| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Jin Chu, Domenico Pratic\\xc3\\xb. The 5-Lipoxygenase as modulator of Alzheimer\'s \\xce\\xb3-secretase and therapeutic target. Brain research bulletin. vol 126. issue Pt 2. 2017-11-06. PMID:27005438.' |
alzheimer's disease (ad) is an age-related, neurodegenerative disorder characterized by cognitive impairment with memory loss, extracellular amyloid beta (aβ) peptides aggregation, and intracellular hyper-phosphorylated tau neurofibrillary tangles (nft) accumulation. |
2017-11-06 |
2023-08-13 |
Not clear |
| Ting-Ting Chu, Na Gao, Qian-Qian Li, Pu-Guang Chen, Xi-Fei Yang, Yong-Xiang Chen, Yu-Fen Zhao, Yan-Mei L. Specific Knockdown of Endogenous Tau Protein by Peptide-Directed Ubiquitin-Proteasome Degradation. Cell chemical biology. vol 23. issue 4. 2017-11-06. PMID:27105281. |
tau, an important pathological protein of alzheimer's disease (ad), can mediate the toxicity of amyloid β (aβ). |
2017-11-06 |
2023-08-13 |
mouse |
| Thomas Arendt, Jens T Stieler, Max Holze. Tau and tauopathies. Brain research bulletin. vol 126. issue Pt 3. 2017-11-06. PMID:27615390. |
the second part deals with the pathophysiology of tau and description of tauopathies which comprise more than 20 disorders including alzheimer's disease, progressive supranuclear palsy, cortico basal degeneration, pick's disease and others. |
2017-11-06 |
2023-08-13 |
Not clear |
| Tae-In Kam, Hyejin Park, Youngdae Gwon, Sungmin Song, Seo-Hyun Kim, Seo Won Moon, Dong-Gyu Jo, Yong-Keun Jun. FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model. eLife. vol 5. 2017-11-06. PMID:27834631. |
fcγriib-ship2 axis links aβ to tau pathology by disrupting phosphoinositide metabolism in alzheimer's disease model. |
2017-11-06 |
2023-08-13 |
Not clear |
| Jesse S Kerr, Bryan A Adriaanse, Nigel H Greig, Mark P Mattson, M Zameel Cader, Vilhelm A Bohr, Evandro F Fan. Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms. Trends in neurosciences. vol 40. issue 3. 2017-11-03. PMID:28190529. |
neurons affected in alzheimer's disease (ad) experience mitochondrial dysfunction and a bioenergetic deficit that occurs early and promotes the disease-defining amyloid beta peptide (aβ) and tau pathologies. |
2017-11-03 |
2023-08-13 |
Not clear |
| Bartosz Nizynski, Wojciech Dzwolak, Krzysztof Nieznansk. Amyloidogenesis of Tau protein. Protein science : a publication of the Protein Society. vol 26. issue 11. 2017-11-03. PMID:28833749. |
the role of microtubule-associated protein tau in neurodegeneration has been extensively investigated since the discovery of tau amyloid aggregates in the brains of patients with alzheimer's disease (ad). |
2017-11-03 |
2023-08-13 |
Not clear |
| Francesca Pistollato, Sandra Sumalla Cano, Iñaki Elio, Manuel Masias Vergara, Francesca Giampieri, Maurizio Battin. Associations between Sleep, Cortisol Regulation, and Diet: Possible Implications for the Risk of Alzheimer Disease. Advances in nutrition (Bethesda, Md.). vol 7. issue 4. 2017-11-02. PMID:27422503. |
accumulation of proteinaceous amyloid β plaques and tau oligomers may occur several years before the onset of alzheimer disease (ad). |
2017-11-02 |
2023-08-13 |
Not clear |
| b' J Chu, E Lauretti, D Pratic\\xc3\\xb. Caspase-3-dependent cleavage of Akt modulates tau phosphorylation via GSK3\\xce\\xb2 kinase: implications for Alzheimer\'s disease. Molecular psychiatry. vol 22. issue 7. 2017-11-02. PMID:28138159.' |
caspase-3-dependent cleavage of akt modulates tau phosphorylation via gsk3β kinase: implications for alzheimer's disease. |
2017-11-02 |
2023-08-13 |
mouse |
| b' J Chu, E Lauretti, D Pratic\\xc3\\xb. Caspase-3-dependent cleavage of Akt modulates tau phosphorylation via GSK3\\xce\\xb2 kinase: implications for Alzheimer\'s disease. Molecular psychiatry. vol 22. issue 7. 2017-11-02. PMID:28138159.' |
the pathological hallmark of alzheimer's disease (ad) is accumulation of misfolded amyloid-β peptides and hyperphosphorylated tau protein in the brain. |
2017-11-02 |
2023-08-13 |
mouse |
| A L Schwarzman, S V Sarantsev. [Transmission of pathogenic protein aggregates in Alzheimer's disease]. Molekuliarnaia biologiia. vol 51. issue 3. 2017-11-01. PMID:28707657. |
deposits of amyloid peptide aβ and intracellular aggregates of hyperphosphorylated tau protein in the brain of patients are major neuropathological features of alzheimer's disease (ad). |
2017-11-01 |
2023-08-13 |
mouse |
| Marie Jouanne, Sylvain Rault, Anne-Sophie Voisin-Chire. Tau protein aggregation in Alzheimer's disease: An attractive target for the development of novel therapeutic agents. European journal of medicinal chemistry. vol 139. 2017-10-31. PMID:28800454. |
tau protein aggregation in alzheimer's disease: an attractive target for the development of novel therapeutic agents. |
2017-10-31 |
2023-08-13 |
human |
| Alejandra D Alonso, Cindy Beharry, Christopher P Corbo, Leah S Cohe. Molecular mechanism of prion-like tau-induced neurodegeneration. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 12. issue 10. 2017-10-30. PMID:27126544. |
accumulation of hyperphosphorylated tau and the disruption of microtubules are correlated with synaptic loss and pathology of alzheimer's disease (ad). |
2017-10-30 |
2023-08-13 |
Not clear |
| Cheng-Xin Gong, Fei Liu, Khalid Iqba. O-GlcNAcylation: A regulator of tau pathology and neurodegeneration. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 12. issue 10. 2017-10-30. PMID:27126545. |
the discovery of o-glcnac modification of tau and its impact on tau phosphorylation has attracted recent research interest in o-glcnac studies in the alzheimer's disease (ad) field. |
2017-10-30 |
2023-08-13 |
mouse |
| Wen Hu, Xinhua Zhang, Yunn Chyn Tung, Shutao Xie, Fei Liu, Khalid Iqba. Hyperphosphorylation determines both the spread and the morphology of tau pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 12. issue 10. 2017-10-30. PMID:27133892. |
neurofibrillary pathology of abnormally hyperphosphorylated tau (p-tau) is a hallmark of alzheimer's disease (ad) and other tauopathies. |
2017-10-30 |
2023-08-13 |
Not clear |
| David M Holtzman, Maria C Carrillo, James A Hendrix, Lisa J Bain, Ana M Catafau, Laura M Gault, Michel Goedert, Eckhard Mandelkow, Eva-Maria Mandelkow, David S Miller, Susanne Ostrowitzki, Manuela Polydoro, Sean Smith, Marion Wittmann, Michael Hutto. Tau: From research to clinical development. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 12. issue 10. 2017-10-30. PMID:27154059. |
tau pathology is recognized as the key driver of disease progression in alzheimer's and other neurodegenerative diseases. |
2017-10-30 |
2023-08-13 |
Not clear |
| David M Holtzman, Maria C Carrillo, James A Hendrix, Lisa J Bain, Ana M Catafau, Laura M Gault, Michel Goedert, Eckhard Mandelkow, Eva-Maria Mandelkow, David S Miller, Susanne Ostrowitzki, Manuela Polydoro, Sean Smith, Marion Wittmann, Michael Hutto. Tau: From research to clinical development. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 12. issue 10. 2017-10-30. PMID:27154059. |
with this in mind, the alzheimer's association convened a research roundtable in october 2015, bringing together experts from academia, industry, and regulatory agencies to discuss the latest understanding of tau pathogenic pathways and review the evolution of tau therapeutics and biomarkers currently in development. |
2017-10-30 |
2023-08-13 |
Not clear |
| Mansi R Khanna, Jane Kovalevich, Virginia M-Y Lee, John Q Trojanowski, Kurt R Brunde. Therapeutic strategies for the treatment of tauopathies: Hopes and challenges. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 12. issue 10. 2017-10-30. PMID:27751442. |
these disorders include alzheimer's disease and frontotemporal lobar degeneration due to tau pathology, including progressive supranuclear palsy, corticobasal degeneration, and pick's disease. |
2017-10-30 |
2023-08-13 |
Not clear |
| Daisuke Tanokashira, Naomi Mamada, Fumiko Yamamoto, Kaori Taniguchi, Akira Tamaoka, Madepalli K Lakshmana, Wataru Arak. The neurotoxicity of amyloid β-protein oligomers is reversible in a primary neuron model. Molecular brain. vol 10. issue 1. 2017-10-30. PMID:28137266. |
alzheimer's disease (ad) is characterized by the accumulation of extracellular amyloid β-protein (aβ) and intracellular hyperphosphorylated tau proteins. |
2017-10-30 |
2023-08-13 |
Not clear |
| Duygu Tosun, Susan Landau, Paul S Aisen, Ronald C Petersen, Mark Mintun, William Jagust, Michael W Weine. Association between tau deposition and antecedent amyloid-β accumulation rates in normal and early symptomatic individuals. Brain : a journal of neurology. vol 140. issue 5. 2017-10-30. PMID:28334939. |
in this study, we first assessed the patterns of brain tau tangle accumulation (measured with the positron emission tomography tracer 18f-av-1451) associated with well-established alzheimer's disease factors in a cohort including cognitively healthy elderly individuals and individuals at early symptomatic stages of alzheimer's disease. |
2017-10-30 |
2023-08-13 |
Not clear |
| Rebecca M Nisbet, Ann Van der Jeugd, Gerhard Leinenga, Harrison T Evans, Phillip W Janowicz, Jürgen Göt. Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model. Brain : a journal of neurology. vol 140. issue 5. 2017-10-30. PMID:28379300. |
alzheimer's disease is characterized by the deposition of amyloid-β as extracellular plaques and hyperphosphorylated tau as intracellular neurofibrillary tangles. |
2017-10-30 |
2023-08-13 |
mouse |