| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masaki Ikeda, Kimie Yonemura, Satoko Kakuda, Yuichi Tashiro, Yukio Fujita, Eriko Takai, Yukiko Hashimoto, Kouki Makioka, Natsumi Furuta, Koichi Ishiguro, Risa Maruki, Jun'ichi Yoshida, Osamu Miyaguchi, Tamao Tsukie, Ryouzou Kuwano, Tsuneo Yamazaki, Haruyasu Yamaguchi, Masakuni Amari, Masamitsu Takatama, Yasuo Harigaya, Koichi Okamot. Cerebrospinal fluid levels of phosphorylated tau and Aβ1-38/Aβ1-40/Aβ1-42 in Alzheimer's disease with PS1 mutations. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. vol 20. issue 2. 2013-12-11. PMID:23638752. |
cerebrospinal fluid levels of phosphorylated tau and aβ1-38/aβ1-40/aβ1-42 in alzheimer's disease with ps1 mutations. |
2013-12-11 |
2023-08-12 |
human |
| Ester Aso, Salvador Juvés, Rafael Maldonado, Isidro Ferre. CB2 cannabinoid receptor agonist ameliorates Alzheimer-like phenotype in AβPP/PS1 mice. Journal of Alzheimer's disease : JAD. vol 35. issue 4. 2013-12-10. PMID:23515018. |
in conclusion, the present study lends support to the idea that stimulation of cb2 receptors ameliorates several altered parameters in alzheimer's disease such as impaired memory and learning, neuroinflammation, oxidative stress damage and oxidative stress responses, selected tau kinases, and tau hyperphosphorylation around plaques. |
2013-12-10 |
2023-08-12 |
mouse |
| Geoffrey A Kerchner, Jeffrey D Bernstein, Michelle C Fenesy, Gayle K Deutsch, Manojkumar Saranathan, Michael M Zeineh, Brian K Rut. Shared vulnerability of two synaptically-connected medial temporal lobe areas to age and cognitive decline: a seven tesla magnetic resonance imaging study. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 42. 2013-12-10. PMID:24133269. |
the medial temporal lobe (mtl) is the first brain area to succumb to neurofibrillary tau pathology in alzheimer's disease (ad). |
2013-12-10 |
2023-08-12 |
human |
| Roshni C George, John Lew, Donald J Grave. Interaction of cinnamaldehyde and epicatechin with tau: implications of beneficial effects in modulating Alzheimer's disease pathogenesis. Journal of Alzheimer's disease : JAD. vol 36. issue 1. 2013-12-09. PMID:23531502. |
interaction of cinnamaldehyde and epicatechin with tau: implications of beneficial effects in modulating alzheimer's disease pathogenesis. |
2013-12-09 |
2023-08-12 |
Not clear |
| Roshni C George, John Lew, Donald J Grave. Interaction of cinnamaldehyde and epicatechin with tau: implications of beneficial effects in modulating Alzheimer's disease pathogenesis. Journal of Alzheimer's disease : JAD. vol 36. issue 1. 2013-12-09. PMID:23531502. |
abnormal modifications in tau such as hyperphosphorylation, oxidation, and glycation interfere with its interaction with microtubules leading to its dissociation and self-aggregation into neurofibrillary tangles, a hallmark of alzheimer's disease (ad). |
2013-12-09 |
2023-08-12 |
Not clear |
| Yuan Tian, Jerry C Chang, Emily Y Fan, Marc Flajolet, Paul Greengar. Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 42. 2013-12-09. PMID:24067654. |
the hallmarks of alzheimer's disease (ad) are the aggregates of amyloid-β (aβ) peptides and tau protein. |
2013-12-09 |
2023-08-12 |
Not clear |
| Bing Bai, Chadwick M Hales, Ping-Chung Chen, Yair Gozal, Eric B Dammer, Jason J Fritz, Xusheng Wang, Qiangwei Xia, Duc M Duong, Craig Street, Gloria Cantero, Dongmei Cheng, Drew R Jones, Zhiping Wu, Yuxin Li, Ian Diner, Craig J Heilman, Howard D Rees, Hao Wu, Li Lin, Keith E Szulwach, Marla Gearing, Elliott J Mufson, David A Bennett, Thomas J Montine, Nicholas T Seyfried, Thomas S Wingo, Yi E Sun, Peng Jin, John Hanfelt, Donna M Willcock, Allan Levey, James J Lah, Junmin Pen. U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 41. 2013-12-04. PMID:24023061. |
the universal presence of β-amyloid and tau in alzheimer's disease (ad) has facilitated advancement of the amyloid cascade and tau hypotheses that have dominated ad pathogenesis research and therapeutic development. |
2013-12-04 |
2023-08-12 |
human |
| Daphne W Frijlink, Joachim J Tilanus, Gerwin Rok. Elevated cerebrospinal fluid tau in Wernicke encephalopathy. BMJ case reports. vol 2012. 2013-12-02. PMID:22879004. |
cerebrospinal fluid (csf) tau is frequently used for diagnosis of several dementia subtypes, predominantly cjd and alzheimer's disease. |
2013-12-02 |
2023-08-12 |
Not clear |
| Timothy J Revett, Glen B Baker, Jack Jhamandas, Satyabrata Ka. Glutamate system, amyloid ß peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology. Journal of psychiatry & neuroscience : JPN. vol 38. issue 1. 2013-12-02. PMID:22894822. |
glutamate system, amyloid ß peptides and tau protein: functional interrelationships and relevance to alzheimer disease pathology. |
2013-12-02 |
2023-08-12 |
Not clear |
| Timothy J Revett, Glen B Baker, Jack Jhamandas, Satyabrata Ka. Glutamate system, amyloid ß peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology. Journal of psychiatry & neuroscience : JPN. vol 38. issue 1. 2013-12-02. PMID:22894822. |
this review discusses how the glutamatergic system is impaired in alzheimer disease and how interactions of amyloid ß and glutamate influence synaptic function, tau phosphorylation and neurodegeneration. |
2013-12-02 |
2023-08-12 |
Not clear |
| Bhumsoo Kim, Carey Backus, Sangsu Oh, Eva L Feldma. Hyperglycemia-induced tau cleavage in vitro and in vivo: a possible link between diabetes and Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 34. issue 3. 2013-12-02. PMID:23254634. |
hyperglycemia-induced tau cleavage in vitro and in vivo: a possible link between diabetes and alzheimer's disease. |
2013-12-02 |
2023-08-12 |
mouse |
| Urszula Wojda, Jacek Kuznick. Alzheimer's disease modeling: ups, downs, and perspectives for human induced pluripotent stem cells. Journal of Alzheimer's disease : JAD. vol 34. issue 3. 2013-12-02. PMID:23313930. |
the majority of the presently used models are based on the amyloid-β and hyperphosphorylated tau hypothesis, which resembles features of familial alzheimer's disease. |
2013-12-02 |
2023-08-12 |
human |
| H S Darusman, D Sajuthi, O Kalliokoski, K R Jacobsen, J Call, S J Schapiro, A Gjedde, K S P Abelson, J Ha. Correlations between serum levels of beta amyloid, cerebrospinal levels of tau and phospho tau, and delayed response tasks in young and aged cynomolgus monkeys (Macaca fascicularis). Journal of medical primatology. vol 42. issue 3. 2013-11-29. PMID:23530983. |
in an attempt to explore cynomolgus monkeys as an animal model for alzheimer's disease, the present study focused on the alzheimer's biomarkers beta amyloid 1-42 (aβ42 ) in serum, and total tau (t-tau) and phosphorylated tau (p-tau) levels in cerebrospinal fluid. |
2013-11-29 |
2023-08-12 |
monkey |
| Zhiyou Cai, Yong Yan, Yonglong Wan. Minocycline alleviates beta-amyloid protein and tau pathology via restraining neuroinflammation induced by diabetic metabolic disorder. Clinical interventions in aging. vol 8. 2013-11-26. PMID:23983461. |
compelling evidence has shown that diabetic metabolic disorder plays a critical role in the pathogenesis of alzheimer's disease, including increased expression of β-amyloid protein (aβ) and tau protein. |
2013-11-26 |
2023-08-12 |
rat |
| Laura J Blair, Bryce A Nordhues, Shannon E Hill, K Matthew Scaglione, John C O'Leary, Sarah N Fontaine, Leonid Breydo, Bo Zhang, Pengfei Li, Li Wang, Carl Cotman, Henry L Paulson, Martin Muschol, Vladimir N Uversky, Torsten Klengel, Elisabeth B Binder, Rakez Kayed, Todd E Golde, Nicole Berchtold, Chad A Dicke. Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. The Journal of clinical investigation. vol 123. issue 10. 2013-11-26. PMID:23999428. |
overexpression of fkbp51 in a tau transgenic mouse model revealed that fkbp51 preserved the species of tau that have been linked to alzheimer's disease (ad) pathogenesis, blocked amyloid formation, and decreased tangle load in the brain. |
2013-11-26 |
2023-08-12 |
mouse |
| Michael S Wolf. The role of tau in neurodegenerative diseases and its potential as a therapeutic target. Scientifica. vol 2012. 2013-11-26. PMID:24278740. |
key questions still remain open, such as the nature of the connection between the amyloid- β protein of alzheimer's disease and tau pathology. |
2013-11-26 |
2023-08-12 |
Not clear |
| Eva Alonso, Carmen Vale, Mercedes R Vieytes, Luis M Botan. Translocation of PKC by yessotoxin in an in vitro model of Alzheimer's disease with improvement of tau and β-amyloid pathology. ACS chemical neuroscience. vol 4. issue 7. 2013-11-25. PMID:23527608. |
translocation of pkc by yessotoxin in an in vitro model of alzheimer's disease with improvement of tau and β-amyloid pathology. |
2013-11-25 |
2023-08-12 |
mouse |
| Eva Alonso, Carmen Vale, Mercedes R Vieytes, Luis M Botan. Translocation of PKC by yessotoxin in an in vitro model of Alzheimer's disease with improvement of tau and β-amyloid pathology. ACS chemical neuroscience. vol 4. issue 7. 2013-11-25. PMID:23527608. |
since phosphodiesterases (pdes) are engaged in learning and memory, we studied the in vitro effect of the toxin against alzheimer's disease hallmarks and observed that pretreatment of cortical 3xtg-ad neurons with a low nanomolar concentration of yessotoxin showed a decrease expression of hyperphosphorylated tau isoforms and intracellular accumulation of amyloid-beta. |
2013-11-25 |
2023-08-12 |
mouse |
| Eva Alonso, Carmen Vale, Mercedes R Vieytes, Luis M Botan. Translocation of PKC by yessotoxin in an in vitro model of Alzheimer's disease with improvement of tau and β-amyloid pathology. ACS chemical neuroscience. vol 4. issue 7. 2013-11-25. PMID:23527608. |
the data presented here shows that 1 nm yessotoxin activates protein kinase c with beneficial effects over the main alzheimer's disease hallmarks, tau and aβ, in a cellular model obtained from 3xtg-ad fetuses. |
2013-11-25 |
2023-08-12 |
mouse |
| Izaak den Daas, Johan Wemer, Khalid Abou Farha, Wim Tamminga, Theo de Boer, Rob Spanjersberg, Michel M R F Struys, Anthony R Absalo. Serial CSF sampling over a period of 30 h via an indwelling spinal catheter in healthy volunteers: headache, back pain, tolerability and measured acetylcholine profile. European journal of clinical pharmacology. vol 69. issue 5. 2013-11-19. PMID:23143156. |
csf sampling in studies on drug candidates for alzheimer's disease have been conducted in evaluations of the biomarkers acetylcholine (ach), tau proteins, amyloid precursor protein and beta-amyloid fragments. |
2013-11-19 |
2023-08-12 |
human |