Shippy, Sophia F Oliai, Tyler K Ullan. Zinc utilization by microglia in Alzheimer's disease. The Journal of biological chemistry. 2024-04-22. PMID:38648940. |
alzheimer's disease (ad) is the most common form of dementia defined by two key pathological characteristics in the brain, amyloid-β (aβ) plaques and neurofibrillary tangles (nfts) composed of hyperphosphorylated tau. |
2024-04-22 |
2024-04-26 |
Not clear |
| Vinita Sharma, Prabodh Chander Sharma, Jurnal Reang, Vivek Yadav, Rajiv Kumar Tonk, Jaseela Majeed, Kalicharan Sharm. Impact of GSK-3β and CK-1δ on Wnt signaling pathway in alzheimer disease: A dual target approach. Bioorganic chemistry. vol 147. 2024-04-21. PMID:38643562. |
gsk-3β and ck-1δ are multifunctional kinases known for their roles in tau hyperphosphorylation, amyloid processing, and synaptic dysfunction, all of which are major hallmarks of alzheimer's disease. |
2024-04-21 |
2024-04-24 |
Not clear |
| Christina D Orrú, Bradley R Groveman, Andrew G Hughson, Tomás Barrio, Kachi Isiofia, Brent Race, Natalia C Ferreira, Pierluigi Gambetti, David A Schneider, Kentaro Masujin, Kohtaro Miyazawa, Bernardino Ghetti, Gianluigi Zanusso, Byron Caughe. Sensitive detection of pathological seeds of α-synuclein, tau and prion protein on solid surfaces. PLoS pathogens. vol 20. issue 4. 2024-04-19. PMID:38640117. |
prions or prion-like aggregates such as those composed of prp, α-synuclein, and tau are key features of proteinopathies such as prion, parkinson's and alzheimer's diseases, respectively. |
2024-04-19 |
2024-04-22 |
mouse |
| Christina D Orrú, Bradley R Groveman, Andrew G Hughson, Tomás Barrio, Kachi Isiofia, Brent Race, Natalia C Ferreira, Pierluigi Gambetti, David A Schneider, Kentaro Masujin, Kohtaro Miyazawa, Bernardino Ghetti, Gianluigi Zanusso, Byron Caughe. Sensitive detection of pathological seeds of α-synuclein, tau and prion protein on solid surfaces. PLoS pathogens. vol 20. issue 4. 2024-04-19. PMID:38640117. |
tau rt-quic detected tau seeding activity on steel exposed to alzheimer's disease brain tissue diluted as much as a billion fold. |
2024-04-19 |
2024-04-22 |
mouse |
| Han Soo Yoo, Han-Kyeol Kim, Jae-Hoon Lee, Joong-Hyun Chun, Hye Sun Lee, Michel J Grothe, Stefan Teipel, Enrica Cavedo, Andrea Vergallo, Harald Hampel, Young Hoon Ryu, Hanna Cho, Chul Hyoung Lyo. Association of Basal Forebrain Volume with Amyloid, Tau, and Cognition in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2024-04-19. PMID:38640150. |
association of basal forebrain volume with amyloid, tau, and cognition in alzheimer's disease. |
2024-04-19 |
2024-04-22 |
Not clear |