| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhi Tang, Eniko Ioja, Erika Bereczki, Kjell Hultenby, Chunxia Li, Zhizhong Guan, Bengt Winblad, Jin-Jing Pe. mTor mediates tau localization and secretion: Implication for Alzheimer's disease. Biochimica et biophysica acta. vol 1853. issue 7. 2015-08-25. PMID:25791428. |
mtor mediates tau localization and secretion: implication for alzheimer's disease. |
2015-08-25 |
2023-08-13 |
human |
| Zhi Tang, Eniko Ioja, Erika Bereczki, Kjell Hultenby, Chunxia Li, Zhizhong Guan, Bengt Winblad, Jin-Jing Pe. mTor mediates tau localization and secretion: Implication for Alzheimer's disease. Biochimica et biophysica acta. vol 1853. issue 7. 2015-08-25. PMID:25791428. |
abnormally hyperphosphorylated tau aggregates form paired helical filaments (phfs) in neurofibrillary tangles, a key hallmark of alzheimer's disease (ad) and other tauopathies. |
2015-08-25 |
2023-08-13 |
human |
| Genadiy Fonar, Abraham O Samso. NMR structure of the water soluble Aβ17-34 peptide. Bioscience reports. vol 34. issue 6. 2015-08-24. PMID:25284368. |
alzheimer's disease is characterized by aggregation of two proteins in the brain namely aβ (amyloid β) and tau. |
2015-08-24 |
2023-08-13 |
Not clear |
| Claire Paquet, Julien Dumurgier, Jacques Hugo. Pro-Apoptotic Kinase Levels in Cerebrospinal Fluid as Potential Future Biomarkers in Alzheimer's Disease. Frontiers in neurology. vol 6. 2015-08-24. PMID:26300842. |
alzheimer's disease (ad) is characterized by the accumulation of aβ peptides, hyperphosphorylated tau proteins, and neuronal loss in the brain of affected patients. |
2015-08-24 |
2023-08-13 |
human |
| Ilaria Dal Prà, Anna Chiarini, Li Gui, Balu Chakravarthy, Raffaella Pacchiana, Emanuela Gardenal, James F Whitfield, Ubaldo Armat. Do astrocytes collaborate with neurons in spreading the "infectious" aβ and Tau drivers of Alzheimer's disease? The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 21. issue 1. 2015-08-21. PMID:24740577. |
do astrocytes collaborate with neurons in spreading the "infectious" aβ and tau drivers of alzheimer's disease? |
2015-08-21 |
2023-08-13 |
human |
| Ilaria Dal Prà, Anna Chiarini, Li Gui, Balu Chakravarthy, Raffaella Pacchiana, Emanuela Gardenal, James F Whitfield, Ubaldo Armat. Do astrocytes collaborate with neurons in spreading the "infectious" aβ and Tau drivers of Alzheimer's disease? The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 21. issue 1. 2015-08-21. PMID:24740577. |
evidence has begun emerging for the "contagious" and destructive aβ42 (amyloid-beta42) oligomers and phosphorylated tau oligomers as drivers of sporadic alzheimer's disease (ad), which advances along a pathway starting from the brainstem or entorhinal cortex and leading to cognition-related upper cerebral cortex regions. |
2015-08-21 |
2023-08-13 |
human |
| Kristina Paholikova, Barbara Salingova, Alena Opattova, Rostislav Skrabana, Petra Majerova, Norbert Zilka, Branislav Kovacech, Monika Zilkova, Peter Barath, Michal Nova. N-terminal truncation of microtubule associated protein tau dysregulates its cellular localization. Journal of Alzheimer's disease : JAD. vol 43. issue 3. 2015-08-21. PMID:25147106. |
under pathological conditions, tau undergoes multiple modifications that lead to the formation of insoluble deposits in neurons, resulting in neuronal dysfunction in several neurodegenerative disorders collectively called tauopathies, with alzheimer's disease being the most frequent example. |
2015-08-21 |
2023-08-13 |
human |
| Sarah M Ciupek, Jingheng Cheng, Yousuf O Ali, Hui-Chen Lu, Daoyun J. Progressive functional impairments of hippocampal neurons in a tauopathy mouse model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 21. 2015-08-20. PMID:26019329. |
the age-dependent progression of tau pathology is a major characteristic of tauopathies, including alzheimer's disease (ad), and plays an important role in the behavioral phenotypes of ad, including memory deficits. |
2015-08-20 |
2023-08-13 |
mouse |
| Kim Henriksen, Inger Byrjalsen, Claus Christiansen, Morten Asser Karsda. Relationship between serum levels of tau fragments and clinical progression of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 43. issue 4. 2015-08-18. PMID:25171717. |
relationship between serum levels of tau fragments and clinical progression of alzheimer's disease. |
2015-08-18 |
2023-08-13 |
Not clear |
| Rasha M Hussein, Reem M Hashem, Laila A Rashe. Evaluation of the amyloid beta-GFP fusion protein as a model of amyloid beta peptides-mediated aggregation: a study of DNAJB6 chaperone. Frontiers in molecular neuroscience. vol 8. 2015-08-18. PMID:26283911. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by the accumulation and aggregation of extracellular amyloid β (aβ) peptides and intracellular aggregation of hyper-phosphorylated tau protein. |
2015-08-18 |
2023-08-13 |
human |
| Bess Frost, Jürgen Götz, Mel B Fean. Connecting the dots between tau dysfunction and neurodegeneration. Trends in cell biology. vol 25. issue 1. 2015-08-17. PMID:25172552. |
identifying the causes of abnormal tau phosphorylation and subsequent aggregation has been the focus of much research, and is currently a major target for the development of therapeutic interventions for tauopathies, including alzheimer's disease (ad). |
2015-08-17 |
2023-08-13 |
Not clear |
| Ting-Ting Chu, Qian-Qian Li, Tian Qiu, Zhan-Yi Sun, Zhi-Wen Hu, Yong-Xiang Chen, Yu-Fen Zhao, Yan-Mei L. Clearance of the intracellular high level of the tau protein directed by an artificial synthetic hydrolase. Molecular bioSystems. vol 10. issue 12. 2015-08-14. PMID:25308803. |
promoting clearance of intracellular excessive tau is a potential therapeutic strategy for treating alzheimer's disease. |
2015-08-14 |
2023-08-13 |
Not clear |
| Juciano Gasparotto, Mario Roberto Senger, Alice Kunzler, Adriana Degrossoli, Salvatore Giovanni de Simone, Rafael Calixto Bortolin, Nauana Somensi, Carolina Saibro Girardi, Celeste da Silva Freitas de Souza, Kátia da Silva Calabrese, Felipe Dal-Pizzol, José Claudio Fonseca Moreira, Floriano Paes Silva, Daniel Pens Gelai. Increased tau phosphorylation and receptor for advanced glycation endproducts (RAGE) in the brain of mice infected with Leishmania amazonensis. Brain, behavior, and immunity. vol 43. 2015-08-07. PMID:25014011. |
the aim of the present work was to investigate if peripheral infection of balb/c mice with leishmania amazonensis affects tau phosphorylation and rage protein content in the brain, which represent biochemical markers of neurodegenerative processes observed in diseases with a pro-inflammatory component, including alzheimer's disease and down syndrome. |
2015-08-07 |
2023-08-13 |
mouse |
| Petra Majerova, Monika Zilkova, Zuzana Kazmerova, Andrej Kovac, Kristina Paholikova, Branislav Kovacech, Norbert Zilka, Michal Nova. Microglia display modest phagocytic capacity for extracellular tau oligomers. Journal of neuroinflammation. vol 11. 2015-08-07. PMID:25217135. |
abnormal misfolded tau protein is a driving force of neurofibrillary degeneration in alzheimer's disease. |
2015-08-07 |
2023-08-13 |
Not clear |
| Nicole Maphis, Guixiang Xu, Olga N Kokiko-Cochran, Shanya Jiang, Astrid Cardona, Richard M Ransohoff, Bruce T Lamb, Kiran Bhaska. Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain. Brain : a journal of neurology. vol 138. issue Pt 6. 2015-08-07. PMID:25833819. |
pathological aggregation of tau is a hallmark of alzheimer's disease and related tauopathies. |
2015-08-07 |
2023-08-13 |
mouse |
| D Felsky, P Szeszko, L Yu, W G Honer, P L De Jager, J A Schneider, A K Malhotra, T Lencz, T Ikuta, J Pipitone, M M Chakravarty, N J Lobaugh, B H Mulsant, B G Pollock, J L Kennedy, D A Bennett, A N Voinesko. The SORL1 gene and convergent neural risk for Alzheimer's disease across the human lifespan. Molecular psychiatry. vol 19. issue 10. 2015-08-06. PMID:24166411. |
four independent samples were analyzed to determine effects of sorl1 genetic risk variants across the lifespan at multiple phenotypic levels: (1) microstructural integrity of white matter using diffusion tensor imaging in two healthy control samples (n=118, age 18-86; n=68, age 8-40); (2) gene expression using the braincloud postmortem healthy control sample (n=269, age 0-92) and (3) alzheimer's neuropathology (amyloid plaques and tau tangles) using a postmortem sample of healthy, mild cognitive impairment (mci) and alzheimer's individuals (n=710, age 66-108). |
2015-08-06 |
2023-08-12 |
human |
| Asami Kondo, Koorosh Shahpasand, Rebekah Mannix, Jianhua Qiu, Juliet Moncaster, Chun-Hau Chen, Yandan Yao, Yu-Min Lin, Jane A Driver, Yan Sun, Shuo Wei, Man-Li Luo, Onder Albayram, Pengyu Huang, Alexander Rotenberg, Akihide Ryo, Lee E Goldstein, Alvaro Pascual-Leone, Ann C McKee, William Meehan, Xiao Zhen Zhou, Kun Ping L. Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy. Nature. vol 523. issue 7561. 2015-08-06. PMID:26176913. |
traumatic brain injury (tbi), characterized by acute neurological dysfunction, is one of the best known environmental risk factors for chronic traumatic encephalopathy and alzheimer's disease, the defining pathologic features of which include tauopathy made of phosphorylated tau protein (p-tau). |
2015-08-06 |
2023-08-13 |
mouse |
| YoungDoo Kim, Hyejin Park, Jihoon Nah, Seowon Moon, WonJae Lee, Se-Hoon Hong, Tae-In Kam, Yong-Keun Jun. Essential role of POLDIP2 in Tau aggregation and neurotoxicity via autophagy/proteasome inhibition. Biochemical and biophysical research communications. vol 462. issue 2. 2015-08-04. PMID:25930997. |
in alzheimer's disease and other tauopathy, abnormal tau proteins form intracellular aggregates and tau filaments. |
2015-08-04 |
2023-08-13 |
human |
| Toshiki Uchihar. Pretangles and neurofibrillary changes: similarities and differences between AD and CBD based on molecular and morphological evolution. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 34. issue 6. 2015-08-03. PMID:24612177. |
in alzheimer disease, such tau deposition is considered to represent a premature state prior to fibril formation (ad-pretangles), later to form neurofibrillary tangles and finally ghost tangles. |
2015-08-03 |
2023-08-12 |
Not clear |
| Irene López-González, Margarita Carmona, Laura Arregui, Gabor G Kovacs, Isidre Ferre. αB-crystallin and HSP27 in glial cells in tauopathies. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 34. issue 6. 2015-08-03. PMID:24985029. |
the objective of this work was to assess the expression of αb-crystallin, phosphorylated αb-crystallin at ser59 and hsp27 in glial cells with and without tau deposits in progressive supranuclear palsy, corticobasal degeneration (cbd), argyrophilic grain disease (agd), pick's disease (pid), alzheimer's disease, frontotemporal lobar degeneration associated with mutations in the tau gene (ftld-tau), globular glial tauopathy (ggt) and tauopathy in the elderly. |
2015-08-03 |
2023-08-13 |
Not clear |